Yanli Yang
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View article: Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells
Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells Open
Primary cilia are antenna‑like organelles on almost all human cells that sense and transduce extracellular cues into cellular response. Primary cilia have been reported to be implicated in drug resistance in several cancer types, but their…
View article: The effect of guideline-directed medicine on patients with new-onset heart failure following acute myocardial infarction
The effect of guideline-directed medicine on patients with new-onset heart failure following acute myocardial infarction Open
Aims To investigate the impact of guideline-directed medical therapy (GDMT) during hospitalization on the prognosis of patients with heart failure (HF) episode complicating post-acute myocardial infarction (AMI). Methods From 01/05/2017 to…
View article: TKT regulates the pentose phosphate pathway via RBKS to promote epithelial-mesenchymal transition during AML progression
TKT regulates the pentose phosphate pathway via RBKS to promote epithelial-mesenchymal transition during AML progression Open
Acute myeloid leukemia is a life-threaten disease. Researches have indicated that increased expression of TKT was closely related to the progression of malignant tumors. However, the mechanism of TKT in the pathogenesis of AML need to be f…
View article: Prognostic role of minimum heart rate in elderly heart failure patients with hypertensive heart disease: an analysis of MIMIC-IV database
Prognostic role of minimum heart rate in elderly heart failure patients with hypertensive heart disease: an analysis of MIMIC-IV database Open
We demonstrated that MHR plays a prognostic role in elderly patients with heart failure and hypertensive heart disease. Low MHR predicts higher all-cause mortality, and the association conforms to a U-shaped pattern. Our findings extend th…
View article: Aberrant lipid profiles and lymphocyte counts in systemic sclerosis population, reassessing predictive value for concurrent cardiovascular diseases
Aberrant lipid profiles and lymphocyte counts in systemic sclerosis population, reassessing predictive value for concurrent cardiovascular diseases Open
Objective To investigate alterations in blood lipid profiles and T cell subsets among systemic sclerosis (SSc) patients, and to assess their potential utility in predicting cardiovascular disease (CVD) risk. Methods 105 SSc patients and 80…
View article: Screening and evaluation of key technologies for non-bioartificial liver care: an empirical study
Screening and evaluation of key technologies for non-bioartificial liver care: an empirical study Open
Introduction To identify key technologies within non-bioartificial liver (NBAL, an extracorporeal support system that temporarily replaces some of the liver’s functions) nursing to offer guidance for clinical practice. In the context of NB…
View article: Prognostic Role of Minimum Heart Rate in Elderly Heart Failure Patients with Hypertensive Heart Disease: An Analysis of MIMIC-IV Database
Prognostic Role of Minimum Heart Rate in Elderly Heart Failure Patients with Hypertensive Heart Disease: An Analysis of MIMIC-IV Database Open
Background Heart rate has been documented as a predictive factor in heart failure. However, its prognostic role in specific heart failure patients are diverse and not comprehensively identified. Methods A retrospective cohort study was con…
View article: Expert consensus on nasal anticholinergics in the treatment of allergic rhinitis
Expert consensus on nasal anticholinergics in the treatment of allergic rhinitis Open
Background: Allergic rhinitis (AR) is a common hyperreactive nasal disease in otolaryngology, mainly manifested as rhinorrhea, nasal obstruction, nasal itching, and sneezing. Despite medication and immunotherapy, a large proportion of pati…
View article: Sustained mTOR inhibition with sirolimus improves respiratory outcomes in LAM patients with COVID-19: a single-center retrospective study
Sustained mTOR inhibition with sirolimus improves respiratory outcomes in LAM patients with COVID-19: a single-center retrospective study Open
Background Lymphangioleiomyomatosis (LAM) is a rare lung disease that predominantly affects women and can lead to severe respiratory complications. The impact of COVID-19 on LAM patients, particularly regarding the use of mechanistic targe…
