Yan Burelle
YOU?
Author Swipe
View article: Extracellular Vesicle Mitochondrial DNA Reflects Podocyte Mitochondrial Stress and Is Associated with Relapse in Nephrotic Syndrome
Extracellular Vesicle Mitochondrial DNA Reflects Podocyte Mitochondrial Stress and Is Associated with Relapse in Nephrotic Syndrome Open
Idiopathic childhood nephrotic syndrome is a common glomerulopathy comprising proteinuria, hypoalbuminemia, and edema. Podocyte dysfunction is central to this disease process. Extracellular vesicles are released from stressed cells and can…
View article: PINK1 deficiency alters muscle stem cell fate decision and muscle regenerative capacity
PINK1 deficiency alters muscle stem cell fate decision and muscle regenerative capacity Open
View article: A genetic mouse model of lean-NAFLD unveils sexual dimorphism in the liver-heart axis
A genetic mouse model of lean-NAFLD unveils sexual dimorphism in the liver-heart axis Open
Lean patients with NAFLD may develop cardiac complications independently of pre-existent metabolic disruptions and comorbidities. To address the underlying mechanisms independent of the development of obesity, we used a murine model of hep…
View article: Perturbations in lipid metabolism and gut microbiota composition precede cardiac dysfunction in a mouse model of thalassemia
Perturbations in lipid metabolism and gut microbiota composition precede cardiac dysfunction in a mouse model of thalassemia Open
Cardiomyopathy is a major complication of thalassemia, yet the precise underlying molecular mechanisms remain unclear. We examined whether altered lipid metabolism is an early driving factor in the development of cardiomyopathy using the T…
View article: Radiation induces long‐term muscle fibrosis and promotes a fibrotic phenotype in fibro‐adipogenic progenitors
Radiation induces long‐term muscle fibrosis and promotes a fibrotic phenotype in fibro‐adipogenic progenitors Open
Background Radiation‐induced muscle pathology, characterized by muscle atrophy and fibrotic tissue accumulation, is the most common debilitating late effect of therapeutic radiation exposure particularly in juvenile cancer survivors. In he…
View article: PINK1 Deficiency Alters Muscle Stem Cell Fate Decision and Muscle Regenerative Capacity
PINK1 Deficiency Alters Muscle Stem Cell Fate Decision and Muscle Regenerative Capacity Open
Maintenance of optimal mitochondrial function plays a crucial role in the regulation of muscle stem cell (MuSC) behavior, but the underlying maintenance mechanisms remain ill defined. In this study, we explored the importance of mitophagy,…
View article: Discovery-Based Proteomics Identify Skeletal Muscle Mitochondrial Alterations as an Early Metabolic Defect in a Mouse Model of β-Thalassemia
Discovery-Based Proteomics Identify Skeletal Muscle Mitochondrial Alterations as an Early Metabolic Defect in a Mouse Model of β-Thalassemia Open
Although metabolic complications are common in thalassemia patients, there is still an unmet need to better understand underlying mechanisms. We used unbiased global proteomics to reveal molecular differences between the th3/+ mouse model …
View article: The mitochondrial protein OPA1 regulates the quiescent state of adult muscle stem cells
The mitochondrial protein OPA1 regulates the quiescent state of adult muscle stem cells Open
View article: The intra-mitochondrial O-GlcNAcylation system rapidly modulates OXPHOS function and ROS release in the heart
The intra-mitochondrial O-GlcNAcylation system rapidly modulates OXPHOS function and ROS release in the heart Open
View article: Cardiac Left Ventricle Mitochondrial Dysfunction After Neonatal Exposure to Hyperoxia: Relevance for Cardiomyopathy After Preterm Birth
Cardiac Left Ventricle Mitochondrial Dysfunction After Neonatal Exposure to Hyperoxia: Relevance for Cardiomyopathy After Preterm Birth Open
Background: Individuals born preterm present left ventricle changes and increased risk of cardiac diseases and heart failure. The pathophysiology of heart disease after preterm birth is incompletely understood. Mitochondria dysfunction is …
