Chenxia Hu
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View article: Landscape and regulation of mRNA translation in the early C. elegans embryo
Landscape and regulation of mRNA translation in the early C. elegans embryo Open
Animal embryos rely on regulated translation of maternally deposited mRNAs to drive early development. Using low-input ribosome profiling combined with RNA sequencing on precisely staged embryos, we measure mRNA translation during the firs…
View article: Chitosan/Sodium Tripolyphosphate Microemulsion Enhanced Oral Insulin Delivery via Intestinal Lymphoid
Chitosan/Sodium Tripolyphosphate Microemulsion Enhanced Oral Insulin Delivery via Intestinal Lymphoid Open
Oral insulin delivery systems are currently being explored as the best alternative to subcutaneous injections, aiming to overcome gastrointestinal barriers and achieve efficient oral insulin delivery. This study presents a microemulsion de…
View article: Bone marrow mesenchymal stem cells alleviate neurological dysfunction by reducing autophagy damage via downregulation of SYNPO2 in neonatal hypoxic–ischemic encephalopathy rats
Bone marrow mesenchymal stem cells alleviate neurological dysfunction by reducing autophagy damage via downregulation of SYNPO2 in neonatal hypoxic–ischemic encephalopathy rats Open
Neonatal hypoxic-ischemic encephalopathy (HIE) is worsened by autophagy-induced neuronal damage, with SYNPO2 playing a key role in this process. This study investigates the involvement of SYNPO2 in neuronal autophagy and explores the poten…
View article: Landscape and regulation of new protein translation in the early <i>C. elegans</i> embryo
Landscape and regulation of new protein translation in the early <i>C. elegans</i> embryo Open
Summary Translation of maternal mRNAs is crucial for early embryonic development. In C. elegans, cell fates become determined from the first division without new transcription, making this organism ideal for studying post-transcriptional r…
View article: Roles of mesenchymal stem cells and exosomes in interstitial cystitis/bladder pain syndrome
Roles of mesenchymal stem cells and exosomes in interstitial cystitis/bladder pain syndrome Open
Interstitial cystitis/bladder pain syndrome (IC/BPS) is characterized by several symptoms of higher sensitivity of the lower urinary tract, such as bladder pain/discomfort, urgency, urinary frequency, pelvic pain and nocturia. Although the…
View article: Regulation of autophagy protects against liver injury in liver surgery‐induced ischaemia/reperfusion
Regulation of autophagy protects against liver injury in liver surgery‐induced ischaemia/reperfusion Open
Transient ischaemia and reperfusion in liver tissue induce hepatic ischaemia/reperfusion (I/R) tissue injury and a profound inflammatory response in vivo. Hepatic I/R can be classified into warm I/R and cold I/R and is characterized by thr…
View article: Melatonin and its protective role in attenuating warm or cold hepatic ischaemia/reperfusion injury
Melatonin and its protective role in attenuating warm or cold hepatic ischaemia/reperfusion injury Open
Although the liver is the only organ with regenerative capacity, various injury factors induce irreversible liver dysfunction and end‐stage liver disease. Liver resection and liver transplantation (LT) are effective treatments for individu…
View article: Induction therapy with mesenchymal stromal cells in kidney transplantation: a meta-analysis
Induction therapy with mesenchymal stromal cells in kidney transplantation: a meta-analysis Open
Objective The aim of this meta-analysis was to evaluate the therapeutic effects of mesenchymal stromal cells (MSCs) versus traditional regimens for induction therapy in kidney transplantation (KT), especially the safety of MSC infusion, pr…
View article: Induction therapy with mesenchymal stromal cells in kidney transplantation: A meta-analysis
Induction therapy with mesenchymal stromal cells in kidney transplantation: A meta-analysis Open
Objective The aim of this meta-analysis was to evaluate the therapeutic effects of mesenchymal stromal cells (MSCs) versus traditional regimens for induction therapy in kidney transplantation (KT), especially the safety of MSC infusion, pr…
View article: Comorbid Bipolar Disorder and Migraine: From Mechanisms to Treatment
Comorbid Bipolar Disorder and Migraine: From Mechanisms to Treatment Open
Bipolar disorder (BD) is a severe psychiatric disorder characterized by recurrent episodes of manic/hypomanic or depressive symptoms and euthymic periods, with some patients suffering a gradual deterioration of illness and consequent cogni…
View article: Cellular senescence, a novel therapeutic target for mesenchymal stem cells in acute kidney injury
Cellular senescence, a novel therapeutic target for mesenchymal stem cells in acute kidney injury Open
Cellular senescence is a widespread cellular programme that is characterized by permanent cell cycle arrest. Senescent cells adopt a changed secretory phenotype that can alter cellular function. For years, cellular senescence has been thou…
View article: Induction therapy with mesenchymal stromal cells in kidney transplantation: A meta-analysis
Induction therapy with mesenchymal stromal cells in kidney transplantation: A meta-analysis Open
