Yan V. Sun
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View article: Proteomic predictors of mortality among people with Coronary Artery Disease
Proteomic predictors of mortality among people with Coronary Artery Disease Open
Background: Coronary artery disease (CAD) continues to pose a significant global health challenge, highlighting the crucial need to enhance prognostic accuracy and improve mortality outcomes for CAD management. Proteomics offers a nuanced …
View article: Genome-wide analysis of heart failure yields insights into disease heterogeneity and enables prognostic prediction in the Japanese population
Genome-wide analysis of heart failure yields insights into disease heterogeneity and enables prognostic prediction in the Japanese population Open
To understand the genetic basis of heart failure (HF) in the Japanese population, we performed genome-wide association studies (GWASs) comprising 16,251 all-cause HF cases, 4254 HF with reduced ejection fraction (HFrEF) cases, 7154 HF with…
View article: An African ancestry-specific nonsense variant in CD36 is associated with a higher risk of dilated cardiomyopathy
An African ancestry-specific nonsense variant in CD36 is associated with a higher risk of dilated cardiomyopathy Open
The high burden of dilated cardiomyopathy (DCM) in individuals of African descent remains incompletely explained. Here, to explore a genetic basis, we conducted a genome-wide association study in 1,802 DCM cases and 93,804 controls of Afri…
View article: Metabolic dysfunction-associated steatotic liver disease, cardiometabolic risk factors, and cardiovascular disease
Metabolic dysfunction-associated steatotic liver disease, cardiometabolic risk factors, and cardiovascular disease Open
This review encompasses clinical aspects of MASLD from risk factors to outcome, including recommended clinical handling of these patients.
View article: Hepatotoxicity risk factors in HIV-infected MSM with HBV/HCV coinfections: A cohort study in Northwestern China
Hepatotoxicity risk factors in HIV-infected MSM with HBV/HCV coinfections: A cohort study in Northwestern China Open
Objective To evaluate the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) coinfections among human immunodeficiency virus (HIV)-infected men who have sex with men (MSM) initiating their first antiretroviral therapy (ART) …
View article: Neuronal FSTL4 negatively regulates BDNF-mediated neuron-glioma interaction
Neuronal FSTL4 negatively regulates BDNF-mediated neuron-glioma interaction Open
Gliomas exploit various molecular pathways to promote their survival, proliferation, and invasion. Recent studies reveal the complex neuron-glioma interaction and BDNF plays a major role in this interaction. However, it's unclear whether a…
View article: Metabolomic Biomarkers Are Independently Associated With Secondary Adverse Cardiovascular Events in Patients With Coronary Artery Disease
Metabolomic Biomarkers Are Independently Associated With Secondary Adverse Cardiovascular Events in Patients With Coronary Artery Disease Open
Background This study evaluated the potential of plasma metabolites as novel biomarkers for secondary major adverse cardiovascular event (MACE) development and risk prediction in patients with coronary artery disease. Methods We analyzed d…
View article: Protein-Predicted Obesity Phenotypes and Cardiovascular Events: A Secondary Analysis of UK Biobank Proteomics Data
Protein-Predicted Obesity Phenotypes and Cardiovascular Events: A Secondary Analysis of UK Biobank Proteomics Data Open
Background: Proteomic profiling may improve the understanding of obesity and cardiovascular risk prediction. This study explores the use of protein-predicted scores for body mass index (PPSBMI), body fat percentage (PPSBFP), and waist–hip …
View article: Predictive performance and temporal dynamics of national early warning score 2 (NEWS2) in detecting clinical deterioration in general ward: A large-scale validation study in Singapore
Predictive performance and temporal dynamics of national early warning score 2 (NEWS2) in detecting clinical deterioration in general ward: A large-scale validation study in Singapore Open
NEWS2 reliably predicts clinical deterioration and mortality in an Asian tertiary care setting. However, its predictive performance for unanticipated ICU/HD admission and code blue activation remains limited, suggesting the need for furthe…
View article: Genome-wide association study provides novel insight into the genetic architecture of severe obesity
Genome-wide association study provides novel insight into the genetic architecture of severe obesity Open
Severe obesity (SevO) is a primary driver of cardiovascular diseases (CVD), cardiometabolic diseases (CMD) and several cancers, with a disproportionate impact on marginalized populations. SevO is an understudied global health disease, limi…
View article: Identification of gene-sex hormone interactions associated with type 2 diabetes among men and women
Identification of gene-sex hormone interactions associated with type 2 diabetes among men and women Open
Background and Objectives Type 2 diabetes affects an increasing number of people worldwide. Although genome-wide association studies (GWAS) of type 2 diabetes have identified hundreds of loci, their interactions with other risk factors are…
View article: Integrated transcriptomic, metabolomic and lipidomic analyses uncover the crucial roles of lipid metabolism pathways in oat (Avena sativa) responses to heat stress
Integrated transcriptomic, metabolomic and lipidomic analyses uncover the crucial roles of lipid metabolism pathways in oat (Avena sativa) responses to heat stress Open
This study demonstrates that lipid metabolism critically regulates heat stress response in oat. The findings provide valuable target genes for genetic improvement in enhancing oat thermotolerance.
