Hongjun Yang
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View article: Comprehensive Characterization of Mycoplasmosis bovis ST52 Strain 16M Reveals Its Pathogenicity and Potential Value in Vaccine Development
Comprehensive Characterization of Mycoplasmosis bovis ST52 Strain 16M Reveals Its Pathogenicity and Potential Value in Vaccine Development Open
This study aimed to characterize Mycoplasmosis bovis strain 16M—a highly virulent isolate from one Chinese outbreak—as a candidate for challenge models and inactivated vaccine development. We assessed strain 16M through morphological obser…
View article: Multi-omics analysis reveals gut microbiota remodeling and lipid metabolism regulation during the treatment of nonalcoholic fatty liver disease with Yindan Pinggan capsule
Multi-omics analysis reveals gut microbiota remodeling and lipid metabolism regulation during the treatment of nonalcoholic fatty liver disease with Yindan Pinggan capsule Open
Background Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disorder with limited treatment options. Yindan Pinggan capsule (YDPG), a traditional Chinese medicine, has demonstrated potential in managing liver diseases, ye…
View article: Lightweight Detection Method of Wheelset Tread Defects Based on Improved YOLOv7
Lightweight Detection Method of Wheelset Tread Defects Based on Improved YOLOv7 Open
Accurate online inspection of train wheelset tread defects is challenging owing to the variety and position uncertainty of defects. This study develops an improved YOLOv7 model capable of inspecting various wheelset tread defects with high…
View article: Maternal Lecithin Supplementation in Sows Regulates the Hepatic Glycolipid Metabolism of Offspring
Maternal Lecithin Supplementation in Sows Regulates the Hepatic Glycolipid Metabolism of Offspring Open
Maternal nutrition during gestation and lactation influences offspring development and metabolic health. Lecithin, a crucial phospholipid commonly used in animal diets to improve lipid absorption and energy metabolism, is a viable approach…
View article: Lightweight Detection Method of Wheelset-Tread Defects Based on Improved YOLOv7
Lightweight Detection Method of Wheelset-Tread Defects Based on Improved YOLOv7 Open
Train wheelsets are key components of high-speed trains and are prone to failure during long-term operation under harsh conditions. Accurate and comprehensive online inspection of defects in wheelset treads are difficult because of their v…
View article: Yin-dan-ping-gan Capsule mitigates CCL 4 -induced liver fibrosis via activating PPAR γ/GPX4 signaling and suppressing ferroptosis
Yin-dan-ping-gan Capsule mitigates CCL 4 -induced liver fibrosis via activating PPAR γ/GPX4 signaling and suppressing ferroptosis Open
Background: Liver fibrosis is a major global public health issue that is only getting worse. The underlying molecular mechanisms of Yindanpinggan Capsule (YDPG), a traditional Chinese medication, are still unknown, although it has shown no…
View article: Multi-omics reveal the neuroprotective mechanisms of Xinshubao tablet against scopolamine-induced cognitive dysfunction in mice
Multi-omics reveal the neuroprotective mechanisms of Xinshubao tablet against scopolamine-induced cognitive dysfunction in mice Open
Introduction Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with limited treatments. Xinshubao tablet (XSB), a traditional Chinese medicine, contains several bioactive compounds with notable neuroprotective effects. O…
View article: Guanxinning attenuates diabetic myocardial ischemia–reperfusion injury by targeting oral Fusobacterium nucleatum and modulating PTEN signaling
Guanxinning attenuates diabetic myocardial ischemia–reperfusion injury by targeting oral Fusobacterium nucleatum and modulating PTEN signaling Open
Background The incidence and severity of diabetic myocardial ischemia reperfusion injury (DMIRI) are increasing, highlighting the urgent need for effective prevention and treatment. Previous studies have revealed that specific oral microbi…
View article: Above-ground xylem genes and below-ground soil carbon genes analyses provide molecular insights into experimental warming in Phoebe chekiangensis
Above-ground xylem genes and below-ground soil carbon genes analyses provide molecular insights into experimental warming in Phoebe chekiangensis Open
Phoebe chekiangensis C. B. Shang is an endemic and endangered species in China, and it is widely used for furniture, building materials and artwork due to its high-quality wood properties and high economic value. However, the impact of spr…
View article: Rhubarb with Different Cooking Methods Restored the Gut Microbiota Dysbiosis and SCFAs in Ischemic Stroke Mice
Rhubarb with Different Cooking Methods Restored the Gut Microbiota Dysbiosis and SCFAs in Ischemic Stroke Mice Open
Ischemic stroke is a significant public health problem worldwide. Growing evidence has shown gut microbiota served a vital function in ischemic stroke. Rhubarb, always used after processing, is a promising therapy for ischemic stroke. Howe…
View article: Exogenous nucleotides contribute to the regulation of hepatic glycolipid metabolism in young animals
Exogenous nucleotides contribute to the regulation of hepatic glycolipid metabolism in young animals Open
Nucleotides involve in regulating cellular energy and glycolipid metabolism.The objective was to figure out the roles of exogenous nucleotides in glycolipid metabolism using 3-day-old piglets as a model. Ninety-six piglets were randomly as…
View article: Multidrug-Resistant Extraintestinal Pathogenic Escherichia coli Exhibits High Virulence in Calf Herds: A Case Report
Multidrug-Resistant Extraintestinal Pathogenic Escherichia coli Exhibits High Virulence in Calf Herds: A Case Report Open
Extraintestinal pathogenic Escherichia coli (ExPEC) is a group of Escherichia coli strains that can cause severe infectious diseases outside the gastrointestinal tract, such as urinary tract infections, meningitis, septicemia, etc. We repo…
View article: Gut microbiota in health and disease: advances and future prospects
Gut microbiota in health and disease: advances and future prospects Open
The gut microbiota plays a critical role in maintaining human health, influencing a wide range of physiological processes, including immune regulation, metabolism, and neurological function. Recent studies have shown that imbalances in gut…
