The increasing complexity of lung surgeries necessitates the need for enhanced imaging support to improve the precision and efficiency of preoperative planning. Despite the promise of 3D reconstruction, clinical adoption remains limited due to time constraints and insufficient validation. To address this, we evaluate an artificial intelligence-driven 3D reconstruction system for pulmonary vessels and bronchi in a retrospective, multi-center multi-reader multi-case study. Using a two-stage crossover design, ten tho…

Abstract Purpose: Immunotherapy has demonstrated promise in small cell lung cancer (SCLC), but certain patients encounter limited benefits, highlighting the need for immunosuppressive biomarkers. Extrachromosomal circular DNA (ecDNA) promotes amplification of MYC paralogs (MYC, MYCN, and MYCL), driving cross-resistance in SCLC. In this study, we aim to investigate whether ecDNA-mediated MYC paralog amplification (ecMYC+) represents immunosuppressive features in SCLC. Experimental Design: Bulk RNA sequencing data w…

An interpretable combined model based on MRI was developed to distinguish between benign and malignant small BI-RADS4 lesions to assist radiologists to make more accurate diagnostic decisions.

Unlocking the potential of organic functional devices requires elucidating structure–property–performance relationships through comprehensive multiscale, multi property characterization. However, this process is limited by high costs and multidisciplinary complexity. This work introduces OCNet, a domain-knowledge-enhanced representation learning network for organic conjugated systems, pre-trained on self-generated ten-million-level structures. OCNet offers a general microscopic representation with strong expressiv…

For weaned Kazakh foals, steam-flaked corn could be recommended in advance of steam-flaked oats and barley in cereal-based energy supplementation alongside basal forage diets. It may reduce amylose intake, improve glycemic responses, increase plasma glucose levels and reduce fecal lactic acid content.