Li Yang Hsu
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View article: Genomic characterization of colorectal tumors: insights into significantly mutated genes, pathways, and survival outcomes
Genomic characterization of colorectal tumors: insights into significantly mutated genes, pathways, and survival outcomes Open
Background Identifying significantly mutated genes in tumors aids in understanding disease etiology and survival and may aid in the discovery of new drug targets. We aimed to detect and characterize mutated genes from a large, well-charact…
View article: Plasmid dynamics driving carbapenemase gene dissemination in healthcare environments: a nationwide analysis of closed Enterobacterales genomes
Plasmid dynamics driving carbapenemase gene dissemination in healthcare environments: a nationwide analysis of closed Enterobacterales genomes Open
Plasmid-mediated transmission can account for half of carbapenem-producing Enterobacterales (CPE) dissemination, underscoring the need to identify genetic determinants of plasmid persistence in the hospital setting. From 1,088 CPE isolates…
View article: ASEAN and the COVID-19 pandemic: a scoping review on the role and response of a regional organisation in a global health emergency
ASEAN and the COVID-19 pandemic: a scoping review on the role and response of a regional organisation in a global health emergency Open
The Association of Southeast Asian Nations (ASEAN) is a state-based membership organisation that facilitates cooperation in Southeast Asia. Over the past two decades, ASEAN has strengthened its cooperation efforts in health, particularly i…
View article: Antibiotic prescribing for children for acute conditions in public primary care clinics in Singapore: a retrospective cohort database study
Antibiotic prescribing for children for acute conditions in public primary care clinics in Singapore: a retrospective cohort database study Open
Objectives: Data on primary care antibiotic prescription practices for children in Southeast Asia, which are essential for policy, quality improvement and patient safety, are lacking. We aimed to describe this gap and to benchmark prescrip…
View article: Increase in Antibiotic Utilisation in Primary Care Post COVID-19 Pandemic
Increase in Antibiotic Utilisation in Primary Care Post COVID-19 Pandemic Open
Introduction: The COVID-19 pandemic has disrupted antibiotic use; easing public health measures may alter infection presentations and antibiotic prescribing in primary care. The study investigated post-pandemic antibiotic utilisation trend…
View article: Mixed-effects polygenic risk score Phenome-wide association study detects genetic correlation between colorectal cancer risk and phenotype data extracted from the electronic health record
Mixed-effects polygenic risk score Phenome-wide association study detects genetic correlation between colorectal cancer risk and phenotype data extracted from the electronic health record Open
Many factors, including environmental and genetic variables, contribute to Colorectal Cancer (CRC) risk. Some of these risk factors may share underlying genetics with CRC. We investigated potential shared genetics by performing a Phenome-w…
View article: Establishing the value of regional cooperation and a critical role for regional organisations in managing future health emergencies
Establishing the value of regional cooperation and a critical role for regional organisations in managing future health emergencies Open
The COVID-19 pandemic revealed the failures of global, multilateral cooperation to respond and adapt to health emergencies while observing the principles of solidarity and equity. This response has raised the question of whether the global…
View article: Genetic Variation and Regulation of MICA Alters Natural Killer Cell-Mediated Immunosurveillance in Early-Onset Colorectal Cancer
Genetic Variation and Regulation of MICA Alters Natural Killer Cell-Mediated Immunosurveillance in Early-Onset Colorectal Cancer Open
The incidence of colorectal cancer (CRC) among individuals under age 50, or early-onset CRC (EOCRC), has been rising over the past few decades for unclear reasons, and the etiology of the disease remains largely unknown. Known genetic risk…
View article: Cost-Effectiveness Analysis for Disease Prevention -- A Case Study on Colorectal Cancer Screening
Cost-Effectiveness Analysis for Disease Prevention -- A Case Study on Colorectal Cancer Screening Open
Cancer Screening has been widely recognized as an effective strategy for preventing the disease. Despite its effectiveness, determining when to start screening is complicated, because starting too early increases the number of screenings o…
View article: Prescribing Antibiotics for Children with Acute Conditions in Public Primary Care Clinics in Singapore: A Retrospective Cohort Database Study
Prescribing Antibiotics for Children with Acute Conditions in Public Primary Care Clinics in Singapore: A Retrospective Cohort Database Study Open
Data on primary care antibiotic prescription practices for children in Singapore, which are essential for health care policy, are lacking. We aimed to address this gap and to benchmark prescription practices against international standards…
View article: Nongenetic Determinants of Risk for Early-Onset Colorectal Cancer
Nongenetic Determinants of Risk for Early-Onset Colorectal Cancer Open
Background: Incidence of early-onset (younger than 50 years of age) colorectal cancer (CRC) is increasing in many countries. Thus, elucidating the role of traditional CRC risk factors in early-onset CRC is a high priority. We sought to det…
View article: Singapore tuberculosis (TB) clinical management guidelines 2024: A modified Delphi adaptation of international guidelines for drug-susceptible TB infection and pulmonary disease
Singapore tuberculosis (TB) clinical management guidelines 2024: A modified Delphi adaptation of international guidelines for drug-susceptible TB infection and pulmonary disease Open
Introduction: Tuberculosis (TB) remains endemic in Singapore. Singapore’s clinical practice guidelines for the management of tuberculosis were first published in 2016. Since then, there have been major new advances in the clinical manageme…
