Yaming Xi
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View article: Gallic acid alleviates visceral hyperalgesia following maternal separation in mice by inhibiting EphrinB2/EphB2 signaling mediated activation of neurons and glial cells
Gallic acid alleviates visceral hyperalgesia following maternal separation in mice by inhibiting EphrinB2/EphB2 signaling mediated activation of neurons and glial cells Open
Background Early life stress (ELS) causes functional gastrointestinal issues linked to visceral hyperalgesia. Activation of spinal neurons and glial cells is key to the development and persistence of visceral hyperalgesia. Our previous res…
View article: Epidemiology and genetic characteristics of <i>Clostridioides difficile</i> isolates in Northwest China
Epidemiology and genetic characteristics of <i>Clostridioides difficile</i> isolates in Northwest China Open
Clostridioides difficile (C. difficile) is a significant hospital-acquired pathogen that can cause antibiotic-associated diarrhea. In this study, we investigate the epidemiological and genetic characteristics of C. difficile isolates from …
View article: PABPN1 as a pan-cancer biomarker: prognostic significance and association with tumor immune microenvironment
PABPN1 as a pan-cancer biomarker: prognostic significance and association with tumor immune microenvironment Open
Objective This study aimed to investigate the role of poly(A) binding protein nuclear 1 (PABPN1) as a potential pan-cancer biomarker for prognosis and immunotherapy. Methods The original datasets were acquired from TCGA and GEO databases. …
View article: 4D quantitative proteomics of ovarian granulosa cells reveals the involvement of oxidative phosphorylation in non-elderly women with diminished ovarian reserve
4D quantitative proteomics of ovarian granulosa cells reveals the involvement of oxidative phosphorylation in non-elderly women with diminished ovarian reserve Open
We present the first data on the protein expression profiles in ovarian GCs from NOR and Poseidon Group III patients using 4D proteomics. The proteins identified in this study could serve as potential novel biomarkers for Poseidon Group II…
View article: FLT3 inhibition upregulates OCT4/NANOG to promote maintenance and TKI resistance of FLT3-ITD+ acute myeloid leukemia
FLT3 inhibition upregulates OCT4/NANOG to promote maintenance and TKI resistance of FLT3-ITD+ acute myeloid leukemia Open
View article: Glymphatic system: a self-purification circulation in brain
Glymphatic system: a self-purification circulation in brain Open
The glymphatic system theory introduces a new perspective on fluid flow and homeostasis in the brain. Here, cerebrospinal fluid and interstitial fluid (CSF-ISF) moves from the perivascular spaces (PVS) of arteries to those of veins for dra…
View article: Combined anti-leukemic effect of gilteritinib and GSK-J4 in FLT3-ITD+ acute myeloid leukemia
Combined anti-leukemic effect of gilteritinib and GSK-J4 in FLT3-ITD+ acute myeloid leukemia Open
View article: Liposomal mitoxantrone monotherapy in patients with relapsed or refractory mature T‐cell and natural killer‐cell neoplasms: A phase 2, multicenter, open‐label, single‐arm trial
Liposomal mitoxantrone monotherapy in patients with relapsed or refractory mature T‐cell and natural killer‐cell neoplasms: A phase 2, multicenter, open‐label, single‐arm trial Open
Introduction The prognosis of relapsed or refractory mature T‐ and natural killer (NK)‐cell lymphoma remains dismal. Novel agents are urgently needed to improve the outcomes for this population. Methods In this phase 2, multicenter, open‐l…
View article: Discovery of Novel Pyrimidine-4,6-Diamine-Based Olig2 Inhibitors as Potent Anti-Glioblastoma Agents
Discovery of Novel Pyrimidine-4,6-Diamine-Based Olig2 Inhibitors as Potent Anti-Glioblastoma Agents Open
View article: Characterization and integrated analysis of extrachromosomal DNA amplification in hematological malignancies
Characterization and integrated analysis of extrachromosomal DNA amplification in hematological malignancies Open
The study of extrachromosomal DNA (ecDNA), an element existing beyond classical chromosomes, contributes to creating a more comprehensive map of the cancer genome. In hematological malignancies, research on ecDNA has lacked comprehensive i…
View article: FLT3 inhibition upregulates OCT4/NANOG to promote proliferation and TKI resistance of FLT3-ITD+ acute myeloid leukemia
FLT3 inhibition upregulates OCT4/NANOG to promote proliferation and TKI resistance of FLT3-ITD+ acute myeloid leukemia Open
