Ying Liu
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View article: Clostridium scindens attenuates acute kidney injury by producing indole-3-acetic acid
Clostridium scindens attenuates acute kidney injury by producing indole-3-acetic acid Open
The association between gut microbiota and acute kidney injury (AKI) has garnered increased attention recently. Herein, we investigated the effect of the gut microbiota and its metabolites on regulating AKI-associated kidney injury and inf…
View article: Clearing the air: Which pollution source matters most for health?
Clearing the air: Which pollution source matters most for health? Open
Objectives Air pollution remains a significant public health challenge, contributing to substantial morbidity and mortality. The aim of this study is to identify effective intervention strategies for mitigating air pollution and its health…
View article: Machine learning-powered discovery of a novel berberine derivative inducing SCD-dependent ferroptosis in osteosarcoma
Machine learning-powered discovery of a novel berberine derivative inducing SCD-dependent ferroptosis in osteosarcoma Open
Background Despite decades of therapeutic development, osteosarcoma survival remains poor. Although berberine (BBR) shows anti-tumor activity, its efficacy is limited. We addressed this through structural modification and machine learning-…
View article: From dry eye to depression: a machine learning-based framework for predicting adolescent mental health
From dry eye to depression: a machine learning-based framework for predicting adolescent mental health Open
Integrating ocular health with psychosocial factors enhances machine-learning prediction of adolescent depression and may support earlier, school-based identification and referral. Given the low-cost, questionnaire-based inputs and favorab…
View article: Case report: First report of metastatic esophageal squamous cell carcinoma with EGFR p.S768I mutation: remarkable response to third-generation EGFR-TKI
Case report: First report of metastatic esophageal squamous cell carcinoma with EGFR p.S768I mutation: remarkable response to third-generation EGFR-TKI Open
We present a 59-year-old male with metastatic esophageal squamous cell carcinoma (ESCC) harboring an uncommon epidermal growth factor receptor (EGFR) exon 20 p.S768I mutation identified through liquid biopsy. Following progression on conve…
View article: A correlation study on triglyceride-glucose index and extensive neovascularization within carotid artery plaques
A correlation study on triglyceride-glucose index and extensive neovascularization within carotid artery plaques Open
This study demonstrates that the TyG index is significantly and independently associated with extensive IPN in carotid plaques. This finding suggests the TyG index has potential as a supplementary serological marker in the assessment of pl…
View article: Glycerol‐Mediated Freeze‐Thaw Stabilization of Probiotic‐Loaded High Internal Phase Emulsions
Glycerol‐Mediated Freeze‐Thaw Stabilization of Probiotic‐Loaded High Internal Phase Emulsions Open
This study developed high internal phase emulsions (HIPEs) using glycerol to partially replace water, aiming to enhance freeze‐thaw stability for Lactiplantibacillus plantarum P9 (P9). Soy protein isolate was employed as the emulsifier to …
View article: Intracranial infection caused by Mycoplasma hominis after neurosurgical operation: an easily overlooked but serious condition
Intracranial infection caused by Mycoplasma hominis after neurosurgical operation: an easily overlooked but serious condition Open
Introduction: Mycoplasma hominis (M. hominis) is a commensal that mainly colonizes in the microflora of the genitourinary tracts and is associated with urogenital tract infections. There are reports of central nervous system (CNS) infectio…
View article: Utilizing atomic-scale grain boundary segregation: a new way for constructing the lamellar heterogeneous magnesium alloy
Utilizing atomic-scale grain boundary segregation: a new way for constructing the lamellar heterogeneous magnesium alloy Open
Heterogeneous structure significantly impacts the applications of wrought magnesium (Mg) alloys. Herein, we put forward a novel idea for constructing the heterogeneous structure by utilizing solute grain boundary (GB) segregation on recrys…
View article: Neutrophil extracellular traps in ischemic stroke: mechanisms, clinical implications, and therapeutic potential
Neutrophil extracellular traps in ischemic stroke: mechanisms, clinical implications, and therapeutic potential Open
Ischemic stroke remains a leading cause of mortality and disability, with many patients failing to benefit from reperfusion therapies due to lysis-resistant thrombus formation and severe neuroinflammation. This highlights an urgent need to…
