Explanipedia

CD33 and clusterin interact biophysically and genetically to modulate Alzheimer risk Open

Roger B. Dodd, Masahiro Enomoto, Ye Zhou, Kenji Satô, Yalun Zhang , et al. · 2025

We report the results of structural, functional and genetic studies on the CD33 sialic acid- binding receptor that reveal how non-coding variants in CD33 alter risk for Alzheimer’s disease (AD). The full-length CD33 M isoform, whose expres…

Investigating the role of SORL1 in mediating AD‐specific endolysosomal phenotypes in neurons and microglia Open

Brooke A. DeRosa, Yalun Zhang, C. Golightly, Lauren Coombs, Lauren E. Rothschild , et al. · 2024

Background Dysregulation of endolysosomal trafficking is a major pathogenic mechanism in Alzheimer’s disease (AD). From the family of AD‐linked endosomal pathway genes, SORL1 stands out as one of the highest risk factors. SORL1 encodes an …

Mechanical Properties, Failure Modes, and Damage Development of Stratified Cemented Tailings Backfill under Uniaxial Compression Open

Wenbin Xu, Yalun Zhang, Wei Chen, Tong Sun, Yilin Sang · 2024

Layered cemented filling leads to a layered composite structure of cemented tailings backfill (CTB) composed of high-strength top and bottom layers, as well as a low-strength middle layer. To solve the problem of the low mechanical propert…

Fine-grained ship image classification and detection based on a vision transformer and multi-grain feature vector FPN model Open

Fengxiang Wang, Deying Yu, Liang Huang, Yalun Zhang, Yongbing Chen , et al. · 2024

In naval and civilian domains, meticulous ship classification and detection are paramount. Nevertheless, predominant research has gravitated toward leveraging Convolutional Neural Network (CNN)-centered methodologies, often overlooking the…

Isolation and Characterization of Yunnan Variants of the Pseudorabies Virus and Their Pathogenicity in Rats Open

Chunlian Song, Hua Ye, Xue Zhang, Yalun Zhang, Yonghui Li , et al. · 2024

Porcine pseudorabies has long existed in China and is a serious threat to the Chinese farming industry. To understand the prevalence and genetic variation of the porcine pseudorabies virus (PRV) and its pathogenicity in Yunnan Province, Ch…

Study on The Mechanism of Lung and Intestinal Injury in Piglets Infected With PRV Open

Xianghua Shu, Chunlian Song, Qiong Pan, Xue Zhang, Ying Zhang , et al. · 2024

In order to explore the relationship between lung and intestinal injury and microorganisms in piglets caused by PRV infection.36 piglets were randomly divided into the blank group and the exposed group (or PRV group). PBS and PRV 1mL/Piggy…

MicroRNA‐128 suppresses tau phosphorylation and reduces amyloid‐beta accumulation by inhibiting the expression of GSK3β, APPBP2, and mTOR in Alzheimer's disease Open

Siwen Li, Chi Him Poon, Zhigang Zhang, Ming Yue, Ruijun Chen , et al. · 2023

Introduction and Aims Alzheimer's disease (AD) is characterized by the abnormal accumulation of hyperphosphorylated tau proteins and amyloid‐beta (Aβ) peptides. Recent studies have shown that many microRNAs (miRNAs) are dysregulated in AD,…

Measuring Ultrasonic and Electrical Properties of Early-Age Cemented Tailings Backfill Open

Weilv Wu, Wenbin Xu, Yalun Zhang · 2023

The setting behavior strongly affects the workability and loading capacity of a fresh cemented tailings backfill (CTB). The Vicat test is a conventional way to measure the setting time of a fresh cementitious mixture, using a standard need…

Cooperative multi-target hunting by unmanned surface vehicles based on multi-agent reinforcement learning Open

