Muyan Cai
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View article: A multimodal synergistic model for personalized neoadjuvant immunochemotherapy in esophageal cancer
A multimodal synergistic model for personalized neoadjuvant immunochemotherapy in esophageal cancer Open
Neoadjuvant immunochemotherapy (nICT) has significantly improved the treatment of locally advanced esophageal cancer (EC), yet accurately identifying patients' response remains a major challenge. In this study, we introduce eSPARK, a multi…
View article: Addressing data heterogeneity in distributed medical imaging with heterosync learning
Addressing data heterogeneity in distributed medical imaging with heterosync learning Open
Data heterogeneity critically limits distributed artificial intelligence (AI) in medical imaging. We propose HeteroSync Learning (HSL), a privacy-preserving framework that addresses heterogeneity through: (1) Shared Anchor Task (SAT) for c…
View article: A clinical-grade universal foundation model for intraoperative pathology
A clinical-grade universal foundation model for intraoperative pathology Open
Intraoperative pathology is pivotal to precision surgery, yet its clinical impact is constrained by diagnostic complexity and the limited availability of high-quality frozen-section data. While computational pathology has made significant …
View article: A Clinical-grade Universal Foundation Model for Intraoperative Pathology
A Clinical-grade Universal Foundation Model for Intraoperative Pathology Open
Intraoperative pathology is pivotal to precision surgery, yet its clinical impact is constrained by diagnostic complexity and the limited availability of high-quality frozen-section data. While computational pathology has made significant …
View article: Standard dose and low-dose rituximab combined with glucocorticoids and cyclophosphamide in the treatment of acquired haemophilia A
Standard dose and low-dose rituximab combined with glucocorticoids and cyclophosphamide in the treatment of acquired haemophilia A Open
Aim To investigate the efficacy and safety of standard dose and low-dose rituximab combined with corticosteroids and cyclophosphamide in the treatment of acquired haemophilia A. Methods A retrospective analysis was conducted on the clinica…
View article: Case Report: Two cases of primary pulmonary endobronchial extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue localized in the trachea and bronchus
Case Report: Two cases of primary pulmonary endobronchial extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue localized in the trachea and bronchus Open
Background Primary pulmonary extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) localized in the trachea and bronchus is rare and diagnostically challenging due to nonspecific clinical and radiological f…
View article: The impacts of polystyrene microplastics on development, energy transfer and nutrient cycling of biofilms: A comprehensive chronic toxicity study
The impacts of polystyrene microplastics on development, energy transfer and nutrient cycling of biofilms: A comprehensive chronic toxicity study Open
The escalating prevalence of microplastics (MPs) in aquatic ecosystems is anticipated to exert a significant impact on the growth and development of aquatic biota. Nonetheless, the current body of research on the mechanisms through which m…
View article: Safety and efficacy of perioperative dual PD-1 and HER2 blockade in HER2-positive gastric cancer
Safety and efficacy of perioperative dual PD-1 and HER2 blockade in HER2-positive gastric cancer Open
The use of trastuzumab and programmed death-1 (PD-1) inhibitor is effective in patients with HER2-positive advanced gastric or gastro-esophageal junction cancer; however, their use has not been investigated in patients with localized disea…
View article: TAOK1 promotes filament formation in HR repair through phosphorylating USP7
TAOK1 promotes filament formation in HR repair through phosphorylating USP7 Open
Poly-ADP-ribose polymerase (PARP) inhibitors are vital therapeutic agents that exploit synthetic lethality, particularly effective in tumors with homologous recombination (HR) defects. However, broadening their clinical utility remains a s…
View article: Clinical Characteristics and Drug Susceptibility Profiling of Multidrug‐Resistant <i>Pseudomonas aeruginosa</i> Infections
Clinical Characteristics and Drug Susceptibility Profiling of Multidrug‐Resistant <i>Pseudomonas aeruginosa</i> Infections Open
Objective: To investigate the epidemiology of Pseudomonas aeruginosa (PA) in hospitalized patients with PA respiratory infections and to analyze the clinical characteristics and antibiotic resistance profiles of drug‐resistant PA, providin…
View article: The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of colorectal cancer, 2024 update
The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of colorectal cancer, 2024 update Open
The 2024 updates of the Chinese Society of Clinical Oncology (CSCO) Clinical Guidelines for the diagnosis and treatment of colorectal cancer emphasize standardizing cancer treatment in China, highlighting the latest advancements in evidenc…
View article: Transcriptional landscape and predictive potential of long noncoding RNAs in peritoneal recurrence of gastric cancer
Transcriptional landscape and predictive potential of long noncoding RNAs in peritoneal recurrence of gastric cancer Open
A lncRNA-based integrated score was constructed in this study to predict peritoneal recurrence in patients clinically.
