Yao Yu
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View article: Genome-wide association study of 398,238 women unveils seven loci associated with high-grade serous ovarian cancer
Genome-wide association study of 398,238 women unveils seven loci associated with high-grade serous ovarian cancer Open
View article: Central Nervous System-Derived Extracellular Vesicles as Biomarkers in Alzheimer’s Disease
Central Nervous System-Derived Extracellular Vesicles as Biomarkers in Alzheimer’s Disease Open
Alzheimer’s disease (AD) has emerged as a global health threat that demands early detection to seize the optimal intervention opportunity. Central nervous system (CNS)-derived extracellular vesicles (EVs), lipid-bilayer nanoparticles relea…
View article: Large-scale genome-wide analyses of stuttering
Large-scale genome-wide analyses of stuttering Open
View article: Application of family whole-exome sequencing for prenatal diagnosis—an analysis of 357 cases
Application of family whole-exome sequencing for prenatal diagnosis—an analysis of 357 cases Open
Objective Translation of fertility risks through whole-exome sequencing of family lines to identify variants that explain patient’s clinical phenotypes. Methods 1. Using techniques such as amniotic fluid, chorionic villus, or umbilical cor…
View article: Large-scale genome-wide analyses of stuttering
Large-scale genome-wide analyses of stuttering Open
View article: Exploration and Practice of Online Clinical Placement Teaching for Intern Nursing Students in the Context of Rural Revitalization
Exploration and Practice of Online Clinical Placement Teaching for Intern Nursing Students in the Context of Rural Revitalization Open
View article: Correction: A Novel Integrated Energy Management Strategy of Energy Storage System for a Pure Electric-Driven Mining Hydraulic Excavator
Correction: A Novel Integrated Energy Management Strategy of Energy Storage System for a Pure Electric-Driven Mining Hydraulic Excavator Open
View article: A Novel Integrated Energy Management Strategy of Energy Storage System for a Pure Electric-Driven Mining Hydraulic Excavator
A Novel Integrated Energy Management Strategy of Energy Storage System for a Pure Electric-Driven Mining Hydraulic Excavator Open
Using electric motors instead of diesel engines as the driving system for mining excavators can reduce the energy consumption and operating costs. However, pure electric-driven mining excavators are prone to unexpected power outages in min…
View article: Supplemental Figure 3 from Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals
Supplemental Figure 3 from Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals Open
Somatic variant filtering for mutation annotation format files (MAF) files from TCGAW samples (n=1272).
View article: Data from Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals
Data from Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals Open
Black individuals experience worse survival after a diagnosis of high-grade serous ovarian carcinoma (HGSC) than White individuals and are underrepresented in ovarian cancer research. To date, the understanding of the molecular and genomic…
View article: Supplemental Figure 2 from Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals
Supplemental Figure 2 from Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals Open
Somatic variant filtering for tumor WES in SchildkrautB analytic samples (n=211) and SchildkrautW analytic samples (n=123).
View article: Supplemental Table 1 from Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals
Supplemental Table 1 from Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals Open
Differences in sequencing and variant calling methods between Schildkraut datasets and TCGA.
View article: Supplemental Figure 5 from Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals
Supplemental Figure 5 from Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals Open
Count of mutations in HGSC genes identified by de novo significantly mutated gene analysis in SchildkrautB, and genes with a coding variant in ≥4% of SchildkrautB.
View article: Supplemental Table 7 from Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals
Supplemental Table 7 from Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals Open
Chromosomal copy number alterations.
View article: Supplemental Figure 6 from Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals
Supplemental Figure 6 from Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals Open
Percentage of population with mutations and the variant classifications for TP53 in SchildkrautB (n=1211), TCGAW (n=1272), and SchildkrautW (n=1123).
View article: Supplemental Table 4 from Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals
Supplemental Table 4 from Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals Open
MutSig2CV significantly mutated gene analysis results for SchildkrautB.
View article: Supplemental Table 3 from Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals
Supplemental Table 3 from Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals Open
Percentage of the study populations with mutations in major HGSC genes identified by TCGA shown in Figure 1.
View article: Supplemental Table 9 from Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals
Supplemental Table 9 from Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals Open
Mismatch repair deficiency (MMRD) genes sensitivity analyses.
View article: Supplemental Figure 4 from Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals
Supplemental Figure 4 from Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals Open
Distributions of allelic changes for single nucleotide variants.
View article: Supplemental Table 6 from Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals
Supplemental Table 6 from Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals Open
Percentage of the population with mutations in HGSC genes in major HGSC genes identified in TCGA, genes identified by de novo significantly mutated gene analysis in SchildkrautB, or mutated in ≥4% of SchildkrautB, by gene expression subtype
View article: Supplemental Table 2 from Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals
Supplemental Table 2 from Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals Open
Distributions of variant classes.
View article: Supplemental Table 5 from Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals
Supplemental Table 5 from Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals Open
HGSC genes identified by de novo significantly mutated gene analysis in SchildkrautB, shown in Figure 2A.
View article: Supplemental Figure 1 from Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals
Supplemental Figure 1 from Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals Open
Flow chart showing inclusion and exclusion criteria for individuals in the SchildkrautB and SchildkrautW study populations.
View article: Supplemental Table 8 from Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals
Supplemental Table 8 from Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals Open
Percentage of the population with COSMIC signatures shown in Figure 4A
View article: Supplemental Figure 7 from Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals
Supplemental Figure 7 from Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals Open
Location of TP53 mutations in SchildkrautB (n=1211), TCGAW (n=1272), and SchildkrautW (n=1123).
View article: Optimal adaptive cancer therapy based on evolutionary game theory
Optimal adaptive cancer therapy based on evolutionary game theory Open
Cancer development is a dynamic and continuously evolving process, with the emergence of drug-resistant cancer cells being one of the primary reasons for the failure of traditional treatments. Adaptive therapy, as an emerging cancer treatm…
View article: Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals
Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals Open
Black individuals experience worse survival after a diagnosis of high-grade serous ovarian carcinoma (HGSC) than White individuals and are underrepresented in ovarian cancer research. To date, the understanding of the molecular and genomic…
View article: Identification of novel COL4A5 variants and prenatal diagnosis in three large families
Identification of novel COL4A5 variants and prenatal diagnosis in three large families Open
View article: Exome Sequencing for Head and Neck Cancer Predisposition Genes
Exome Sequencing for Head and Neck Cancer Predisposition Genes Open
Introduction While genome-wide association studies (GWAS) have identified several common variants associated with head and neck cancer (HNC) risk, large-scale sequence-based studies to evaluate the contribution of rare variants to head and…
View article: Identification of shared genetic etiology of cardiovascular and cerebrovascular diseases through common cardiometabolic risk factors
Identification of shared genetic etiology of cardiovascular and cerebrovascular diseases through common cardiometabolic risk factors Open
Cardiovascular diseases (CVDs) and cerebrovascular diseases (CeVDs) are closely related vascular diseases, sharing common cardiometabolic risk factors (RFs). Although pleiotropic genetic variants of these two diseases have been reported, t…