Yanghui Bi YOU? Author Swipe

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LncRNA‐DANCR Promotes ESCC Progression and Function as ceRNA to Regulate DDIT3 Expression by Sponging microRNA‐3193 Open

Heng Xiao, Tong Zhou, Yanfang Yang, Xin Yang, Yanghui Bi , et al. · 2025

Long non‐coding RNAs (lncRNAs) have emerged as crucial regulators of cancer development and progression. Among them, Differentiation Antagonizing Non‐Protein Coding RNA (DANCR) has been implicated in various malignancies, including esophag…

FBXW7 metabolic reprogramming inhibits the development of colon cancer by down-regulating the activity of arginine/mToR pathways Open

Qing Li, Yan Li, Tong Zhou, Yong Zhang, Huiyu Li , et al. · 2025

FBXW7 is a tumor suppressor gene that regulates metabolism and is associated with the onset and progression of colorectal cancer (CRC)), however, the precise mechanism whereby FBXW7 participates in the metabolic reprogramming of CRC remain…

Nedd4L signaling contributes to carbon tetrachloride-induced liver fibrosis in female mice and is associated with enteric dysbacteriosis Open

Cheng Chen, Yanghui Bi, Bangtao Chen, Song He · 2025

Background Liver fibrosis is characterized by hepatic stellate cell (HSC) activation and collagen overproduction, but its pathogenesis remains largely unknown. This study aimed to uncover the role of neural precursor cell expressed develop…

TMEtyper: A computational method for tumor microenvironment subtyping with applications in immunotherapy Open

Ya‐Ru Miao, Tong Zhou, Yan Li, Jie Yao, Yanghui Bi , et al. · 2025

Background: The heterogeneity of the tumor microenvironment (TME) is a critical determinant of outcomes in immune checkpoint blockade (ICB) therapy. However, robust methodological frameworks for systematically characterizing this heterogen…

Rspo2-LGR4 exacerbates hepatocellular carcinoma progression via activation of Wnt/β-catenin signaling pathway Open

Yanghui Bi, Liping Zhang, Yan Song, Lijun Sun, Michael W. Mulholland , et al. · 2024

The leucine-rich repeat-containing G-protein-coupled receptor 4 (LGR4) plays an important role in stem cell differentiation, organ development and cancer. Whether LGR4 affects the progression of hepatocellular carcinoma (HCC) remains unkno…

Tumor-derived extracellular vesicle drug delivery system for chemo-photothermal-immune combination cancer treatment Open

Yanghui Bi, Jieya Chen, Qing Li, Yan Li, Ling Zhang , et al. · 2024

Tumor extracellular vesicles (EVs) demonstrate considerable promise for medication delivery and tumor targeting owing to their natural long-term blood circulation and tissue targeting capabilities. We extracted EVs from mouse breast cancer…

FBXW7 inhibits the progression of ESCC by directly inhibiting the stemness of tumor cells Open

Yanghui Bi, Yanfang Yang, Yong Zhang, Caixia Cheng, Peisen Tang , et al. · 2023

F-box and WD repeat domain containing 7 (FBXW7) is an aboriginal and high-frequency mutant gene associated with esophageal squamous cell carcinoma (ESCC). This study was designed to determine the clinical value and molecular mechanisms of …

Rspo2-LGR4 exacerbates hepatocellular carcinoma progression via activation of Wnt/β-catenin signaling pathway Open

Yanghui Bi, Ping Zhang, Yan Song, Lijun Sun, Michael W. Mulholland , et al. · 2023

LGR4 promotes HCC progression via Wnt/β-catenin signaling pathway.

Hepatic G Protein-Coupled Receptor 180 Deficiency Ameliorates High Fat Diet-Induced Lipid Accumulation via the Gi-PKA-SREBP Pathway Open

Yunhua Zhang, Ziming Zhu, Lijun Sun, Wenzhen Yin, Yuan Liang , et al. · 2023

Single-nucleotide polymorphisms in G protein-coupled receptor 180 (GPR180) are associated with hypertriglyceridemia. The aim of this study was to determine whether hepatic GPR180 impacts lipid metabolism. Hepatic GPR180 was knocked down us…

FBXW7 inhibits the Progression of ESCC by directly inhibiting the Stemness of Tumor Cells Open

Yanfang Yang, Yanghui Bi, Caixia Cheng, Peisen Tang, Heng Xiao , et al. · 2023

Background F-box and WD repeat domain containing 7 ( FBXW7 ), is an aboriginal and high frequency mutant gene associated with esophageal squamous cell carcinoma (ESCC). This study was designed to determine the clinical value and molecular …

Characterization of somatic structural variations in 528 Chinese individuals with Esophageal squamous cell carcinoma Open

Heyang Cui, Yong Zhou, Fang Wang, Caixia Cheng, Weimin Zhang , et al. · 2022

FBXW7 as a potential prognostic biomarker for ESCC inhibits the progression of ESCC by directly inhibiting the stemness of tumor cells Open