View article: A stroke organoids-multiomics platform to study injury mechanism and drug response
A stroke organoids-multiomics platform to study injury mechanism and drug response Open
Stroke is one of the top causes of death and disability worldwide, and its pathogenesis and mechanism have not been fully elucidated. Several agents have shown protective effects against stroke in animal models; however, few studies have s…
View article: The novel target, mechanism and agonist of α-Ketoglutaric acid in delaying mesenchymal stem cell senescence
The novel target, mechanism and agonist of α-Ketoglutaric acid in delaying mesenchymal stem cell senescence Open
α-Ketoglutaric acid (aKG) participates in the tricarboxylic acid cycle in the process of cell aerobic metabolism and is of significant physiological importance. Although aKG is genetically associated with human longevity and decreased fert…
View article: Advances in human cellular mechanistic understanding and drug discovery of brain organoids for neurodegenerative diseases
Advances in human cellular mechanistic understanding and drug discovery of brain organoids for neurodegenerative diseases Open
The prevalence of neurodegenerative diseases (NDs) is increasing rapidly as the aging population accelerates, and there are still no treatments to halt or reverse the progression of these diseases. While traditional 2D cultures and animal …
View article: Nervonic acid alleviates stroke and its associated poststroke depression behaviors
Nervonic acid alleviates stroke and its associated poststroke depression behaviors Open
Nervonic acid (NA) is an important long-chain monounsaturated fatty acid found in mammalian nervous tissue. It has recently garnered research attention due to its therapeutic potential in treating psychiatric and neurodegenerative disorder…
View article: Intervention effects of Naoxintong capsules on psychological and cardiac status in depressed rats after heart failure
Intervention effects of Naoxintong capsules on psychological and cardiac status in depressed rats after heart failure Open
Background Depression is a common clinical phenomenon in the patients with heart failure (HF). In traditional Chinese medicine (TCM), diseases in the brain and heart are thought to be correlated and interact. Naoxintong capsules (NXT) has …
View article: Identification of multiple miRNA-encoded peptide reveals OsmiPEP162a stabilizes OsMIR162 in rice
Identification of multiple miRNA-encoded peptide reveals OsmiPEP162a stabilizes OsMIR162 in rice Open
MicroRNAs (miRNAs) are derivatives of primary miRNAs (pri-miRNAs) and govern the expression of target genes. Plant pri-miRNAs encode regulatory peptides known as miPEPs, which specifically boost the transcription of their originating pri-m…
View article: Modulation of audiovisual integration in the left and right sides: effects of side and spatial coherency
Modulation of audiovisual integration in the left and right sides: effects of side and spatial coherency Open
Audiovisual letter information presented on the right side was easier to integrate, process, and represent. Additionally, only one significant integrative component peaked at 140 ms in the parietal cortex for spatially non-coherent AV stim…
View article: The brain-protective mechanism of fecal microbiota transplantation from young donor mice in the natural aging process via exosome, gut microbiota, and metabolomics analyses
The brain-protective mechanism of fecal microbiota transplantation from young donor mice in the natural aging process via exosome, gut microbiota, and metabolomics analyses Open
The natural aging process is accompanied by changes in exosomes, gut microbiota, and metabolites. This study aimed to reveal the anti-aging effect and mechanisms of fecal microbiota transplantation (FMT) from young donors on the natural ag…
View article: Recent advances in protein precipitation-based methods for drug-target screening
Recent advances in protein precipitation-based methods for drug-target screening Open
Drug targets are biological macromolecules that bind drug molecules in vivo. Therefore, the system-wide identification of drug targets plays a vital role in fully understanding the mechanism of drug action, efficacy, and side effects. The …
View article: Microfluidics-enabled mesenchymal stem cell derived Neuron like cell membrane coated nanoparticles inhibit inflammation and apoptosis for Parkinson’s Disease
Microfluidics-enabled mesenchymal stem cell derived Neuron like cell membrane coated nanoparticles inhibit inflammation and apoptosis for Parkinson’s Disease Open
Parkinson’s disease (PD) is the second largest group of neurodegenerative diseases, and its existing drug treatments are not satisfactory. Natural cell membrane drugs are used for homologous targeting to enhance efficacy. In this study, mi…
View article: Research on the anti-aging mechanisms of Panax ginseng extract in mice: a gut microbiome and metabolomics approach
Research on the anti-aging mechanisms of Panax ginseng extract in mice: a gut microbiome and metabolomics approach Open
Introduction: Aged-related brain damage and gut microbiome disruption are common. Research affirms that modulating the microbiota-gut-brain axis can help reduce age-related brain damage. Methods: Ginseng, esteemed in traditional Chinese me…
View article: Accurate exploration of the clinical efficacy of maca based on characteristic metabolites
Accurate exploration of the clinical efficacy of maca based on characteristic metabolites Open
Lepidium meyenii (Maca) is a food and traditional herbal medicine derived from the roots of perennial plants cultivated at high altitudes in the Andes Mountains. Although many studies have shown the potential clinical value of maca, its in…
View article: Alterations of tau and Camk2 in acute stroke and effects of a multicomponent drug
Alterations of tau and Camk2 in acute stroke and effects of a multicomponent drug Open
Background Stroke is one of the leading causes of death around the world. The sequelae of ischemic stroke cause drastic effects on the quality of life for patients. Sanwujiaowan (SWJW) is a mixture prepared with 5 herbal medicines (Aconiti…