View article: Association between dietary vitamin B6 intake and constipation: a population-based study
Association between dietary vitamin B6 intake and constipation: a population-based study Open
Background Numerous studies have suggested a link between dietary micronutrient intake and the onset of constipation. Nevertheless, there has not been much research done on the potential relationship between vitamin B6 and constipation. Th…
View article: Development and validation of a hierarchical approach for lymphoma classification using immunohistochemical markers
Development and validation of a hierarchical approach for lymphoma classification using immunohistochemical markers Open
Background Accurate lymphoma classification is critical for effective treatment and immunohistochemistry is a cost‐effective and time‐saving approach. Although several machine learning algorithms showed effective results, they focused on a…
View article: Single-cell and spatial transcriptome analyses reveal tertiary lymphoid structures linked to tumour progression and immunotherapy response in nasopharyngeal carcinoma
Single-cell and spatial transcriptome analyses reveal tertiary lymphoid structures linked to tumour progression and immunotherapy response in nasopharyngeal carcinoma Open
Tertiary lymphoid structures are immune cell aggregates linked with cancer outcomes, but their interactions with tumour cell aggregates are unclear. Using nasopharyngeal carcinoma as a model, here we analyse single-cell transcriptomes of 3…
View article: Clinicopathological and immune characterization of mismatch repair deficient endocervical adenocarcinoma
Clinicopathological and immune characterization of mismatch repair deficient endocervical adenocarcinoma Open
Endocervical adenocarcinoma (ECA) is reported increasingly often in young women, and this aggressive disease lacks effective methods of targeted therapy. Since mismatch repair deficiency (dMMR) is an important biomarker for predicting resp…
View article: A multi-classifier system integrated by clinico-histology-genomic analysis for predicting recurrence of papillary renal cell carcinoma
A multi-classifier system integrated by clinico-histology-genomic analysis for predicting recurrence of papillary renal cell carcinoma Open
Integrating genomics and histology for cancer prognosis demonstrates promise. Here, we develop a multi-classifier system integrating a lncRNA-based classifier, a deep learning whole-slide-image-based classifier, and a clinicopathological c…
View article: A multicenter proof-of-concept study on deep learning-based intraoperative discrimination of primary central nervous system lymphoma
A multicenter proof-of-concept study on deep learning-based intraoperative discrimination of primary central nervous system lymphoma Open
Accurate intraoperative differentiation of primary central nervous system lymphoma (PCNSL) remains pivotal in guiding neurosurgical decisions. However, distinguishing PCNSL from other lesions, notably glioma, through frozen sections challe…
View article: 49P Perioperative circulating tumor DNA redefines induced oligometastatic non-small cell lung cancer at the molecular level
49P Perioperative circulating tumor DNA redefines induced oligometastatic non-small cell lung cancer at the molecular level Open
Substantial heterogeneity exists in the benefits from local treatments for oligometastatic non-small cell lung cancer (NSCLC). We propose that circulating tumor DNA (ctDNA) can molecularly redefine populations with induced oligopersistence…