Young‐Su Yi
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View article: Regulatory Roles of Noncanonical Inflammasomes in Diabetes Mellitus and Diabetes-Associated Complications
Regulatory Roles of Noncanonical Inflammasomes in Diabetes Mellitus and Diabetes-Associated Complications Open
Inflammation is an innate immune system protecting the body from infection and injury. This process proceeds through two distinct stages: a priming phase, characterized by transcriptional activation, and a triggering phase, in which inflam…
View article: Pyroptosis: A pharmacological target of ginseng and its phytochemical components for human inflammatory diseases
Pyroptosis: A pharmacological target of ginseng and its phytochemical components for human inflammatory diseases Open
Pyroptosis is an intensely inflammatory form of lytic programmed cell death, typically triggered by pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) and is likely to form part of the inflammat…
View article: Roles of Inflammasomes in Inflammatory Responses and Human Diseases
Roles of Inflammasomes in Inflammatory Responses and Human Diseases Open
Inflammation is an innate immune defense that protects our bodily tissues from pathogens and cellular dangers [...]
View article: Silymarin in Silybum marianum ameliorated acute lethal sepsis in mice by targeting caspase-11 noncanonical inflammasome in macrophages
Silymarin in Silybum marianum ameliorated acute lethal sepsis in mice by targeting caspase-11 noncanonical inflammasome in macrophages Open
View article: Regulatory Roles of Noncanonical Inflammasomes in Inflammatory Lung Diseases
Regulatory Roles of Noncanonical Inflammasomes in Inflammatory Lung Diseases Open
The inflammatory response consists of two stages: priming and triggering. The triggering stage is marked by the activation of inflammasomes, which are cytosolic protein complexes acting as platforms for inflammation. Inflammasomes are divi…
View article: Quercetin Ameliorates Acute Lethal Sepsis in Mice by Inhibiting Caspase-11 Noncanonical Inflammasome in Macrophages
Quercetin Ameliorates Acute Lethal Sepsis in Mice by Inhibiting Caspase-11 Noncanonical Inflammasome in Macrophages Open
Quercetin is a natural polyphenolic flavonoid widely found in plants, fruits, and vegetables, and has been reported to play pharmacological roles in numerous pathogenic conditions. The anti-inflammatory effects of quercetin in various infl…
View article: Functional interplay between non-canonical inflammasomes and autophagy in inflammatory responses and diseases
Functional interplay between non-canonical inflammasomes and autophagy in inflammatory responses and diseases Open
The inflammasome is a cytosolic multiprotein platform that plays a key role in the inflammatory response, an essential innate immune response that protects the body from pathogens and cellular danger signals. Autophagy is a fundamental cel…
View article: Effect of traditional Chinese medicine therapy on labor pain in patients with natural childbirth: A network meta-analysis
Effect of traditional Chinese medicine therapy on labor pain in patients with natural childbirth: A network meta-analysis Open
Background: This systematic review compared the efficacy of traditional Chinese medicine (TCM) treatments for outcomes of different stages and labor pain among pregnant women. Methods: Eight databases were electronically searched for TCM o…
View article: The Regulatory Roles of Inflammation and Inflammasomes in Liver Diseases
The Regulatory Roles of Inflammation and Inflammasomes in Liver Diseases Open
Inflammation is an innate immune response that protects our body from various pathogens and cellular dangers [...]
View article: Roles of the Caspase-11 Non-Canonical Inflammasome in Rheumatic Diseases
Roles of the Caspase-11 Non-Canonical Inflammasome in Rheumatic Diseases Open
Inflammasomes are intracellular multiprotein complexes that activate inflammatory signaling pathways. Inflammasomes comprise two major classes: canonical inflammasomes, which were discovered first and are activated in response to a variety…
View article: Pharmacological potential of ginseng and ginsenosides in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
Pharmacological potential of ginseng and ginsenosides in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis Open
Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease characterized by hepatic fat accumulation, while nonalcoholic steatohepatitis (NASH) is an advanced form of NAFLD characterized by hepatic inflammation, fibrosis, and live…
View article: Regulatory Roles of Flavonoids in Caspase-11 Non-Canonical Inflammasome-Mediated Inflammatory Responses and Diseases
Regulatory Roles of Flavonoids in Caspase-11 Non-Canonical Inflammasome-Mediated Inflammatory Responses and Diseases Open
Inflammasomes are multiprotein complexes that activate inflammatory responses by inducing pyroptosis and secretion of pro-inflammatory cytokines. Along with many previous studies on inflammatory responses and diseases induced by canonical …
View article: Regulatory Roles of Flavonoids in Caspase-11 Non-canonical Inflammasome-mediated Inflammatory Responses and Diseases
Regulatory Roles of Flavonoids in Caspase-11 Non-canonical Inflammasome-mediated Inflammatory Responses and Diseases Open
Inflammasomes are multiprotein complexes that activate inflammatory responses by inducing pyroptosis and secretion of pro-inflammatory cytokines. Along with many previous studies on inflammatory responses and diseases induced by canonical …
View article: Inflammation, Inflammatory Diseases, and Inflammasomes
Inflammation, Inflammatory Diseases, and Inflammasomes Open
Inflammation represents the innate immune response of the body tissues against invading microbes and cellular danger signals, and, in this way, it is beneficial [...]
View article: Korean Red Ginseng Saponins Play an Anti-Inflammatory Role by Targeting Caspase-11 Non-Canonical Inflammasome in Macrophages
Korean Red Ginseng Saponins Play an Anti-Inflammatory Role by Targeting Caspase-11 Non-Canonical Inflammasome in Macrophages Open
We previously reported that Korean red ginseng (KRG) exerts an anti-inflammatory role through inhibiting caspase-11 non-canonical inflammasome in macrophages; however, the components responsible for the anti-inflammatory role remained uncl…
View article: Editorial of Special Issue “Roles of Inflammasomes and Methyltransferases in Inflammation”
Editorial of Special Issue “Roles of Inflammasomes and Methyltransferases in Inflammation” Open
Inflammation is the first line of defense against pathogens and cellular dangers [...]
