Yan Lin
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View article: A CART-based prognostic model for risk stratification of postoperative early recurrence in hepatocellular carcinoma with microvascular invasion
A CART-based prognostic model for risk stratification of postoperative early recurrence in hepatocellular carcinoma with microvascular invasion Open
Background Postoperative early recurrence (ER) poses a major threat to long-term survival in hepatocellular carcinoma (HCC), especially in patients with microvascular invasion (MVI). Although conventional staging systems provide prognostic…
View article: WITHDRAWN: Identifying and validating the prognosis and potential significance of Mitophagy related genes in breast cancer
WITHDRAWN: Identifying and validating the prognosis and potential significance of Mitophagy related genes in breast cancer Open
The full text of this preprint has been withdrawn by the authors since they no longer stand by the findings/conclusions of this work. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to …
View article: Patient-Reported Tolerability of Selpercatinib Compared to Cabozantinib/Vandetanib: A Secondary Analysis of the LIBRETTO-531 Randomized-Controlled Trial in <i>RET</i> -Mutant Medullary Thyroid Cancer
Patient-Reported Tolerability of Selpercatinib Compared to Cabozantinib/Vandetanib: A Secondary Analysis of the LIBRETTO-531 Randomized-Controlled Trial in <i>RET</i> -Mutant Medullary Thyroid Cancer Open
Background: Progression-free survival (PFS) may not fully capture the impact of treatment on patients, especially in cancers with longer natural histories and thus, could be complemented by robust measures of patient-reported tolerability …
View article: Postoperative Adjuvant Transcatheterarterial Chemoembolization Should Be Considered Selectively for Patients with Cytokeratin-19 Positive Hepatocellular Carcinoma
Postoperative Adjuvant Transcatheterarterial Chemoembolization Should Be Considered Selectively for Patients with Cytokeratin-19 Positive Hepatocellular Carcinoma Open
Among CK19+ HCC patients with higher recurrence of postoperative risk, PA-TACE could greatly improve RFS and OS.
View article: Study on recharge test and numerical simulation of deep foundation pit of subway in Jinan silty clay stratum
Study on recharge test and numerical simulation of deep foundation pit of subway in Jinan silty clay stratum Open
As urban underground space development advances toward greater depth and intensity, the scale of foundation pit construction has expanded considerably, presenting increasing challenges for groundwater seepage control. This study investigat…
View article: Is Complement C3 a Reliable Indicator of Endometriosis Severity? Insights from a Retrospective Study
Is Complement C3 a Reliable Indicator of Endometriosis Severity? Insights from a Retrospective Study Open
Objective This study evaluates the potential of complement C3 as a predictive biomarker for endometriosis severity and examines its correlation with clinical features and biochemical markers. Methods In this retrospective analysis, 82 wome…
View article: Assessing tolerability with the Functional Assessment of Cancer Therapy item GP5: psychometric evidence from LIBRETTO-531, a phase 3 trial of selpercatinib in medullary thyroid cancer
Assessing tolerability with the Functional Assessment of Cancer Therapy item GP5: psychometric evidence from LIBRETTO-531, a phase 3 trial of selpercatinib in medullary thyroid cancer Open
Background This psychometric analysis generated evidence to support the use of the Functional Assessment of Cancer Therapy item GP5 (GP5) as a measure of tolerability and confirms the appropriateness of categorizing “high side-effect burde…
View article: Integrative multi-omics analysis reveals a novel subtype of hepatocellular carcinoma with biological and clinical relevance
Integrative multi-omics analysis reveals a novel subtype of hepatocellular carcinoma with biological and clinical relevance Open
Background Hepatocellular carcinoma (HCC) is a highly heterogeneous tumor, and the development of accurate predictive models for prognosis and drug sensitivity remains challenging. Methods We integrated laboratory data and public cohorts t…
View article: Gut commensal Agathobacter rectalis alleviates microglia-mediated neuroinflammation against pathogenesis of Alzheimer disease
