H. J. Yang
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View article: Rapid visual detection and differentiation of canine and feline parvovirus via a one-tube RPA-CRISPR/Cas13a assay
Rapid visual detection and differentiation of canine and feline parvovirus via a one-tube RPA-CRISPR/Cas13a assay Open
Canine parvovirus type 2 (CPV-2) and feline parvovirus (FPV) are highly contagious pathogens that pose significant threats to domestic and wild carnivores. Rapid and accurate diagnosis is crucial for outbreak control and wildlife conservat…
View article: Assessing the Impact of Digital Transformation on Manufacturing Enterprises’ Performances: An Efficiency Perspective
Assessing the Impact of Digital Transformation on Manufacturing Enterprises’ Performances: An Efficiency Perspective Open
In recent years, the impacts of the new scientific and technological revolution on the industrial system and production modes have begun to emerge. Digital transformation is gradually being integrated into the production behaviors of manuf…
View article: Computational Study on Complex Wind Field Environments in Urban and Marine Low-Altitude Based on Multi-Wind-Turbine Coordination
Computational Study on Complex Wind Field Environments in Urban and Marine Low-Altitude Based on Multi-Wind-Turbine Coordination Open
With the rise of the low-altitude economy, there is growing demand for performance and safety evaluation of logistics drones and urban aircraft operating in complex turbulent environments. Conventional wind tunnels, however, face challenge…
View article: Prophylactic donor lymphocyte infusions after first allogeneic hematopoietic stem cell transplantation in children with acute leukemia
Prophylactic donor lymphocyte infusions after first allogeneic hematopoietic stem cell transplantation in children with acute leukemia Open
Prophylactic DLI transfusion following allogeneic HSCT remains a safe and effective treatment for pediatric patients with AL and can reduce post-transplant relapse and improve long-term survival.
View article: Development and Application of Online Rapid Monitoring Devices for Volatile Organic Compounds in Soil–Water–Air Systems
Development and Application of Online Rapid Monitoring Devices for Volatile Organic Compounds in Soil–Water–Air Systems Open
To overcome the limitations of lengthy laboratory testing cycles and insufficient on-site responsiveness, this study developed an online rapid monitoring device for volatile organic compounds (VOCs) in soil–water–air systems based on photo…
View article: Tumorigenic p53N236S balances aging and tumorigenesis via regulating DREAM/MMB and downstream telomere DNA replication pathways
Tumorigenic p53N236S balances aging and tumorigenesis via regulating DREAM/MMB and downstream telomere DNA replication pathways Open
The Werner syndrome (WS) is characterized with both premature aging and tumorigenic phenotypes. In this study, we introduced a tumorigenic mutation p53N236S (referred as p53S later), which is found in immortalized WS mouse embryo fibroblas…
View article: Penetrating aortic ulcer following endoscopic dilatation of esophageal anastomotic stenosis: a case report
Penetrating aortic ulcer following endoscopic dilatation of esophageal anastomotic stenosis: a case report Open
Background Endoscopic balloon dilation serves as the first-line treatment for anastomotic strictures after esophagectomy. While generally safe, the procedure can, in rare instances, lead to severe vascular complications. Case presentation …
View article: Bushen Huatan formula alleviates polycystic ovary syndrome in rats by activating the PI3K/Akt pathway to inhibit GSDMD-mediated pyroptosis and mitochondrial damage
Bushen Huatan formula alleviates polycystic ovary syndrome in rats by activating the PI3K/Akt pathway to inhibit GSDMD-mediated pyroptosis and mitochondrial damage Open
This study shows that BSHT dose-dependently activates the PI3K/Akt pathway, inhibits GSDMD-mediated pyroptosis, and improves mitochondrial dysfunction in PCOS. Its regulation of inflammation, oxidative stress, metabolism, and ovarian funct…
View article: Functional, Pharmacogenomic, and Immune Landscapes of Long Non‐Coding RNAs in Cancer
Functional, Pharmacogenomic, and Immune Landscapes of Long Non‐Coding RNAs in Cancer Open
Long non‐coding RNAs (lncRNAs) are emerging as key regulators in cancer, with significant potential as diagnostic, prognostic, and therapeutic targets. Here, this work systematically analyzes lncRNA associations with targeted therapies and…
View article: Relationships among anxiety, psychological resilience, and physical activity in university students: variable-centred and person-centred perspectives
Relationships among anxiety, psychological resilience, and physical activity in university students: variable-centred and person-centred perspectives Open
Background Anxiety is significantly correlated with levels of physical activity in university students. This research assessed the effects of anxiety on engagement in physical activity and explored the potential mediating function of psych…
View article: Xeligekimab, an Interleukin-17A Antagonist for Active Radiographic Axial Spondyloarthritis in Chinese Patients: 16- and 48-Week Results from a Phase III, Randomized, Double-Blind, Placebo-Controlled Study
Xeligekimab, an Interleukin-17A Antagonist for Active Radiographic Axial Spondyloarthritis in Chinese Patients: 16- and 48-Week Results from a Phase III, Randomized, Double-Blind, Placebo-Controlled Study Open
ClinicalTrials.gov identifier: NCT05881785 (Date: 21 May 2023).
