Yan Cui
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View article: Temporal dynamic of cognitive decline in type 2 diabetes mellitus patients: a multimodal biomarker analysis using event-based modal and principal component analysis
Temporal dynamic of cognitive decline in type 2 diabetes mellitus patients: a multimodal biomarker analysis using event-based modal and principal component analysis Open
Background Type 2 diabetes mellitus (T2DM) is an important risk factor for cognitive impairment. Prior research has shown cognitive deficits and neural alterations across multiple domains in T2DM patients. However, the sequential dynamics …
View article: d‐Band Optimized Hydrogen Adsorption and Dynamic Reconstruction‐Accelerated Oxygen Evolution on RuS <sub>2</sub> /(FeNi)S <sub>1.03</sub> Heterointerfaces for Water/Seawater Splitting
d‐Band Optimized Hydrogen Adsorption and Dynamic Reconstruction‐Accelerated Oxygen Evolution on RuS <sub>2</sub> /(FeNi)S <sub>1.03</sub> Heterointerfaces for Water/Seawater Splitting Open
Designing efficient bifunctional electrocatalysts for the kinetically divergent hydrogen and oxygen evolution reactions (HER/OER) is challenging due to their conflicting interfacial requirements. Herein, precisely engineered RuS 2 /(FeNi)S…
View article: Preoperative n-terminal pro-b-type natriuretic peptide and postoperative acute kidney injury in cardiac surgery: a mediation analysis of intraoperative hypotension
Preoperative n-terminal pro-b-type natriuretic peptide and postoperative acute kidney injury in cardiac surgery: a mediation analysis of intraoperative hypotension Open
Background: Preoperative N-terminal pro-B-type natriuretic peptide (NT-proBNP) and intraoperative hypotension (IOH) are associated with acute kidney injury (AKI) after cardiac surgery. However, the mediating role of IOH between preoperativ…
View article: Lung Adenocarcinoma Just Desserts: An Expanding Pie of Activating Oncogenes or a Layer Cake of Integrated Alterations
Lung Adenocarcinoma Just Desserts: An Expanding Pie of Activating Oncogenes or a Layer Cake of Integrated Alterations Open
The molecular landscape of lung adenocarcinoma (LUAD) is often summarized as a “pie chart” of driver oncogenes, suggesting identification and targeting of oncogenic drivers is the best clinical approach. However, this model oversimplifies …
View article: Temporal Dynamic of Cognitive Decline in Type 2 Diabetes Mellitus Patients: A Multimodal Biomarker Analysis using Event-Based Modal and Principal Component Analysis
Temporal Dynamic of Cognitive Decline in Type 2 Diabetes Mellitus Patients: A Multimodal Biomarker Analysis using Event-Based Modal and Principal Component Analysis Open
Background Type 2 diabetes mellitus (T2DM) is associated with cognitive impairment, affecting life quality. The progression of cognitive decline and its neural basis in T2DM are unclear due to limitations in previous studies. This study in…
View article: Phosphoglycerate dehydrogenase interacts with and inhibits the protein kinase TAK1 to mitigate septic shock
Phosphoglycerate dehydrogenase interacts with and inhibits the protein kinase TAK1 to mitigate septic shock Open
View article: Preventive effect and prognosis of carbetocin on postpartum hemorrhage
Preventive effect and prognosis of carbetocin on postpartum hemorrhage Open
【摘要】目的： 探讨卡贝缩宫素在医院产后出血（PPH）治疗中的临床价值。方法： 从 2018 年到 2022 年，共纳入 38948 例住院的高危产妇。所有产妇均接受卡贝缩宫素治疗，并比较和分析治疗效果。结果：所有产妇均出现产后出血，新生儿状况良好。与产前相比，产后经阴道分娩后产后血红蛋白 （Hb） 、红细胞体积 （RCV） 和红细胞计数 （RBC） 均降低，遗憾无统计学意义 （P > 0.05）。此外，不良反应的总发生率为 0.1% （11/38948），较低。此外，我们…
View article: Knowledge and Emergency Management of Traumatic Dental Injuries Among Primary School Caregivers in Yulin, China: A Cross-Sectional Study
Knowledge and Emergency Management of Traumatic Dental Injuries Among Primary School Caregivers in Yulin, China: A Cross-Sectional Study Open