View article: Singapore tuberculosis (TB) clinical management guidelines 2024: A modified Delphi adaptation of international guidelines for drug-susceptible TB infection and pulmonary disease
Singapore tuberculosis (TB) clinical management guidelines 2024: A modified Delphi adaptation of international guidelines for drug-susceptible TB infection and pulmonary disease Open
Introduction: Tuberculosis (TB) remains endemic in Singapore. Singapore’s clinical practice guidelines for the management of tuberculosis were first published in 2016. Since then, there have been major new advances in the clinical manageme…
View article: The <i>Acinetobacter baumannii</i> K70 and K9 capsular polysaccharides consist of related K-units linked by the same Wzy polymerase and cleaved by the same phage depolymerases
The <i>Acinetobacter baumannii</i> K70 and K9 capsular polysaccharides consist of related K-units linked by the same Wzy polymerase and cleaved by the same phage depolymerases Open
The extensively antibiotic-resistant Acinetobacter baumannii GC1(ST1 IP ) isolate SGH0807 from Singapore carries the KL70 gene cluster. The structure of the K70 capsular polysaccharide (CPS) produced by SGH0807 was determined using sugar a…
View article: Assessing care quality: impact on renal outcomes in non-diabetic chronic kidney disease patients
Assessing care quality: impact on renal outcomes in non-diabetic chronic kidney disease patients Open
Background Chronic kidney disease (CKD) is a major global noncommunicable disease, with significant burden on healthcare systems. Quality indicators (QIs) are useful tools for evaluating healthcare quality, but existing QIs for renal care …
View article: ACORN (A Clinically-Oriented Antimicrobial Resistance Surveillance Network) II: protocol for case based antimicrobial resistance surveillance
ACORN (A Clinically-Oriented Antimicrobial Resistance Surveillance Network) II: protocol for case based antimicrobial resistance surveillance Open
Background : Antimicrobial resistance surveillance is essential for empiric antibiotic prescribing, infection prevention and control policies and to drive novel antibiotic discovery. However, most existing surveillance systems are isolat…
View article: A Qualitative Study on the Policy Process and Development of the National Action Plan on Antimicrobial Resistance in Singapore
A Qualitative Study on the Policy Process and Development of the National Action Plan on Antimicrobial Resistance in Singapore Open
The global public health threat of antimicrobial resistance (AMR) has been accelerated by many interrelated factors spanning across One Health—human health, animal health, and the environment. Singapore launched its own National Strategic …
View article: A Qualitative Study on the Implementation of the National Action Plan on Antimicrobial Resistance in Singapore
A Qualitative Study on the Implementation of the National Action Plan on Antimicrobial Resistance in Singapore Open
Antimicrobial resistance (AMR) is a global public health threat that affects humans, animals, and the environment across the One Health spectrum. Singapore launched its own National Strategic Action Plan (NSAP) on AMR in 2017 with the aim …
View article: Bridging Borders for Health: The Vital Role of Regional Cooperation in Infectious Disease Control and Mitigation of Health Emergencies; A Response to the Recent Commentaries
Bridging Borders for Health: The Vital Role of Regional Cooperation in Infectious Disease Control and Mitigation of Health Emergencies; A Response to the Recent Commentaries Open
Background: The COVID-19 pandemic underlined the importance of\neffective regional collaboration to control infectious diseases.\nIn December 2021, we published a scoping review in this\njournal examining research on how to operationalise …
View article: Whole genome sequencing of multidrug resistant Enterobacterales identified in children and their household members within Siem Reap, Cambodia
Whole genome sequencing of multidrug resistant Enterobacterales identified in children and their household members within Siem Reap, Cambodia Open
Objectives To explore the association of recent hospitalization and asymptomatic carriage of multidrug-resistant Enterobacterales (MDRE) and determine the prevailing strains and antibiotic resistance genes in Siem Reap, Cambodia using WGS.…
View article: Prescribing Antibiotics in Public Primary Care Clinics in Singapore: A Retrospective Cohort Study
Prescribing Antibiotics in Public Primary Care Clinics in Singapore: A Retrospective Cohort Study Open
Background: Antibiotic prescription practices in primary care in Singapore have received little scholarly attention. In this study, we ascertained prescription prevalence and identified care gaps and predisposing factors. Methods: A retros…
View article: Understanding networks in rural Cambodian farming communities and how they influence antibiotic use: A mixed methods study
Understanding networks in rural Cambodian farming communities and how they influence antibiotic use: A mixed methods study Open
Biosecurity and preventive animal health services in Cambodian smallholder backyard farming systems are often limited, leading to an over-reliance on antibiotics. However, data on factors influencing antibiotic use in these settings are la…
View article: SG-APSIC1097: The impact of COVID-19 on the incidence of carbapenem-resistant Enterobacterales (CRE) in Singapore: An interrupted time-series analysis
SG-APSIC1097: The impact of COVID-19 on the incidence of carbapenem-resistant Enterobacterales (CRE) in Singapore: An interrupted time-series analysis Open
Objectives: Over the past 2 years, many infection prevention and control (IPC) resources have been diverted to manage the COVID-19 pandemic. Its impact on the incidence of antimicrobial-resistant organisms has not been adequately studied. …
View article: LipidA-IDER to Explore the Global Lipid A Repertoire of Drug-Resistant Gram-Negative Bacteria
LipidA-IDER to Explore the Global Lipid A Repertoire of Drug-Resistant Gram-Negative Bacteria Open
With the global emergence of drug-resistant bacteria causing difficult-to-treat infections, there is an urgent need for a tool to facilitate studies on key virulence and antimicrobial resistant factors. Mass spectrometry (MS) has contribut…