Yangxi Zheng
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View article: Epidemiological analysis of infectious diseases in older people in China from 2014 to 2022: a population-based study
Epidemiological analysis of infectious diseases in older people in China from 2014 to 2022: a population-based study Open
Summary: Background: The whole world is undergoing an unprecedented rapid population aging, and the accompanying threat of infectious diseases epidemic among the older people will pose a serious challenge to the national public health. Met…
View article: Association between weekend catch-up sleep and glycemic control among individuals with diabetes: a population-based study
Association between weekend catch-up sleep and glycemic control among individuals with diabetes: a population-based study Open
Objectives Weekend catch-up sleep (WCUS), a compensation for insufficient sleep during weekdays, was associated with desirable metabolic effects. However, its relationship with glycemic control among adults with diabetes was not fully esta…
View article: Association between the weight-adjusted-waist index and testosterone deficiency in adult males: a cross-sectional study
Association between the weight-adjusted-waist index and testosterone deficiency in adult males: a cross-sectional study Open
Testosterone deficiency has been recognized as a significant health concern and is closely related to obesity. The weight-adjusted-waist index (WWI) is an innovative adiposity parameter that is superior to BMI in certain aspects, but its r…
View article: Lung cell transplantation for pulmonary fibrosis
Lung cell transplantation for pulmonary fibrosis Open
Idiopathic pulmonary fibrosis is a major cause of death with few treatment options. Here, we demonstrate the therapeutic efficacy for lung fibrosis of adult lung cell transplantation using a single-cell suspension of the entire lung in two…
View article: Exogenous Hydrogen Sulfide Mitigates Oxidative Stress and Mitochondrial Damages Induced by Polystyrene Microplastics in Osteoblastic Cells of Mice
Exogenous Hydrogen Sulfide Mitigates Oxidative Stress and Mitochondrial Damages Induced by Polystyrene Microplastics in Osteoblastic Cells of Mice Open
Polystyrene microplastics (mic-PS) have become harmful pollutants that attracted substantial attention about their potential toxicity. Hydrogen sulfide (H2S) is the third reported endogenous gas transmitter with protective functions on num…
View article: <scp>AMPK</scp> regulates homeostasis of invasion and viability in trophoblasts by redirecting glucose metabolism: Implications for pre‐eclampsia
<span>AMPK</span> regulates homeostasis of invasion and viability in trophoblasts by redirecting glucose metabolism: Implications for pre‐eclampsia Open
Pre‐eclampsia (PE) is deemed an ischemia‐induced metabolic disorder of the placenta due to defective invasion of trophoblasts during placentation; thus, the driving role of metabolism in PE pathogenesis is largely ignored. Since trophoblas…
View article: miR21 modulates the Hippo signaling pathway via interference with PP2A Bβ to inhibit trophoblast invasion and cause preeclampsia
miR21 modulates the Hippo signaling pathway via interference with PP2A Bβ to inhibit trophoblast invasion and cause preeclampsia Open
View article: Lung Regeneration by Transplantation of Allogeneic Lung Progenitors Using a Safer Conditioning Regimen and Clinical-grade Reagents
Lung Regeneration by Transplantation of Allogeneic Lung Progenitors Using a Safer Conditioning Regimen and Clinical-grade Reagents Open
Over the last decades, several studies demonstrated the possibility of lung regeneration through transplantation of various lung progenitor populations. Recently, we showed in mice that fetal or adult lung progenitors could potentially pro…
View article: Gestational Diabetes Mellitus-Associated Hyperglycemia Impairs Glucose Transporter 3 Trafficking in Trophoblasts Through the Downregulation of AMP-Activated Protein Kinase
Gestational Diabetes Mellitus-Associated Hyperglycemia Impairs Glucose Transporter 3 Trafficking in Trophoblasts Through the Downregulation of AMP-Activated Protein Kinase Open
AMP-activated protein kinase (AMPK) is an important regulator of glucose metabolism, and glucose transporter 3 (GLUT3) is an efficient glucose transporter in trophoblasts. Whether placental AMPK and GLUT3 respond accordingly to gestational…
View article: Characteristics of online medical care consultation for pregnant women during the COVID-19 outbreak: cross-sectional study
Characteristics of online medical care consultation for pregnant women during the COVID-19 outbreak: cross-sectional study Open
Objectives This study described the needs of pregnant women and the contents of online obstetric consultation in representative areas with various severity of the epidemic in China. Design This was a cross- sectional study. Setting Yue Yi …
View article: Maternal erythrocyte ENT1–mediated AMPK activation counteracts placental hypoxia and supports fetal growth
Maternal erythrocyte ENT1–mediated AMPK activation counteracts placental hypoxia and supports fetal growth Open
Insufficient O2 supply is frequently associated with fetal growth restriction (FGR), a leading cause of perinatal mortality and morbidity. Although the erythrocyte is the most abundant and only cell type to deliver O2 in our body, its func…
View article: [Subcellular localization of GTPase of immunity-associated protein 2].