Background: Up to 30% of acute myeloid leukemia (AML) patients face unfavorable outcomes due to the FMS-like receptor tyrosine kinase-3 (FLT3) internal tandem duplication (ITD) mutation. Although FLT3 inhibitors show encouraging outcomes i…
View article: Epigenetic regulatory differentiation of hematopoietic stem cells to the red lineage
Epigenetic regulatory differentiation of hematopoietic stem cells to the red lineage Open
The differentiation process from hematopoietic stem cells (HSCs) to mature red blood cells (RBCs) is characterized by remarkable precision and is tightly controlled from the initial lineage commitment to eventual terminal differentiation. …
View article: Retraction Note: Three-Dimensional Ni(II)-MOF Containing an Asymmetric Pyridyl-Carboxylate Ligand: Catalytic Cyanosilylation of Aldehydes and Inhibits Human Promyelocytic Leukemia Cancer Cells
Retraction Note: Three-Dimensional Ni(II)-MOF Containing an Asymmetric Pyridyl-Carboxylate Ligand: Catalytic Cyanosilylation of Aldehydes and Inhibits Human Promyelocytic Leukemia Cancer Cells Open
View article: GOLIDOCITINIB IN TREATING REFRACTORY OR RELAPSED PERIPHERAL T‐CELL LYMPHOMA: PRIMARY ANALYSIS OF THE MULTINATIONAL PIVOTAL STUDY RESULTS (JACKPOT8)
GOLIDOCITINIB IN TREATING REFRACTORY OR RELAPSED PERIPHERAL T‐CELL LYMPHOMA: PRIMARY ANALYSIS OF THE MULTINATIONAL PIVOTAL STUDY RESULTS (JACKPOT8) Open
Introduction: Currently there is no consensus on the treatment of relapsed/refractory (r/r) PTCL, and patient prognosis was poor. Golidocitinib is an orally available, JAK1-selective inhibitor currently being evaluated in a multinational, …
View article: Identifying a prognostic model and screening of potential natural compounds for acute myeloid leukemia
Identifying a prognostic model and screening of potential natural compounds for acute myeloid leukemia Open
The predictive model of RHOBTB2, PLA2G4A, IL2RA, CSRP1, and OLFML2A combined with clinical features can better guide the prognosis of AML. In addition, the stable docking of PLA2G4A, IL2RA, …
View article: The non-coding competing endogenous RNAs in acute myeloid leukemia: biological and clinical implications
The non-coding competing endogenous RNAs in acute myeloid leukemia: biological and clinical implications Open
Acute myeloid leukemia (AML) is a hematologic carcinoma that has seen a considerable improvement in patient prognosis because of genetic diagnostics and molecularly-targeted therapies. Nevertheless, recurrence and drug resistance remain si…
View article: Efficacy and safety of the B‐domain‐deleted TQG202 for on‐demand treatment in moderate and severe haemophilia A patients: A multicentre, single‐arm trial
Efficacy and safety of the B‐domain‐deleted TQG202 for on‐demand treatment in moderate and severe haemophilia A patients: A multicentre, single‐arm trial Open
Introduction On‐demand treatment is the most common treatment strategy for haemophilia A in China. Aim This study aims to evaluate the efficacy and safety of a human‐derived B‐domain‐deleted recombinant factor VIII (TQG202) in the on‐deman…
View article: Efficacy, safety and bioequivalence of the human‐derived B‐domain‐deleted recombinant factor VIII TQG202 for prophylaxis in severe haemophilia A patients
Efficacy, safety and bioequivalence of the human‐derived B‐domain‐deleted recombinant factor VIII TQG202 for prophylaxis in severe haemophilia A patients Open
Introduction Current treatment of severe haemophilia A includes prophylaxis with factor VIII (FVIII) replacement. The supply of plasma‐derived FVIII is short in China. Purpose To evaluate the efficacy and safety of a new B‐domain deleted (…
View article: Associations between morphokinetic parameters of temporary-arrest embryos and the clinical prognosis in FET cycles
Associations between morphokinetic parameters of temporary-arrest embryos and the clinical prognosis in FET cycles Open
Infertility is a major health concern worldwide. This retrospective study aimed to assess the predictive value of the morphokinetic parameters of temporary-arrest embryos for the pregnancy outcomes of women undergoing frozen embryo transfe…
View article: Higher red blood cell distribution width at diagnose is a simple negative prognostic factor in chronic phase-chronic myeloid leukemia patients treated with tyrosine kinase inhibitors
Higher red blood cell distribution width at diagnose is a simple negative prognostic factor in chronic phase-chronic myeloid leukemia patients treated with tyrosine kinase inhibitors Open
The aim of this study was to evaluate the ability of the red blood cell distribution width (RDW) to predict prognosis and treatment response in chronic myeloid leukemia (CML)-chronic phase (CP) patients treated with tyrosine kinase inhibit…