View article: Revealing the Influence of Zn Content on the Microstructure and Mechanical Properties of Bimodal Mg-Zn-Gd-Sm Alloy
Revealing the Influence of Zn Content on the Microstructure and Mechanical Properties of Bimodal Mg-Zn-Gd-Sm Alloy Open
The development of low-cost and high-performance Mg alloys is an important way to achieve further application of magnesium alloys. In this work, the as-extruded Mg98.3−xZnxGd1Sm0.7 alloy with excellent mechanical properties is successfully…
View article: Distribution for platelet antibody in patients with immune-mediated platelet transfusion refractoriness
Distribution for platelet antibody in patients with immune-mediated platelet transfusion refractoriness Open
This study clarified platelet antibody distribution in Chinese iPTR patients. Besides HLA Class I antibodies, autoantibodies against platelet glycoproteins play a key role. Among HPA antibodies, HPA-5b may predominate in the Chinese popula…
View article: Quantitative study of vestibular endolymphatic hydrops in Meniere’s disease based on Three-Dimensional real Inversion Recovery (3D-real IR) sequence
Quantitative study of vestibular endolymphatic hydrops in Meniere’s disease based on Three-Dimensional real Inversion Recovery (3D-real IR) sequence Open
3D-real IR MRI enables quantitative EH assessment, with ELR thresholds providing objective grading criteria. EH severity reflects pathophysiological progression through its associations with auditory/vestibular dysfunction and disease stag…
View article: FGFR1-amplified colorectal cancer: a distinct prognostic subtype identified through integrated genomic and immunohistochemical profiling
FGFR1-amplified colorectal cancer: a distinct prognostic subtype identified through integrated genomic and immunohistochemical profiling Open
This study provides the first comprehensive characterization of FGFR genomic alterations in CRC through large-scale profiling (n = 7606), establishing FGFR1 amplification as the predominant alteration. Unlike FGFR2/3-driven malignancies, F…
View article: Glycosylated extracellular matrix drives immune suppression by controlling T cell movement, macrophage phenotype, and macrophage-T cell crosstalk in triple negative breast cancer
Glycosylated extracellular matrix drives immune suppression by controlling T cell movement, macrophage phenotype, and macrophage-T cell crosstalk in triple negative breast cancer Open
The tumor extracellular matrix (ECM) is increasingly recognized as a key driver of immune suppression and therapy resistance in cancer. However, the specific ECM components and mechanisms that create this immunosuppressive environment rema…
View article: The “Clover” solution – 4-lumen double-loop stoma in managing multifocal intestinal obstruction due to peritoneal metastases
The “Clover” solution – 4-lumen double-loop stoma in managing multifocal intestinal obstruction due to peritoneal metastases Open
Multifocal intestinal obstruction (IO) due to peritoneal metastases (PM) presents significant surgical challenges, with traditional approaches often falling short. The Clover stoma, a four-lumen technique, combines a loop ileostomy and tra…
View article: Isoquercitrin mitigates intestinal ischemia-reperfusion injury by regulating intestinal flora and inhibiting NLRP3 inflammasome activation
Isoquercitrin mitigates intestinal ischemia-reperfusion injury by regulating intestinal flora and inhibiting NLRP3 inflammasome activation Open
Intestinal ischemia-reperfusion (II/R) injury, frequently observed in clinical emergencies such as trauma, infection, and transplantation, leads to severe epithelial necrosis, loss of villi, and alarmingly high mortality rates (50 %-90 %),…
View article: Induction of Autophagy as a Therapeutic Breakthrough for NAFLD: Current Evidence and Perspectives
Induction of Autophagy as a Therapeutic Breakthrough for NAFLD: Current Evidence and Perspectives Open
Nonalcoholic fatty liver disease (NAFLD) is a clinicopathological syndrome characterised by hepatic steatosis in the absence of significant alcohol consumption or other specific causes of liver injury. It has become one of the leading caus…
View article: Therapeutic potential of mesenchymal stem cell exosomes for tumors in the digestive system: From bench to bedside
Therapeutic potential of mesenchymal stem cell exosomes for tumors in the digestive system: From bench to bedside Open
Exosomes are small, bilayer lipid vesicles with diameters ranging from approximately 40–160 nm. These vesicles carry a diverse array of molecular cargo, including DNA, RNA, lipids, and proteins, which play a critical role in intercel…