Yangyang Zhao
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View article: Nanotechnology-Driven Strategies in Osteosarcoma Advances in Treatment: Immunotherapy and Drug Delivery
Nanotechnology-Driven Strategies in Osteosarcoma Advances in Treatment: Immunotherapy and Drug Delivery Open
Osteosarcoma (OS), the most prevalent primary malignant bone tumor, exhibits highly aggressive and metastatic potential, accounting approximately 56% of all primary malignant bone malignancies. While neoadjuvant chemotherapy with surgery r…
View article: Molecular insights into neurodevelopmental abnormalities and rescue mechanisms in the fetal prefrontal cortex with tetralogy of Fallot
Molecular insights into neurodevelopmental abnormalities and rescue mechanisms in the fetal prefrontal cortex with tetralogy of Fallot Open
Previous studies have suggested that individuals with tetralogy of Fallot (TOF) may exhibit neurodevelopmental abnormalities in the prefrontal cortex (PFC), potentially originating during the fetal period, although conclusive evidence rema…
View article: Hfq modulates system-wide regulatory networks controlling biocontrol property in Lysobacter enzymogenes
Hfq modulates system-wide regulatory networks controlling biocontrol property in Lysobacter enzymogenes Open
Lysobacter enzymogenes is a beneficial soil bacterium renowned for its potent biocontrol properties, primarily attributed to antimicrobial secondary metabolites such as HSAF and WAP-8294A2, as well as specialized secretion systems. …
View article: A Single‐Molecule Pleuripotent Scaffold for Combinational Therapy of Alzheimer's Disease via Intranasal Administration
A Single‐Molecule Pleuripotent Scaffold for Combinational Therapy of Alzheimer's Disease via Intranasal Administration Open
The intricate pathological mechanisms of Alzheimer's disease (AD), along with the restrictive nature of the blood‐brain barrier (BBB) that further impedes the drug brain entry, underscore the pressing need for innovative combinational ther…
View article: Risk factors for surgical site infections following microwave ablation of the uterus: a retrospective cohort study
Risk factors for surgical site infections following microwave ablation of the uterus: a retrospective cohort study Open
View article: The effect of <i>N</i>‐oxide phenazine producer <i>Lysobacter antibioticus</i> on bacterial leaf streak in rice and the rhizosphere microbial community
The effect of <i>N</i>‐oxide phenazine producer <i>Lysobacter antibioticus</i> on bacterial leaf streak in rice and the rhizosphere microbial community Open
Bacterial leaf streak (BLS) of rice, caused by Xanthomonas oryzae pv. oryzicola , severely compromises crop yield and grain quality. This study evaluates the biocontrol potential of Lysobacter antibioticus OH13, a soil bacterium producing …
View article: Community-Level Urban Vitality Intensity and Diversity Analysis Supported by Multisource Remote Sensing Data
Community-Level Urban Vitality Intensity and Diversity Analysis Supported by Multisource Remote Sensing Data Open
Urban vitality serves as a crucial metric for evaluating sustainable urban development and the well-being of residents. Existing studies have predominantly focused on analyzing the direct effects of urban vitality intensity (VI) and its in…
View article: Diabetes Advances Cardiomyocyte Senescence Through Interfering <i>Rnd3</i> Expression and Function
Diabetes Advances Cardiomyocyte Senescence Through Interfering <i>Rnd3</i> Expression and Function Open
Rnd3 is a small Rho‐GTPase that has been implicated in various cardiovascular diseases. Yet, its role in diabetes‐induced cardiomyocyte senescence remains unknown. Here we tested the role of Rnd3 in cardiomyocyte senescence and diabetic ca…
