Yama Abassi
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View article: Bio-functional hydrogel coated membranes to decrease T-cell exhaustion in manufacturing of CAR T-cells
Bio-functional hydrogel coated membranes to decrease T-cell exhaustion in manufacturing of CAR T-cells Open
Introduction Cell therapies have revolutionized cancer treatment, with chimeric antigen receptor (CAR) T-cell therapies at the forefront for the treatment of hematological cancers. However, current manufacturing protocols rely on rapid T-c…
View article: 442-G Metabolic reprogramming regulates anti-tumor effects of engineered CAR/TCR T cells
442-G Metabolic reprogramming regulates anti-tumor effects of engineered CAR/TCR T cells Open
Background Immunotherapy (IMT) has shown tremendous success in hematological cancers. However, an important obstacle to using IMT for solid tumors is the aggressive tumor microenvironment (TME). To significantly improve clinical prognosis …
View article: Data from Natural product derivative Bis(4-fluorobenzyl)trisulfide inhibits tumor growth by modification of β-tubulin at Cys 12 and suppression of microtubule dynamics
Data from Natural product derivative Bis(4-fluorobenzyl)trisulfide inhibits tumor growth by modification of β-tubulin at Cys 12 and suppression of microtubule dynamics Open
Bis(4-fluorobenzyl)trisulfide (BFBTS) is a synthetic molecule derived from a bioactive natural product, dibenzyltrisulfide, found in a subtropical shrub, Petiveria allieacea. BFBTS has potent anticancer activities to a broad spectrum of tu…
View article: Data from Natural product derivative Bis(4-fluorobenzyl)trisulfide inhibits tumor growth by modification of β-tubulin at Cys 12 and suppression of microtubule dynamics
Data from Natural product derivative Bis(4-fluorobenzyl)trisulfide inhibits tumor growth by modification of β-tubulin at Cys 12 and suppression of microtubule dynamics Open
Bis(4-fluorobenzyl)trisulfide (BFBTS) is a synthetic molecule derived from a bioactive natural product, dibenzyltrisulfide, found in a subtropical shrub, Petiveria allieacea. BFBTS has potent anticancer activities to a broad spectrum of tu…
View article: Supplementary Figure 1, Table 1 from Natural product derivative Bis(4-fluorobenzyl)trisulfide inhibits tumor growth by modification of β-tubulin at Cys 12 and suppression of microtubule dynamics
Supplementary Figure 1, Table 1 from Natural product derivative Bis(4-fluorobenzyl)trisulfide inhibits tumor growth by modification of β-tubulin at Cys 12 and suppression of microtubule dynamics Open
Supplementary Figure 1, Table 1 from Natural product derivative Bis(4-fluorobenzyl)trisulfide inhibits tumor growth by modification of β-tubulin at Cys 12 and suppression of microtubule dynamics
View article: Supplementary Figure 1, Table 1 from Natural product derivative Bis(4-fluorobenzyl)trisulfide inhibits tumor growth by modification of β-tubulin at Cys 12 and suppression of microtubule dynamics
Supplementary Figure 1, Table 1 from Natural product derivative Bis(4-fluorobenzyl)trisulfide inhibits tumor growth by modification of β-tubulin at Cys 12 and suppression of microtubule dynamics Open
Supplementary Figure 1, Table 1 from Natural product derivative Bis(4-fluorobenzyl)trisulfide inhibits tumor growth by modification of β-tubulin at Cys 12 and suppression of microtubule dynamics
View article: 188 Arginine pre-conditioning enhances T-cell potency and metabolic fitness
188 Arginine pre-conditioning enhances T-cell potency and metabolic fitness Open
Background Enhanced T-cell performance is imperative for the success of adoptive T-cell-based therapies. Here we assessed the killing efficiency of MART-1 specific TCR T-cells after Arg, Gln, and Leu pre-conditioning using the Agilent xCEL…
View article: 12 Evaluating the contribution of extracellular matrix invasion for killing of tumor cells by natural killer cells
12 Evaluating the contribution of extracellular matrix invasion for killing of tumor cells by natural killer cells Open
Background Extracellular matrix (ECM) is a generic term for the diverse types of acellular structural component in tissues that play an important role in homeostasis. The ECM in solid tumors is greatly altered and can contribute to the mod…
View article: Analysis of acute lymphoblastic leukemia drug sensitivity by changes in impedance via stromal cell adherence
Analysis of acute lymphoblastic leukemia drug sensitivity by changes in impedance via stromal cell adherence Open
The bone marrow is a frequent location of primary relapse after conventional cytotoxic drug treatment of human B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Because stromal cells have a major role in promoting chemotherapy resis…
View article: A Real-time Potency Assay for Chimeric Antigen Receptor T Cells Targeting Solid and Hematological Cancer Cells
A Real-time Potency Assay for Chimeric Antigen Receptor T Cells Targeting Solid and Hematological Cancer Cells Open
Chimeric antigen receptor (CAR) T-cell therapy for cancer has achieved significant clinical benefit for resistant and refractory hematological malignancies such as childhood acute lymphocytic leukemia. Efforts are currently underway to ext…
View article: Cross-Site Reliability of Human Induced Pluripotent stem cell-derived Cardiomyocyte Based Safety Assays Using Microelectrode Arrays: Results from a Blinded CiPA Pilot Study
Cross-Site Reliability of Human Induced Pluripotent stem cell-derived Cardiomyocyte Based Safety Assays Using Microelectrode Arrays: Results from a Blinded CiPA Pilot Study Open
Recent in vitro cardiac safety studies demonstrate the ability of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to detect electrophysiologic effects of drugs. However, variability contributed by unique approaches, …
View article: In vitro immunotherapy potency assays using real-time cell analysis
In vitro immunotherapy potency assays using real-time cell analysis Open
A growing understanding of the molecular interactions between immune effector cells and target tumor cells, coupled with refined gene therapy approaches, are giving rise to novel cancer immunotherapeutics with remarkable efficacy in the cl…
View article: Measurement of myofilament calcium in living cardiomyocytes using a targeted genetically encoded indicator
Measurement of myofilament calcium in living cardiomyocytes using a targeted genetically encoded indicator Open
Visualising when and where calcium appears and disappears in cardiomyocytes is a major goal of cardiovascular research. Surprisingly we find that the chemical dyes widely used for this purpose disrupt cell contractility, due at least in pa…
View article: 31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two Open
Background
\nThe immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune chec…
View article: Using impedance-based approaches for measuring cell-mediated cytotoxicity and antibody-dependent cell-mediated cytotoxicity (ADCC)
Using impedance-based approaches for measuring cell-mediated cytotoxicity and antibody-dependent cell-mediated cytotoxicity (ADCC) Open
Meeting abstracts The most common method for measuring cell-mediated cytotoxicity is the release assay. Effector cell-mediated disruption of the target cell membrane results in leakage of its cytoplasmic contents into the culture medium. E…