Yan Shi
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Author Swipe
View article: Citywide community-based colorectal cancer screening in urban Shanghai: age and sex variations in risk mitigation from 1973 to 2020
Citywide community-based colorectal cancer screening in urban Shanghai: age and sex variations in risk mitigation from 1973 to 2020 Open
Aims To evaluate the impact of Shanghai’s community colorectal cancer (CRC) screening program on CRC epidemiology and risk reduction. Materials and methods Data from the Shanghai Cancer Registry (1973-2020) were analyzed. Launched in 2013,…
View article: A family-based blended psychological intervention for adolescents with non-suicidal self-injury: A quasi-experimental study (Preprint)
A family-based blended psychological intervention for adolescents with non-suicidal self-injury: A quasi-experimental study (Preprint) Open
BACKGROUND Adolescent non-suicidal self-injury (NSSI) is a major public health concern. Digital and family-based psychological interventions have shown promise for addressing NSSI; however, evidence for the effectiveness and accessibility…
View article: Site-specific ligase-dependent conjugation with ring-opening linker improves safety and stability of HER2-targeting ADCs
Site-specific ligase-dependent conjugation with ring-opening linker improves safety and stability of HER2-targeting ADCs Open
Most of current ADCs have the problems of heterogeneity and payload-mediated off-target toxicities due to random conjugation and unstable linker. Herein we apply site-specific ligase-dependent conjugation (LDC) for GQ1001 and GQ1005, where…
View article: Revealing the potential value of urine microbiota in ureteral stent encrustation after renal transplantation via Illumina sequencing of 16S rRNA genes
Revealing the potential value of urine microbiota in ureteral stent encrustation after renal transplantation via Illumina sequencing of 16S rRNA genes Open
The results of this study suggest that urine microbiota may be closely related to the formation of USE, which provides a new perspective for understanding the pathogenesis of USE, which may contribute to early clinical diagnosis and treatm…
View article: Trends in cancer incidence and mortality in the process of metropolitanization of Shanghai, 1973–2017
Trends in cancer incidence and mortality in the process of metropolitanization of Shanghai, 1973–2017 Open
Background Shanghai has become a modern and international metropolis. A more comprehensive understanding of cancer incidence and mortality rates and socioenvironmental factors is explored to develop effective cancer control policies in Sha…
View article: LncRNA MALAT1 knockdown inhibits apoptosis of mouse hippocampus neuron cells with high glucose by Silencing autophagy
LncRNA MALAT1 knockdown inhibits apoptosis of mouse hippocampus neuron cells with high glucose by Silencing autophagy Open
View article: Structure, sensing and control of pneumatic upper limb rehabilitation system: Review and prospect
Structure, sensing and control of pneumatic upper limb rehabilitation system: Review and prospect Open
With the development of society, the service level of rehabilitation institutions needs to be improved. Pneumatic drive technology has attracted widespread attention due to its high safety and easy control. As a new type of driving element…
View article: Sport Motivation and Health: Relationship Between Health and Sport Motivation Among Key Junior High Schools’ Students in China
Sport Motivation and Health: Relationship Between Health and Sport Motivation Among Key Junior High Schools’ Students in China Open
The existing research has focused on physical and mental health, yet exploring the relationship between sports motivation and overall health remains indispensable. This study investigates sports motivation and health levels of students in …
View article: Assessment measures for chemotherapy-induced peripheral neuropathy among pediatric oncology patients: an updated systematic review
Assessment measures for chemotherapy-induced peripheral neuropathy among pediatric oncology patients: an updated systematic review Open
Objective To update the systematic review of assessment tools on chemotherapy-induced peripheral neuropathy (CIPN) for pediatric oncology patients based on the evidence available after the published review in 2020. Data sources Seven Engli…
View article: Commentary on “Effectiveness of tele‐guidance for physiotherapy in older patients with type 2 diabetes: A randomized controlled trial”
Commentary on “Effectiveness of tele‐guidance for physiotherapy in older patients with type 2 diabetes: A randomized controlled trial” Open
View article: Multi‑omics analysis identifies different molecular subtypes with unique outcomes in early-stage poorly differentiated lung adenocarcinoma
Multi‑omics analysis identifies different molecular subtypes with unique outcomes in early-stage poorly differentiated lung adenocarcinoma Open
View article: Multi‑omics analysis identifies different molecular subtypes with unique outcomes in early-stage poorly differentiated lung adenocarcinoma
Multi‑omics analysis identifies different molecular subtypes with unique outcomes in early-stage poorly differentiated lung adenocarcinoma Open
Introduction: Early-stage poorly differentiated lung adenocarcinoma (LUAD) is plagued by a high risk of postoperative recurrence, and its prognostic heterogeneity complicates treatment and surveillance planning. We conducted this integrati…
View article: Cirrhosis Promotes Cardiac Fibrosis Development by Inhibiting Notch1 in Cardiac Fibroblasts
Cirrhosis Promotes Cardiac Fibrosis Development by Inhibiting Notch1 in Cardiac Fibroblasts Open
Cardiovascular disease risk is elevated in patients with cirrhosis. However, the underlying molecular mechanisms remain poorly understood. Herein, we found that high levels of circulating transforming growth factor (TGF)-β1 were associated…
View article: [Preliminary study on preparation of decellularized nerve grafts from GGTA1 gene-edited pigs and their immune rejection in xenotransplantation].
