Yong‐Liang Jiang
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View article: Activation of Lysosomal Retrograde Transport Triggers TPC1‐IP3R1 Ca <sup>2+</sup> Crosstalk at Lysosome‐ER MCSs Leading to Lethal Depleting of ER Calcium
Activation of Lysosomal Retrograde Transport Triggers TPC1‐IP3R1 Ca <sup>2+</sup> Crosstalk at Lysosome‐ER MCSs Leading to Lethal Depleting of ER Calcium Open
Inter‐organellar signaling linkages in oncology are increasingly elucidated. However, the impact of lysosome‐endoplasmic reticulum (ER) interaction on tumor cell fate remains relatively unexplored. A novel interaction between lysosomes and…
View article: Case Report: Rare diffuse giant cell tumor of the tendon sheath in the cervical facet joint
Case Report: Rare diffuse giant cell tumor of the tendon sheath in the cervical facet joint Open
Giant Cell Tumor of the Tendon Sheath (GCTTS) is a rare neoplasm that can exhibit local aggressiveness but is generally benign. GCTTS is commonly classified into two subtypes: localized and diffuse, and rarely affects the axial skeleton. D…
View article: Assembly mechanism of the β‐carboxysome shell mediated by the chaperone <scp>CcmS</scp>
Assembly mechanism of the β‐carboxysome shell mediated by the chaperone <span>CcmS</span> Open
Summary Carboxysomes are self‐assembled bacterial microcompartments (BMCs) that encapsulate the enzymes RuBisCO and carbonic anhydrase into a proteinaceous shell, enhancing the efficiency of photosynthetic carbon fixation. The chaperone Cc…
View article: Case report: Intradural-extramedullary cervical spine clear cell meningioma mimicking a schwannoma in a child
Case report: Intradural-extramedullary cervical spine clear cell meningioma mimicking a schwannoma in a child Open
Clear cell meningioma (CCM) is an exceedingly rare subtype of meningioma, with spinal occurrences being even more uncommon. It predominantly affects children and is characterized by a high recurrence rate and poor prognosis, posing signifi…
View article: Rare posterior mediastinal hemangiomas invading the spinal cord through the intervertebral foramen and causing acute symptoms: illustrative case
Rare posterior mediastinal hemangiomas invading the spinal cord through the intervertebral foramen and causing acute symptoms: illustrative case Open
BACKGROUND Hemangioma is a rare vascular tumor characterized by endothelial cell proliferation that primarily occurs in soft tissues. While most cases in the paraspinal posterior mediastinum are clinically indolent, they can also exhibit a…
View article: Enhanced Flotation Separation of Iron and Silicon with Branched Block Polyethylene Oxide Polypropylene Oxide and Sodium Oleate: Mechanisms and Flotation Behavior
Enhanced Flotation Separation of Iron and Silicon with Branched Block Polyethylene Oxide Polypropylene Oxide and Sodium Oleate: Mechanisms and Flotation Behavior Open
This study explores the strengthening mechanism of the surfactant branched block polyethylene oxide–polypropylene oxide (BB-PEO-PPO) in sodium oleate (NaOL) flotation systems. A comprehensive characterization of BB-PEO-PPO was performed us…
View article: Atomized Reagent Addition with Synchronized Jet Pre-Mineralization to Enhance the Flotation Process: Study on Atomization Parameters and Mechanisms of Enhancement
Atomized Reagent Addition with Synchronized Jet Pre-Mineralization to Enhance the Flotation Process: Study on Atomization Parameters and Mechanisms of Enhancement Open
The atomized reagent and synchronous jet pre-mineralization technology, as a novel method to enhance the flotation process, increases the solubility of fatty acid collectors in pulp through atomized reagent application and improves the min…
View article: Modulation of Comorbid Chronic Neuropathic Pain and Anxiety-Like Behaviors by Glutamatergic Neurons in the Ventrolateral Periaqueductal Gray and the Analgesic and Anxiolytic Effects of Electroacupuncture
Modulation of Comorbid Chronic Neuropathic Pain and Anxiety-Like Behaviors by Glutamatergic Neurons in the Ventrolateral Periaqueductal Gray and the Analgesic and Anxiolytic Effects of Electroacupuncture Open
Comorbid chronic neuropathic pain and anxiety is a common disease that represents a major clinical challenge. The underlying mechanisms of chronic neuropathic pain and anxiety are not entirely understood, which limits the exploration of ef…
View article: Allosteric regulation of nitrate transporter NRT via the signaling protein PII
Allosteric regulation of nitrate transporter NRT via the signaling protein PII Open
Coordinated carbon and nitrogen metabolism is crucial for bacteria living in the fluctuating environments. Intracellular carbon and nitrogen homeostasis is maintained by a sophisticated network, in which the widespread signaling protein PI…
View article: A neural circuit associated with anxiety‐like behaviors induced by chronic inflammatory pain and the anxiolytic effects of electroacupuncture
A neural circuit associated with anxiety‐like behaviors induced by chronic inflammatory pain and the anxiolytic effects of electroacupuncture Open
Aims Negative emotions induced by chronic pain are a serious clinical problem. Electroacupuncture (EA) is a clinically proven safe and effective method to manage pain‐related negative emotions. However, the circuit mechanisms underlying th…
View article: Nonribosomal peptide synthetases require dynamic interaction between modular domains
Nonribosomal peptide synthetases require dynamic interaction between modular domains Open
