Y. Cheng
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View article: TRIM21-NUP98 interface accommodates structurally diverse molecular glue degraders
TRIM21-NUP98 interface accommodates structurally diverse molecular glue degraders Open
Molecular glue degraders enable targeted protein degradation by bridging interactions between target proteins and E3 ubiquitin ligases. Whereas some protein-protein interfaces exhibit the capacity to accommodate structurally diverse degrad…
View article: Selective degradation of multimeric proteins via chemically induced proximity to TRIM21
Selective degradation of multimeric proteins via chemically induced proximity to TRIM21 Open
Targeted protein degradation (TPD) has emerged as an effective strategy to eliminate disease-causing proteins by inducing their interactions with the protein degradation machinery. First-generation TPD agents exploit a limited set of broad…