View article: Novel approaches and applications in identifying DNA methylation markers of cardio-kidney-metabolic disease
Novel approaches and applications in identifying DNA methylation markers of cardio-kidney-metabolic disease Open
Cardio-kidney-metabolic (CKM) diseases represent a major public health challenge, accounting for a large proportion of global burden of morbidity and mortality. These conditions share risk factors, including genetic predisposition, environ…
View article: Type 2 Diabetes Subtyping via Phenotype and Genotype Co-Learning
Type 2 Diabetes Subtyping via Phenotype and Genotype Co-Learning Open
Interpreting and subtyping type 2 diabetes (T2D) is challenging yet essential for achieving fine-grained pathophysiological insights and precise clinical stratification. Previous studies have primarily relied on a small number of pre-selec…
View article: Genetic Ancestry and Risk of Atrial Fibrillation in Individuals of Black Ethnicity in the UK Biobank
Genetic Ancestry and Risk of Atrial Fibrillation in Individuals of Black Ethnicity in the UK Biobank Open
Background Black individuals have a lower incidence of atrial fibrillation (AF) than White individuals, despite a higher burden of traditional risk factors. Prior studies have suggested that European genetic ancestry may contribute to this…
View article: Genome-wide characterization of monoacylglycerol lipase (MAGL) gene family in soybean and functional analysis of GmMAGLs in storage lipid metabolism and drought resistance
Genome-wide characterization of monoacylglycerol lipase (MAGL) gene family in soybean and functional analysis of GmMAGLs in storage lipid metabolism and drought resistance Open
This study represents the first comprehensive identification of 18 members of GmMAGL gene family in soybean. GmMAGL10 and 14 may impact seed oil content negatively while GmMAGL3 function importantly in seed germination. GmMAGL1/3/4/6/8/12 …
View article: Subtypes of Type 2 Diabetes and Prediabetes: Mortality and Excess Life Lost in South Asians
Subtypes of Type 2 Diabetes and Prediabetes: Mortality and Excess Life Lost in South Asians Open
Background Current definitions of type 2 diabetes (T2D) and prediabetes do not capture their pathophysiological heterogeneity. We investigated data-driven subtypes of T2D and prediabetes and evaluated their associations with mortality.Meth…
View article: Levonorgestre-lintrauterine system(LNG-IUS) plus Metformin compared with Megestrol Acetate (MA)plus Metformin as fertility-sparing treatment in patients with atypical endometrial hyperplasia and well differentiated endometrial cancer:a single-center retrospective study
Levonorgestre-lintrauterine system(LNG-IUS) plus Metformin compared with Megestrol Acetate (MA)plus Metformin as fertility-sparing treatment in patients with atypical endometrial hyperplasia and well differentiated endometrial cancer:a single-center retrospective study Open
Background The prevalence of early-stage endometrial cancer who have not given birth has risen signiffcantly in recent years.This study aimed to investigate the efficacy of Levonorgestre-lintrauterine system(LNG-IUS) combined with high-dos…
View article: Sex and racial differences in prevalence and clinical characteristics of people living with LDLR and PCSK9 familial hypercholesterolemia genetic variants: Data from the All of Us Research program
Sex and racial differences in prevalence and clinical characteristics of people living with LDLR and PCSK9 familial hypercholesterolemia genetic variants: Data from the All of Us Research program Open
Significant racial, ethnic, and sex disparities exist in the prevalence, ASCVD burden, and LLT use among FH variant carriers. Further targeted efforts, including increased genetic testing, are needed to improve FH detection and optimize tr…
View article: Proteomics‐Based Soluble Urokinase Plasminogen Activator Receptor Levels and Long‐Term Cardiovascular Outcomes in Survivors of Breast Cancer: A UK Biobank Study
Proteomics‐Based Soluble Urokinase Plasminogen Activator Receptor Levels and Long‐Term Cardiovascular Outcomes in Survivors of Breast Cancer: A UK Biobank Study Open
Background Breast cancer is associated with increased risk for cardiovascular disease. suPAR (soluble urokinase plasminogen activator receptor) is an immune‐derived signaling glycoprotein implicated in the pathogenesis of atherosclerosis, …
View article: Ubiquitin–proteasome system in the different stages of dominantly inherited Alzheimer's disease
Ubiquitin–proteasome system in the different stages of dominantly inherited Alzheimer's disease Open
INTRODUCTION This study investigated the role of the ubiquitin–proteasome system (UPS) in dominantly inherited Alzheimer's disease (DIAD) by examining cerebrospinal fluid (CSF) levels of UPS proteins. METHOD The SOMAscan assay was used to …
View article: The Association Between Preoperative Triglyceride Glucose Index and Postoperative Adverse Cardiovascular Events in Non-Cardiac Surgery: A Single-Center Study From China
The Association Between Preoperative Triglyceride Glucose Index and Postoperative Adverse Cardiovascular Events in Non-Cardiac Surgery: A Single-Center Study From China Open
This cohort study indicates that preoperative TyG index is linearly and positively correlated with an increased incidence of PACE in the non-cardiac surgery population. This finding suggests that intensifying the evaluation of the TyG inde…