Lei Fu
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View article: A free energy perturbation-assisted machine learning strategy for mimotope screening in neoantigen-based vaccine design
A free energy perturbation-assisted machine learning strategy for mimotope screening in neoantigen-based vaccine design Open
Neoantigen-based immunotherapy has emerged as a promising approach for cancer treatment. One key strategy in neoantigen-based vaccine design is to alter known neoantigens into enhanced mimotopes that elicit more robust immune responses. Ho…
View article: MGPRAG: Enhancing Medical Large Language Models via Precision Retrieval-Augmented Generation
MGPRAG: Enhancing Medical Large Language Models via Precision Retrieval-Augmented Generation Open
Large language models(LLMs) have demonstrated strong performance in general tasks, but remain insufficiently trusted in complex clinical question answering (CQA). This is largely due to concerns about the accuracy of the generated content.…
View article: Research on the current frequency forecasting of a power supply converter for heating the oil pipeline based on gradient boosting decision tree
Research on the current frequency forecasting of a power supply converter for heating the oil pipeline based on gradient boosting decision tree Open
When large-sized oil pipelines are subjected to skin effect heating under the constraint of limited current, the power supply converter must provide a higher current frequency. However, an inappropriate frequency can lead to increased ener…
View article: Differentiation of Multi-objective Data-driven Decision Pipeline
Differentiation of Multi-objective Data-driven Decision Pipeline Open
Real-world scenarios frequently involve multi-objective data-driven optimization problems, characterized by unknown problem coefficients and multiple conflicting objectives. Traditional two-stage methods independently apply a machine learn…
View article: Formation Criterion of Hydrogen-Induced Cracking in Steel Based on Fracture Mechanics
Formation Criterion of Hydrogen-Induced Cracking in Steel Based on Fracture Mechanics Open
A new criterion for hydrogen-induced cracking (HIC) that includes both the embrittlement effect and the loading effect of hydrogen was obtained theoretically. The surface cohesive energy and plastic deformation energy are reduced by hydrog…
View article: Interaction between plastic deformation and hydrogen damage behavior of 30CrMnSiNi2A steel
Interaction between plastic deformation and hydrogen damage behavior of 30CrMnSiNi2A steel Open
The interaction between plastic deformation and hydrogen damage behavior of 30CrMnSiNi2A steel was investigated by pre-strain tensile tests and hydrogen charging by electrochemical method. This paper mainly contains two parts. The plastic …