View article: Hfq Modulates System-Wide Regulatory Networks Controlling Biocontrol Property in Lysobacter Enzymogenes
Hfq Modulates System-Wide Regulatory Networks Controlling Biocontrol Property in Lysobacter Enzymogenes Open
View article: A fractal-based supremum and infimum complex belief entropy in complex evidence theory
A fractal-based supremum and infimum complex belief entropy in complex evidence theory Open
View article: Identification of potential therapeutic targets for nonischemic cardiomyopathy in European ancestry: an integrated multiomics analysis
Identification of potential therapeutic targets for nonischemic cardiomyopathy in European ancestry: an integrated multiomics analysis Open
View article: Risk factors of surgical site infections after microwave ablation of uterus
Risk factors of surgical site infections after microwave ablation of uterus Open
Purpose: As microwave ablation (MWA) becomes increasingly common in treating gynecological diseases, the complications, particularly surgical site infections (SSIs), have become a significant concern. It is crucial to identify the independ…
View article: Trimethylamine-N-oxide promotes osteoclast differentiation and oxidative stress by activating NF-κB pathway
Trimethylamine-N-oxide promotes osteoclast differentiation and oxidative stress by activating NF-κB pathway Open
In conclusion, TMAO enhances RANKL and M-CSF-induced osteoclast differentiation and inflammation in RAW 264.7 cells by activating the NF-κB signaling pathway. These findings offer a new rationale for further academic and clinical research …
View article: Incidence and risk factors for blood transfusion after abdominal radical hysterectomy for cervical cancer: A 10-year retrospective study of the US nationwide inpatient sample
Incidence and risk factors for blood transfusion after abdominal radical hysterectomy for cervical cancer: A 10-year retrospective study of the US nationwide inpatient sample Open
Purpose With the increasing prevalence of abdominal radical hysterectomy, the need for perioperative blood transfusion has emerged as a significant clinical challenge. The independent risk factors for blood transfusion during abdominal rad…
View article: Lysobacter enzymogenes: a fully armed biocontrol warrior1
Lysobacter enzymogenes: a fully armed biocontrol warrior1 Open
Lysobacter enzymogenes is less-studied, but emerging as a powerful biocontrol bacterium producing multiple antimicrobial weapons including lytic enzymes, toxins, secondary metabolites and protein secretion systems. The loss of surface-atta…
View article: Diabetes Advances Cardiomyocyte Senescence through miR-103a-3p/Rnd3/STAT3 Signaling
Diabetes Advances Cardiomyocyte Senescence through miR-103a-3p/Rnd3/STAT3 Signaling Open
BACKGROUND Rnd3, a small Rho-GTPase, is involved in various cardiovascular diseases, but its role in diabetes-induced cardiomyocyte senescence is unclear. This study aims to investigate the role of Rnd3 in cardiomyocyte senescence in diabe…
View article: Novel Drug Targets for Nonischaemic Cardiomyopathy Identified by Integrated Proteomic and Genomic Analysis
Novel Drug Targets for Nonischaemic Cardiomyopathy Identified by Integrated Proteomic and Genomic Analysis Open
View article: Knockdown of LCN2 Attenuates Brain Injury After Intracerebral Hemorrhage via Suppressing Pyroptosis
Knockdown of LCN2 Attenuates Brain Injury After Intracerebral Hemorrhage via Suppressing Pyroptosis Open
Inhibition of LCN2 attenuates brain injury after ICH via suppressing pyroptosis, which provide guidance for ICH management.