View article: Dietary Cocoa Flavanols Enhance Mitochondrial Function in Skeletal Muscle and Modify Whole-Body Metabolism in Healthy Mice
Dietary Cocoa Flavanols Enhance Mitochondrial Function in Skeletal Muscle and Modify Whole-Body Metabolism in Healthy Mice Open
Mitochondrial dysfunction is widely reported in various diseases and contributes to their pathogenesis. We assessed the effect of cocoa flavanols supplementation on mitochondrial function and whole metabolism, and we explored whether the m…
View article: A recurrent de novo ATP5F1A substitution associated with neonatal complex V deficiency
A recurrent de novo ATP5F1A substitution associated with neonatal complex V deficiency Open
View article: Adaptive optimization of the OXPHOS assembly line partially compensates lrpprc-dependent mitochondrial translation defects in mice
Adaptive optimization of the OXPHOS assembly line partially compensates lrpprc-dependent mitochondrial translation defects in mice Open
Mouse models of genetic mitochondrial disorders are generally used to understand specific molecular defects and their biochemical consequences, but rarely to map compensatory changes allowing survival. Here we took advantage of the extraor…
View article: The intra-mitochondrial O-GlcNAcylation system acutely regulates OXPHOS capacity and ROS dynamics in the heart
The intra-mitochondrial O-GlcNAcylation system acutely regulates OXPHOS capacity and ROS dynamics in the heart Open
Protein O-GlcNAcylation is increasingly recognized as an important cellular regulatory mechanism, in multiple organs including the heart. However, the mechanisms leading to O-GlcNAcylation in mitochondria and the consequences on their func…
View article: Proteomics characterization of mitochondrial‐derived vesicles under oxidative stress
Proteomics characterization of mitochondrial‐derived vesicles under oxidative stress Open
Mitochondria share attributes of vesicular transport with their bacterial ancestors given their ability to form mitochondrial‐derived vesicles (MDVs). MDVs are involved in mitochondrial quality control and their formation is enhanced with …
View article: Grx2 Regulates Skeletal Muscle Mitochondrial Structure and Autophagy
Grx2 Regulates Skeletal Muscle Mitochondrial Structure and Autophagy Open
Glutathione is an important antioxidant that regulates cellular redox status and is disordered in many disease states. Glutaredoxin 2 ( Grx2 ) is a glutathione-dependent oxidoreductase that plays a pivotal role in redox control by catalyzi…
View article: Mitophagy: A New Player in Stem Cell Biology
Mitophagy: A New Player in Stem Cell Biology Open
The fundamental importance of functional mitochondria in the survival of most eukaryotic cells, through regulation of bioenergetics, cell death, calcium dynamics and reactive oxygen species (ROS) generation, is undisputed. However, with ne…
View article: Protein <i>O</i>‐GlcNAcylation levels are regulated independently of dietary intake in a tissue and time‐specific manner during rat postnatal development
Protein <i>O</i>‐GlcNAcylation levels are regulated independently of dietary intake in a tissue and time‐specific manner during rat postnatal development Open
Aim Metabolic sources switch from carbohydrates in utero , to fatty acids after birth and then a mix once adults. O ‐GlcNAcylation ( O ‐GlcNAc) is a post‐translational modification considered as a nutrient sensor. The purpose of this work …
View article: Effects of (−)-epicatechin on mitochondria
Effects of (−)-epicatechin on mitochondria Open
Mitochondrial dysfunction is observed in a broad range of human diseases, including rare genetic disorders and complex acquired pathologies. For this reason, there is increasing interest in identifying safe and effective strategies to miti…
View article: MCL-1Matrix maintains neuronal survival by enhancing mitochondrial integrity and bioenergetic capacity under stress conditions
MCL-1Matrix maintains neuronal survival by enhancing mitochondrial integrity and bioenergetic capacity under stress conditions Open
