Yangchan Li
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View article: Redox phenotype confers T cell-exclusion microenvironment and resistance to immunotherapy by suppressing STING/MDA5 expression and interferon signaling in lung cancers harboring KEAP1/STK11 mutations
Redox phenotype confers T cell-exclusion microenvironment and resistance to immunotherapy by suppressing STING/MDA5 expression and interferon signaling in lung cancers harboring KEAP1/STK11 mutations Open
Background KEAP1 and STK11 are frequently mutated in NSCLC, and are associated with compromised response to immunotherapy, the underlying mechanism of which is not fully understood. Methods To assess the impact of KEAP1 / STK11 mutations o…
View article: Limited Benefit of Postoperative Chemoradiotherapy in Intermediate-Risk Locally Advanced Head and Neck Squamous Cell Carcinoma: Real-World Evidence from the IMRT Era
Limited Benefit of Postoperative Chemoradiotherapy in Intermediate-Risk Locally Advanced Head and Neck Squamous Cell Carcinoma: Real-World Evidence from the IMRT Era Open
Background In the era of intensity-modulated radiotherapy (IMRT), the benefit of adding concurrent chemotherapy to postoperative radiotherapy (PORT) for intermediate-risk locally advanced head and neck squamous cell carcinoma (LA-HNSCC) wi…
View article: Comparison of efficacy and side effects between short-course radiotherapy and chemotherapy with or without immunotherapy in the neoadjuvant treatment for patients with locally advanced rectal cancer
Comparison of efficacy and side effects between short-course radiotherapy and chemotherapy with or without immunotherapy in the neoadjuvant treatment for patients with locally advanced rectal cancer Open
Purpose To evaluate the efficacy and safety of short-course radiotherapy (SCRT) combined with chemotherapy (ChT) with or without immunotherapy (IT) in the neoadjuvant treatment for patients with locally advanced rectal cancer (LARC). Mater…
View article: Redox phenotype confers T cell-exclusion microenvironment and resistance to immunotherapy by suppressing STING/MDA5 expression and Interferon signaling in lung cancers harboring KEAP1/STK11 mutations
Redox phenotype confers T cell-exclusion microenvironment and resistance to immunotherapy by suppressing STING/MDA5 expression and Interferon signaling in lung cancers harboring KEAP1/STK11 mutations Open
Background KEAP1 and STK11 are frequently mutated in NSCLC, and are associated with compromised response to immunotherapy, the underlying mechanism of which is not fully understood. Methods To assess the impact of KEAP1/STK11 mutations on …
View article: CRISPR screening reveals ZNF217 as a vulnerability in high-risk B-cell acute lymphoblastic leukemia
CRISPR screening reveals ZNF217 as a vulnerability in high-risk B-cell acute lymphoblastic leukemia Open
Rationale: Despite substantial advancement in the treatment of B-cell acute lymphoblastic leukemia (B-ALL), it remains a leading cause of cancer mortality in children due to the high relapse rate. Moreover, the long-term survival ra…
View article: A generalized model of cardiac surface motion for evaluating left anterior descending coronary artery dose in left breast cancer radiotherapy
A generalized model of cardiac surface motion for evaluating left anterior descending coronary artery dose in left breast cancer radiotherapy Open
Background Retrospective studies indicate that radiation damage to left anterior descending coronary artery (LAD) may be critical for late‐stage radiation‐induced cardiac morbidity. Developing a method that accurately depicts LAD motion an…
View article: METTL16 promotes liver cancer stem cell self-renewal via controlling ribosome biogenesis and mRNA translation
METTL16 promotes liver cancer stem cell self-renewal via controlling ribosome biogenesis and mRNA translation Open
Background While liver cancer stem cells (CSCs) play a crucial role in hepatocellular carcinoma (HCC) initiation, progression, recurrence, and treatment resistance, the mechanism underlying liver CSC self-renewal remains elusive. We aim to…
View article: TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal
TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal Open
View article: QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism
QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism Open
View article: Phosphorylation stabilized TET1 acts as an oncoprotein and therapeutic target in B cell acute lymphoblastic leukemia
Phosphorylation stabilized TET1 acts as an oncoprotein and therapeutic target in B cell acute lymphoblastic leukemia Open
Although the overall survival rate of B cell acute lymphoblastic leukemia (B-ALL) in childhood is more than 80%, it is merely 30% in refractory/relapsed and adult patients with B-ALL. This demonstrates a need for improved therapy targeting…
View article: Targeting fat mass and obesity-associated protein mitigates human colorectal cancer growth in vitro and in a murine model
Targeting fat mass and obesity-associated protein mitigates human colorectal cancer growth in vitro and in a murine model Open
Introduction Colorectal cancer (CRC) remains a significant cause of cancer related mortality. Fat mass and obesity-associated protein (FTO) is a m6A mRNA demethylase that plays an oncogenic role in various malignancies. In this study we ev…
View article: METTL16 exerts an m6A-independent function to facilitate translation and tumorigenesis
METTL16 exerts an m6A-independent function to facilitate translation and tumorigenesis Open
View article: R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis
R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis Open
View article: Co-culture Systems of Drug-Treated Acute Myeloid Leukemia Cells and T Cells for In Vitro and In Vivo Study
Co-culture Systems of Drug-Treated Acute Myeloid Leukemia Cells and T Cells for In Vitro and In Vivo Study Open
A combination of immunotherapy and chemotherapy strategies could strengthen antitumor effects. This protocol elucidates a robust method via co-culturing drug pre-treated acute myeloid leukemia cells with CD3+ T cells, derived fr…
View article: Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion
Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion Open