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View article: Muscle Structure and Function Recovery: Adalimumab‐Calcium Channel Synergy in Post–Ischemic Stroke Sarcopenia
Muscle Structure and Function Recovery: Adalimumab‐Calcium Channel Synergy in Post–Ischemic Stroke Sarcopenia Open
Background Adalimumab, a TNF‐α inhibitor, is widely used clinically. Recent studies suggest Adalimumab can improve muscle damage after ischemic stroke (IS), but its protective mechanisms remain unclear. This study investigates the effect o…
View article: CD5 ablation enhances persistence and antitumor potency of engineered T cells by mitigating exhaustion and promoting cytotoxicity
CD5 ablation enhances persistence and antitumor potency of engineered T cells by mitigating exhaustion and promoting cytotoxicity Open
Background While chimeric antigen receptor (CAR)-T cell therapy has transformed the treatment landscape for certain hematologic malignancies, therapeutic resistance and disease relapse highlight the critical need to improve the durability …
View article: <scp>CAR19</scp>/22 T‐Cell Cocktail Therapy Combined With Autologous Stem Cell Transplantation for a Patient With Mosaic <scp><i>TP53</i></scp> Mutation and 17p Deletion
<span>CAR19</span>/22 T‐Cell Cocktail Therapy Combined With Autologous Stem Cell Transplantation for a Patient With Mosaic <span><i>TP53</i></span> Mutation and 17p Deletion Open
Although most cases of Burkitt lymphoma (BL) respond well to chemotherapy, relapsed or refractory BL, particularly in the presence of TP53 aberrations, presents a significant therapeutic challenge. TP53 germline or mosaic mutations, though…
View article: Mixed-Curvature Multi-Modal Knowledge Graph Completion
Mixed-Curvature Multi-Modal Knowledge Graph Completion Open
Multi-modal Knowledge Graph Completion (KGC), which aims to enrich knowledge graph embeddings by incorporating images and text as supplementary information alongside triplets, is an significant task in learning KGs. Existing multi-modal KG…
View article: The NAE1-mediated neddylation operates as an essential post-translational modification checkpoint for effector CD8 <sup>+</sup> T cells
The NAE1-mediated neddylation operates as an essential post-translational modification checkpoint for effector CD8 <sup>+</sup> T cells Open
Optimal activation of CD8+ T cells is crucial for immunity-mediated destruction of cancer, requiring a substantial amount of proteins involved in metabolism, proliferation, and effector function. Despite extensive studies emphasizing the r…
View article: Predictive Significance of Admission-Day Blood Routine-Derived Indices for 30-Day Mortality Risk in Elderly Patients with Bacterial Pneumonia
Predictive Significance of Admission-Day Blood Routine-Derived Indices for 30-Day Mortality Risk in Elderly Patients with Bacterial Pneumonia Open
In elderly patients with community-acquired bacterial pneumonia, increased NLR, SII, SIRI and NMLR can predict 30-day mortality to a certain extent, but further multicenter studies are needed to verify.
View article: Analysis of clinical characteristics of hemorrhagic fever with renal syndrome with acute pancreatitis: a retrospective study
Analysis of clinical characteristics of hemorrhagic fever with renal syndrome with acute pancreatitis: a retrospective study Open
Patients with HFRS with AP exhibit higher disease severity and poorer prognosis. Smoking, elevated ferritin and white blood cell levels, decreased fibrinogen and platelet levels are more susceptible to developing AP.