Gut commensal Agathobacter rectalis alleviates microglia-mediated neuroinflammation against pathogenesis of Alzheimer disease Open
Gut microbiota plays a crucial role in the pathogenesis of Alzheimer disease (AD). Here, we found that AD patients had significantly lower abundance of Agathobacter, which were negatively correlated with cognitive impairment. Animal experi…
View article: Preoperative magnetic resonance imaging-radiomics in cervical cancer: a systematic review and meta-analysis
Preoperative magnetic resonance imaging-radiomics in cervical cancer: a systematic review and meta-analysis Open
Background The purpose of this systematic review and meta-analysis is to evaluate the potential significance of radiomics, derived from preoperative magnetic resonance imaging (MRI), in detecting deep stromal invasion (DOI), lymphatic vasc…
View article: BTLA deficiency promotes HSC activation and protects against hepatic ischemia-reperfusion injury
BTLA deficiency promotes HSC activation and protects against hepatic ischemia-reperfusion injury Open
Background and Aims: Hepatic ischemia-reperfusion injury (IRI) is unavoidable even despite the development of more effective surgical approaches. During hepatic IRI, activated HSC (aHSC) are involved in liver injury and recovery. Approach …
View article: Controlled attenuation parameter (CAP): the clinical value based on MRI-PDFF in children with obesity
Controlled attenuation parameter (CAP): the clinical value based on MRI-PDFF in children with obesity Open
Objectives Controlled attenuation parameter (CAP) is a noninvasive and quantitative method to evaluate hepatic steatosis, which is not well evaluated in children. The aim of this study was to examine the diagnostic value of CAP for hepatic…
View article: WITHDRAWN: Identifying and validating the prognosis and potential significance of Mitophagy related genes in breast cancer
WITHDRAWN: Identifying and validating the prognosis and potential significance of Mitophagy related genes in breast cancer Open
Background Breast cancer (BC) is a common malignant tumor with high incidence and mortality rates. Mitophagy refers to a selective form of autophagy that is believed to be closely related to the occurrence and progression of BC. Identifyin…
View article: 3.0 T multi-parametric MRI reveals metabolic and microstructural abnormalities in the posterior visual pathways in patients with thyroid eye disease
3.0 T multi-parametric MRI reveals metabolic and microstructural abnormalities in the posterior visual pathways in patients with thyroid eye disease Open
Introduction We aim to explore the microstructural and metabolic changes in visual pathways in patients with thyroid eye disease (TED) using 3T multi-parametric MRI. Methods Thirty-four TED patients (inactive group = 20; active group = 14;…
View article: Integrating Single-Cell and Spatial Transcriptomics to Uncover and Elucidate GP73-Mediated Pro-Angiogenic Regulatory Networks in Hepatocellular Carcinoma
Integrating Single-Cell and Spatial Transcriptomics to Uncover and Elucidate GP73-Mediated Pro-Angiogenic Regulatory Networks in Hepatocellular Carcinoma Open
Hepatocellular carcinoma (HCC) was characterized as being hypervascular. In the present study, we generated a single-cell spatial transcriptomic landscape of the vasculogenic etiology of HCC and illustrated overexpressed Golgi phosphoprote…
View article: A Case of Curative Treatment with Apatinib and Camrelizumab Following Liver Resection for Advanced Hepatocellular Carcinoma
A Case of Curative Treatment with Apatinib and Camrelizumab Following Liver Resection for Advanced Hepatocellular Carcinoma Open
Hepatocellular carcinoma (HCC), a highly malignant digestive system tumor, poses substantial challenges due to its intricate underlying causes and pronounced post-surgery recurrence. Consequently, the prognosis for HCC remains notably unfa…
View article: Computed tomography radiomics signature via machine learning predicts RRM2 and overall survival in hepatocellular carcinoma
Computed tomography radiomics signature via machine learning predicts RRM2 and overall survival in hepatocellular carcinoma Open
The RRM2 expression level in HCC can considerably affect prognosis of these patients. Expression levels of RRM2 and prognosis of HCC individuals can be predicted through radiomics features by utilizing CT scan data.
