Hui Zeng
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View article: Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review)
Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review) Open
Migrasomes are novel extracellular organelles that were first reported in 2015. The present review summarizes the discovery, structural characteristics, biological functions and relationships of this new cellular organelle with diseases. M…
View article: 2-Deoxy-D-glucose reshapes the sepsis-trained stressed granulocytes by comprehensive alterations of the transcriptional landscape
2-Deoxy-D-glucose reshapes the sepsis-trained stressed granulocytes by comprehensive alterations of the transcriptional landscape Open
The secondary infections following sepsis pose a significant clinical challenge due to hyperinflammatory organ injury, which is primarily driven by maladaptive trained immunity (TRIM) in stressed granulocytes. Glucose metabolic reprogrammi…
View article: Corrigendum to “ROS-induced imbalance of the miR-34a-5p/SIRT1/p53 axis triggers chronic chondrocyte injury and inflammation” [Heliyon Volume 10, Issue 11, June 25 2024, Article e31654]
Corrigendum to “ROS-induced imbalance of the miR-34a-5p/SIRT1/p53 axis triggers chronic chondrocyte injury and inflammation” [Heliyon Volume 10, Issue 11, June 25 2024, Article e31654] Open
View article: <scp>CYP2C19</scp> Loss‐of‐Function Is an Independent Risk Factor of Coronary Artery Disease in Patients With Hypertension
<span>CYP2C19</span> Loss‐of‐Function Is an Independent Risk Factor of Coronary Artery Disease in Patients With Hypertension Open
Objective Cytochrome P450 2C19 (CYP2C19) is affected by its gene polymorphisms and is involved in the occurrence and development of diseases. To assess the relationship between CYP2C19 polymorphisms and coronary artery disease (CAD) suscep…
View article: Spi1 aggravates neuropathic pain by modulating Clec7a-mediated neuroinflammation and microglial phagocytosis
Spi1 aggravates neuropathic pain by modulating Clec7a-mediated neuroinflammation and microglial phagocytosis Open
Background Microglia are essential in mediating responses to nerve injury, with neuroinflammation and engulfment of interneuron inhibitory synapses driving heightened neuronal excitability and pain hypersensitivity. Spi1 is the main regula…
View article: Consensus Guided Multi-View Unsupervised Feature Selection with Hybrid Regularization
Consensus Guided Multi-View Unsupervised Feature Selection with Hybrid Regularization Open
Multi-source heterogeneous data has been widely adopted in developing artificial intelligence systems in recent years. In real-world scenarios, raw multi-source data are generally unlabeled and inherently contain multi-view noise and featu…
View article: Avian Influenza A(H5N1) Isolated from Dairy Farm Worker, Michigan
Avian Influenza A(H5N1) Isolated from Dairy Farm Worker, Michigan Open
Influenza A(H5N1) viruses have been detected in US dairy cow herds since 2024. We assessed the pathogenesis, transmission, and airborne release of A/Michigan/90/2024, an H5N1 isolate from a dairy farm worker in Michigan, in the ferret mode…
View article: Reduced Pain Scores during Indocyanine Green Lymphography by using a Different Preparation Formula
Reduced Pain Scores during Indocyanine Green Lymphography by using a Different Preparation Formula Open
Purpose: The purpose of this study was to investigate whether a different indocyanine green lymphography formula can reduce the severe pain encountered during this investigation. Methods: Indocyanine green ICG lymphography frequently induc…
View article: Ocular infectivity and replication of a clade 2.3.4.4b A(H5N1) influenza virus associated with human conjunctivitis in a dairy farm worker in the USA: an in-vitro and ferret study
Ocular infectivity and replication of a clade 2.3.4.4b A(H5N1) influenza virus associated with human conjunctivitis in a dairy farm worker in the USA: an in-vitro and ferret study Open
View article: 76P Fruquintinib combined with sintilimab plus transarterial chemoembolization (TACE) for unresectable hepatocellular carcinoma (uHCC): A single-arm phase II study
76P Fruquintinib combined with sintilimab plus transarterial chemoembolization (TACE) for unresectable hepatocellular carcinoma (uHCC): A single-arm phase II study Open
View article: Effect of Prior Influenza A(H1N1)pdm09 Virus Infection on Pathogenesis and Transmission of Human Influenza A(H5N1) Clade 2.3.4.4b Virus in Ferret Model