View article: The Landscape of Gain and Loss of Function Mutations in Melanoma
The Landscape of Gain and Loss of Function Mutations in Melanoma Open
View article: Chinese expert consensus on flow cytometric detection of hematological malignant cells in tissue samples
Chinese expert consensus on flow cytometric detection of hematological malignant cells in tissue samples Open
View article: Development and validation of a deep learning model for morphological assessment of myeloproliferative neoplasms using clinical data and digital pathology
Development and validation of a deep learning model for morphological assessment of myeloproliferative neoplasms using clinical data and digital pathology Open
Summary The subjectivity of morphological assessment and the overlapping pathological features of different subtypes of myeloproliferative neoplasms (MPNs) make accurate diagnosis challenging. To improve the pathological assessment of MPNs…
View article: TET2 mutation in acute myeloid leukemia: biology, clinical significance, and therapeutic insights
TET2 mutation in acute myeloid leukemia: biology, clinical significance, and therapeutic insights Open
TET2 is a critical gene that regulates DNA methylation, encoding a dioxygenase protein that plays a vital role in the regulation of genomic methylation and other epigenetic modifications, as well as in hematopoiesis. Mutations in TET2 are …
View article: 921 The NAE1-mediated Neddylation operates as an essential post-translational modification checkpoint for effector CD8<sup>+</sup> T cells
921 The NAE1-mediated Neddylation operates as an essential post-translational modification checkpoint for effector CD8<sup>+</sup> T cells Open
View article: Exploring the potential link between gut microbiota and chronic kidney disease in causality: A 2-sample Mendelian randomization study
Exploring the potential link between gut microbiota and chronic kidney disease in causality: A 2-sample Mendelian randomization study Open
Increasing evidence indicates a significant correlation between gut microbiota (GM) and susceptibility to chronic kidney disease (CKD). However, causal relationship presence remains uncertain. Mendelian randomization (MR) was applied to ev…
View article: The landscape of gain and loss of function mutations in melanoma
The landscape of gain and loss of function mutations in melanoma Open
Melanoma is a common and aggressive cancer, with a rising incidence in most developed countries. Major discoveries in melanoma biology have been rapidly translated, allowing cures for some late-stage patients. Despite these advances, incom…
View article: Development and Characterization of Paclitaxel-Loaded Li-pid-Coated Mesoporous Silica Nanoparticles for pH-Responsive Tumor-Targeted Drug Delivery
Development and Characterization of Paclitaxel-Loaded Li-pid-Coated Mesoporous Silica Nanoparticles for pH-Responsive Tumor-Targeted Drug Delivery Open
Nanoparticle carriers can selectively deliver the drug cargo to tumor cells, thus having the ability to pre-vent early drug release, reduce non-specific cell binding, and prolong in vivo drug retention. We con-structed paclitaxel (PTX)-loa…
View article: Subdivision of <scp>M1</scp> category and prognostic stage for de novo metastatic breast cancer to enhance prognostic prediction and guide the selection of locoregional therapy
Subdivision of <span>M1</span> category and prognostic stage for de novo metastatic breast cancer to enhance prognostic prediction and guide the selection of locoregional therapy Open
Background Although de novo metastatic breast cancer (dnMBC) is acknowledged as a heterogeneous disease, the current staging systems do not distinguish between patients within the M1 or stage IV category. This study aimed to refine the M1 …
View article: Major pathologic response and long-term clinical benefit in hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer after neoadjuvant chemotherapy
Major pathologic response and long-term clinical benefit in hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer after neoadjuvant chemotherapy Open
View article: MYH9-related inherited thrombocytopenia: the genetic spectrum, underlying mechanisms, clinical phenotypes, diagnosis, and management approaches
MYH9-related inherited thrombocytopenia: the genetic spectrum, underlying mechanisms, clinical phenotypes, diagnosis, and management approaches Open
Inherited thrombocytopenias have been considered exceedingly rare for a long time, but recent advances have facilitated diagnosis and greatly enabled the discovery of new causative genes. MYH9-related disease (MYH9-RD) repres…
View article: Investigating the mechanism of tricyclic decyl benzoxazole -induced apoptosis in liver Cancer cells through p300-mediated FOXO3 activation
Investigating the mechanism of tricyclic decyl benzoxazole -induced apoptosis in liver Cancer cells through p300-mediated FOXO3 activation Open
TDB induces proliferation inhibition and promotes apoptosis of SMMC-7721 cells by activating p300-mediated FOXO3 acetylation.
View article: Correction to: Monozygotic Twins with MAGT1 Deficiency and Epstein-Barr virus-positive Classic Hodgkin Lymphoma Receiving anti-CD30 CAR T-cell Immunotherapy: A case Report
Correction to: Monozygotic Twins with MAGT1 Deficiency and Epstein-Barr virus-positive Classic Hodgkin Lymphoma Receiving anti-CD30 CAR T-cell Immunotherapy: A case Report Open
View article: Association between the stress–hyperglycemia ratio and all‐cause mortality in community‐dwelling populations: An analysis of the National Health and Nutrition Examination Survey (<scp>NHANES</scp>) 1999–2014
Association between the stress–hyperglycemia ratio and all‐cause mortality in community‐dwelling populations: An analysis of the National Health and Nutrition Examination Survey (<span>NHANES</span>) 1999–2014 Open
Background Reportedly, the stress–hyperglycemia ratio (SHR) is closely associated with poor prognosis in patients with severe acute disease. However, the community‐dwelling may also be in a state of stress due to environmental exposure. Ou…
View article: Using Mendelian randomization and bioinformatics methods to explore the causal effect of hypothyroidism on urticaria
Using Mendelian randomization and bioinformatics methods to explore the causal effect of hypothyroidism on urticaria Open
Observational studies connect hypothyroidism with urticaria, but causality is unclear. This study explores genetic variations in hypothyroidism and their potential influence on urticaria risk.We collected statistical data from open genome-…
View article: Combination of chidamide and PD-1 blockade in Refractory/Relapsed aggressive large B-cell lymphomas with high risk of failing CAR-T therapy
Combination of chidamide and PD-1 blockade in Refractory/Relapsed aggressive large B-cell lymphomas with high risk of failing CAR-T therapy Open
Our results indicate that the combination of chidamide and PD-1 blockade as maintenance therapy could improve the outcomes of aggressive LBCL patients at high risk of failing CAR-T cell therapy.
