Yangliu Xia
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View article: Global burden of ischemic heart disease due to insufficient physical activity in middle-aged and elderly populations from 1990 to 2021 and projections for 2050
Global burden of ischemic heart disease due to insufficient physical activity in middle-aged and elderly populations from 1990 to 2021 and projections for 2050 Open
Background: With the consistent growth of aging population, ischemic heart disease (IHD) has become one of the primary causes of death among middle-aged and elderly individuals. This study analyzes the global, regional, and national trends…
View article: Coumarin derivatives as inhibitors against monoamine oxidase: structure-activity relationships and inhibitory mechanisms
Coumarin derivatives as inhibitors against monoamine oxidase: structure-activity relationships and inhibitory mechanisms Open
Monoamine oxidase (MAO) is a useful target in the treatment of neurodegenerative diseases and depressive disorders. Understanding the structure-activity relationship (SAR) and mechanisms underlying MAO inhibitors is crucial but challenging…
View article: Intestinal stearoyl-coenzyme A desaturase-inhibition improves obesity-associated metabolic disorders
Intestinal stearoyl-coenzyme A desaturase-inhibition improves obesity-associated metabolic disorders Open
Stearoyl-coenzyme A desaturase 1 (SCD1) catalyzes the rate-limiting step of de novo lipogenesis and modulates lipid homeostasis. Although numerous SCD1 inhibitors were tested for treating metabolic disorders both in preclinical and …
View article: Hepatocyte-specific CCAAT/enhancer binding protein α restricts liver fibrosis progression
Hepatocyte-specific CCAAT/enhancer binding protein α restricts liver fibrosis progression Open
Metabolic dysfunction-associated steatohepatitis (MASH) - previously described as nonalcoholic steatohepatitis (NASH) - is a major driver of liver fibrosis in humans, while liver fibrosis is a key determinant of all-cause mortality in live…
View article: Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis
Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis Open
Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was exam…
View article: Discovery and Characterization of the Key Constituents in Ginkgo biloba Leaf Extract With Potent Inhibitory Effects on Human UDP-Glucuronosyltransferase 1A1
Discovery and Characterization of the Key Constituents in Ginkgo biloba Leaf Extract With Potent Inhibitory Effects on Human UDP-Glucuronosyltransferase 1A1 Open
Human UDP-glucuronosyltransferase 1A1 (hUGT1A1) is one of the most essential phase II enzymes in humans. Dysfunction or strong inhibition of hUGT1A1 may result in hyperbilirubinaemia and clinically relevant drug/herb-drug interactions (DDI…
View article: Withaferin A alleviates ethanol-induced liver injury by inhibiting hepatic lipogenesis
Withaferin A alleviates ethanol-induced liver injury by inhibiting hepatic lipogenesis Open
View article: Withaferin A in the Treatment of Liver Diseases: Progress and Pharmacokinetic Insights
Withaferin A in the Treatment of Liver Diseases: Progress and Pharmacokinetic Insights Open
View article: St. John’s Wort alleviates dextran sodium sulfate‐induced colitis through pregnane X receptor‐dependent NFκB antagonism
St. John’s Wort alleviates dextran sodium sulfate‐induced colitis through pregnane X receptor‐dependent NFκB antagonism Open
St. John's wort (SJW), from traditional herbs, activates the pregnane X receptor (PXR), a potential drug target for treating inflammatory bowel disease (IBD). However, how SJW alleviates dextran sodium sulfate (DSS)‐induced experimental IB…
View article: Comparison of Hepatotoxicity Associated With New BCR-ABL Tyrosine Kinase Inhibitors vs Imatinib Among Patients With Chronic Myeloid Leukemia
Comparison of Hepatotoxicity Associated With New BCR-ABL Tyrosine Kinase Inhibitors vs Imatinib Among Patients With Chronic Myeloid Leukemia Open
When compared to imatinib, bosutinib, nilotinib, and ponatinib had higher relative risks of hepatotoxicity. Treatment with new-generation TKIs was associated with a higher MMR rate at 1 year but not with 1-year overall survival.
View article: Combination of dabrafenib with irinotecan might trigger off a higher frequency of adverse events by pharmacokinetic interaction
Combination of dabrafenib with irinotecan might trigger off a higher frequency of adverse events by pharmacokinetic interaction Open
Dabrafenib and irinotecan are two drugs that can be utilized to treat melanoma. A previous in vivo study has shown that dabrafenib enhances the antitumor activity of irinotecan in a xenograft model with unclear mechanism. This study aims t…
View article: Withaferin A alleviates fulminant hepatitis by targeting macrophage and NLRP3
Withaferin A alleviates fulminant hepatitis by targeting macrophage and NLRP3 Open
View article: Discovery and characterization of naturally occurring potent inhibitors of catechol-<i>O</i>-methyltransferase from herbal medicines
Discovery and characterization of naturally occurring potent inhibitors of catechol-<i>O</i>-methyltransferase from herbal medicines Open
Discovery and characterization of natural human catechol-O-methyltransferase (hCOMT) inhibitors for Parkinson's disease treatment.
