Yi‐Chen Lai
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View article: Association between iron deficiency anemia and risk of hearing loss among female patients: a multi-institutional cohort study
Association between iron deficiency anemia and risk of hearing loss among female patients: a multi-institutional cohort study Open
Background Iron deficiency anemia (IDA) represents the most prevalent nutritional deficiency worldwide, disproportionately affecting women of reproductive age. Emerging evidence suggests IDA may have underappreciated consequences for senso…
View article: Association of zinc deficiency and risk of new-onset dementia: a retrospective cohort study
Association of zinc deficiency and risk of new-onset dementia: a retrospective cohort study Open
Background Zinc deficiency may contribute to cognitive decline through neuroinflammation and synaptic dysfunction; however, epidemiological evidence linking zinc deficiency to incident dementia remains limited. We investigated whether zinc…
View article: Impact of zinc deficiency on mortality risk in patients with chronic obstructive pulmonary disease: a retrospective analysis
Impact of zinc deficiency on mortality risk in patients with chronic obstructive pulmonary disease: a retrospective analysis Open
Background Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Although nutritional deficiencies are increasingly recognized as modifiable factors in COPD progression, the relationship betw…
View article: Zinc deficiency predicts new-onset diabetic kidney disease in type 2 diabetes: a retrospective cohort study
Zinc deficiency predicts new-onset diabetic kidney disease in type 2 diabetes: a retrospective cohort study Open
Background Type 2 diabetes mellitus (T2DM) is a major global health challenge, with diabetic kidney disease (DKD) representing one of its most serious complications. Although zinc deficiency is common in diabetes, large-scale clinical evid…
View article: Thromboembolic safety and clinical benefits of tranexamic acid beyond hemostasis in post-COVID-19 patients undergoing major arthroplasty: A STROBE-compliant retrospective study
Thromboembolic safety and clinical benefits of tranexamic acid beyond hemostasis in post-COVID-19 patients undergoing major arthroplasty: A STROBE-compliant retrospective study Open
The safety of tranexamic acid (TXA) in patients with recent coronavirus disease (COVID-19) infection undergoing major arthroplasty remains unclear. We aimed to evaluate whether TXA increases thromboembolic risk in post-COVID-19 patients un…
View article: Recombination alters the receptor binding and furin cleavage site in novel bat-borne HKU5-CoV-2 coronavirus
Recombination alters the receptor binding and furin cleavage site in novel bat-borne HKU5-CoV-2 coronavirus Open
HKU5-CoV-2 is a new bat-infecting coronavirus phylogenetically related to MERS-CoV. It has recently been confirmed that HKU5-CoV-2 can enter human cells and organoids in vitro via the ACE2 receptor, raising concerns about its pandemic pote…
View article: Standard complete blood count to predict long‐term outcomes in febrile infection–related epilepsy syndrome (FIRES): A multicenter study
Standard complete blood count to predict long‐term outcomes in febrile infection–related epilepsy syndrome (FIRES): A multicenter study Open
Objective We investigated whether complete blood count (CBC) analyses during intensive care unit stay could predict 12‐month outcomes in patients with cryptogenic febrile infection–related epilepsy syndrome (FIRES), a subset of new‐onset r…
View article: Preoperative vitamin D deficiency and postoperative delirium risk: multicenter retrospective study
Preoperative vitamin D deficiency and postoperative delirium risk: multicenter retrospective study Open
Background To assess the impact of preoperative vitamin D deficiency (VDD) on the risk of postoperative delirium (POD) in patients undergoing musculoskeletal surgery. Methods This cohort study utilized the TriNetX Healthcare Commercial Org…
View article: De novo pathogenic <scp><i>CSF1R</i></scp> variant implicates microglial dysfunction in pathogenesis of febrile infection‐related epilepsy syndrome
De novo pathogenic <span><i>CSF1R</i></span> variant implicates microglial dysfunction in pathogenesis of febrile infection‐related epilepsy syndrome Open
Febrile infection‐related epilepsy syndrome (FIRES) is a rare presentation of refractory status epilepticus following a febrile illness with resulting refractory epilepsy. Evidence supports the presence of immune dysregulation in patients …
View article: Time to treatment in pediatric patients with repeated episodes of status epilepticus
Time to treatment in pediatric patients with repeated episodes of status epilepticus Open
Time to treatment with benzodiazepine and non-benzodiazepine ASM in patients with repeated episodes of status epilepticus does not improve for a second episode of status epilepticus, suggesting additional opportunities for intervention and…
View article: Identification of Distinct Biological Groups of Patients With Cryptogenic NORSE via Inflammatory Profiling
Identification of Distinct Biological Groups of Patients With Cryptogenic NORSE via Inflammatory Profiling Open
The identification of distinct inflammatory subgroups in c-NORSE suggests that variations in the underlying immune mechanisms contribute to differential treatment responses. These findings underscore the importance of personalized therapeu…
View article: A Comprehensive Review of VOCs as a Key Indicator in Food Authentication
A Comprehensive Review of VOCs as a Key Indicator in Food Authentication Open
This article presents an in‐depth review of the role of volatile organic compounds (VOCs) in food authentication, an area of increasing importance due to the rising complexity of food fraud cases. The inherent and unique profiles of VOCs i…