[Subcellular localization of GTPase of immunity-associated protein 2]. Open
GIMAP2 localizes in the endoplasmic reticulum and on the surface of LDs, suggesting potential involvement of GIMAP2 in lipid metabolism.
View article: Characteristics of online medical care consultation for pregnant women during the COVID-19 outbreak: a cross-sectional study
Characteristics of online medical care consultation for pregnant women during the COVID-19 outbreak: a cross-sectional study Open
Background During the Coronavirus Disease 2019 (COVID-19) outbreak, emergency traffic bans limited accessibility of some medical resource for pregnant women. Fear of viral transmission also prevented pregnant women from seeking routine ant…
View article: Safe delivery for pregnancies affected by COVID‐19
Safe delivery for pregnancies affected by COVID‐19 Open
Since December 2019, a new coronavirus infection (COVID-19) has rapidly become prevalent in central China. On the basis of knowledge obtained from a previous coronavirus outbreak, pregnant women are believed to be susceptible to this virus…
View article: Safe Delivery for COVID-19 Infected Pregnancies.
Safe Delivery for COVID-19 Infected Pregnancies. Open
Since December 2019, a new coronavirus (COVID-19) infection has rapidly become prevalent in central China1 . On the basis of knowledge obtained from a previous coronavirus outbreak2 , pregnant women are believed to be susceptible to this v…
View article: Upregulated LncZBTB39 in pre-eclampsia and its effects on trophoblast invasion and migration via antagonizing the inhibition of miR-210 on THSD7A expression
Upregulated LncZBTB39 in pre-eclampsia and its effects on trophoblast invasion and migration via antagonizing the inhibition of miR-210 on THSD7A expression Open
View article: Safe Delivery Solutions for COVID-19 Infected Pregnancies
Safe Delivery Solutions for COVID-19 Infected Pregnancies Open
Since December 2019, a new coronavirus (COVID-19) infection has rapidly become prevalent in central China [1]. On the basis of knowledge obtained from a previous coronavirus outbreak [2], pregnant women are believed to be susceptible to th…
View article: Gestational Diabetes Mellitus Changes the Metabolomes of Human Colostrum, Transition Milk and Mature Milk
Gestational Diabetes Mellitus Changes the Metabolomes of Human Colostrum, Transition Milk and Mature Milk Open
BACKGROUND Gestational diabetes mellitus (GDM) is a pregnancy complication that is diagnosed by the novel onset of abnormal glucose intolerance. Our study aimed to investigate the changes in human breast milk metabolome over the first mont…
View article: The Regulation of Trophoblastic p53 Homeostasis by the p38-Wip1 Feedback Loop is Disturbed in Placentas from Pregnancies Complicated by Preeclampsia
The Regulation of Trophoblastic p53 Homeostasis by the p38-Wip1 Feedback Loop is Disturbed in Placentas from Pregnancies Complicated by Preeclampsia Open
Trophoblastic p53 homeostasis is maintained by the p38-Wip1 feedback regulatory loop in response to hypoxic stress, which is dysregulated in the placentas of pregnancies complicated by PE, and thereby leads to excessive apoptosis.
View article: Association Between Gestational Weight Gain and Pregnancy Complications or Adverse Delivery Outcomes in Chinese Han Dichorionic Twin Pregnancies: Validation of the Institute of Medicine (IOM) 2009 Guidelines
Association Between Gestational Weight Gain and Pregnancy Complications or Adverse Delivery Outcomes in Chinese Han Dichorionic Twin Pregnancies: Validation of the Institute of Medicine (IOM) 2009 Guidelines Open
BACKGROUND Excessive or insufficient gestational weight gain (GWG) is associated with increased risks of pregnancy complications and adverse delivery outcomes in dichorionic twin pregnancies. The provisional Institute of Medicine (IOM) 200…
View article: Metabolic Biomarkers of Monochorionic Twins Complicated With Selective Intrauterine Growth Restriction in Cord Plasma and Placental Tissue
Metabolic Biomarkers of Monochorionic Twins Complicated With Selective Intrauterine Growth Restriction in Cord Plasma and Placental Tissue Open
View article: AMPK Hyper-Activation Alters Fatty Acids Metabolism and Impairs Invasiveness of Trophoblasts in Preeclampsia
AMPK Hyper-Activation Alters Fatty Acids Metabolism and Impairs Invasiveness of Trophoblasts in Preeclampsia Open
Background/Aims: Preeclampsia (PE) has long been assumed to be an ischemic disease of the placenta, although there is limited evidence as to how the ischemia impacts on the placenta. AMP-activated protein kinase (AMPK) is a key regulator o…