Yangjin Bae
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View article: ATRX silences Cartpt expression in osteoblastic cells during skeletal development
ATRX silences Cartpt expression in osteoblastic cells during skeletal development Open
ATP-dependent chromatin remodeling protein ATRX is an essential regulator involved in maintenance of DNA structure and chromatin state and regulation of gene expression during development. ATRX was originally identified as the monogenic ca…
View article: Knee histology protocol for immunohistochemistry on cryosections v1
Knee histology protocol for immunohistochemistry on cryosections v1 Open
Osteoarthritis (OA) is a chronic, degenerative condition characterized by whole-joint involvement, affecting the bone, cartilage, synovium, ligaments, and joint capsule. Given its widespread impact on millions of individuals, continued inv…
View article: Histology Protocol for Paraffin Embedded Mouse Knee v1
Histology Protocol for Paraffin Embedded Mouse Knee v1 Open
This method describes how to harvest, embed, and process, mouse knee joints for paraffin-based histological analysis.
View article: DDRGK1 is required for the proper development and maintenance of the growth plate cartilage
DDRGK1 is required for the proper development and maintenance of the growth plate cartilage Open
Loss-of-function mutations in DDRGK1 have been shown to cause Shohat type spondyloepimetaphyseal dysplasia (SEMD). In zebrafish, loss of function of ddrgk1 leads to defects in early cartilage development. Ddrgk1−/− mice show delayed mesenc…
View article: <scp> <i>miRNA‐34c</i> </scp> Suppresses Osteosarcoma Progression In Vivo by Targeting Notch and <scp>E2F</scp>
<span> <i>miRNA‐34c</i> </span> Suppresses Osteosarcoma Progression In Vivo by Targeting Notch and <span>E2F</span> Open
The expression of microRNAs (miRNAs) is dysregulated in many types of cancers including osteosarcoma (OS) due to genetic and epigenetic alterations. Among these, miR‐34c , an effector of tumor suppressor P53 and an upstream negative regula…
View article: <i>miRNA-34c</i> suppresses osteosarcoma progression <i>in vivo</i> by targeting Notch and E2F
<i>miRNA-34c</i> suppresses osteosarcoma progression <i>in vivo</i> by targeting Notch and E2F Open
The expression of microRNAs (miRNAs) is dysregulated in many types of cancers including osteosarcoma (OS) due to genetic and epigenetic alterations. Among these, miR-34c , an effector of tumor suppressor P53 and an upstream negative regula…
View article: <i>ATRAID</i> regulates the action of nitrogen-containing bisphosphonates on bone
<i>ATRAID</i> regulates the action of nitrogen-containing bisphosphonates on bone Open
ATRAID is essential for responses to the commonly prescribed osteoporosis drugs nitrogen-containing bisphosphonates.
View article: Notch Signaling in Skeletal Development, Homeostasis and Pathogenesis
Notch Signaling in Skeletal Development, Homeostasis and Pathogenesis Open
Skeletal development is a complex process which requires the tight regulation of gene activation and suppression in response to local signaling pathways. Among these pathways, Notch signaling is implicated in governing cell fate determinat…
View article: Loss of DDRGK1 modulates SOX9 ubiquitination in spondyloepimetaphyseal dysplasia
Loss of DDRGK1 modulates SOX9 ubiquitination in spondyloepimetaphyseal dysplasia Open
Shohat-type spondyloepimetaphyseal dysplasia (SEMD) is a skeletal dysplasia that affects cartilage development. Similar skeletal disorders, such as spondyloepiphyseal dysplasias, are linked to mutations in type II collagen (COL2A1), but th…
View article: Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis
Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis Open
Intra-iliac artery (IIA) injection is an efficient approach to introduce metastatic lesions of various cancer cells in animals. Compared to the widely used intra-cardiac and intra-tibial injections, IIA injection brings several advantages.…
View article: RECQL4 Regulates p53 Function In Vivo During Skeletogenesis
RECQL4 Regulates p53 Function In Vivo During Skeletogenesis Open
RECQ DNA helicases play critical roles in maintaining genomic stability, but their role in development has been less well studied. Rothmund-Thomson syndrome, RAPADILINO, and Baller-Gerold syndrome are rare genetic disorders caused by mutat…