Effect of Prior Influenza A(H1N1)pdm09 Virus Infection on Pathogenesis and Transmission of Human Influenza A(H5N1) Clade 2.3.4.4b Virus in Ferret Model Open
Reports of human infections with influenza A(H5N1) clade 2.3.4.4b viruses associated with outbreaks in dairy cows in the United States underscore the need to assess the potential cross-protection conferred by existing influenza immunity. W…
View article: Digital Ethnography of Douban's Car Group: Polymedia Ecosystems, Offline-Online Interplay, and Conviviality Community Construction
Digital Ethnography of Douban's Car Group: Polymedia Ecosystems, Offline-Online Interplay, and Conviviality Community Construction Open
View article: Broad-Spectrum Virus Elimination by Nasal Mucosa-Colonized Wild-Type <i>Bacillus subtilis</i>
Broad-Spectrum Virus Elimination by Nasal Mucosa-Colonized Wild-Type <i>Bacillus subtilis</i> Open
Outbreaks and the widespread prevalence of porcine respiratory infectious diseases have led to substantial economic losses worldwide. In this study, epidemiological surveillance revealed lower viral detection in association with an increas…
View article: Harnessing dendritic cells for pancreatic cancer immunotherapy: a novel promising approach
Harnessing dendritic cells for pancreatic cancer immunotherapy: a novel promising approach Open
View article: Global Divergence in Esophageal Cancer and Gastroesophageal Reflux Disease Burden: Temporal Dynamics, Regional Disparities, and Epidemiologic Associations
Global Divergence in Esophageal Cancer and Gastroesophageal Reflux Disease Burden: Temporal Dynamics, Regional Disparities, and Epidemiologic Associations Open
View article: Functionally active modulators targeting the LRRK2 WD40 repeat domain identified by FRASE-bot in CACHE Challenge #1
Functionally active modulators targeting the LRRK2 WD40 repeat domain identified by FRASE-bot in CACHE Challenge #1 Open
Critical Assessment of Computational Hit-Finding Experiments (CACHE) Challenges emerged as real-life stress tests for computational hit-finding strategies. In CACHE Challenge #1, 23 participants contributed their original workflows to iden…
View article: Machine learning prediction of hepatic encephalopathy for long-term survival after transjugular intrahepatic portosystemic shunt in acute variceal bleeding
Machine learning prediction of hepatic encephalopathy for long-term survival after transjugular intrahepatic portosystemic shunt in acute variceal bleeding Open
BACKGROUND Transjugular intrahepatic portosystemic shunt (TIPS) is an effective intervention for managing complications of portal hypertension, particularly acute variceal bleeding (AVB). While effective in reducing portal pressure and pre…
View article: Hypoimmunogenic CD19 CAR-NK cells derived from embryonic stem cells suppress the progression of human B-cell malignancies in xenograft animals
Hypoimmunogenic CD19 CAR-NK cells derived from embryonic stem cells suppress the progression of human B-cell malignancies in xenograft animals Open
Background Chimeric antigen receptor (CAR) engineered natural killer (NK) cells exhibit advantages such as MHC-independent recognition and strong anti-tumor functions. However, allogeneic CAR-NK cells derived from human tissues are heterog…
View article: Dissecting the role of the HA1-226 leucine residue in the fitness and airborne transmission of an A(H9N2) avian influenza virus
Dissecting the role of the HA1-226 leucine residue in the fitness and airborne transmission of an A(H9N2) avian influenza virus Open
A better understanding of viral factors that contribute to influenza A virus (IAV) airborne transmission is crucial for pandemic preparedness. A limited capacity for airborne transmission was recently observed in a human A(H9N2) virus isol…
View article: Transmission of a human isolate of clade 2.3.4.4b A(H5N1) virus in ferrets
Transmission of a human isolate of clade 2.3.4.4b A(H5N1) virus in ferrets Open
View article: Homoharringtonine is highly effective against SARS-CoV-2: a potential first-line defense in future coronavirus epidemics
Homoharringtonine is highly effective against SARS-CoV-2: a potential first-line defense in future coronavirus epidemics Open
As COVID-19 is the third coronavirus epidemic in this century, it would be desirable to have a treatment scheme in anticipation of a fourth one. We here present a scheme that could clear SARS-CoV-2 in 2–4 days post-infection from the upper…