Background Traumatic dental injuries (TDIs) represent a prevalent public health concern among school-aged children, with suboptimal caregiver knowledge frequently leading to delayed management in China. This study evaluated TDI-related kno…
View article: Advances in the application of macrogenomic next generation and targeted next generation sequencing technologies in the diagnosis of infectious lung pathogens
Advances in the application of macrogenomic next generation and targeted next generation sequencing technologies in the diagnosis of infectious lung pathogens Open
View article: Data Representation Bias and Conditional Distribution Shift Drive Predictive Performance Disparities in Multi-Population Machine Learning
Data Representation Bias and Conditional Distribution Shift Drive Predictive Performance Disparities in Multi-Population Machine Learning Open
Machine learning frequently encounters challenges when applied to population-stratified datasets, where data representation bias and data distribution shifts can substantially impact model performance and generalizability across different …
View article: Estradiol Alleviates Elevated Temperature-Induced Damage in Yak Oviductal Epithelial Cells by Maintaining Endoplasmic Reticulum Calcium Homeostasis
Estradiol Alleviates Elevated Temperature-Induced Damage in Yak Oviductal Epithelial Cells by Maintaining Endoplasmic Reticulum Calcium Homeostasis Open
Background: The oviduct is an organ that participates in multiple critical reproductive processes and provides essential nutritional support while maintaining a specialized microenvironment. It is particularly vulnerable to damage followin…
View article: Predictive models of severe disease in patients with COVID-19 pneumonia at an early stage on CT images using topological properties
Predictive models of severe disease in patients with COVID-19 pneumonia at an early stage on CT images using topological properties Open
Prediction of severe disease (SVD) in patients with coronavirus disease (COVID-19) pneumonia at an early stage could allow for more appropriate triage and improve patient prognosis. Moreover, the visualization of the topological properties…
View article: Mechanism of Mitophagy to Protect Yak Kidney from Hypoxia-Induced Fibrosis Damage by Regulating Ferroptosis Pathway
Mechanism of Mitophagy to Protect Yak Kidney from Hypoxia-Induced Fibrosis Damage by Regulating Ferroptosis Pathway Open
Renal fibrosis is a critical pathological feature of various chronic kidney diseases, with hypoxia being recognized as an important factor in inducing fibrosis. Yaks have long inhabited high-altitude hypoxic environments and do not exhibit…
View article: Correction: Promotion of NLRP3 autophagosome degradation by PV-K nanodevice for protection against macrophage pyroptosis-mediated lung injury
Correction: Promotion of NLRP3 autophagosome degradation by PV-K nanodevice for protection against macrophage pyroptosis-mediated lung injury Open
View article: Assessment of knowledge on traumatized immature permanent teeth among dentists in China: a cross-sectional study
Assessment of knowledge on traumatized immature permanent teeth among dentists in China: a cross-sectional study Open
View article: Digital pathways connecting social and biological factors to health outcomes and equity
Digital pathways connecting social and biological factors to health outcomes and equity Open
View article: Dysregulated brain dynamics in the visual motor network in type 2 diabetes patients and their relationship with cognitive impairment
Dysregulated brain dynamics in the visual motor network in type 2 diabetes patients and their relationship with cognitive impairment Open
Our findings provide insights into the neurobiological mechanisms of the cognitive impairment of T2DM patients from a dynamic network perspective, which may ultimately inform more targeted and effective strategies to prevent MCI.
