Yangpo Cao
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View article: Mitochondria-derived vesicles serve as reactors in response to stress in cardiomyocytes
Mitochondria-derived vesicles serve as reactors in response to stress in cardiomyocytes Open
MDVs in cardiomyocytes colocalize with other organelles, which might facilitate inter-organelle communication, and serve as reactors in response to stress in adult cardiomyocytes.
View article: Disentangling shared genetic etiologies for kidney function and cardiovascular diseases
Disentangling shared genetic etiologies for kidney function and cardiovascular diseases Open
Cardiovascular diseases (CVDs) are the leading cause of death worldwide, with chronic kidney disease (CKD) identified as a significant risk factor. CKD is primarily monitored through the estimated glomerular filtration rate (eGFR), calcula…
View article: Therapeutic Inhibition of <i>LincRNA-p21</i> Protects Against Cardiac Hypertrophy
Therapeutic Inhibition of <i>LincRNA-p21</i> Protects Against Cardiac Hypertrophy Open
BACKGROUND: Cardiac hypertrophy is an adaptive response to pressure overload aimed at maintaining cardiac function. However, prolonged hypertrophy significantly increases the risk of maladaptive cardiac remodeling and heart failure. Recent…
View article: In vivo proximity proteomics uncovers palmdelphin (PALMD) as a Z-line-associated mitigator of isoproterenol-induced cardiac injury
In vivo proximity proteomics uncovers palmdelphin (PALMD) as a Z-line-associated mitigator of isoproterenol-induced cardiac injury Open
Summary Z-lines are core ultrastructural organizers of cardiomyocytes that modulate many facets of cardiac pathogenesis. Yet a comprehensive proteomic atlas of Z-line-associated components remain incomplete. Here, we established an adeno-a…
View article: CD63-snorkel tagging for isolation of exosomes
CD63-snorkel tagging for isolation of exosomes Open
Exosomes (Exo) are important mediators of inter-cellular communications; however, no effective method is available for isolating, thus characterizing, cellular-specific exosomes in vivo. Since CD63 is a reliable marker for exosomes, we hav…
View article: <i>Tbx5</i>maintains atrial identity by regulating an atrial enhancer network
<i>Tbx5</i>maintains atrial identity by regulating an atrial enhancer network Open
Understanding how the atrial and ventricular chambers of the heart maintain their distinct identity is a prerequisite for treating chamber-specific diseases. Here, we selectively inactivated the transcription factor Tbx5 in the atrial work…
View article: In Vivo Dissection of Chamber-Selective Enhancers Reveals Estrogen-Related Receptor as a Regulator of Ventricular Cardiomyocyte Identity
In Vivo Dissection of Chamber-Selective Enhancers Reveals Estrogen-Related Receptor as a Regulator of Ventricular Cardiomyocyte Identity Open
Background: Cardiac chamber-selective transcriptional programs underpin the structural and functional differences between atrial and ventricular cardiomyocytes (aCMs and vCMs). The mechanisms responsible for these chamber-selective transcr…
View article: GATA4 Regulates Developing Endocardium Through Interaction With ETS1
GATA4 Regulates Developing Endocardium Through Interaction With ETS1 Open
Background: The pioneer transcription factor (TF) GATA4 (GATA Binding Protein 4) is expressed in multiple cardiovascular lineages and is essential for heart development. GATA4 lineage-specific occupancy in the developing heart underlies it…
View article: FUNDC1-mediated mitophagy and HIF1α activation drives pulmonary hypertension during hypoxia
FUNDC1-mediated mitophagy and HIF1α activation drives pulmonary hypertension during hypoxia Open
Hypoxic pulmonary hypertension (PH) is a progressive disease characterized by hyper-proliferation of pulmonary vascular cells including pulmonary artery smooth muscle cells (PASMCs) and can lead to right heart failure and early death. Sele…
View article: Ryanodine receptor 2 (RYR2) dysfunction activates the unfolded protein response and perturbs cardiomyocyte maturation
Ryanodine receptor 2 (RYR2) dysfunction activates the unfolded protein response and perturbs cardiomyocyte maturation Open
Aims Calcium-handling capacity is a major gauge of cardiomyocyte maturity. Ryanodine receptor 2 (RYR2) is the pre-dominant calcium channel that releases calcium from the sarcoplasmic reticulum/endoplasmic reticulum (SR/ER) to activate card…
View article: Mitophagy‐regulated mitochondrial health strongly protects the heart against cardiac dysfunction after acute myocardial infarction
Mitophagy‐regulated mitochondrial health strongly protects the heart against cardiac dysfunction after acute myocardial infarction Open
Autophagy including mitophagy serves as an important regulatory mechanism in the heart to maintain the cellular homeostasis and to protect against heart damages caused by myocardial infarction (MI). The current study aims to dissect roles …
View article: Sarcomeres regulate murine cardiomyocyte maturation through MRTF-SRF signaling
Sarcomeres regulate murine cardiomyocyte maturation through MRTF-SRF signaling Open
Significance Mature cardiomyocytes are highly adapted to pump efficiently over billions of cycles. The mechanisms that regulate and coordinate the acquisition of the specialized features of mature cardiomyocytes in the postnatal period are…
View article: Miro2 Regulates Inter-Mitochondrial Communication in the Heart and Protects Against TAC-Induced Cardiac Dysfunction
Miro2 Regulates Inter-Mitochondrial Communication in the Heart and Protects Against TAC-Induced Cardiac Dysfunction Open
Rationale: The constrained mitochondria in cardiomyocytes communicate with each other, through mitochondrial kissing or nanotunneling, forming a dynamically continuous network to share content and transfer signals. However, the molecular m…
View article: HuR regulates phospholamban expression in isoproterenol-induced cardiac remodelling
HuR regulates phospholamban expression in isoproterenol-induced cardiac remodelling Open
Aims The elevated expression of phospholamban (PLB) has been observed in heart failure and cardiac remodelling, inhibiting the affinity of Ca2+ pump to Ca2+ thereby impairing heart relaxation. However, the mechanisms underlying the regulat…
View article: PTPIP51 regulates mouse cardiac ischemia/reperfusion through mediating the mitochondria-SR junction
PTPIP51 regulates mouse cardiac ischemia/reperfusion through mediating the mitochondria-SR junction Open
Protein tyrosine phosphatase interacting protein 51 (PTPIP51) participates in multiple cellular processes, and dysfunction of PTPIP51 is implicated in diseases such as cancer and neurodegenerative disorders. However, there is no functional…