Xinghuan Wang
YOU?
Author Swipe
View article: YKT6 Promotes Bladder Cancer Progression by Stabilizing β‐catenin Through USP7‐Mediated Deubiquitination
YKT6 Promotes Bladder Cancer Progression by Stabilizing β‐catenin Through USP7‐Mediated Deubiquitination Open
Bladder cancer (BLCA) remains a highly lethal genitourinary malignancy with complex tumor biology and limited therapeutic strategies. This study investigates the oncogenic role of YKT6, a SNARE protein, in BLCA progression and molecular me…
View article: MOOC-virtual simulation integration enhances surgical clinical skills: a quasi-experimental study
MOOC-virtual simulation integration enhances surgical clinical skills: a quasi-experimental study Open
This study aimed to evaluate the impact of a teaching model combining massive open online course (MOOC) with virtual simulation experiments on clinical skills training. A quasi-experimental design was employed in the Second Clinical Colleg…
View article: Obstetric Rectal Buttonhole Tear: Case Series, Literature Review, and Management Recommendations
Obstetric Rectal Buttonhole Tear: Case Series, Literature Review, and Management Recommendations Open
ORBT can occur irrespective of delivery mode, birth weight, or episiotomy but is more frequent in primiparas. Avoidance of rapid descent of the fetal head through the birth canal is recommended. Early diagnosis and primary layered repair b…
View article: Molecular mechanisms governing the differentiation and expansion of myeloid-derived suppressor cells
Molecular mechanisms governing the differentiation and expansion of myeloid-derived suppressor cells Open
Myeloid-derived suppressor cells (MDSCs) play critical roles in tumor immune evasion. These heterogeneous cells are broadly classified into granulocytic (G-MDSC), monocytic (M-MDSC), and their immature precursors, early-stage MDSCs (e-MDSC…
View article: An analytical pipeline for dose-response effect: laboratory tests assessment and early pregnancy preeclampsia risk
An analytical pipeline for dose-response effect: laboratory tests assessment and early pregnancy preeclampsia risk Open
NA.
View article: Efficacy of erythrocyte apheresis in the management of severe high-altitude deacclimatization syndrome: a retrospective cohort study
Efficacy of erythrocyte apheresis in the management of severe high-altitude deacclimatization syndrome: a retrospective cohort study Open
Background High-altitude deacclimatization syndrome (HADAS, commonly known as Oxygen toxicity) manifests through multi-organ system dysfunction and significantly deteriorates the quality of life. Unfortunately, there are no effective metho…
View article: Safety and Immunogenicity of aerosolized adenovirus-vectored COVID-19 vaccine and intramuscular mRNA vaccine bivalent boosters: a randomized open-label clinical trial
Safety and Immunogenicity of aerosolized adenovirus-vectored COVID-19 vaccine and intramuscular mRNA vaccine bivalent boosters: a randomized open-label clinical trial Open
Both SARS-CoV-2 mRNA and mucosal vaccines induce protective immunity against COVID-19 but showed different immune profiles. We conducted a longitudinal head-to-head analysis of the safety and immunogenicity of the aerosolized adenovirus-ve…
View article: 14eP Sacituzumab govitecan (SG) vs treatment of physician’s choice (TPC) in Chinese patients (pts) with hormone receptor-positive and human epidermal growth factor receptor 2-negative (HR+/HER2–) metastatic breast cancer (mBC): Sub analysis of the results from the phase III EVER-132-002 study
14eP Sacituzumab govitecan (SG) vs treatment of physician’s choice (TPC) in Chinese patients (pts) with hormone receptor-positive and human epidermal growth factor receptor 2-negative (HR+/HER2–) metastatic breast cancer (mBC): Sub analysis of the results from the phase III EVER-132-002 study Open
View article: Sirtuin1 mitigation of calcium oxalate nephropathy via enhancing itaconate abundance through reduction of histone trimethylation
Sirtuin1 mitigation of calcium oxalate nephropathy via enhancing itaconate abundance through reduction of histone trimethylation Open
