Yanfang Yang
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View article: Integrated network toxicology and experimental validation reveal nephrotoxic effects of acetyl tributyl citrate in HK-2 cells
Integrated network toxicology and experimental validation reveal nephrotoxic effects of acetyl tributyl citrate in HK-2 cells Open
Acetyl tributyl citrate (ATBC) is an eco-friendly plasticizer widely used in plastic products, yet its potential nephrotoxicity remains unclear. This study integrated network toxicology, molecular docking, and molecular dynamics (MD) simul…
View article: Pigment epithelium-derived factor prevents endothelial dysfunction in early stage of hyperlipidemia by regulating endothelial fatty acid transport
Pigment epithelium-derived factor prevents endothelial dysfunction in early stage of hyperlipidemia by regulating endothelial fatty acid transport Open
View article: Shanling Jiangzhi Tea treats hyperuricemia by inhibition of COMT/MAOA signaling pathway and p53/SERPINE1/NLRP3 signaling pathway
Shanling Jiangzhi Tea treats hyperuricemia by inhibition of COMT/MAOA signaling pathway and p53/SERPINE1/NLRP3 signaling pathway Open
Objective To evaluate the therapeutic efficacy of Shanling Jiangzhi Tea (SLJZ) on hyperuricemia (HUA) mice and to investigate its mechanism. Methods A HUA mouse model was established using a combination of uric acid (UA)and potassium oxona…
View article: Development and validation of a static multiple light scattering (SMLS) method for real-time colloidal stability assessment in nanoparticle formulations
Development and validation of a static multiple light scattering (SMLS) method for real-time colloidal stability assessment in nanoparticle formulations Open
View article: Author Correction: Revealing the pharmacological mechanisms of nao-an dropping pill in preventing and treating ischemic stroke via the PI3K/Akt/eNOS and Nrf2/HO-1 pathways
Author Correction: Revealing the pharmacological mechanisms of nao-an dropping pill in preventing and treating ischemic stroke via the PI3K/Akt/eNOS and Nrf2/HO-1 pathways Open
View article: Bioactive metallic nanoparticles for synergistic cancer immunotherapy
Bioactive metallic nanoparticles for synergistic cancer immunotherapy Open
View article: Exploring the Empowerment of New Quality Productive Forces in Library Service Innovation
Exploring the Empowerment of New Quality Productive Forces in Library Service Innovation Open
Service innovation enhancement constitutes a specific requirement for library development in the new era and serves as a crucial safeguard for advancing high-quality national reading initiatives. The empowerment of new quality productive f…
View article: Application of deep learning for real-time detection, localization, and counting of the malignant invasive weed Solanum rostratum Dunal
Application of deep learning for real-time detection, localization, and counting of the malignant invasive weed Solanum rostratum Dunal Open
Solanum rostratum Dunal (SrD) is a globally harmful invasive weed that has spread widely across many countries, posing a serious threat to agriculture and ecosystem security. A deep learning network model, TrackSolanum, was designed for re…
View article: Integrated Network Toxicology and Experimental Validation Reveal Nephrotoxic Effects of Acetyl Tributyl Citrate in Hk-2 Cells
Integrated Network Toxicology and Experimental Validation Reveal Nephrotoxic Effects of Acetyl Tributyl Citrate in Hk-2 Cells Open
View article: Glabridin inhibits proliferation and migration in hepatocellular carcinoma by regulating multi-targets
Glabridin inhibits proliferation and migration in hepatocellular carcinoma by regulating multi-targets Open
Gla regulates the expression levels of DUSP5, ZFP36, KLF10, NR4A1, and RMI2 to against HCC, providing valuable insights for the application of Gla in HCC treatment.