Jiawei Xia, Yasong Luo, Zhikun Liu, Yalun Zhang, Haoran Shi , et al. · 2022

To solve the problem of multi-target hunting by an unmanned surface vehicle (USV) fleet, a hunting algorithm based on multi-agent reinforcement learning is proposed. Firstly, the hunting environment and kinematic model without boundary con…

Fine-Grained Ship Classification by Combining CNN and Swin Transformer Open

Liang Huang, Fengxiang Wang, Yalun Zhang, Qingxia Xu · 2022

The mainstream algorithms used for ship classification and detection can be improved based on convolutional neural networks (CNNs). By analyzing the characteristics of ship images, we found that the difficulty in ship image classification …

Recognition and Classification of Ship Images Based on SMS-PCNN Model Open

Fengxiang Wang, Liang Huang, Yalun Zhang, Qingxia Xu, Ruirui Zong · 2022

In the field of ship image recognition and classification, traditional algorithms lack attention to the differences between the grain of ship images. The differences in the hull structure of different categories of ships are reflected in t…

Author Correction: Anatomically revealed morphological patterns of pyramidal neurons in layer 5 of the motor cortex Open

Siqi Jiang, Yue Guan, Xing‐Qiu Chen, Xueyan Jia, Hong Ni , et al. · 2022

Objective Recognition of Tinnitus Location Using Electroencephalography Connectivity Features Open

Zhaobo Li, Xinzui Wang, Weidong Shen, Shiming Yang, David Zhao , et al. · 2022

Purpose: Tinnitus is a common but obscure auditory disease to be studied. This study will determine whether the connectivity features in electroencephalography (EEG) signals can be used as the biomarkers for an efficient and fast diagnosis…

The Investigation into the Internal Temperature Evolution and Mechanical Performance of Early-Age Cemented Tailings Backfill Suffering Frost Damage Open

Yalun Zhang, Wenbin Xu · 2022

Establishment of ddPCR detection technology system for three contaminants in fermented milk Open

Wei Zhou, LI Yong-bo, Yalun Zhang, Xian Li, Guohua Shi , et al. · 2022

Three typical contaminant bacteria, namely, Gluconobacter, Acetobacter, and Lactobacillus, were selected from fermented milk. The strong specific genes were screened as target sequences, and the droplet digital polymerase chain reaction (d…

Comparison of Essential Oils of Houttuynia cordata Thunb. from Different Processing Methods and Harvest Seasons Based on GC-MS and Chemometric Analysis Open

Xue Pan, Haiying Li, Dingfang Chen, Jinjin Zheng, Longhua Yin , et al. · 2021

Houttuyniae Herba (HH) refers to the dried aerial part of Houttuynia cordata Thunb. (DHC) or the fresh whole grass of Houttuynia cordata Thunb. (FHC), where DHC are harvested in summer and FHC around the year. However, harvest seasons and …

Amyloid-β toxicity modulates tau phosphorylation through the PAX6 signalling pathway Open

Yalun Zhang, Yi Zhang, Yahyah Aman, Cheung Toa Ng, Wing-Hin Chau , et al. · 2021

The molecular link between amyloid-β plaques and neurofibrillary tangles, the two pathological hallmarks of Alzheimer’s disease, is still unclear. Increasing evidence suggests that amyloid-β peptide activates multiple regulators of cell cy…

Signals classification based on IA-optimal CNN Open

Yalun Zhang, Wenjing Yu, Lin He, Lilin Cui, Guo Cheng · 2021

Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation Open

Anna Vilalta, Zhou Ye, Jean Sévalle, Jennifer K. Griffin, Kanayo Satoh , et al. · 2021

TREM2 is a pattern recognition receptor, expressed on microglia and myeloid cells, detecting lipids andAβ and inducing an innate immune response. Missense mutations (e.g., R47H) of TREM2 increase risk of Alzheimer’s disease (AD). The solub…

A Vibrational Signal Fault Diagnosis Rule Extraction Method Based on DST‐ACI Discriminant Criterion Open