View article: Association between Early Life Course-Related Characteristics and Childhood Neurodevelopmental Disorders: A Two-Sample Mendelian Randomization Study
Association between Early Life Course-Related Characteristics and Childhood Neurodevelopmental Disorders: A Two-Sample Mendelian Randomization Study Open
View article: Association between Early Life Course-Related Characteristics and Childhood Neurodevelopmental Disorders: A Two-Sample Mendelian Randomization Study
Association between Early Life Course-Related Characteristics and Childhood Neurodevelopmental Disorders: A Two-Sample Mendelian Randomization Study Open
View article: Methyltransferase SETD4 mediates macrophages proliferation through EGFR signaling
Methyltransferase SETD4 mediates macrophages proliferation through EGFR signaling Open
This study explored the effects of SET domain-containing protein (SETD)4, a histone lysine methyltransferase, on the general biological functions of bone marrow-derived macrophages (BMMs). BMMs from SETD4 knockout (KO) mice exhibited signi…
View article: Deciphering biomarker related to 12 programmed cell death to predict prognosis and response to immunotherapy in lung squamous cell carcinoma
Deciphering biomarker related to 12 programmed cell death to predict prognosis and response to immunotherapy in lung squamous cell carcinoma Open
Background Different programmed cell death (PCD) plays different roles in lung squamous cell carcinoma (LUSC). We integrated twelve programmed cell death patterns, investigated the expression patterns of PCD-related genes to identify promi…
View article: Editorial: Pathogenic mechanism and biocontrol of Xanthomonas on plants
Editorial: Pathogenic mechanism and biocontrol of Xanthomonas on plants Open
EDITORIAL article Front. Cell. Infect. Microbiol., 18 August 2023Sec. Molecular Bacterial Pathogenesis Volume 13 - 2023 | https://doi.org/10.3389/fcimb.2023.1270750
View article: Mechanistic role of RND3-regulated IL33/ST2 signaling on cardiomyocyte senescence
Mechanistic role of RND3-regulated IL33/ST2 signaling on cardiomyocyte senescence Open
Objective: Hyperinflammatory responses are pivotal in the pathophysiology of cardiomyocyte senescence, with IL33 serving as a crucial pro-inflammatory mediator. Our previous findings highlighted RND3's suppressive effect on IL33 expression…
View article: Mechanistic role of RND3-regulated IL33/ST2 signaling on cardiomyocyte senescence
Mechanistic role of RND3-regulated IL33/ST2 signaling on cardiomyocyte senescence Open
BACKGROUND: Hyperinflammatory responses are pivotal in the pathophysiology of cardiomyocyte senescence, with IL33 serving as a crucial pro-inflammatory mediator. Our previous findings highlighted RND3's suppressive effect on IL33 expressio…
View article: Methyltransferase SETD4 mediates macrophages proliferation through EGFR signaling
Methyltransferase SETD4 mediates macrophages proliferation through EGFR signaling Open
Purpose: Epigenetic modifications have important impacts on the biological functions of cells. This study explored the effects of SET domain-containing protein (SETD)4, a histone lysine methyltransferase, on the general biological function…
View article: LexR Positively Regulates the LexABC Efflux Pump Involved in Self-Resistance to the Antimicrobial Di- <i>N</i> -Oxide Phenazine in Lysobacter antibioticus
LexR Positively Regulates the LexABC Efflux Pump Involved in Self-Resistance to the Antimicrobial Di- <i>N</i> -Oxide Phenazine in Lysobacter antibioticus Open
Antibiotic-producing bacteria exhibit various sophisticated mechanisms for self-protection against their own secondary metabolites. RND efflux pumps that eliminate antibiotics from cells are ubiquitous in Gram-negative bacteria.
View article: A novel biplanar positioning technique to guide iliosacral screw insertion: a retrospective study
A novel biplanar positioning technique to guide iliosacral screw insertion: a retrospective study Open
View article: miR-100-5p is upregulated in multiple myeloma and involves in the pathogenesis of multiple myeloma through targeting MTMR3
miR-100-5p is upregulated in multiple myeloma and involves in the pathogenesis of multiple myeloma through targeting MTMR3 Open
These results indicates that miR-100-5p is a promising biomarker for MM, and that it may involve in the pathogenesis of MM by targeting MTMR3.
View article: SstF, a novel sulforaphane‐sensing transcription factor of <i>Xanthomonas campestris</i> , is required for sulforaphane tolerance and virulence
SstF, a novel sulforaphane‐sensing transcription factor of <i>Xanthomonas campestris</i> , is required for sulforaphane tolerance and virulence Open
Avoiding the host defence system is necessary for the survival of pathogens. However, the mechanisms by which pathogenic bacteria sense and resist host defence signals are still unknown. Sulforaphane (SFN) is a secondary metabolite of cruc…