Yangxin Chen
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View article: Multi-trait genome-wide analysis identified risk loci and candidate drugs for heart failure
Multi-trait genome-wide analysis identified risk loci and candidate drugs for heart failure Open
Heart failure (HF) is a common cardiovascular syndrome that poses significant morbidity and mortality risks. While genome-wide association studies reporting on HF abound, its genetic etiology remains poorly elucidated, primarily due to its…
View article: Time-dependent S-wave areas by 24-hour ECG are correlated with a high risk of sudden cardiac death: ECG prediction model development and validation for SCD risk
Time-dependent S-wave areas by 24-hour ECG are correlated with a high risk of sudden cardiac death: ECG prediction model development and validation for SCD risk Open
Dynamic ECG parameters, especially time-dependent variations in the S-wave area, were strongly associated with the SCD risk. They may develop into promising markers enhancing predictive accuracy for SCD stratification after further large-s…
View article: Sleep Patterns and Frailty
Sleep Patterns and Frailty Open
Maintaining a healthy sleep pattern and a nonfrail status were jointly associated with a significantly decreased risk of MACE. These results emphasize the importance of promoting sleep health to mitigate CVD risk in prefrail participants.
View article: Cardiovascular-kidney-metabolic health, genetic susceptibility, and the risk of dementia: A prospective cohort study
Cardiovascular-kidney-metabolic health, genetic susceptibility, and the risk of dementia: A prospective cohort study Open
Poor CKM health was independently associated with cognitive impairment and an increased risk of dementia. The association between CKM syndrome and risk of dementia could be further strengthened by genetic susceptibility.
View article: Severe Mitral Regurgitation in Mirror-Image Dextrocardia
Severe Mitral Regurgitation in Mirror-Image Dextrocardia Open
TEER in patients with mirror-image dextrocardia and severe MR requires specific adaptations. Successful outcomes require operators with substantial TEER experience and excellent 3-dimensional spatial reasoning.
View article: Comparative outcomes of on-label and off-label transcatheter aortic valve replacement for aortic regurgitation: a systematic review and meta-analysis
Comparative outcomes of on-label and off-label transcatheter aortic valve replacement for aortic regurgitation: a systematic review and meta-analysis Open
Background Transcatheter aortic valve replacement (TAVR) has emerged as an alternative treatment for aortic regurgitation (AR) in patients at high surgical risk. However, evidence comparing outcomes of different new-generation devices rema…
View article: Correlation of non-esterified fatty acids with acute coronary syndrome risk in young Chinese adults
Correlation of non-esterified fatty acids with acute coronary syndrome risk in young Chinese adults Open
Objective Circulating non-esterified fatty acids (NEFAs) are linked to endothelial dysfunction and coronary artery disease (CAD) mainly in older adults. This study examines the association between NEFAs and acute coronary syndrome (ACS) ri…
View article: A novel nomogram model for diagnosing isolated atrial functional mitral regurgitation in patients with significant functional mitral regurgitation
A novel nomogram model for diagnosing isolated atrial functional mitral regurgitation in patients with significant functional mitral regurgitation Open
This study developed a simple way to diagnose AFMR using a nomogram model that incorporated the LAd, LVDd, LVEF, AF, and MI. This model could help cardiologists in treatment determination and prognosis evaluation.
View article: Integrative Analysis of Lactylation-Associated Features in Abdominal Aortic Aneurysm and Its Immune Microenvironment Utilizing scRNA-seq and Bulk RNA Sequencing
Integrative Analysis of Lactylation-Associated Features in Abdominal Aortic Aneurysm and Its Immune Microenvironment Utilizing scRNA-seq and Bulk RNA Sequencing Open
This study highlighted a potentially critical link between lactylation and immune dysregulation in AAA, thereby advancing our comprehension of the function of lactylation in AAA.