[Preliminary study on preparation of decellularized nerve grafts from GGTA1 gene-edited pigs and their immune rejection in xenotransplantation]. Open
The decellularized nerve grafts from GGTA1 gene-edited pigs have well-preserved nerve structure, complete decellularization, retain the natural nerve basement membrane tube structure and components, and low immune response after xenotransp…
View article: A family-based blended psychological intervention for adolescents with non-suicidal self-injury: A quasi-experimental study (Preprint)
A family-based blended psychological intervention for adolescents with non-suicidal self-injury: A quasi-experimental study (Preprint) Open
BACKGROUND Adolescent non-suicidal self-injury (NSSI) is a pressing public health concern, with families playing a pivotal role in its management. Despite this, specific, evidence-based, and accessible family-based blended psychological i…
View article: Yitangkang in the Treatment of Glomerular Filtration Barrier Damage Through Tgf-Β/Smad/Slc7a11 Signaling Pathway:A Multi-Omics Analysis
Yitangkang in the Treatment of Glomerular Filtration Barrier Damage Through Tgf-Β/Smad/Slc7a11 Signaling Pathway:A Multi-Omics Analysis Open
View article: Salidroside from Rhodiola Rosea L. Attenuates High-Altitude Hypoxic Myocardial Injury Via Modulating Oxidative Stress and Akt/Gsk-3β Signaling
Salidroside from Rhodiola Rosea L. Attenuates High-Altitude Hypoxic Myocardial Injury Via Modulating Oxidative Stress and Akt/Gsk-3β Signaling Open
View article: Proteomic Identification and Functional Analysis of <i>Babesia microti</i> Reveals Heparin‐Binding Proteins
Proteomic Identification and Functional Analysis of <i>Babesia microti</i> Reveals Heparin‐Binding Proteins Open
Glycosaminoglycan (GAG) molecules on the surface of red blood cells play an important regulatory role in the invasion of merozoites of apicomplexan protozoa. Heparan sulfate, a type of GAG molecule, has been identified as an important rece…
View article: Role of Psychological Distress in the Assessment of Chronic Illness Care and Self-Management Behaviors of Elderly Patients with T2DM Chronic Complications
Role of Psychological Distress in the Assessment of Chronic Illness Care and Self-Management Behaviors of Elderly Patients with T2DM Chronic Complications Open
Psychological distress is intricately linked to self-management behaviour among elderly patients suffering from T2DM and chronic complications. Our findings carry significant implications for T2DM healthcare, indicating that addressing psy…
View article: Salidroside from Rhodiola Rosea L. Attenuates High-Altitude Hypoxic Myocardial Injury Via Modulating Oxidative Stress and Akt/Gsk-3β Signaling
Salidroside from Rhodiola Rosea L. Attenuates High-Altitude Hypoxic Myocardial Injury Via Modulating Oxidative Stress and Akt/Gsk-3β Signaling Open
View article: A novel hollow iron nanoparticle system loading PEG-Fe3O4 with C5a receptor antagonist for breast cancer treatment
A novel hollow iron nanoparticle system loading PEG-Fe3O4 with C5a receptor antagonist for breast cancer treatment Open
Breast cancer is the most diagnosed malignancy and major cause of cancer death among women population in the worldwide. Ferroptosis is a recently discovered iron-dependent regulated cell death involved in tumor progression and therapeutic …
View article: DUSP5 regulated by YTHDF1-mediated m6A modification promotes epithelial-mesenchymal transition and EGFR-TKI resistance via the TGF-β/Smad signaling pathway in lung adenocarcinoma
DUSP5 regulated by YTHDF1-mediated m6A modification promotes epithelial-mesenchymal transition and EGFR-TKI resistance via the TGF-β/Smad signaling pathway in lung adenocarcinoma Open
Background Lung adenocarcinoma (LUAD) patients have a dismal survival rate because of cancer metastasis and drug resistance. The study aims to identify the genes that concurrently modulate EMT, metastasis and EGFR-TKI resistance, and to in…