Objective The aim of this meta-analysis was to evaluate the therapeutic effects of mesenchymal stromal cells (MSCs) versus traditional regimens for induction therapy in kidney transplantation (KT), especially the safety of MSC infusion, pr…
View article: Serum ammonia is a strong prognostic factor for patients with acute-on-chronic liver failure
Serum ammonia is a strong prognostic factor for patients with acute-on-chronic liver failure Open
Ammonia is thought to be central to the pathogenesis of hepatic encephalopathy (HE), but its prognostic role in acute-on-chronic liver failure (ACLF) is still unknown. We aimed to determine the association between serum ammonia level and s…
View article: Induction therapy with mesenchymal stromal cells in kidney transplantation: A meta-analysis
Induction therapy with mesenchymal stromal cells in kidney transplantation: A meta-analysis Open
Objective The aim of this meta-analysis was to evaluate the therapeutic effects of mesenchymal stromal cells (MSCs) versus traditional regimens for induction therapy in kidney transplantation (KT), especially the safety of MSC infusion, pr…
View article: Autophagy regulation is an effective strategy to improve the prognosis of chemically induced acute liver injury based on experimental studies
Autophagy regulation is an effective strategy to improve the prognosis of chemically induced acute liver injury based on experimental studies Open
Acute liver injury (ALI) induced by chemicals in current experimental studies is characterized by inflammation, oxidative stress and necrosis, which can greatly influence the long‐term outcome and lead to liver failure. In liver cells, dif…
View article: Induction Therapy With Mesenchymal Stem Cells in Kidney Transplantation: A Meta-Analysis
Induction Therapy With Mesenchymal Stem Cells in Kidney Transplantation: A Meta-Analysis Open
Objective The aim of this meta-analysis was to evaluate the therapeutic effects of mesenchymal stem cells (MSCs) versus other regimens as induction therapy in kidney transplantation patients. Methods PubMed, Embase, EBSCO, Ovid and the Coc…
View article: Regenerative abilities of mesenchymal stem cells via acting as an ideal vehicle for subcellular component delivery in acute kidney injury
Regenerative abilities of mesenchymal stem cells via acting as an ideal vehicle for subcellular component delivery in acute kidney injury Open
Cell‐to‐cell communication and information exchange is one of the most important events in multiple physiological processes, including multicellular organism development, cellular function regulation, external stress response, homeostasis …
View article: Transplantation of mesenchymal stem cells and their derivatives effectively promotes liver regeneration to attenuate acetaminophen-induced liver injury
Transplantation of mesenchymal stem cells and their derivatives effectively promotes liver regeneration to attenuate acetaminophen-induced liver injury Open
Acetaminophen (APAP)-induced injury is a common clinical phenomenon that not only occurs in a dose-dependent manner but also occurs in some idiosyncratic individuals in a dose-independent manner. APAP overdose generally results in acute li…
View article: Mesenchymal stromal cells promote liver regeneration through regulation of immune cells
Mesenchymal stromal cells promote liver regeneration through regulation of immune cells Open
The liver is sensitive to pathogen-induced acute or chronic liver injury, and liver transplantation (LT) is the only effective strategy for end-stage liver diseases. However, the clinical application is limited by a shortage of liver organ…
View article: Melatonin preconditioning is an effective strategy for mesenchymal stem cell‐based therapy for kidney disease
Melatonin preconditioning is an effective strategy for mesenchymal stem cell‐based therapy for kidney disease Open
Based on multiple studies in animal models, mesenchymal stem cell (MSC)‐based therapy appears to be an innovative intervention approach with tremendous potential for the management of kidney disease. However, the clinical therapeutic effec…
View article: Pre‐treatments enhance the therapeutic effects of mesenchymal stem cells in liver diseases
Pre‐treatments enhance the therapeutic effects of mesenchymal stem cells in liver diseases Open
Liver diseases caused by viral infection, alcohol abuse and metabolic disorders can progress to end‐stage liver failure, liver cirrhosis and liver cancer, which are a growing cause of death worldwide. Although liver transplantation and hep…
View article: Protective role of melatonin in early‐stage and end‐stage liver cirrhosis
Protective role of melatonin in early‐stage and end‐stage liver cirrhosis Open
The liver is composed of hepatocytes, cholangiocytes, Kupffer cells, sinusoidal endothelial cells, hepatic stellate cells (HSCs) and dendritic cells; all these functional and interstitial cells contribute to the synthesis and secretion fun…
View article: Current understanding of adipose-derived mesenchymal stem cell-based therapies in liver diseases
Current understanding of adipose-derived mesenchymal stem cell-based therapies in liver diseases Open
The liver, the largest organ with multiple synthetic and secretory functions in mammals, consists of hepatocytes, cholangiocytes, hepatic stellate cells (HSCs), sinusoidal endothelial cells, Kupffer cells (KCs), and immune cells, among oth…