View article: Mitochondrial Metabolic Uncoupling in Maladaptive Right Ventricular Remodeling in Response to Pressure Overload in Fischer Rats
Mitochondrial Metabolic Uncoupling in Maladaptive Right Ventricular Remodeling in Response to Pressure Overload in Fischer Rats Open
View article: Lipidomics unveils lipid dyshomeostasis and low circulating plasmalogens as biomarkers in a monogenic mitochondrial disorder
Lipidomics unveils lipid dyshomeostasis and low circulating plasmalogens as biomarkers in a monogenic mitochondrial disorder Open
Mitochondrial dysfunction characterizes many rare and common age-associated diseases. The biochemical consequences, underlying clinical manifestations, and potential therapeutic targets, remain to be better understood. We tested the hypoth…
View article: Mitochondrial psychobiology: foundations and applications
Mitochondrial psychobiology: foundations and applications Open
View article: Hybrid Clear/Blue Native Electrophoresis for the Separation and Analysis of Mitochondrial Respiratory Chain Supercomplexes
Hybrid Clear/Blue Native Electrophoresis for the Separation and Analysis of Mitochondrial Respiratory Chain Supercomplexes Open
Complexes of the oxidative phosphorylation machinery form supramolecular protein arrangements named supercomplexes (SCs), which are believed to confer structural and functional advantages to mitochondria. SCs have been identified in many s…
View article: A Linear Fragment of Unacylated Ghrelin (UAG6−13) Protects Against Myocardial Ischemia/Reperfusion Injury in Mice in a Growth Hormone Secretagogue Receptor-Independent Manner
A Linear Fragment of Unacylated Ghrelin (UAG6−13) Protects Against Myocardial Ischemia/Reperfusion Injury in Mice in a Growth Hormone Secretagogue Receptor-Independent Manner Open
Unacylated ghrelin (UAG), the most abundant form of ghrelin in circulation, has been shown to exert cardioprotective effect in experimental cardiopathies. The present study aimed to investigate the cardioprotective effect of a linear bioac…
View article: Protective role of Parkin in skeletal muscle contractile and mitochondrial function
Protective role of Parkin in skeletal muscle contractile and mitochondrial function Open
Key points Parkin, an E3 ubiquitin ligase encoded by the Park2 gene, has been implicated in the regulation of mitophagy, a quality control process in which defective mitochondria are degraded. The exact physiological significance of Parkin…
View article: A Mitochondrial Health Index Sensitive to Mood and Caregiving Stress
A Mitochondrial Health Index Sensitive to Mood and Caregiving Stress Open
Daily mood and chronic caregiving stress are associated with mitochondrial functional capacity. Mitochondrial health may represent a nexus between psychological stress and health.
View article: Mitochondrial Oxidative Stress Reduces the Immunopotency of Mesenchymal Stromal Cells in Adults With Coronary Artery Disease
Mitochondrial Oxidative Stress Reduces the Immunopotency of Mesenchymal Stromal Cells in Adults With Coronary Artery Disease Open
Rationale: Mesenchymal stromal cells (MSCs) are promising therapeutic strategies for coronary artery disease; however, donor-related variability in cell quality is a main cause of discrepancies in preclinical studies. In vitro, MSCs from i…
View article: Regulation of ULK1 Expression and Autophagy by STAT1
Regulation of ULK1 Expression and Autophagy by STAT1 Open
Autophagy involves the lysosomal degradation of cytoplasmic contents for regeneration of anabolic substrates during nutritional or inflammatory stress. Its initiation occurs rapidly after inactivation of the protein kinase mammalian target…
View article: The rise of mitochondria in medicine
The rise of mitochondria in medicine Open
Once considered exclusively the cell's powerhouse, mitochondria are now recognized to perform multiple essential functions beyond energy production, impacting most areas of cell biology and medicine. Since the emergence of molecular biolog…