View article: The bidirectional relationship between sarcopenia and disability in China: a longitudinal study from CHARLS
The bidirectional relationship between sarcopenia and disability in China: a longitudinal study from CHARLS Open
Objectives Sarcopenia and disability represent significant concerns impacting the health of older people. This study aimed to explore the bidirectional relationship between sarcopenia and disability in Chinese older people. Methods This st…
View article: The relationship between social frailty and loneliness in community-dwelling older adults: a cross-sectional study
The relationship between social frailty and loneliness in community-dwelling older adults: a cross-sectional study Open
Background Social frailty (SF) is associated with multiple adverse health outcomes, yet there has been an inadequate focus on social frailty. The convoy model portrays the social networks through the perspective of the life course, thus pr…
View article: Anomalous Reduced Sequence: Potential Hazards of Disinfection Byproduct Chlorate In Reclaimed Water
Anomalous Reduced Sequence: Potential Hazards of Disinfection Byproduct Chlorate In Reclaimed Water Open
View article: The suppressive efficacy of THZ1 depends on <i>KRAS</i> mutation subtype and is associated with super‐enhancer activity and the PI3K/AKT/mTOR signalling in pancreatic ductal adenocarcinoma: A hypothesis‐generating study
The suppressive efficacy of THZ1 depends on <i>KRAS</i> mutation subtype and is associated with super‐enhancer activity and the PI3K/AKT/mTOR signalling in pancreatic ductal adenocarcinoma: A hypothesis‐generating study Open
Background Inhibition of CDK7, a potent transcription regulator, may bring new hope for treating pancreatic ductal adenocarcinoma (PDAC), which is featured by large genetic heterogeneity and abundant KRAS mutations. This investigation aime…
View article: Efficacy and safety of the integration of traditional Chinese medicine and western medicine in the treatment of diabetes-associated cognitive decline: a systematic review and meta-analysis
Efficacy and safety of the integration of traditional Chinese medicine and western medicine in the treatment of diabetes-associated cognitive decline: a systematic review and meta-analysis Open
Objective: In order to offer possible therapeutic treatment evidence for diabetes-associated cognitive decline (DACD), we thoroughly evaluated the effectiveness and safety of combining Traditional Chinese Medicine (TCM) and Western Medicin…
View article: EP07.05-02 NEOEAST: A Phase II Study of Ensartinib as Neoadjuvant Therapy for Stage II-IIIB ALK-rearranged Non-small Cell Lung Cancer
EP07.05-02 NEOEAST: A Phase II Study of Ensartinib as Neoadjuvant Therapy for Stage II-IIIB ALK-rearranged Non-small Cell Lung Cancer Open
View article: The Difference in Paraspinal Muscle Parameters and the Correlation with Health-Related Quality of Life among Healthy Individuals, Patients with Degenerative Lumbar Scoliosis and Lumbar Spinal Stenosis
The Difference in Paraspinal Muscle Parameters and the Correlation with Health-Related Quality of Life among Healthy Individuals, Patients with Degenerative Lumbar Scoliosis and Lumbar Spinal Stenosis Open
(1) Background: Paraspinal muscle degeneration affects the quality of life in patients with degenerative lumbar scoliosis (DLS) and lumbar spinal stenosis (LSS). We aimed to describe the characteristics and differences in the paraspinal mu…
View article: Pancreatic cancer incidence and mortality trends in urban Shanghai, China from 1973 to 2017: a joinpoint regression and age-period-cohort analysis
Pancreatic cancer incidence and mortality trends in urban Shanghai, China from 1973 to 2017: a joinpoint regression and age-period-cohort analysis Open
Background and purpose To provide a comprehensive overview of epidemiological features and temporal trends of pancreatic cancer in urban Shanghai from 1973 to 2017. Methods Data on pancreatic cancer in urban Shanghai were obtained through …