View article: Integrating network pharmacology and in vivo pharmacological investigation for deciphering the mechanism of Simiao Yong’an decoction in alleviating rheumatoid arthritis
Integrating network pharmacology and in vivo pharmacological investigation for deciphering the mechanism of Simiao Yong’an decoction in alleviating rheumatoid arthritis Open
Objective: To investigate the mechanism of Simiao Yong’an Decoction in alleviating the damage of rheumatoid arthritis (RA), and accordingly provide pharmacological evidence and further experimental support for the application of Simiao Yon…
View article: Apolipoprotein E E3/E4 genotype is associated with an increased risk of coronary atherosclerosis in patients with hypertension
Apolipoprotein E E3/E4 genotype is associated with an increased risk of coronary atherosclerosis in patients with hypertension Open
Objective Apolipoprotein E ( APOE ) gene polymorphisms were associated with coronary atherosclerosis and hypertension. However, the relationship between APOE polymorphisms and coronary atherosclerosis susceptibility in hypertensive patient…
View article: The Exploratory Study of the PTEN-AKT/mTOR Signaling Pathway in the Corresponding Dorsal Root Ganglion during Compensatory Repair via Small Gap Amplification in Sciatic Nerve Injury
The Exploratory Study of the PTEN-AKT/mTOR Signaling Pathway in the Corresponding Dorsal Root Ganglion during Compensatory Repair via Small Gap Amplification in Sciatic Nerve Injury Open
Background: Peripheral nerve injury is a challenging orthopedic issue in clinical management that often leads to limb dysfunction or even disability in severe cases. A thorough exploration of the repair process of peripheral nerve injury a…
View article: Microaerobic-mediated suppression of <i>Klebsiella pneumoniae</i> mucoviscosity is restored by <i>rmpD</i> overexpression
Microaerobic-mediated suppression of <i>Klebsiella pneumoniae</i> mucoviscosity is restored by <i>rmpD</i> overexpression Open
Aims Hypervirulent Klebsiella pneumoniae (hvKp) causes invasive community-acquired infections in healthy individuals, and hypermucoviscosity (HMV) is the main phenotype associated with hvKp. This study investigates the impact of microaerob…
View article: Efficient generation of CAR NK cells from human umbilical cord blood CD34<sup>+</sup>stem and progenitors for democratizing affordable immunotherapy
Efficient generation of CAR NK cells from human umbilical cord blood CD34<sup>+</sup>stem and progenitors for democratizing affordable immunotherapy Open
Chimeric antigen receptor (CAR) natural killer cells (CAR NK) cells, leveraging safety and not requiring HLA match in adoptive infusion, have emerged as promising alternative cells to CAR-T cells for immunotherapies. High and multiple dose…
View article: A retrospective study of the anterolateral thigh perforator flap in the treatment of chronic osteomyelitis of the leg with skin defects
A retrospective study of the anterolateral thigh perforator flap in the treatment of chronic osteomyelitis of the leg with skin defects Open
View article: Exosome for mRNA delivery: strategies and therapeutic applications
Exosome for mRNA delivery: strategies and therapeutic applications Open
Messenger RNA (mRNA) has emerged as a promising therapeutic molecule with numerous clinical applications in treating central nervous system disorders, tumors, COVID-19, and other diseases. mRNA therapies must be encapsulated into safe, sta…
View article: LDLR c.89_92dup: a novel frameshift variation in familial hypercholesterolemia
LDLR c.89_92dup: a novel frameshift variation in familial hypercholesterolemia Open
Background Familial hypercholesterolemia (FH) is a common inherited metabolic disease that causes premature atherosclerosis, cardiovascular disease, and even death at a young age. Approximately 95% of FH-causing genetic variants that have …
View article: ROS-induced imbalance of the miR-34a-5p/SIRT1/p53 axis triggers chronic chondrocyte injury and inflammation
ROS-induced imbalance of the miR-34a-5p/SIRT1/p53 axis triggers chronic chondrocyte injury and inflammation Open
Osteoarthritis is a chronic degenerative disease based on the degeneration and loss of articular cartilage. Inflammation and aging play an important role in the destruction of the extracellular matrix, in which microRNA (miRNA) is a key po…