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View article: Sexually dimorphic cannabinoid 1 receptors on CaMKIIα neurons in the medial prefrontal cortex mediate sex differences in ACEA-induced antinociception in mice
Sexually dimorphic cannabinoid 1 receptors on CaMKIIα neurons in the medial prefrontal cortex mediate sex differences in ACEA-induced antinociception in mice Open
Patients suffer greatly from neuropathic pain, and pharmacological therapies usually prove insufficient. Although the causes are yet unknown, sex differences in reaction to analgesics help to explain poor outcomes. Cannabinoid-based treatm…
View article: Pre-clinical development of a wireless neural interface system for osseointegrated prosthetic control in sheep
Pre-clinical development of a wireless neural interface system for osseointegrated prosthetic control in sheep Open
The Osseointegrated Neural Interface (ONI) is an innovative peripheral nerve interface design that houses a transected nerve and coupled electrical components within the medullary canal of long bones for eventual prosthetic control. Before…
View article: Effect of midwife-led continuity of care combined with individualized breast management on postpartum recovery and lactation function in women undergoing cesarean section
Effect of midwife-led continuity of care combined with individualized breast management on postpartum recovery and lactation function in women undergoing cesarean section Open
Objective The aim of this study was to investigate the effects of midwife-led continuity of care (MLCC) combined with individualized breast management on postoperative recovery, lactation function, and pelvic floor function in women underg…
View article: Ras p21 protein activator 1 regulates trophoblast function and its association with preeclampsia through the Ras/mitogen-activated protein kinase pathway
Ras p21 protein activator 1 regulates trophoblast function and its association with preeclampsia through the Ras/mitogen-activated protein kinase pathway Open
Objective: Ras p21 protein activator 1 (RASA1) plays a crucial role in the placenta. However, its effects and mechanisms of RASA1 on trophoblast function in preeclampsia (PE) are unclear. This study aims to investigate the relationship bet…
View article: Predicting Biochemical Recurrence After Robot-Assisted Prostatectomy with Interpretable Machine Learning Model
Predicting Biochemical Recurrence After Robot-Assisted Prostatectomy with Interpretable Machine Learning Model Open
Background: This study aimed to develop and evaluate machine learning (ML) models to predict biochemical recurrence (BCR) after robot-assisted radical prostatectomy (RARP). Methods: We retrospectively analyzed clinical data from 1125 patie…
View article: Dynamic Changes in Peripheral Immune Cells During Efgartigimod Treatment in Naive Generalized Myasthenia Gravis
Dynamic Changes in Peripheral Immune Cells During Efgartigimod Treatment in Naive Generalized Myasthenia Gravis Open
Background Efgartigimod is a neonatal Fc receptor (FcRn) antagonist that reduces pathogenic IgG and improves clinical symptoms in generalized myasthenia gravis (gMG). However, its immunomodulatory effects on innate and adaptive immune cell…
View article: Efficacy and safety of guselkumab in Chinese patients with moderate-to-severe plaque psoriasis: A randomized, double-blind, placebo-controlled trial
Efficacy and safety of guselkumab in Chinese patients with moderate-to-severe plaque psoriasis: A randomized, double-blind, placebo-controlled trial Open
Background: Guselkumab is effective in treating moderate-to-severe plaque psoriasis; however, data from randomized controlled trials in the Chinese population are limited. This study evaluated and verified the efficacy and safety profile o…
View article: Redesign of the Trivers-Willard Hypothesis Measurement Tool
Redesign of the Trivers-Willard Hypothesis Measurement Tool Open
The Trivers-Willard Hypothesis posits that parents in favorable conditions tend to invest more in male offspring, while those in disadvantaged conditions focus on female offspring under the disadvantaged condition based on the reproductive…
View article: Lipid biomarkers of GVHD in allogeneic stem hematopoietic cell transplantation patients
Lipid biomarkers of GVHD in allogeneic stem hematopoietic cell transplantation patients Open
Objective While dyslipidemia is established as a key modulator of innate and adaptive immune responses, its role in hematopoietic reconstitution remains unclear. This study aimed to characterize lipid profiles in patients undergoing alloge…
View article: Factors associated with early response to efgartigimod in patients with generalized myasthenia gravis: a multicenter retrospective observational study
Factors associated with early response to efgartigimod in patients with generalized myasthenia gravis: a multicenter retrospective observational study Open
Efgartigimod demonstrated robust efficacy in gMG patients. Early response was linked to shorter disease duration and severe bulbar symptoms, which promotes the identification of patients who are likely to benefit quickly from efgartigimod.