View article: Efficacy and safety of geptanolimab (GB226) for relapsed or refractory peripheral T cell lymphoma: an open-label phase 2 study (Gxplore-002)
Efficacy and safety of geptanolimab (GB226) for relapsed or refractory peripheral T cell lymphoma: an open-label phase 2 study (Gxplore-002) Open
View article: Identification of mast cells as a candidate significant target of immunotherapy for acute myeloid leukemia
Identification of mast cells as a candidate significant target of immunotherapy for acute myeloid leukemia Open
The hub genes and drugs have high research value and clinical application in AML therapy. Our study not only provides gene targets and small molecule drugs for AML immunotherapy concerning mast cells but also provides new ideas for researc…
View article: Occult olfactory neuroblastoma presenting with multiple bone metastases: a case report
Occult olfactory neuroblastoma presenting with multiple bone metastases: a case report Open
Rationable: Olfactory neuroblastoma (ONB) is a rare malignant tumor of the nasal cavity, the primary local symptoms are usually inconspicuous. Patients are often admitted to various specialties based on different primary symptoms, which ma…
View article: Identification of co-expressed genes associated with <i>MLL</i> rearrangement in pediatric acute lymphoblastic leukemia
Identification of co-expressed genes associated with <i>MLL</i> rearrangement in pediatric acute lymphoblastic leukemia Open
Rearrangements involving the mixed lineage leukemia (MLL) gene are common adverse prognostic factors of pediatric acute lymphoblastic leukemia (ALL). Even allogeneic hematopoietic stem cell transplantation does not improve the outcome of A…
View article: Efficacy and Safety of Geptanolimab (GB226) for Relapsed or Refractory Peripheral T-Cell Lymphoma: An Open-Label Phase 2 Study (Gxplore-002)
Efficacy and Safety of Geptanolimab (GB226) for Relapsed or Refractory Peripheral T-Cell Lymphoma: An Open-Label Phase 2 Study (Gxplore-002) Open
View article: Identification of hub genes and molecular mechanisms in infant acute lymphoblastic leukemia with <i>MLL</i> gene rearrangement
Identification of hub genes and molecular mechanisms in infant acute lymphoblastic leukemia with <i>MLL</i> gene rearrangement Open
Infant acute lymphoblastic leukemia (ALL) with the mixed lineage leukemia ( MLL ) gene rearrangement ( MLL -R) is considered a distinct leukemia from childhood or non- MLL -R infant ALL. To detect key genes and elucidate the molecular mech…
View article: Peer Review #3 of "Identification of hub genes and molecular mechanisms in infant acute lymphoblastic leukemia with MLL gene rearrangement (v0.2)"
Peer Review #3 of "Identification of hub genes and molecular mechanisms in infant acute lymphoblastic leukemia with MLL gene rearrangement (v0.2)" Open
Infant acute lymphoblastic leukemia (ALL) with the mixed lineage leukemia (MLL) gene rearrangement (MLL-R) is considered a distinct leukemia from childhood or non-MLL-R infant ALL.To detect key genes and elucidate the molecular mechanisms …
View article: Peer Review #3 of "Identification of hub genes and molecular mechanisms in infant acute lymphoblastic leukemia with MLL gene rearrangement (v0.1)"
Peer Review #3 of "Identification of hub genes and molecular mechanisms in infant acute lymphoblastic leukemia with MLL gene rearrangement (v0.1)" Open
Infant acute lymphoblastic leukemia (ALL) with the mixed lineage leukemia (MLL) gene rearrangement (MLL-R) is considered a distinct leukemia from childhood or non-MLL-R infant ALL.To detect key genes and elucidate the molecular mechanisms …
View article: Peer Review #2 of "Identification of hub genes and molecular mechanisms in infant acute lymphoblastic leukemia with MLL gene rearrangement (v0.1)"
Peer Review #2 of "Identification of hub genes and molecular mechanisms in infant acute lymphoblastic leukemia with MLL gene rearrangement (v0.1)" Open
Infant acute lymphoblastic leukemia (ALL) with the mixed lineage leukemia (MLL) gene rearrangement (MLL-R) is considered a distinct leukemia from childhood or non-MLL-R infant ALL.To detect key genes and elucidate the molecular mechanisms …
View article: Bleeding with negative coagulation screening test as initial presentation of chronic myelogenous leukemia managed by fresh frozen plasma
Bleeding with negative coagulation screening test as initial presentation of chronic myelogenous leukemia managed by fresh frozen plasma Open
Introduction: Chronic myelogenous leukemia (CML), a clonal disorder of pluripotent stem cell, rarely presents with bleeding in chronic phase due to the function preservation of the platelets. Factor (F) XIII deficiency, an extremely rare h…