View article: Macrophage-specific PHGDH protects against MAFLD by suppressing TAK1
Macrophage-specific PHGDH protects against MAFLD by suppressing TAK1 Open
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a progressive disease with only one approved treatment currently available. Hepatic phosphoglycerate dehydrogenase (PHGDH), the rate-limiting enzyme of the serine biosynthesis…
View article: Integrating explainable deep learning with multi-omics for screening progressive diagnostic biomarkers of hepatocellular carcinoma covering the “inflammation-cancer” transformation
Integrating explainable deep learning with multi-omics for screening progressive diagnostic biomarkers of hepatocellular carcinoma covering the “inflammation-cancer” transformation Open
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View article: Promotion of NLRP3 autophagosome degradation by PV-K nanodevice for protection against macrophage pyroptosis-mediated lung injury
Promotion of NLRP3 autophagosome degradation by PV-K nanodevice for protection against macrophage pyroptosis-mediated lung injury Open
View article: PCSK9 with a gain of function D374Y mutation aggravates atherosclerosis by inhibiting PPARα expression
PCSK9 with a gain of function D374Y mutation aggravates atherosclerosis by inhibiting PPARα expression Open
View article: Sequence of episodic memory-related behavioral and brain-imaging abnormalities in type 2 diabetes
Sequence of episodic memory-related behavioral and brain-imaging abnormalities in type 2 diabetes Open
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View article: Effect of Ga<sub>2</sub>O<sub>3</sub> on interfacial enhancement behaviour of Sn-3.0Ag-0.5Cu Lead-free solder
Effect of Ga<sub>2</sub>O<sub>3</sub> on interfacial enhancement behaviour of Sn-3.0Ag-0.5Cu Lead-free solder Open
Sn-3.0Ag-0.5Cu-x Ga 2 O 3 /Cu solder joints with different contents (x=0wt%, 0.2wt%, 0.4wt%, 0.6wt%, 0.8wt%, 1.2wt%) were prepared by Ga 2 O 3 nanosized particles and isothermal aging at 170 °C for distinct time. And the effect of Ga 2 O 3…
View article: JIS-TIG: A Joint Model for Intent Detection and Slot Filling with Two-Stage Interactive Guidance
JIS-TIG: A Joint Model for Intent Detection and Slot Filling with Two-Stage Interactive Guidance Open
View article: Bridging the Dimensional Gap from Planar Spatial Transcriptomics to 3D Cell Atlases
Bridging the Dimensional Gap from Planar Spatial Transcriptomics to 3D Cell Atlases Open
Spatial transcriptomics (ST) has revolutionized our understanding of tissue architecture, yet constructing comprehensive three-dimensional (3D) cell atlases remains challenging due to technical limitations and high cost. Current approaches…
View article: NicheTrans: Spatial-aware Cross-omics Translation
NicheTrans: Spatial-aware Cross-omics Translation Open
Spatial omics technologies have revolutionized our studies on tissue architecture and cellular interactions at single-cell resolution. While spatial multi-omics approaches offer unprecedented insights into complex biological systems, their…
View article: Abnormal changes of brain function and structure in patients with T2DM-related cognitive impairment: a neuroimaging meta-analysis and an independent validation
Abnormal changes of brain function and structure in patients with T2DM-related cognitive impairment: a neuroimaging meta-analysis and an independent validation Open
Type 2 diabetes mellitus (T2DM) seriously threatens human health and the quality of life, cognitive impairment is considered as a common complication of T2DM. Neuroimaging meta-analysis found brain functional and structural abnormality in …
View article: MARVEL: Microenvironment Annotation by Supervised Graph Contrastive Learning
MARVEL: Microenvironment Annotation by Supervised Graph Contrastive Learning Open
Recent advancements in in situ molecular profiling technologies, including spatial proteomics and transcriptomics, have enabled detailed characterization of the microenvironment at cellular and subcellular levels. While these techniques pr…
View article: Riboflavin kinase binds and activates inducible nitric oxide synthase to reprogram macrophage polarization
Riboflavin kinase binds and activates inducible nitric oxide synthase to reprogram macrophage polarization Open
View article: Causal Relationship Between Gut Microbiota and Acquired Immune Deficiency Syndrome: A Two-Sample Mendelian Randomization Study
Causal Relationship Between Gut Microbiota and Acquired Immune Deficiency Syndrome: A Two-Sample Mendelian Randomization Study Open
Background Emerging evidence suggests that changes in the composition of the gut microbiota may not only be a consequence of AIDS but may also influence the risk of disease. However, it is not clear that these associations point to the cer…