View article: Regulatory Roles of Caspase-11 Non-Canonical Inflammasome in Inflammatory Liver Diseases
Regulatory Roles of Caspase-11 Non-Canonical Inflammasome in Inflammatory Liver Diseases Open
An inflammatory response consists of two consecutive steps: priming and triggering, to prepare and activate inflammatory responses, respectively. The cardinal feature of the triggering step is the activation of intracellular protein comple…
View article: Potential benefits of ginseng against COVID-19 by targeting inflammasomes
Potential benefits of ginseng against COVID-19 by targeting inflammasomes Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogenic virus that causes coronavirus disease 2019 (COVID-19), with major symptoms including hyper-inflammation and cytokine storm, which consequently impairs the respi…
View article: Syk promotes phagocytosis by inducing reactive oxygen species generation and suppressing SOCS1 in macrophage-mediated inflammatory responses
Syk promotes phagocytosis by inducing reactive oxygen species generation and suppressing SOCS1 in macrophage-mediated inflammatory responses Open
Objective Inflammation, a vital innate immune response against infection and injury, is mediated by macrophages. Spleen tyrosine kinase (Syk) regulates inflammatory responses in macrophages; however, its role and underlying mechanisms are …
View article: Editorial of Special Issue “Inflammasomes and Inflammation”
Editorial of Special Issue “Inflammasomes and Inflammation” Open
Although inflammation is a host-protective mechanism from infection and cellular danger signals, chronic inflammation is a major risk factor for various human diseases [...]
View article: Korean Red Ginseng saponin fraction exerts anti-inflammatory effects by targeting the NF-κB and AP-1 pathways
Korean Red Ginseng saponin fraction exerts anti-inflammatory effects by targeting the NF-κB and AP-1 pathways Open
RGSF contains ginsenosides that have anti-inflammatory action via restraining the NF-κB and AP-1 signaling pathways in macrophages during inflammatory responses.
View article: A novel mechanism of Korean Red Ginseng-mediated anti-inflammatory action via targeting caspase-11 non-canonical inflammasome in macrophages
A novel mechanism of Korean Red Ginseng-mediated anti-inflammatory action via targeting caspase-11 non-canonical inflammasome in macrophages Open
View article: Syk-MyD88 Axis Is a Critical Determinant of Inflammatory-Response in Activated Macrophages
Syk-MyD88 Axis Is a Critical Determinant of Inflammatory-Response in Activated Macrophages Open
Background Inflammation, a vital immune response to infection and injury, is mediated by macrophage activation. While spleen tyrosine kinase (Syk) and myeloid differentiation primary response 88 (MyD88) are reportedly involved in inflammat…
View article: Functional Interplay between Methyltransferases and Inflammasomes in Inflammatory Responses and Diseases
Functional Interplay between Methyltransferases and Inflammasomes in Inflammatory Responses and Diseases Open
An inflammasome is an intracellular protein complex that is activated in response to a pathogenic infection and cellular damage. It triggers inflammatory responses by promoting inflammatory cell death (called pyroptosis) and the secretion …
View article: 14-3-3 epsilon is an intracellular component of TNFbib2 receptor complex and its activation protects against osteoarthritis
14-3-3 epsilon is an intracellular component of TNFbib2 receptor complex and its activation protects against osteoarthritis Open
View article: TNFR2/14-3-3ε signaling complex instructs macrophage plasticity in inflammation and autoimmunity
TNFR2/14-3-3ε signaling complex instructs macrophage plasticity in inflammation and autoimmunity Open
TNFR1 and TNFR2 have received prominent attention because of their dominance in the pathogenesis of inflammation and autoimmunity. TNFR1 has been extensively studied and primarily mediates inflammation. TNFR2 remains far less studied, alth…
View article: BONE DEVELOPMENT AND FRACTURE HEALING IS NORMAL IN MICE THAT HAVE A DEFECT IN THE DEVELOPMENT OF THE LYMPHATIC SYSTEM
BONE DEVELOPMENT AND FRACTURE HEALING IS NORMAL IN MICE THAT HAVE A DEFECT IN THE DEVELOPMENT OF THE LYMPHATIC SYSTEM Open
Ectopic lymphatics form in bone and promote bone destruction in diseases such as Gorham-Stout disease, generalized lymphatic anomaly, and kaposiform lymphangiomatosis. However, the role lymphatics serve in normal bone development and repai…
View article: Editorial of Special Issue “Regulatory Roles of Inflammasomes in Human Diseases”
Editorial of Special Issue “Regulatory Roles of Inflammasomes in Human Diseases” Open
Inflammation is an innate immunity protecting the body from pathogens and cellular damages and comprises two steps; 1) priming (preparatory step) and triggering (activation step). The key feature of the triggering step is the activation of…
View article: Flavonoids: Nutraceuticals for Rheumatic Diseases via Targeting of Inflammasome Activation
Flavonoids: Nutraceuticals for Rheumatic Diseases via Targeting of Inflammasome Activation Open
Inflammation, an innate immune response that prevents cellular damage caused by pathogens, consists of two successive mechanisms, namely priming and triggering. While priming is an inflammation-preparation step, triggering is an inflammati…
View article: Role of Inflammasomes in Inflammatory and Infectious Diseases
Role of Inflammasomes in Inflammatory and Infectious Diseases Open