View article: Relative Risk of Hepatotoxicity Associated With BCR-ABL Tyrosine Kinase Inhibitors in the Treatment of Chronic Myeloid Leukemia: A Systematic Review and Meta-Analysis
Relative Risk of Hepatotoxicity Associated With BCR-ABL Tyrosine Kinase Inhibitors in the Treatment of Chronic Myeloid Leukemia: A Systematic Review and Meta-Analysis Open
View article: Identification of a New Heterocyclic Scaffold for Inhibitors of the Polo-Box Domain of Polo-like Kinase 1
Identification of a New Heterocyclic Scaffold for Inhibitors of the Polo-Box Domain of Polo-like Kinase 1 Open
As a mitotic-specific target widely deregulated in various human cancers, polo-like kinase 1 (Plk1) has been extensively explored for anticancer activity and drug discovery. Although multiple catalytic domain inhibitors were tested in prec…
View article: Synthesis and structure-activity relationship of coumarins as potent Mcl-1 inhibitors for cancer treatment
Synthesis and structure-activity relationship of coumarins as potent Mcl-1 inhibitors for cancer treatment Open
View article: Analytical methodologies for sensing catechol-O-methyltransferase activity and their applications
Analytical methodologies for sensing catechol-O-methyltransferase activity and their applications Open
View article: Herbal drug discovery for the treatment of nonalcoholic fatty liver disease
Herbal drug discovery for the treatment of nonalcoholic fatty liver disease Open
Few medications are available for meeting the increasing disease burden of nonalcoholic fatty liver disease (NAFLD) and its progressive stage, nonalcoholic steatohepatitis (NASH). Traditional herbal medicines (THM) have been used for centu…
View article: Synthesis and Structure-Activity Relationship of Daphnetin Derivatives as Potent Antioxidant Agents
Synthesis and Structure-Activity Relationship of Daphnetin Derivatives as Potent Antioxidant Agents Open
In this study, daphnetin 1 was chosen as the lead compound, and C-3 or C-4-substituted daphnetins were designed and synthesized to explore the potential relationship between the antioxidant activities and the chemical structures of daphnet…
View article: Recent progress and challenges in screening and characterization of UGT1A1 inhibitors
Recent progress and challenges in screening and characterization of UGT1A1 inhibitors Open
Uridine-diphosphate glucuronosyltransferase 1A1 (UGT1A1) is an important conjugative enzyme in mammals that is responsible for the conjugation and detoxification of both endogenous and xenobiotic compounds. Strong inhibition of UGT1A1 may …
View article: Interspecies comparison in the COMT-mediated methylation of 3-BTD
Interspecies comparison in the COMT-mediated methylation of 3-BTD Open
The methylation behaviour of 3-BTD in liver S9 from eight different species was characterized with respect to the similarities and differences of their metabolic profiles, catalytic efficacy and inhibitory potency by a known chemical inhib…
View article: Supplementary material from "<i>In vitro</i> evaluation of the effect of C-4 substitution on methylation of 7,8-dihydroxycoumarin: metabolic profile and catalytic kinetics"
Supplementary material from "<i>In vitro</i> evaluation of the effect of C-4 substitution on methylation of 7,8-dihydroxycoumarin: metabolic profile and catalytic kinetics" Open
Daphnetin (7,8-dihydroxycoumarin (7,8-DHC)) and its C-4 derivatives have multiple pharmacological activities, but the poor metabolic stability of these catechols has severely restricted their application in the clinic. Methylation plays im…
View article: <i>In vitro</i>evaluation of the effect of C-4 substitution on methylation of 7,8-dihydroxycoumarin: metabolic profile and catalytic kinetics
<i>In vitro</i>evaluation of the effect of C-4 substitution on methylation of 7,8-dihydroxycoumarin: metabolic profile and catalytic kinetics Open
Daphnetin (7,8-dihydroxycoumarin (7,8-DHC)) and its C-4 derivatives have multiple pharmacological activities, but the poor metabolic stability of these catechols has severely restricted their application in the clinic. Methylation plays im…
View article: Identification and characterization of human UDP-glucuronosyltransferases responsible for the in-vitro glucuronidation of arctigenin
Identification and characterization of human UDP-glucuronosyltransferases responsible for the in-vitro glucuronidation of arctigenin Open
Objectives This study aimed to characterize the glucuronidation pathway of arctigenin (AR) in human liver microsomes (HLM) and human intestine microsomes (HIM). Methods HLM and HIM incubation systems were employed to catalyse the formation…
View article: Tissue and species differences in the glucuronidation of glabridin with UDP-glucuronosyltransferases
Tissue and species differences in the glucuronidation of glabridin with UDP-glucuronosyltransferases Open
View article: Structural Modifications at the C-4 Position Strongly Affect the Glucuronidation of 6,7-Dihydroxycoumarins
Structural Modifications at the C-4 Position Strongly Affect the Glucuronidation of 6,7-Dihydroxycoumarins Open