View article: Nogo-B inhibition facilitates cholesterol metabolism to reduce hypercholesterolemia
Nogo-B inhibition facilitates cholesterol metabolism to reduce hypercholesterolemia Open
The strategy of lowering cholesterol levels by promoting cholesterol excretion is still lacking, and few molecular targets act on multiple cholesterol metabolic processes. In this study, we find that Nogo-B deficiency/inhibition simultaneo…
View article: Revealing the pharmacological mechanisms of nao-an dropping pill in preventing and treating ischemic stroke via the PI3K/Akt/eNOS and Nrf2/HO-1 pathways
Revealing the pharmacological mechanisms of nao-an dropping pill in preventing and treating ischemic stroke via the PI3K/Akt/eNOS and Nrf2/HO-1 pathways Open
Nao-an Dropping Pill (NADP) is a Chinese patent medicine which commonly used in clinic for ischemic stroke (IS). However, the material basis and mechanism of its prevention or treatment of IS are unclear, then we carried out this study. 52…
View article: Comparative Colloidal Stability of Commercial Amphotericin B Nanoformulations Using Dynamic and Static Multiple Light Scattering Techniques [Corrigendum]
Comparative Colloidal Stability of Commercial Amphotericin B Nanoformulations Using Dynamic and Static Multiple Light Scattering Techniques [Corrigendum] Open
[This corrects the article DOI: 10.2147/IJN.S387681.].
View article: Picroside II Inhibits Glycolysis and Migration in HepG2 Cells
Picroside II Inhibits Glycolysis and Migration in HepG2 Cells Open
Objectives The objective of this study was to investigate the impacts and mechanisms of Picroside II on hepatocellular carcinoma (HCC). Materials and Methods The GeneCards database was mined for HCC-related targets. The targets of Picrosid…
View article: Endoplasmic reticulum stress in breast cancer: a predictive model for prognosis and therapy selection
Endoplasmic reticulum stress in breast cancer: a predictive model for prognosis and therapy selection Open
Background Breast cancer (BC) is a leading cause of mortality among women, underscoring the urgent need for improved therapeutic predictio. Developing a precise prognostic model is crucial. The role of Endoplasmic Reticulum Stress (ERS) in…
View article: Oxyepiberberine from the Active Site of <i>Coptidis Rhizoma</i> Inhibits Lung Adenocarcinoma by Regulating SRC-related Pathways <i>in vivo</i>
Oxyepiberberine from the Active Site of <i>Coptidis Rhizoma</i> Inhibits Lung Adenocarcinoma by Regulating SRC-related Pathways <i>in vivo</i> Open
Background Huanglian (HL), also known as Coptis chinensis Franch., was initially documented in “Sheng Nong’s Herbal Classic” as a high-quality product used to cure ailments such as fever, indigestion, bloating, nausea, dysentery, diarrhea,…
View article: Essential Oil from Cinnamomum Cassia Presl Bark Regulates Macrophage Polarization and Ameliorates Lipopolysaccharide-Induced Acute Lung Injury Through Tlr4/Myd88/Nf-Κb Pathway
Essential Oil from Cinnamomum Cassia Presl Bark Regulates Macrophage Polarization and Ameliorates Lipopolysaccharide-Induced Acute Lung Injury Through Tlr4/Myd88/Nf-Κb Pathway Open
View article: Drug-like properties of serial phenanthroindolizidine alkaloid compounds: ADMET characteristic prediction and validation
Drug-like properties of serial phenanthroindolizidine alkaloid compounds: ADMET characteristic prediction and validation Open
Phenanthroindolizidine alkaloids (PAs) are a series of compounds that have been isolated from traditional herbal medicines and have significant therapeutic potential, such as anti-arthritic, anti-viral, anti-inflammatory, and anti-glioma e…
View article: New advances of adiponectin in regulating obesity and related metabolic syndromes
New advances of adiponectin in regulating obesity and related metabolic syndromes Open
View article: FBXW7 inhibits the progression of ESCC by directly inhibiting the stemness of tumor cells
FBXW7 inhibits the progression of ESCC by directly inhibiting the stemness of tumor cells Open
F-box and WD repeat domain containing 7 (FBXW7) is an aboriginal and high-frequency mutant gene associated with esophageal squamous cell carcinoma (ESCC). This study was designed to determine the clinical value and molecular mechanisms of …