Yanfang Yang, Yanghui Bi, Caixia Cheng, Peisen Tang, Heng Xiao , et al. · 2022

Background Esophageal cancer is a gastrointestinal tumor with high morbidity and mortality worldwide. FBXW7 , is an aboriginal and high frequency mutant gene associated with ESCC. However, the current understanding of its clinical signific…

The Role of DBR1 as a Candidate Prognosis Biomarker in Esophageal Squamous Cell Carcinoma Open

Xiaoqin Xu, Xin Yang, Xue Liu, Yanghui Bi, Pengzhou Kong , et al. · 2022

Aims: Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent malignancies with unfavorable clinical outcomes and limited therapeutic methods. As a key enzyme in RNA metabolism, debranching RNA Lariats 1 (DBR1) is involved i…

CDCA7 Facilitates Tumor Progression by Directly Regulating CCNA2 Expression in Esophageal Squamous Cell Carcinoma Open

Hongyi Li, Yongjia Weng, Shaojie Wang, Fang Wang, Yanqiang Wang , et al. · 2021

Background CDCA7 is a copy number amplified gene identified not only in esophageal squamous cell carcinoma (ESCC) but also in various cancer types. Its clinical relevance and underlying mechanisms in ESCC have remained unknown. Methods Tis…

Genomic Analyses Reveal Mutational Signatures and Frequently Altered Genes in Esophageal Squamous Cell Carcinoma Open

Ling Zhang, Yong Zhou, Caixia Cheng, Heyang Cui, Le Cheng , et al. · 2020

(The American Journal of Human Genetics 96, 597–611; April 2, 2015) In the article referenced here, Figure 6B mistakenly includes the immunohistochemical image of AKT1 for normal tissue instead of tumor tissue on the right panel. A correct…

Genomic Analyses Reveal Mutational Signatures and Frequently Altered Genes in Esophageal Squamous Cell Carcinoma Open

Ling Zhang, Yong Zhou, Caixia Cheng, Heyang Cui, Le Cheng , et al. · 2020

Decreased ZNF750 promotes angiogenesis in a paracrine manner via activating DANCR/miR-4707-3p/FOXC2 axis in esophageal squamous cell carcinoma Open

Yanghui Bi, Shixing Guo, Xiaoqin Xu, Pengzhou Kong, Heyang Cui , et al. · 2020

ZNF750 is one novel significantly mutated gene identified in esophageal squamous cell carcinoma (ESCC) using next-generation sequencing. However, its clinically relevant and potential mechanisms have remained elusive. Using genomic sequenc…

Potential Role of Targeting KDR and Proteasome Inhibitors in the Therapy of Esophageal Squamous Cell Carcinoma Open

Ling Zhang, Xia Niu, Yanghui Bi, Heyang Cui, Hongyi Li , et al. · 2020

Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive cancer types in China. In recent years, progress has been made in various types of cancer genomics including ESCC. However, the clinical significance of genomic variat…

TSTA3 facilitates esophageal squamous cell carcinoma progression through regulating fucosylation of LAMP2 and ERBB2 Open

Ling Zhang, Yingzhen Gao, Xiaojuan Zhang, Min Guo, Jie Yang , et al. · 2020

Background: TSTA3 gene encodes an enzyme responsible for synthesis of GDP-L-fucose as the only donor in fucosylation. This study was designed to explore clinical value, function and underlying mechanism of TSTA3 in the development o…

Novel ESCC-related gene ZNF750 as potential Prognostic biomarker and inhibits Epithelial-Mesenchymal Transition through directly depressing SNAI1 promoter in ESCC Open

Pengzhou Kong, Enwei Xu, Yanghui Bi, Xiaoqin Xu, Xue Liu , et al. · 2020

Background: Cancer genomic studies have identified Zinc Finger Protein 750 (ZNF750) was a novel significantly mutated gene in esophageal squamous cell carcinoma (ESCC). This study was designed to determine the clinical value and mol…

MYH9 promotes cell metastasis via inducing Angiogenesis and Epithelial Mesenchymal Transition in Esophageal Squamous Cell Carcinoma Open

Bin Yang, Huijuan Liu, Yanghui Bi, Caixia Cheng, Guodong Li , et al. · 2020

Non-muscle myosin heavy chain 9 (MYH9) is one novel low frequency mutated gene identified in esophageal squamous cell carcinoma (ESCC) using next-generation sequencing. However, its clinical relevance, potential function and mechani…

Signal transducer and activator of transcription 3 promotes the Warburg effect possibly by inducing pyruvate kinase M2 phosphorylation in liver precancerous lesions Open

Yanghui Bi, Wenqi Han, Ruofei Li, Yunjiao Wang, Zunshu Du , et al. · 2019

The Warburg effect is initiated in liver precancerous lesions in rats. STAT3 activation promotes the Warburg effect by enhancing the phosphorylation of PKM2 in transformed WB-F344 cells.