View article: Overexpression of GADD45g inhibits proliferation and invasion of acute myeloid leukemia cell lines with FLT3-ITD+ by downregulating the JNK pathway
Overexpression of GADD45g inhibits proliferation and invasion of acute myeloid leukemia cell lines with FLT3-ITD+ by downregulating the JNK pathway Open
To Explore the effects of overexpression of GADD45g inhibits proliferation and invasion of acute myeloid leukemia (AML) cell lines with FLT3-ITD + by downregulating the JNK pathway. A total of 30 bone marrow specimens from patients with in…
View article: Analysis of status quo and influencing factors of oral health literacy among the elderly in Hangzhou
Analysis of status quo and influencing factors of oral health literacy among the elderly in Hangzhou Open
Objective This study aimed to investigate the current status of oral healthy literacy (OHL) among the elderly in Hangzhou and analyze its influencing factors. Methods A convenience sampling method was used to select 230 elderly people livi…
View article: Sustained mTOR inhibition with sirolimus improves respiratory outcomes in LAM patients with COVID-19
Sustained mTOR inhibition with sirolimus improves respiratory outcomes in LAM patients with COVID-19 Open
Background Lymphangioleiomyomatosis (LAM) is a rare lung disease that predominantly affects women and can lead to severe respiratory complications. The impact of COVID-19 on LAM patients, particularly regarding the use of mammalian target …
View article: Rapid Plaque Progression in a Patient with Non-ST-Segment Elevation Acute Coronary Syndrome: A Case Report
Rapid Plaque Progression in a Patient with Non-ST-Segment Elevation Acute Coronary Syndrome: A Case Report Open
Acute coronary syndrome (ACS), diagnosed by optical coherence tomography (OCT), is caused primarily by plaque rupture, plaque erosion, and calcified nodules. Plaque erosion is more common in patients with non-ST-segment elevation myocardia…
View article: Effects of COVID-19 infection in patients with autoimmune pulmonary alveolar proteinosis: a single-center study
Effects of COVID-19 infection in patients with autoimmune pulmonary alveolar proteinosis: a single-center study Open
Background:Autoimmune pulmonary alveolar proteinosis (aPAP) is a rare interstitial lung disease. COVID-19 is associated with worse prognosis in previous lung diseases patients. But the prognosis of aPAP patients after infection with COVID-…
View article: Determinants of Progression and Mortality in Lymphangioleiomyomatosis
Determinants of Progression and Mortality in Lymphangioleiomyomatosis Open
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View article: Chinese Expert Consensus on the Use of Biologics in Patients with Chronic Rhinosinusitis (2022, Zhuhai)
Chinese Expert Consensus on the Use of Biologics in Patients with Chronic Rhinosinusitis (2022, Zhuhai) Open
Background: Chronic rhinosinusitis (CRS) is a common inflammatory disease in otolaryngology, mainly manifested as nasal congestion, nasal discharge, facial pain/pressure, and smell disorder. CRS with nasal polyps (CRSwNP), an important phe…
View article: Nuclear factor E2-related factor-2 (Nrf2) regulates renal tubulointerstitial fibrosis and Gasdermin D-driven pyroptosis induced by high glucose in HK-2 cells via Caspase-1
Nuclear factor E2-related factor-2 (Nrf2) regulates renal tubulointerstitial fibrosis and Gasdermin D-driven pyroptosis induced by high glucose in HK-2 cells via Caspase-1 Open
Previous studies have shown that tubulointerstitial fibrosis (TIF) and pyroptosis are crucial in high-glucose (HG)-induced renal tubular epithelial cell injury and thus contribute to the development of diabetic nephropathy (DN). Previous r…
View article: Scoop thrombectomy: A declotting technique for the treatment of thrombosed autologous arteriovenous fistula. A single-center retrospective study
Scoop thrombectomy: A declotting technique for the treatment of thrombosed autologous arteriovenous fistula. A single-center retrospective study Open
Background Thrombosis is one of the main complications leading to the failure of autologous arteriovenous fistula (AVF) for patients with renal failure. Thrombectomy is one of the major therapies to remove thrombi to salvage the AVF and pr…