View article: Piezo1 regulates autophagy in HT22 hippocampal neurons through the Ca2+/Calpain and Calcineurin/TFEB signaling pathways
Piezo1 regulates autophagy in HT22 hippocampal neurons through the Ca2+/Calpain and Calcineurin/TFEB signaling pathways Open
Objective To investigate the functional and molecular mechanisms by which Piezo1regulates HT-22 hippocampal neuronal autophagy, and to explore whether Piezo1 regulates hippocampal neuronal autophagy via the Ca 2+ /Calpain, CaMKKβ, or Calci…
View article: Pre-treatment monocytic myeloid-derived suppressor cells as predictive biomarkers for immune checkpoint inhibitor response in clear cell renal cell carcinoma
Pre-treatment monocytic myeloid-derived suppressor cells as predictive biomarkers for immune checkpoint inhibitor response in clear cell renal cell carcinoma Open
Background Immune checkpoint inhibitors (ICIs) are a cornerstone of systemic therapy for clear cell renal cell carcinoma (ccRCC), yet response rates remain variable and predictive biomarkers are lacking. This study aimed to determine wheth…
View article: Effectiveness of acupuncture and moxibustion combined with rehabilitation training for post-stroke shoulder-hand syndrome: a systematic review and meta-analysis
Effectiveness of acupuncture and moxibustion combined with rehabilitation training for post-stroke shoulder-hand syndrome: a systematic review and meta-analysis Open
Background Post-stroke shoulder-hand syndrome (SHS) significantly impacts patients' quality of life and functional recovery. While both acupuncture and rehabilitation training have shown promise individually, their combined effect needs sy…
View article: Impact of Symptoms of Late-Onset Hypogonadism as a Potential Driver of Presenteeism
Impact of Symptoms of Late-Onset Hypogonadism as a Potential Driver of Presenteeism Open
Presenteeism, defined as attending work despite physical or mental health issues that impair full productivity, is a prevalent concern with significant implications for workplace efficiency and employee well-being. Testosterone, the primar…
View article: Bile acid metabolism and hepatocellular carcinoma: mechanisms of drug resistance and intervention strategies
Bile acid metabolism and hepatocellular carcinoma: mechanisms of drug resistance and intervention strategies Open
Hepatocellular carcinoma (HCC) is the predominant malignant liver tumor, characterized by high morbidity, mortality, and rapid progression, and it ranks among the leading causes of cancer-related fatalities worldwide. Its treatment is faci…
View article: Scientists' First Exam: Probing Cognitive Abilities of MLLM via Perception, Understanding, and Reasoning
Scientists' First Exam: Probing Cognitive Abilities of MLLM via Perception, Understanding, and Reasoning Open
Scientific discoveries increasingly rely on complex multimodal reasoning based on information-intensive scientific data and domain-specific expertise. Empowered by expert-level scientific benchmarks, scientific Multimodal Large Language Mo…
View article: Prenatal diagnosis of balanced translocation from three families: Six case reports
Prenatal diagnosis of balanced translocation from three families: Six case reports Open
BACKGROUND Carriers of chromosomal balanced translocations are often physically healthy with no obvious developmental problems. However, potential chromosomal imbalance in their gametes can lead to implantation failure, miscarriage, or the…
View article: Prostate-Specific Antigen Decline Rate in the First Month Is a Timely Predictive Factor for Biochemical Recurrence After Robot-Assisted Radical Prostatectomy
Prostate-Specific Antigen Decline Rate in the First Month Is a Timely Predictive Factor for Biochemical Recurrence After Robot-Assisted Radical Prostatectomy Open
Objectives: We attempt to assess whether prostate-specific antigen decline rate in the first month (PSADR1M = postoperative PSA in the first month/initial PSA) acts as a predictor for biochemical recurrence (BCR) and to evaluate other preo…
View article: Retraction notice to “G-quadruplex formation within the promoter region of HSPB2 and its effect on transcription” [Heliyon 10 (2024) e24396]
Retraction notice to “G-quadruplex formation within the promoter region of HSPB2 and its effect on transcription” [Heliyon 10 (2024) e24396] Open
[This retracts the article DOI: 10.1016/j.heliyon.2024.e24396.].