Yalun Zhang, Lin He, Guo Cheng · 2021

A fault diagnosis rule extraction method oriented to machine foot signal based on dynamic support threshold and association coefficient interestingness (DST‐ACI) discriminant criterion is proposed in this paper. The new method includes thr…

Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation Open

Anna Vilalta, Ye Zhou, Jean Sévalle, Jennifer K. Griffin, Kanayo Satoh , et al. · 2021

Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, while the Alzheimer’s R47H mutant does the opposite Open

Anna Vilalta, Ye Zhou, Jean Sévalle, Jennifer K. Griffin, Kanayo Satoh , et al. · 2020

Missense mutations (e.g. R47H) of the microglial receptor TREM2 increase risk of Alzheimer’s disease (AD), and the soluble ectodomain of wild-type TREM2 (sTREM2) appears to protect in vivo, but the underlying mechanisms are unclear. We sho…

Anatomically revealed morphological patterns of pyramidal neurons in layer 5 of the motor cortex Open

Siqi Jiang, Yue Guan, Xing‐Qiu Chen, Xueyan Jia, Ní Hóng , et al. · 2020

Identification and quantification of cassava starch adulteration in different food starches by droplet digital PCR Open

Jia Chen, Yalun Zhang, Chen Chen, Yan Zhang, Wei Zhou , et al. · 2020

We report a rapid and accurate quantitative detection method using droplet digital PCR (ddPCR) technology to identify cassava adulteration in starch products. The ddPCR analysis showed that the weight of cassava (M) and cassava-extracted D…

APPLICATION ANALYSIS OF SIMILARITY PRINCIPLE IN THE DESIGN OF THE UNDERWATER RECEIVING ANTENNA Open

Shiyu Wang, Lihua Li, Yalun Zhang, Yongbin Wang · 2020

Pinpointing Morphology and Projection of Excitatory Neurons in Mouse Visual Cortex Open

Yalun Zhang, Siqi Jiang, Zhengchao Xu, Hui Gong, Anan Li , et al. · 2019

The excitatory neurons in the visual cortex are of great significance for us in understanding brain functions. However, the diverse neuron types and their morphological properties have not been fully deciphered. In this paper, we applied t…

Identification of Common Adulterants in Walnut Beverage Based on Plant DNA Barcode Technology Open

Qing Han, Yan Zhang, Ying Shu, Jia Chen, Yalun Zhang , et al. · 2018

Walnut beverage is a common vegetable protein drink that is rich in proteins and has a wide consumption market. In this study, a plant DNA barcode technology was used to establish a method to identify common adulterated ingredients (peanut…

Mutations in Hnrnpa1 cause congenital heart defects Open

Zhe Yu, Paul Ling-Fung Tang, Jing Wang, Suying Bao, Joseph T.C. Shieh , et al. · 2018

Incomplete penetrance of congenital heart defects (CHDs) was observed in a mouse model. We hypothesized that the contribution of a major genetic locus modulates the manifestation of the CHDs. After genome-wide linkage mapping, fine mapping…

Generation of a whole-brain atlas for the cholinergic system and mesoscopic projectome analysis of basal forebrain cholinergic neurons Open

Xiangning Li, Bin Yu, Qingtao Sun, Yalun Zhang, Miao Ren , et al. · 2017

Significance The cholinergic system plays a critical role in neural modulation of the mammalian brain. Here, we generated a comprehensive atlas of the cholinergic system in the mouse brain via the whole-brain imaging and reconstruction sys…

Single-axon level morphological analysis of corticofugal projection neurons in mouse barrel field Open

Congdi Guo, Jie Peng, Yalun Zhang, Anan Li, Yuxin Li , et al. · 2017

Corticofugal projection neurons are key components in connecting the neocortex and the subcortical regions. In the barrel field, these neurons have various projection targets and play crucial roles in the rodent whisker sensorimotor system…

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