View article: RBM38 Reverses Sorafenib Resistance in Hepatocellular Carcinoma Cells by Combining and Promoting lncRNA-GAS5
RBM38 Reverses Sorafenib Resistance in Hepatocellular Carcinoma Cells by Combining and Promoting lncRNA-GAS5 Open
Background: Hepatocellular carcinoma (HCC) is a life-threatening human malignancy and the fourth leading cause of cancer-related deaths worldwide. Patients with HCC are often diagnosed at an advanced stage with a poor prognosis. Sorafenib …
View article: Circadian Activity and Clock Genes in Pachycrepoideus vindemmiae: Implications for Field Applications and Circadian Clock Mechanisms of Parasitoid Wasps
Circadian Activity and Clock Genes in Pachycrepoideus vindemmiae: Implications for Field Applications and Circadian Clock Mechanisms of Parasitoid Wasps Open
Despite the importance of circadian rhythms in insect behavior, our understanding of circadian activity and the molecular oscillatory mechanism in parasitoid wasp circadian clocks is limited. In this study, behavioral activities expected t…
View article: Data from Inhibition of Soluble Tumor Necrosis Factor Prevents Chemically Induced Carcinogenesis in Mice
Data from Inhibition of Soluble Tumor Necrosis Factor Prevents Chemically Induced Carcinogenesis in Mice Open
TNF is a potent promoter of carcinogenesis and potentially important target for cancer prevention. TNF is produced as functionally distinct transmembrane and soluble molecules (tmTNF and sTNF, respectively), but their individual roles in c…
View article: STIM1-regulated exosomal EBV-LMP1 empowers endothelial cells with aggressive phenotype by activating the Akt/ERK pathway in nasopharyngeal carcinoma
STIM1-regulated exosomal EBV-LMP1 empowers endothelial cells with aggressive phenotype by activating the Akt/ERK pathway in nasopharyngeal carcinoma Open
Background Stromal interaction molecule 1 (STIM1)-mediated Ca 2+ signaling regulates tumor angiogenesis in nasopharyngeal carcinoma (NPC), an Epstein-Barr virus (EBV)-related human malignancy. However, the mechanism by which STIM1 modulate…
View article: Advances in post-operative prognostic models for hepatocellular carcinoma
Advances in post-operative prognostic models for hepatocellular carcinoma Open
Hepatocellular carcinoma (HCC) is one of the most common malignancies and a leading cause of cancer-related death worldwide. Surgery remains the primary and most successful therapy option for the treatment of early- and mid-stage HCCs, but…
View article: The miRNA-185-5p/STIM1 Axis Regulates the Invasiveness of Nasopharyngeal Carcinoma Cell Lines by Modulating EGFR Activation-Stimulated Switch from E- to N-Cadherin
The miRNA-185-5p/STIM1 Axis Regulates the Invasiveness of Nasopharyngeal Carcinoma Cell Lines by Modulating EGFR Activation-Stimulated Switch from E- to N-Cadherin Open
Distant metastasis remains the primary cause of treatment failure and suggests a poor prognosis in nasopharyngeal carcinoma (NPC). Epithelial-mesenchymal transition (EMT) is a critical cellular process for initiating a tumor invasion and r…
View article: Prognosis-Related Molecular Subtypes and Immune Features Associated with Hepatocellular Carcinoma
Prognosis-Related Molecular Subtypes and Immune Features Associated with Hepatocellular Carcinoma Open
Bioinformatics tools were used to identify prognosis-related molecular subtypes and biomarkers of hepatocellular carcinoma (HCC). Differential expression analysis of four datasets identified 3330 overlapping differentially expressed genes …
View article: A New Surgical Scheme for Determining Hepatectomy to Hepatocellular Carcinoma Patients with Clinically Significant Portal Hypertension
A New Surgical Scheme for Determining Hepatectomy to Hepatocellular Carcinoma Patients with Clinically Significant Portal Hypertension Open
Objective To establish a new surgical scheme defining risk classes of post-hepatectomy liver failure (PHLF) to facilitate the surgical decision-making and identify suitable candidates for individual hepatectomy among hepatocellular carcino…