Background Clinical therapeutic approaches to prevent and treat renal injury in patients with acute kidney injury (AKI) and chronic kidney disease (CKD) induced by calcium oxalate (CaOx) are limited. As a pivotal deacetylase, Sirtuin1 (Sir…
View article: Comparative long-term outcomes of first-line CDK4/6 inhibitors plus endocrine therapy versus endocrine therapy in patients with HR+/HER2-metastatic or advanced breast cancer: a meta-analysis
Comparative long-term outcomes of first-line CDK4/6 inhibitors plus endocrine therapy versus endocrine therapy in patients with HR+/HER2-metastatic or advanced breast cancer: a meta-analysis Open
Introduction This meta-analysis was designed to compare the long-term outcomes of first-line cyclin-dependent kinase 4/6 (CDK4/6) inhibitors plus endocrine therapy (ET) versus ET in patients with HR+/HER2-metastatic or advanced breast canc…
View article: Evaluation of the therapeutic effect of estrogen replacement therapy combined with autologous serum therapy in controlling severe dry eye disease in perimenopausal women
Evaluation of the therapeutic effect of estrogen replacement therapy combined with autologous serum therapy in controlling severe dry eye disease in perimenopausal women Open
View article: Temperature-related hospitalization burden under climate change
Temperature-related hospitalization burden under climate change Open
View article: Mass Spectrometry Imaging: Revolutionizing Molecular Insights in Infectious Diseases Research
Mass Spectrometry Imaging: Revolutionizing Molecular Insights in Infectious Diseases Research Open
Infectious diseases remain a leading cause of mortality worldwide. The pathogenesis that comprises infection, focal inflammation, and immuno-response, typically occurs in one or multiple organs or tissues. Analysis of the molecular composi…
View article: Dihydroquercetin/Taxifolin Inhibits METTL3/m<sup>6</sup>A/PIM2 Expression by Suppressing RIPK2 Phosphorylation Mediated NF-κB p65 Signaling Pathway to Alleviates Renal Ischemia-Reperfusion Injury in Mice
Dihydroquercetin/Taxifolin Inhibits METTL3/m<sup>6</sup>A/PIM2 Expression by Suppressing RIPK2 Phosphorylation Mediated NF-κB p65 Signaling Pathway to Alleviates Renal Ischemia-Reperfusion Injury in Mice Open
Introduction: There is a close relationship between oxidative stress and renal ischemia-reperfusion injury (RIRI). Dihydroquercetin (DHQ, also known as Taxifolin) can reduce kidney damage, and suppress cellular damage caused by oxidative s…
View article: Global and regional burden of nasopharyngeal cancer in older adults attributable to smoking and high alcohol use from 1990 to 2021
Global and regional burden of nasopharyngeal cancer in older adults attributable to smoking and high alcohol use from 1990 to 2021 Open
Background Nasopharyngeal cancer (NPC) poses a considerable global health burden, with behavioral risk factors such as smoking and high alcohol use contributing to disparities across sociodemographic groups. The growing aging population fa…
View article: Correction to: Downregulation of TRPM7 suppressed migration and invasion by regulating epithelial–mesenchymal transition in prostate cancer cells
Correction to: Downregulation of TRPM7 suppressed migration and invasion by regulating epithelial–mesenchymal transition in prostate cancer cells Open
View article: Upper pole calyx fornix subapical puncture in percutaneous nephrolithotomy
Upper pole calyx fornix subapical puncture in percutaneous nephrolithotomy Open
Upper pole calyx fornix subapical puncture achieved higher stone-free rates and shorter operative times compared to middle calyx puncture, with comparable safety profiles. Prospective trials are needed to validate these findings.
View article: Enhancing laparoscopic surgery training: a comparative study of traditional models and automated error detection system
Enhancing laparoscopic surgery training: a comparative study of traditional models and automated error detection system Open
Not applicable.
