Mo Yang
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Optimizing Colorectal Polyp Screening: A Novel Artificial Intelligence‐Assisted Colonoscopy Diagnostic System Based on NICE Classification Open
Background This study aims to evaluate the diagnostic performance of an enhanced artificial intelligence‐assisted colonoscopy system, CAD‐N‐Pro, based on the NICE (Narrow‐band Imaging International Colorectal Endoscopic) classification. Me…
Thrombopoietin mitigates neuronal death by enhancing mitophagy and suppressing NLRP3 inflammasome activation under oxygen-glucose deprivation conditions Open
TPO, known for its role in megakaryocytes development and platelets production, also protects neurons from damage caused by oxygen and glucose deprivation. Thrombopoietin (TPO) boosts the A20 protein, which enhances the cell’s mitophagy fo…
View article: Targeting Mitochondrial Quality Control for the Treatment of Triple-Negative Breast Cancer: From Molecular Mechanisms to Precision Therapy
Targeting Mitochondrial Quality Control for the Treatment of Triple-Negative Breast Cancer: From Molecular Mechanisms to Precision Therapy Open
Breast cancer is the leading threat to the health of women, with a rising global incidence linked to social and psychological factors. Among its subtypes, triple-negative breast cancer (TNBC), which lacks estrogen receptor (ER), progestero…
Dietary saturated fatty acids and prostate cancer: insights into NF-κB pathway and lipid metabolism mechanisms Open
Prostate cancer (PCa) is one of the most prevalent malignancies in men, with dietary factors, particularly saturated fatty acids (SFAs), emerging as significant contributors to its pathogenesis. This review synthesizes current literature l…
View article: Efficacy and safety of Y-3 intracalvariosseous injection versus intravenous injection in the treatment of acute large hemispheric infarction (SOLUTION-2): rationale and design of a multicentre, prospective, randomised, open-label, blind endpoint (PROBE) trial
Efficacy and safety of Y-3 intracalvariosseous injection versus intravenous injection in the treatment of acute large hemispheric infarction (SOLUTION-2): rationale and design of a multicentre, prospective, randomised, open-label, blind endpoint (PROBE) trial Open
Rationale The blood–brain barrier (BBB) largely restricts the efficacy of neuroprotectants, which is an important approach in treating large hemispheric infarction (LHI). In this study, we harnessed intracalvariosseous (ICO) injection to b…
Harnessing Photo‐Energy Conversion in Nanomaterials for Precision Theranostics Open
The rapidly advancing field of theranostics aims to integrate therapeutic and diagnostic functionalities into a single platform for precision medicine, enabling the simultaneous treatment and monitoring of diseases. Photo‐energy conversion…
A novel model for predicting immunotherapy response and prognosis in NSCLC patients Open
In this study, we developed a novel model (RF model) to predict the response to immunotherapy and prognosis in NSCLC patients. The RF model demonstrated better predictive performance for immunotherapy responses than the Nomogram model. Mor…
View article: Causal relationship between immune cells, metabolites and polycystic ovary syndrome identified by Mendelian randomization and mediation analyses
Causal relationship between immune cells, metabolites and polycystic ovary syndrome identified by Mendelian randomization and mediation analyses Open
Immune cells and blood metabolites play essential roles in the development of polycystic ovary syndrome (PCOS); however, it remains unclear whether blood metabolites mediate the causal relationship between immune cells and PCOS. This study…
A new stage for predicting the prognosis of granulomatous lobular mastitis Open
Introduction The prognosis of granulomatous lobular mastitis (GLM) had been poor, primarily due to the lack of a unified disease assessment standard. Objective The purpose of this cohort study was to establish a staging system for GLM to m…
Local soft niches in mechanically heterogeneous primary tumors promote brain metastasis via mechanotransduction-mediated HDAC3 activity Open
Tumor cells with organ-specific metastasis traits arise in primary lesions with substantial variations of local niche mechanics owing to intratumoral heterogeneity. However, the roles of mechanically heterogeneous primary tumor microenviro…
A buoyant plasmonic microbubble-based SERS sensing platform for amyloid-beta protein detection in Alzheimer's disease Open
We developed a buoyant plasmonic Au/microbubble (MB) substrate functionalized with copper ions (Cu 2+ ) and 4-mercaptobenzoic acid (4-MBA) to establish a SERS-based sensing platform for detecting amyloid-β (Aβ) proteins.
