Yang‐Gen Hu
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View article: Preparation of ketonyl <i>C</i> -glycosides from designed glycosyl sulfides and styrenes by a radical pathway
Preparation of ketonyl <i>C</i> -glycosides from designed glycosyl sulfides and styrenes by a radical pathway Open
Ketonyl C -glycosides, a vital subclass of alkyl C -glycosides, play essential roles in drug discovery, biochemistry, and materials sciences. However, a practical strategy that merges bench-stable glycosyl donors with styrenes—a ubiquitous…
View article: [Treatment strategy for severe radiation-induced ulcers near major blood vessels].
[Treatment strategy for severe radiation-induced ulcers near major blood vessels]. Open
Objective: To investigate the treatment strategy for severe radiation-induced ulcers near major blood vessels. Methods: This study was a retrospective observational study. From January 2016 to December 2023, 23 patients with radiation-indu…
View article: AILDE Computer-Aided Discovery of Novel Ibuprofen–Coumarin Antitumor Lead Compounds Targeting Cyclooxygenase-2
AILDE Computer-Aided Discovery of Novel Ibuprofen–Coumarin Antitumor Lead Compounds Targeting Cyclooxygenase-2 Open
Starting from three ibuprofen-coumarin hit compounds, we designed 18 derivative compounds targeting cyclooxygenase-2 (COX-2) by introducing different substituents onto them by using the computational auto in silico ligand directing evoluti…
View article: Coumarin–furo[2,3-<i>d</i>]pyrimidone hybrid molecules targeting human liver cancer cells: synthesis, anticancer effect, EGFR inhibition and molecular docking studies
Coumarin–furo[2,3-<i>d</i>]pyrimidone hybrid molecules targeting human liver cancer cells: synthesis, anticancer effect, EGFR inhibition and molecular docking studies Open
Coupling a furopyrimidone scaffold with coumarin through a hydrazide linker can effectively improve their synergistic anticancer activity targeting HepG2.
View article: Rational synthesis and evaluation of 2,4-diamino-thieno[2,3-d]pyrimidines as antitumor agents
Rational synthesis and evaluation of 2,4-diamino-thieno[2,3-d]pyrimidines as antitumor agents Open
Based on structure-guided of thieno[2,3-d]pyrimidine skelecton functionalities and computer-aided drug development strategy, a series of novel 2,4-diamino-thieno[2,3-d]pyrimidine derivatives were designed and synthesized, and their structu…
View article: Synthesis and antifungal activities of 3-alkyl substituted thieno[2,3-d]pyrimidinones
Synthesis and antifungal activities of 3-alkyl substituted thieno[2,3-d]pyrimidinones Open
The 3-aryl substituted thieno[2,3-d]pyrimidinones 3 by sequential reaction of iminophosphorane 1, aromatic isocyanates and various nucleophiles (HY), found some compounds showed good antitumor and antibacterial activities. Meanwhile, aliph…