View article: Monozygotic Twins with MAGT1 Deficiency and Epstein–Barr virus-positive Classic Hodgkin Lymphoma Receiving anti-CD30 CAR T-cell Immunotherapy: A case Report
Monozygotic Twins with MAGT1 Deficiency and Epstein–Barr virus-positive Classic Hodgkin Lymphoma Receiving anti-CD30 CAR T-cell Immunotherapy: A case Report Open
1000G 1000 Genomes Project allo-HSCT allogeneic hematopoietic stem cell transplantation anti-PD-1 anti-programmed cell death protein 1 antibody
View article: The link between ten-eleven translocation-2 (Tet2) related clonal hematopoiesis and sequential onset of two hematologic malignancies
The link between ten-eleven translocation-2 (Tet2) related clonal hematopoiesis and sequential onset of two hematologic malignancies Open
View article: Genetic association of lipid-lowering drugs with aortic aneurysms: a Mendelian randomization study
Genetic association of lipid-lowering drugs with aortic aneurysms: a Mendelian randomization study Open
Aims The lack of effective pharmacotherapies for aortic aneurysms (AA) is a persistent clinical challenge. Lipid metabolism plays an essential role in AA. However, the impact of lipid-lowering drugs on AA remains controversial. The study a…
View article: A single‐centre, real‐world study of <scp>BTK</scp> inhibitors for the initial treatment of <scp>MYD88<sup>mut</sup></scp>/<scp>CD79B<sup>mut</sup></scp> diffuse large B‐cell lymphoma
A single‐centre, real‐world study of <span>BTK</span> inhibitors for the initial treatment of <span>MYD88<sup>mut</sup></span>/<span>CD79B<sup>mut</sup></span> diffuse large B‐cell lymphoma Open
Background MCD (MYD88 L265P /CD79B mut ) diffuse large B‐cell lymphoma has a poor prognosis. There is no published clinical research conclusion regarding zanubrutinib or orelabrutinib for the initial treatment of MCD DLBCL. Aims This study…
View article: Issue Information
Issue Information Open
The IeDEA West Africa Collaboration HIV favours the persistence of high-risk HPV and progression of cervical intraepithelial neoplasia to cancer, with universal access to antiretroviral therapy also possibly influencing high-risk HPV distr…
View article: Green Synthesis of Gold Nanoparticles for Catalytic Reduction of 4-Nitrophenol and Methylene Blue for Sustainable Development
Green Synthesis of Gold Nanoparticles for Catalytic Reduction of 4-Nitrophenol and Methylene Blue for Sustainable Development Open
Unique structural features and wide applications of gold nanoparticles (GNPs) are inspiring researchers to develop biocompatible, reliable and cost-effective methods for their synthesis. Herein, a clean, eco-friendly and non-toxic method t…
View article: Upper gastrointestinal tract immune‐related adverse events: Two cases of obstructive complications occurred in immune consolidation therapy after sequential chimeric antigen receptor T cell therapy with autologous hematopoietic stem cell transplantation for refractory/relapsed diffuse large B cell lymphoma
Upper gastrointestinal tract immune‐related adverse events: Two cases of obstructive complications occurred in immune consolidation therapy after sequential chimeric antigen receptor T cell therapy with autologous hematopoietic stem cell transplantation for refractory/relapsed diffuse large B cell lymphoma Open
Key Clinical Message Immune checkpoint inhibitors are a very popular method of treating malignant tumors. But its side effects cannot be ignored. This study revealed obstructive complications during immune consolidation therapy following s…