Mps1 is associated with the BRAFV600E mutation and predicts poor outcome in patients with colorectal cancer Open

Yanyan Zhang, Jinyao Dong, Ruyi Shi, Liguo Feng, Yike Li , et al. · 2019

Colorectal cancer (CRC) with the V600E mutation of B-Raf proto-oncogene serine/threonine kinase (BRAF^V600E) mutation is insensitive to chemotherapy and is indicative of a poor patient prognosis. Although BRAF inhibitors have a m…

EP300 as an oncogene correlates with poor prognosis in esophageal squamous carcinoma Open

Yanghui Bi, Pengzhou Kong, Ling Zhang, Heyang Cui, Xiaoqin Xu , et al. · 2019

E1A Binding Protein P300 (EP300) is one of the mutations of genes involved in histone modifications in esophageal squamous cell carcinoma (ESCC). However, its clinical relevance, potential function and mechanisms have remained elusive. …

View article: Recent advances in research on aspartate β-hydroxylase (ASPH) in pancreatic cancer: A brief update

Recent advances in research on aspartate β-hydroxylase (ASPH) in pancreatic cancer: A brief update Open

Guofang Hou, Boran Xu, Yanghui Bi, Chuanlin Wu, Beibei Ru , et al. · 2018

Pancreatic cancer (PC) is a highly aggressive tumor, often difficult to diagnose and treat. Aspartate β-hydroxylase (ASPH) is a type II transmembrane protein and the member of α-ketoglutarate-dependent dioxygenase family, found to be overe…

View article: FAT1 inhibits cell migration and invasion by affecting cellular mechanical properties in esophageal squamous cell carcinoma

FAT1 inhibits cell migration and invasion by affecting cellular mechanical properties in esophageal squamous cell carcinoma Open

Xiao Hu, Yuanfang Zhai, Ruyi Shi, Yu Qian, Heyang Cui , et al. · 2018

FAT atypical cadherin 1 (FAT1) belongs to the cadherin superfamily and has been reported to regulate cell‑cell adhesion and other cell behaviors, suggesting its pivotal roles in human cancers. We previously identified FAT1 as one of the si…

View article: WITHDRAWN: Potential therapeutic targets screening for esophageal squamous cell carcinoma via combined analysis of genomic sequencing data and target pharmacophore database

WITHDRAWN: Potential therapeutic targets screening for esophageal squamous cell carcinoma via combined analysis of genomic sequencing data and target pharmacophore database Open

Ling Zhang, Ling Zhang, Feng Liu, Feng Liu, Yanghui Bi , et al. · 2018

// Ling Zhang 1,2,3,* , Feng Liu 4,* , Yanghui Bi 1,2,* , Heyang Cui 1,2,* , Pengzhou Kong 1,2,* , Jiayi Li 5,* , Bin Song 1,6 , Binbin Zou 1,2 , Caixia Cheng 1,7 , Ting Yan 1,2 , Jian Yang 1,2 , Yu Qian 1,2 , Yanchun Ma 1,2 , Fang Wang 1,…

View article: High TSTA3 Expression as a Candidate Biomarker for Poor Prognosis of Patients With ESCC

High TSTA3 Expression as a Candidate Biomarker for Poor Prognosis of Patients With ESCC Open

Jie Yang, Pengzhou Kong, Jian Yang, Zhiwu Jia, Xiao Hu , et al. · 2018

Esophageal squamous cell carcinoma is the sixth most lethal cancer worldwide and the fourth most lethal cancer in China. Tissue-specific transplantation antigen P35B codifies the enzyme GDP-d-mannose-4,6-dehydratase, which participates in …

View article: WITHDRAWN: EP300 promotes tumor development and correlates with poor prognosis in esophageal squamous carcinoma

WITHDRAWN: EP300 promotes tumor development and correlates with poor prognosis in esophageal squamous carcinoma Open

Yanghui Bi, Yanghui Bi, Ling Zhang, Ling Zhang, Heyang Cui , et al. · 2017

// Yanghui Bi 1, 2, 3, * , Ling Zhang 1, 2, 3, 4, * , Heyang Cui 1, 2, 3, * , Pengzhou Kong 1, 2, 3, * , Ting Yan 1, 2, 3 , Jiayi Li 5 , Zianyi Wang 6 , Caixia Cheng 1, 2, 3, 7 , Bin Song 1, 2, 3, 8 , Bin Yang 1, 2, 3, 9 , Enwei Xu 1, 2, 3…

View article: The macro-evolutionary events in esophageal squamous cell carcinoma

The macro-evolutionary events in esophageal squamous cell carcinoma Open

Bin Yang, Ting Yan, Heyang Cui, Enwei Xu, Yanchun Ma , et al. · 2017

Understanding the evolutionary processes operative in cancer genome may provide insights into clinical outcome and drug-resistance. However, studies focus on genomic signatures, especially for macro-evolutionary events, in esophageal squam…