View article: Community burden of acute respiratory infections in Shanghai, a longitudinal cohort study in respiratory pathogens, China, 2024–2027
Community burden of acute respiratory infections in Shanghai, a longitudinal cohort study in respiratory pathogens, China, 2024–2027 Open
Purpose We are conducting a longitudinal cohort study—the Community Burden of Acute Respiratory Infections in Shanghai—to assess age-stratified incidence, healthcare utilisation and risk factors of influenza virus, respiratory syncytial vi…
View article: Microbial and metabolic profiles associated with HPV infection and cervical intraepithelial neoplasia: a multi-omics study
Microbial and metabolic profiles associated with HPV infection and cervical intraepithelial neoplasia: a multi-omics study Open
Cervical cancer is the most common malignancy of the female reproductive system, with the incidence of human papillomavirus (HPV) being a crucial factor in its pathogenesis. Emerging evidence indicates that cervicovaginal microbiota may in…
View article: Global burden of metabolic disorders among women of child-bearing age, 1990–2021: a population-based study
Global burden of metabolic disorders among women of child-bearing age, 1990–2021: a population-based study Open
Given the marked increase in the burden of metabolic disorders among younger WCBA, it is recommended that healthcare management be reinforced for this demographic. Furthermore, based on the varying burdens observed across regions, targeted…
View article: Correction: Optimal parameter settings of thulium fiber laser for ureteral stone lithotripsy: a comparative study in two different testing environments
Correction: Optimal parameter settings of thulium fiber laser for ureteral stone lithotripsy: a comparative study in two different testing environments Open
View article: Global burden of TBL cancer in older adults: the role of dietary factors (1990–2021)
Global burden of TBL cancer in older adults: the role of dietary factors (1990–2021) Open
View article: Zero-shot Autonomous Microscopy for Scalable and Intelligent Characterization of 2D Materials
Zero-shot Autonomous Microscopy for Scalable and Intelligent Characterization of 2D Materials Open
Characterization of atomic-scale materials traditionally requires human experts with months to years of specialized training. Even for trained human operators, accurate and reliable characterization remains challenging when examining newly…
View article: Serum Klotho levels and epilepsy among U.S. adults in the NHANES 2013–2016: a cross-sectional study
Serum Klotho levels and epilepsy among U.S. adults in the NHANES 2013–2016: a cross-sectional study Open
The relationship between Klotho and epilepsy is poorly understood. This study aimed to investigate the association between serum Klotho levels and epilepsy. A total of 99,966 individuals who participated in the NHANES from the 2013 to 2016…
View article: A Mendelian randomization study: causal relationship between immune cells and the risks of social phobia, specific phobia, and agoraphobia
A Mendelian randomization study: causal relationship between immune cells and the risks of social phobia, specific phobia, and agoraphobia Open
Immune cell traits closely related to phobias were screened out through genomics, which provides a reference for the subsequent research on the immune system-phobia interaction.
View article: RNF112 Facilitates Ubiquitin‐Mediated Degradation of c‐Myc, Suppressing Proliferation, Migration and Lipid Synthesis in Bladder Cancer
RNF112 Facilitates Ubiquitin‐Mediated Degradation of c‐Myc, Suppressing Proliferation, Migration and Lipid Synthesis in Bladder Cancer Open
The E3 ubiquitin ligase RNF112 is significantly downregulated in bladder cancer (BLCA) and is correlated with disease progression. In vitro and in vivo studies indicated that RNF112 suppresses BLCA cell proliferation, migration, and lipid …
View article: THBS2-producing matrix CAFs promote colorectal cancer progression and link to poor prognosis via the CD47-MAPK axis
THBS2-producing matrix CAFs promote colorectal cancer progression and link to poor prognosis via the CD47-MAPK axis Open
Cancer-associated fibroblasts (CAFs) display significant functional and molecular heterogeneity within the tumor microenvironment, playing diverse roles in cancer progression. Employing single-cell RNA sequencing data of colorectal cancer …
View article: ZDHHC3-mediated SCAP S-acylation promotes cholesterol biosynthesis and tumor immune escape in hepatocellular carcinoma
ZDHHC3-mediated SCAP S-acylation promotes cholesterol biosynthesis and tumor immune escape in hepatocellular carcinoma Open
View article: Trampling and Dung and Urine Addition of Livestock Increase the Soil Organic Carbon in Mountain Meadows by Augmenting the Organic Carbon in Different Aggregates
Trampling and Dung and Urine Addition of Livestock Increase the Soil Organic Carbon in Mountain Meadows by Augmenting the Organic Carbon in Different Aggregates Open
Grassland soil carbon stocks contain substantial amounts of organic carbon and play a crucial role in the global carbon cycle. Grazing is one of the most primary land use types in grasslands. However, few studies have focused on the impact…