View article: A Machine Vision Perspective on Droplet‐Based Microfluidics
A Machine Vision Perspective on Droplet‐Based Microfluidics Open
Microfluidic droplets, with their unique properties and broad applications, are essential in in chemical, biological, and materials synthesis research. Despite the flourishing studies on artificial intelligence‐accelerated microfluidics, m…
View article: Structural basis for human DPP4 receptor recognition by a pangolin MERS-like coronavirus
Structural basis for human DPP4 receptor recognition by a pangolin MERS-like coronavirus Open
Middle East respiratory syndrome coronavirus (MERS-CoV) and the pangolin MERS-like coronavirus MjHKU4r-CoV-1 employ dipeptidyl peptidase 4 (DPP4) as an entry receptor. MjHKU4r-CoV-1 could infect transgenic mice expressing human DPP4. To un…
Delayed Blastocyst Formation Reduces the Quality and Hatching Ability of Porcine Parthenogenetic Blastocysts by Increasing DNA Damage, Decreasing Cell Proliferation, and Altering Transcription Factor Expression Patterns Open
The purpose of this study was to investigate the influence of blastocyst formation timing on the quality of porcine embryos derived from parthenogenetic activation. Newly formed blastocysts at days 6, 7, and 8 of culture [termed formation …
Thrombectomy Alone or Alongside Intravenous Thrombolysis in Managing Acute Ischemic Stroke Caused by Basilar Artery Occlusion: A Multicenter Observational Study Open
In patients with BAO-induced AIS, DEVT demonstrates a comparable functional outcome to bridging therapy within 4.5 hours of symptom onset, but IVT reduces the number of thrombectomy attempts.
A biomimetic upconversion nanoreactors for near-infrared driven H2 release to inhibit tauopathy in Alzheimer's disease therapy Open
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Research and design for a storage liquid refrigerator considering the characteristics of energy storage batteries Open
At present, energy storage in industrial and commercial scenarios has problems such as poor protection levels, flexible deployment, and poor battery performance. Aiming at the pain points and storage application scenarios of industrial and…
Photoreceptor‐Mimetic Microflowers for Restoring Light Responses in Degenerative Retina through a 2D Nanopetal/Cell Biointerface Open
Retinitis pigmentosa is the main cause of inherited human blindness and is associated with dysfunctional photoreceptors (PRs). Compared with traditional methods, optoelectronic stimulation can better preserve the structural integrity and g…
View article: Mesenchymal Stem Cell Membrane‐Camouflaged Liposomes for Biomimetic Delivery of Cyclosporine A for Hepatic Ischemia‐Reperfusion Injury Prevention
Mesenchymal Stem Cell Membrane‐Camouflaged Liposomes for Biomimetic Delivery of Cyclosporine A for Hepatic Ischemia‐Reperfusion Injury Prevention Open
Hepatic ischemia‐reperfusion injury (HIRI) is a prevalent issue during liver resection and transplantation, with currently no cure or FDA‐approved therapy. A promising drug, Cyclosporin A (CsA), ameliorates HIRI by maintaining mitochondria…
SIRT5-mediated PRKAA2 succinylation ameliorates apoptosis of human placental trophoblasts in hypertensive disorder complicating pregnancy Open
Our findings indicated that SIRT5-mediated PRKAA2 succinylation modulates placental cell apoptosis in HDCP, suggesting that PRKAA2 is a potential therapeutic target for HDCP treatment.
Assessment of Land Quality for Siamese Orange (Citrus nobilis var. microcarpa) Development in Pacitan Regency, Indonesia Open
Siamese oranges are one of the most widely developed horticultural crops in Indonesia. Arjosari and Ngadirojo are some of the sub-districts that produce Siamese orange in Pacitan Regency. One of the factors that can affect the development …
Portulaca oleracea L. polysaccharide inhibits ovarian cancer via inducing ACSL4-dependent ferroptosis Open
The antitumor effect of Portulaca oleracea L. polysaccharide (POL) has been demonstrated, but whether it curbs the development of ovarian cancer has not been reported. Here, we treated ovarian cancer cells with different concentrations of …
Microfluidic Chip‐Assisted Upconversion Luminescence Biosensing Platform for Point‐of‐Care Virus Diagnostics Open
Epidemics caused by multiple viruses continue to emerge, which have brought a terrible impact on human society. Identification of viral infections with high sensitivity and portability is of significant importance for the screening and man…
View article: Intracalvariosseous injection bypasses the blood-brain barrier as a novel drug delivery approach for pre-clinical and clinical trials in stroke
Intracalvariosseous injection bypasses the blood-brain barrier as a novel drug delivery approach for pre-clinical and clinical trials in stroke Open
Central nervous system (CNS) accessibility constitutes a major hurdle for drug development to treat neurological diseases. Existing drug delivery methods rely integrity of the blood-brain barrier (BBB) for CNS penetration. Here we showed t…