View article: <i>Olsenella scatoligenes</i> -derived skatole promotes smooth muscle cell proliferation and migration to aggravate atherosclerosis
<i>Olsenella scatoligenes</i> -derived skatole promotes smooth muscle cell proliferation and migration to aggravate atherosclerosis Open
Coronary artery disease (CAD) remains the leading cause of mortality and morbidity globally. The gut microbiota has been implicated in the development of CAD through unclear mechanisms. Here, we demonstrate that the abundance and interspec…
View article: CTRhythm: Accurate Atrial Fibrillation Detection from Single-Lead ECG by Convolutional Neural Network and Transformer Integration
CTRhythm: Accurate Atrial Fibrillation Detection from Single-Lead ECG by Convolutional Neural Network and Transformer Integration Open
Atrial Fibrillation (AF) is a common supraventricular arrhythmia that affects about 30 million people globally. Electrocardiogram (ECG) analysis is the primary diagnostic approach. The widespread adoption of wearable devices monitoring hea…
View article: Predictive value of NT pro BNP for new‐onset atrial fibrillation in heart failure and preserved ejection fraction
Predictive value of NT pro BNP for new‐onset atrial fibrillation in heart failure and preserved ejection fraction Open
Aims The prognostic significance of N‐terminal pro B‐type natriuretic peptide (NT‐proBNP) in heart failure with preserved ejection fraction (HFpEF) has been well established. HFpEF and atrial fibrillation (AF) commonly coexist, and each co…
View article: Comprehensive Multiple Risk Factor Control in Type 2 Diabetes to Mitigate Heart Failure Risk: Insights from a Prospective Cohort Study
Comprehensive Multiple Risk Factor Control in Type 2 Diabetes to Mitigate Heart Failure Risk: Insights from a Prospective Cohort Study Open
OBJECTIVESThis study evaluates the impact of comprehensive risk factor control on heart failure (HF) risk and HF-free survival time in individuals with type 2 diabetes (T2D).RESEARCH DESIGN AND METHODSThis prospective study included 11,949…
View article: Comprehensive Multiple Risk Factor Control in Type 2 Diabetes to Mitigate Heart Failure Risk: Insights from a Prospective Cohort Study
Comprehensive Multiple Risk Factor Control in Type 2 Diabetes to Mitigate Heart Failure Risk: Insights from a Prospective Cohort Study Open
OBJECTIVESThis study evaluates the impact of comprehensive risk factor control on heart failure (HF) risk and HF-free survival time in individuals with type 2 diabetes (T2D).RESEARCH DESIGN AND METHODSThis prospective study included 11,949…
View article: Sleep Patterns and Traditional Cardiovascular Health Metrics: Joint Impact on Major Adverse Cardiovascular Events in a Prospective Cohort Study
Sleep Patterns and Traditional Cardiovascular Health Metrics: Joint Impact on Major Adverse Cardiovascular Events in a Prospective Cohort Study Open
Background This study examines the association between traditional cardiovascular health (CVH) metrics and major adverse cardiovascular events (MACE) incidence in individuals with diverse sleep patterns. Methods and Results We analyzed dat…
View article: Multi-trait genome-wide analysis identified novel risk loci and candidate drugs for heart failure
Multi-trait genome-wide analysis identified novel risk loci and candidate drugs for heart failure Open
Heart failure (HF) is a common cardiovascular syndrome that poses significant morbidity and mortality risks. While genome-wide association studies reporting on HF abound, its genetic etiology remains poorly elucidated, primarily due to its…
View article: Time-dependent S-wave areas predict sudden cardiac death risk: a prospective, multicentre registered study
Time-dependent S-wave areas predict sudden cardiac death risk: a prospective, multicentre registered study Open
Objectives The present study aimed to detect novel and time-dependent ECG parameters by analysing 24-h ECG data, especially the area under ECG waves. Design: Prospective, multicentre cohort study Setting: Four hospitals in China Participan…
View article: Erratum to: Bioinformatic analysis for potential biological processes and key targets of heart failure-related stroke
Erratum to: Bioinformatic analysis for potential biological processes and key targets of heart failure-related stroke Open
The original version of this article (Liu et al., 2021) unfortunately contained a mistake: statement of equal contribution is missing. This correction article shows that Chiyu LIU and Sixu CHEN contributed equally to this work. The origina…
View article: Genetic Analysis Reveals Key Regulatory Axis in Aortic Dissection: CBL Regulated by HOXB13 and microRNA-1321
Genetic Analysis Reveals Key Regulatory Axis in Aortic Dissection: CBL Regulated by HOXB13 and microRNA-1321 Open
Background: Aortic dissection (AD) is a fatal cardiovascular disease for which the key involved genes are largely unknown. Here, we aimed to identify promising AD biomarkers from high-throughput RNA expressing data. Methods: In the GSE9877…
View article: Performance of Subcutaneous Implantable Cardioverter Defibrillator (S-ICD) in Chinese Population with Primary Prevention Indications: A Prospective Observational Cohort Study
Performance of Subcutaneous Implantable Cardioverter Defibrillator (S-ICD) in Chinese Population with Primary Prevention Indications: A Prospective Observational Cohort Study Open
BACKGROUND International studies have shown that use of a subcutaneous implantable cardioverter defibrillator (S-ICD) could reduce lead-related complications while maintaining adequate defibrillation performance; however, data from the Chi…