Nonribosomal peptide synthetases (NRPSs) are large multidomain enzymes for the synthesis of a variety of bioactive peptides in a modular and pipelined fashion. Here, we investigated how the condensation (C) domain and the adenylation (A) d…
View article: Behaviors of anthracite under differential cyclic loading (DCL) after wet and dry cycling: Deformability and hysteresis characteristics
Behaviors of anthracite under differential cyclic loading (DCL) after wet and dry cycling: Deformability and hysteresis characteristics Open
This work focuses on the behaviours of anthracite under differential cyclic loading (DCL), also examining the impact of wet and dry cycles on behaviour of coal pillars in coal mine based underground water reservoirs (CMUWR). Seven sets of …
View article: Structural and enzymatic characterization of the sialidase SiaPG from <i>Porphyromonas gingivalis</i>
Structural and enzymatic characterization of the sialidase SiaPG from <i>Porphyromonas gingivalis</i> Open
The sialidases, which catalyze the hydrolysis of sialic acid from extracellular glycoconjugates, are a group of major virulence factors in various pathogenic bacteria. In Porphyromonas gingivalis , which causes human periodontal disease, s…
View article: Role of posttranslational modifications in memory and cognitive impairments caused by neonatal sevoflurane exposure
Role of posttranslational modifications in memory and cognitive impairments caused by neonatal sevoflurane exposure Open
With the advancement of technology, increasingly many newborns are receiving general anesthesia at a young age for surgery, other interventions, or clinical assessment. Anesthetics cause neurotoxicity and apoptosis of nerve cells, leading …
View article: Fine structure and assembly pattern of a minimal myophage Pam3
Fine structure and assembly pattern of a minimal myophage Pam3 Open
The myophage possesses a contractile tail that penetrates its host cell envelope. Except for investigations on the bacteriophage T4 with a rather complicated structure, the assembly pattern and tail contraction mechanism of myophage remain…
View article: Structural Insights into the Chaperone-Assisted Assembly of a Simplified Tail Fiber of the Myocyanophage Pam3
Structural Insights into the Chaperone-Assisted Assembly of a Simplified Tail Fiber of the Myocyanophage Pam3 Open
At the first step of phage infection, the receptor-binding proteins (RBPs) such as tail fibers are responsible for recognizing specific host surface receptors. The proper folding and assembly of tail fibers usually requires a chaperone enc…
View article: DNA looping mediates cooperative transcription activation
DNA looping mediates cooperative transcription activation Open
Transcription factors respond to multi-level stimuli and co-occupy promoter regions of target genes to activate RNA polymerase (RNAP) in a cooperative manner. To decipher the molecular mechanism, here we report two cryo-electron microscopy…
View article: Aspirin in combination with gastrodin protects cardiac function and mitigates gastric mucosal injury in response to myocardial ischemia/reperfusion
Aspirin in combination with gastrodin protects cardiac function and mitigates gastric mucosal injury in response to myocardial ischemia/reperfusion Open
Myocardial ischemia/reperfusion (I/R) injury after percutaneous coronary intervention (PCI) is common in acute myocardial infarction. Aspirin is commonly prescribed as anti-thrombotic therapy with coronary heart disease (CHD). However, lon…
View article: Effects of early lumbar cistern drainage of cerebrospinal fluid and combination of edaravone and nimodipine on vasospasm, intracranial pressure, inflammatory factors in traumatic subarachnoid hemorrhage
Effects of early lumbar cistern drainage of cerebrospinal fluid and combination of edaravone and nimodipine on vasospasm, intracranial pressure, inflammatory factors in traumatic subarachnoid hemorrhage Open
Purpose: To investigate the effect of early lumbar cistern drainage (LCD) of cerebrospinal fluid (CSF) and combination of edaravone and nimodipine on vasospasm, intracranial pressure (ICP), serum inflammation, S100 and vascular endothelial…
View article: Integration of the cyanophage-encoded phosphate binding protein into the cyanobacterial phosphate uptake system
Integration of the cyanophage-encoded phosphate binding protein into the cyanobacterial phosphate uptake system Open
To acquire phosphorus, cyanobacteria use the typical bacterial ABC-type phosphate transporter, which is composed of a periplasmic high-affinity phosphate-binding protein PstS and a channel formed by two transmembrane proteins PstC and PstA…
View article: Complex structure reveals <scp>CcmM</scp> and <scp>CcmN</scp> form a heterotrimeric adaptor in β‐carboxysome
Complex structure reveals <span>CcmM</span> and <span>CcmN</span> form a heterotrimeric adaptor in β‐carboxysome Open
Carboxysome is an icosahedral self‐assembled microcompartment that sequesters RuBisCO and carbonic anhydrases within a selectively permeable protein shell. The scaffolding proteins, CcmM, and CcmN were proposed to act as adaptors that cros…
View article: Analysis of Structure and function by the LysR-Type Transcriptional Regulator CbbR of Nostoc sp. PCC 7120
Analysis of Structure and function by the LysR-Type Transcriptional Regulator CbbR of Nostoc sp. PCC 7120 Open
The LysR-type Calvin–Benson–Bassham cycle transcriptional regulator CbbR plays an important role in CO 2 fixation in carbon metabolism in nature, which regulates the gene expression of the key enzyme RibisCO in the Calvin–Benson–Bassham (C…