View article: Hugan Buzure Granule Alleviates Acute Kidney Injury in Mice by Inhibiting NLRP3/Caspase-1 Pathway and TLR4/NF-κB Pathway
Hugan Buzure Granule Alleviates Acute Kidney Injury in Mice by Inhibiting NLRP3/Caspase-1 Pathway and TLR4/NF-κB Pathway Open
Background: Hugan Buzure Granule (HBG) is a traditional prescription of Uygur nationality in China mainly used to treat liver cold, stomachache, spleen and rib pain, arthralgia, rheumatism and urinary system diseases. Its mechanism of acti…
View article: Unlocking the potential of amorphous calcium carbonate: A star ascending in the realm of biomedical application
Unlocking the potential of amorphous calcium carbonate: A star ascending in the realm of biomedical application Open
View article: Inhibition of Tumor Glycolysis by Umbelliferone and its Binding to Glycolytic Proteins
Inhibition of Tumor Glycolysis by Umbelliferone and its Binding to Glycolytic Proteins Open
Background and Objectives Both primary and secondary cancers require the involvement of glycolytic pathways. Cancer cell proliferation leads to the upregulation of glycolysis, which results in increased glucose consumption. For demonstrati…
View article: Ramulus mori (Sangzhi) alkaloids regulates gut microbiota disorder and its metabolism profiles in obese mice induced by a high-fat diet
Ramulus mori (Sangzhi) alkaloids regulates gut microbiota disorder and its metabolism profiles in obese mice induced by a high-fat diet Open
The imbalance of gut microbiota has been confirmed to have a close pathological and physiological correlation with obesity and metabolic syndrome. Ramulus Mori (Sangzhi) Alkaloids (SZ-A) derived from twigs of mulberry was approved by the N…
View article: Glycolysis, a new mechanism of oleuropein against liver tumor
Glycolysis, a new mechanism of oleuropein against liver tumor Open
GPI is a crucial enzyme in glycolysis and the immediate target of oleuropein. GPI expression inside tumor cells affects different physiological functions and signal transduction. Oleuropein has depicted anti-tumor action in vivo without ha…
View article: FBXW7 inhibits the Progression of ESCC by directly inhibiting the Stemness of Tumor Cells
FBXW7 inhibits the Progression of ESCC by directly inhibiting the Stemness of Tumor Cells Open
Background F-box and WD repeat domain containing 7 ( FBXW7 ), is an aboriginal and high frequency mutant gene associated with esophageal squamous cell carcinoma (ESCC). This study was designed to determine the clinical value and molecular …
View article: Additional file 8 of Combination of RUNX1 inhibitor and gemcitabine mitigates chemo‐resistance in pancreatic ductal adenocarcinoma by modulating BiP/PERK/eIF2α-axis-mediated endoplasmic reticulum stress
Additional file 8 of Combination of RUNX1 inhibitor and gemcitabine mitigates chemo‐resistance in pancreatic ductal adenocarcinoma by modulating BiP/PERK/eIF2α-axis-mediated endoplasmic reticulum stress Open
Additional file 8. Clinical drug file of patients for PDAC from TCGA dataset.
View article: Comparative Colloidal Stability of Commercial Amphotericin B Nanoformulations Using Dynamic and Static Multiple Light Scattering Techniques
Comparative Colloidal Stability of Commercial Amphotericin B Nanoformulations Using Dynamic and Static Multiple Light Scattering Techniques Open
To the best of our knowledge, this study is the first to compare the colloidal stability of commercial AmB nanoformulations. These findings will provide useful information not only to inform the clinical use of available AmB nanoformulatio…
View article: Tumor-targeting intravenous lipid emulsion of paclitaxel: Characteristics, stability, toxicity, and toxicokinetics
Tumor-targeting intravenous lipid emulsion of paclitaxel: Characteristics, stability, toxicity, and toxicokinetics Open
View article: Ethnobotanical study of Hakka traditional medicine in Ganzhou, China and their antibacterial, antifungal, and cytotoxic assessments
Ethnobotanical study of Hakka traditional medicine in Ganzhou, China and their antibacterial, antifungal, and cytotoxic assessments Open