View article: Recombination alters the receptor binding and furin cleavage site in novel bat-borne HKU5-CoV-2 coronavirus
Recombination alters the receptor binding and furin cleavage site in novel bat-borne HKU5-CoV-2 coronavirus Open
HKU5-CoV-2 is a new bat-infecting coronavirus phylogenetically related to MERS-CoV. It has recently been confirmed that HKU5-CoV-2 can enter human cells and organoids in vitro via the ACE2 receptor, raising concerns about its pandemic pote…
View article: Bioinspired Nanoscale 3D Printing of Calcium Phosphates Using Bone Prenucleation Clusters
Bioinspired Nanoscale 3D Printing of Calcium Phosphates Using Bone Prenucleation Clusters Open
Calcium phosphates (CaPs) are ubiquitous in biological structures, such as vertebrate bones and teeth, and have been widely used in biomedical applications. However, fabricating CaPs at the nanoscale in 3D has remained a significant challe…
View article: Combined Systemic Immunotherapy and Intrathecal Dexamethasone in Febrile Infection Related Epilepsy Syndrome
Combined Systemic Immunotherapy and Intrathecal Dexamethasone in Febrile Infection Related Epilepsy Syndrome Open
Febrile infection related epilepsy syndrome (FIRES) is a rare presentation of refractory status epilepticus with immune dysregulation as a potential pathologic mechanism. Despite promising results from second‐line immunomodulators, approxi…
View article: Association between vitamin D deficiency and major depression in patients with chronic kidney disease: a cohort study
Association between vitamin D deficiency and major depression in patients with chronic kidney disease: a cohort study Open
Background Patients with chronic kidney disease (CKD) have an elevated risk of both vitamin D deficiency (VDD) and depression. However, the relationship between VDD and the risk of depression in this population remains unclear. Methods Usi…
View article: Comparative evaluation of allograft particulate bone and cortical bone blocks combined with xenograft bone for labial bone defects in the aesthetic zone: a prospective cohort study
Comparative evaluation of allograft particulate bone and cortical bone blocks combined with xenograft bone for labial bone defects in the aesthetic zone: a prospective cohort study Open
The study was retrospectively registered in the Chinese Clinical Trial Registry ( http://www.chictr.org.cn/ ) with the registration number ChiCTR2300070538 on April 14, 2023.
View article: Perioperative administration of sub-anesthetic ketamine/esketamine for preventing postpartum depression symptoms: A trial sequential meta-analysis
Perioperative administration of sub-anesthetic ketamine/esketamine for preventing postpartum depression symptoms: A trial sequential meta-analysis Open
Objective Postpartum depression (PPD) is a major mental health issue affecting 10%–15% of women globally. This meta-analysis synthesized updated evidence on sub-anesthetic ketamine/esketamine’s efficacy in preventing PPD. Methods Randomize…
View article: Seasonal variations in peptic ulcer disease incidence in Taiwan, a country spanning both tropical and subtropical regions: a real-world database analysis
Seasonal variations in peptic ulcer disease incidence in Taiwan, a country spanning both tropical and subtropical regions: a real-world database analysis Open
Objective Previous studies have shown that the incidence of peptic ulcer disease (PUD) exhibits seasonal variations. This study aimed to investigate the seasonal variation in PUD incidence in Taiwan, which spans both tropical and subtropic…
View article: Feasibility of Achieving Nutritional Adequacy in Critically Ill Children with Critical Neurological Illnesses (CNIs)?—A Quaternary Hospital Experience
Feasibility of Achieving Nutritional Adequacy in Critically Ill Children with Critical Neurological Illnesses (CNIs)?—A Quaternary Hospital Experience Open
The literature on the nutritional needs and outcomes of critically ill children is scarce, especially on those with critical neurological illnesses (CNIs). Current evidence shows a lower mortality in patients who achieve two-thirds of thei…
View article: 3D-printing of calcium phosphates at nanoscale resolution
3D-printing of calcium phosphates at nanoscale resolution Open
Calcium phosphates (CaPs) are ubiquitous in biological structures, such as vertebrate bones and teeth, and have diverse biomedical applications. Shaping CaPs at the nanoscale in 3D can unlock new possibilities in a myriad of research and i…
View article: Time to Treatment in Pediatric Patients with Repeated Episodes of Status Epilepticus
Time to Treatment in Pediatric Patients with Repeated Episodes of Status Epilepticus Open
Objective To compare pediatric patients who presented with repeated status epilepticus episodes to patients with a single episode of status epilepticus and identify distinguishing clinical factors. Methods Retrospective analysis of a multi…
View article: Dynamic electrical synapses rewire brain networks for persistent oscillations and epileptogenesis
Dynamic electrical synapses rewire brain networks for persistent oscillations and epileptogenesis Open
One of the very fundamental attributes for telencephalic neural computation in mammals involves network activities oscillating beyond the initial trigger. The continuing and automated processing of transient inputs shall constitute the bas…
View article: Impact of intravenous dexmedetomidine on postoperative gastrointestinal function recovery: an updated meta-analysis
Impact of intravenous dexmedetomidine on postoperative gastrointestinal function recovery: an updated meta-analysis Open
Background: Postoperative ileus (POI) is a complication that may occur after abdominal or nonabdominal surgery. Intravenous dexmedetomidine (Dex) has been reported to accelerate postoperative gastrointestinal function recovery; however, up…