View article: Short-term and long-term prognoses in AChR-Ab positive very-late-onset myasthenia gravis patients
Short-term and long-term prognoses in AChR-Ab positive very-late-onset myasthenia gravis patients Open
Background: Very-late-onset myasthenia gravis (VLOMG) refers to myasthenia gravis (MG) with onset at age 65 or older. Current research on VLOMG prognosis remains limited, especially regarding factors influencing outcomes. Objectives: To id…
View article: Impaired Basal Forebrain Cholinergic Neuron <scp>GDNF</scp> Signaling Contributes to Perioperative Sleep Deprivation–Induced Chronicity of Postsurgical Pain in Mice Through Regulating Cholinergic Neuronal Activity, Apoptosis, and Autophagy
Impaired Basal Forebrain Cholinergic Neuron <span>GDNF</span> Signaling Contributes to Perioperative Sleep Deprivation–Induced Chronicity of Postsurgical Pain in Mice Through Regulating Cholinergic Neuronal Activity, Apoptosis, and Autophagy Open
Aims This study investigated the roles of lateral basal forebrain glial cell line–derived neurotrophic factor (GDNF) signaling and cholinergic neuron activity, apoptosis, and autophagy dysfunction in sleep deprivation–induced increased ris…
View article: Genetic burden in neonatal and pediatric-onset pulmonary hypertension: A single-center retrospective study using exome sequencing in a Chinese population
Genetic burden in neonatal and pediatric-onset pulmonary hypertension: A single-center retrospective study using exome sequencing in a Chinese population Open
Our findings demonstrate the significant diagnostic value of trio-WES in pediatric pulmonary hypertension, supporting its recommendation for these patients.
View article: The Impact of COVID-19 Vaccination and Infection on the Exacerbation of Myasthenia Gravis
The Impact of COVID-19 Vaccination and Infection on the Exacerbation of Myasthenia Gravis Open
Objectives: Myasthenia Gravis (MG) is an autoimmune disorder that can exacerbate for various reasons, including vaccination and infection. This study aimed to investigate the safety of COVID-19 vaccines for MG patients, factors influencing…
View article: Prenatal diagnosis of recurrent Kagami–Ogata syndrome inherited from a mother affected by Temple syndrome: a case report and literature review
Prenatal diagnosis of recurrent Kagami–Ogata syndrome inherited from a mother affected by Temple syndrome: a case report and literature review Open
Given the rarity of KOS as an imprinting disorder, accurate prenatal diagnosis of this rare imprinting disorder depends on two factors: (1) increasing clinician recognition of the clinical phenotype and related genetic mechanism, and (2) e…
View article: Research on multi-source sparse optimization method and its application on gearbox compound fault detection
Research on multi-source sparse optimization method and its application on gearbox compound fault detection Open
In general, gearbox is prone to occur compound fault frequently because of its harsh working environment, its fault vibration signal often contains polymorphic-oscillatory components and is corrupted by heavy background noise, which brings…
View article: Epidemiological features and temporal trends of the co-infection between HIV and tuberculosis, 1990–2021: findings from the Global Burden of Disease Study 2021
Epidemiological features and temporal trends of the co-infection between HIV and tuberculosis, 1990–2021: findings from the Global Burden of Disease Study 2021 Open
Background The co-infection of human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) and tuberculosis (TB) poses a significant clinical challenge and is a major global public health issue. This study aims to elucida…
View article: A bioactive supramolecular and covalent polymer scaffold for cartilage repair in a sheep model
A bioactive supramolecular and covalent polymer scaffold for cartilage repair in a sheep model Open
Regeneration of hyaline cartilage in human-sized joints remains a clinical challenge, and it is a critical unmet need that would contribute to longer healthspans. Injectable scaffolds for cartilage repair that integrate both bioactivity an…