View article: Unraveling the causal relationship between gut microbiota and chronic hepatitis B: A large-scale mediation Mendelian randomization analysis
Unraveling the causal relationship between gut microbiota and chronic hepatitis B: A large-scale mediation Mendelian randomization analysis Open
Observational evidence links gut microbiota dysbiosis to chronic hepatitis B (CHB) progression, but causal mechanisms remain unclear. Genome-wide association study (GWAS) data for gut microbiota were sourced from the MiBioGen Consortium an…
View article: Effects of Vitamin E Supplementation on Growth Performance, Antioxidant Capacity, and Hepatic Lipid Metabolism in Juvenile Chinese Sturgeon (Acipenser sinensis)
Effects of Vitamin E Supplementation on Growth Performance, Antioxidant Capacity, and Hepatic Lipid Metabolism in Juvenile Chinese Sturgeon (Acipenser sinensis) Open
This study investigated the effects of vitamin E supplementation on growth performance, antioxidant capacity, and hepatic lipid metabolism in one-year-old juvenile Chinese sturgeon (Acipenser sinensis). A total of 270 fish (initial weight …
View article: The performance of DWI and ADC values with different b-values for the diagnosis and staging of endometrial carcinoma at 3T
The performance of DWI and ADC values with different b-values for the diagnosis and staging of endometrial carcinoma at 3T Open
DWI images, ADCmean and ADCmin values with b = 1000 s/mm2 had higher performance than those of b = 800 s/mm2 in the assessment of EC diagnosis and staging. This study highlights the potential of using b = 1000 s/mm² as an optimized protoco…
View article: Paeonol alleviates acetaminophen-induced acute liver injury partly through Nrf2/HO-1/GPX4 signaling pathways
Paeonol alleviates acetaminophen-induced acute liver injury partly through Nrf2/HO-1/GPX4 signaling pathways Open
Acetaminophen (APAP) overdose often leads to drug-induced acute liver injury (ALI), characterized by ferroptosis, an iron-dependent form of cell death associated with lipid peroxide (LPO) accumulation. Although paeonol (PAE) is known for i…
View article: Site-specific ligase-dependent conjugation with ring-opening linker improves safety and stability of HER2-targeting ADCs
Site-specific ligase-dependent conjugation with ring-opening linker improves safety and stability of HER2-targeting ADCs Open
Most of current ADCs have the problems of heterogeneity and payload-mediated off-target toxicities due to random conjugation and unstable linker. Herein we apply site-specific ligase-dependent conjugation (LDC) for GQ1001 and GQ1005, where…
View article: Integrative pharmacovigilance and AI-based framework uncovers potential drug triggers in juvenile idiopathic arthritis
Integrative pharmacovigilance and AI-based framework uncovers potential drug triggers in juvenile idiopathic arthritis Open
Background Management of juvenile idiopathic arthritis (JIA) relies heavily on long-term pharmacotherapy, yet an increasing number of case reports suggest that some drugs may themselves precipitate or worsen the disease. But systematic met…
View article: Grazing Is Associated With Dietary Diversity and Gastrointestinal Microbiota in Subterranean Rodents
Grazing Is Associated With Dietary Diversity and Gastrointestinal Microbiota in Subterranean Rodents Open
Diet significantly influences gut microbiota composition. Grazing activities alter local vegetation communities, which in turn are related to changes in the availability of food resources for wildlife. However, the relationships between gr…
View article: Firsekibart as a Prophylactic Treatment for Acute Gout Flare in Participants Initiating Urate‐Lowering Therapy: A Phase 2, Randomized, Open‐Label, Multicenter, Active‐Controlled Trial
Firsekibart as a Prophylactic Treatment for Acute Gout Flare in Participants Initiating Urate‐Lowering Therapy: A Phase 2, Randomized, Open‐Label, Multicenter, Active‐Controlled Trial Open
Objective To evaluate the efficacy and safety of firsekibart versus colchicine for prophylaxis against acute gout flares in participants initiating urate‐lowering therapy (ULT). Methods In this randomized, multicenter, open‐label, active‐c…
View article: Species-level enterosignatures predict clinical phenotypes in chronic hepatitis B and causal triangulation of gut-metabolite-CHB interactions
Species-level enterosignatures predict clinical phenotypes in chronic hepatitis B and causal triangulation of gut-metabolite-CHB interactions Open
Chronic hepatitis B (CHB) remains a significant global health challenge, with research indicating the gut microbiota’s influence on disease progression, although investigations have primarily been limited to the genus level. This study con…
View article: Electromagnetic generalized Schell-model vortex beams
Electromagnetic generalized Schell-model vortex beams Open
In this work, we study what we believe to be a new class of electromagnetic generalized Schell-model vortex beams. The distinct feature of these beams lies in their source field coherence function, which depends on the n th power differenc…
View article: P2-HNF4α alters linoleic acid metabolism and mitigates soybean oil-induced obesity: role for oxylipins
P2-HNF4α alters linoleic acid metabolism and mitigates soybean oil-induced obesity: role for oxylipins Open
Oxylipins-oxidized metabolites of polyunsaturated fatty acids (PUFAs)-are associated with several pathological conditions. We previously showed that oxylipin metabolites of linoleic acid (LA) and alpha-linolenic acid positively correlate w…
View article: Silica nanoparticles alleviate cadmium toxicity to Pisum sativum L. seedling growth by remodeling carbon-nitrogen metabolism
Silica nanoparticles alleviate cadmium toxicity to Pisum sativum L. seedling growth by remodeling carbon-nitrogen metabolism Open
The increasing incidence of soil cadmium (Cd) pollution significantly hinders the sustainable development of agriculture and food security. Improving crop stress resistance through nanobiotechnology represents a secure and sustainable appr…