Yanhua H. Huang
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View article: Sleep Deprivation Engages the Orexin/Hypocretin System to Regulate Food Reward Seeking
Sleep Deprivation Engages the Orexin/Hypocretin System to Regulate Food Reward Seeking Open
Background Inadequate sleep is a prevalent health issue in modern society, with unintended consequences in dysregulation of the reward system. For example, acute sleep deprivation (SD) in humans increases craving for and intake of calorie-…
View article: Isolation, characterization and therapeutic efficacy of lytic bacteriophage ZK22 against Salmonella Typhimurium in mice
Isolation, characterization and therapeutic efficacy of lytic bacteriophage ZK22 against Salmonella Typhimurium in mice Open
In summary, bacteriophage ZK22 presents favorable application prospects as a potential biological agent for the control of Salmonella infections in livestock and poultry farming.
View article: Molecular and cellular rhythms in excitatory and inhibitory neurons in the mouse prefrontal cortex
Molecular and cellular rhythms in excitatory and inhibitory neurons in the mouse prefrontal cortex Open
Previous studies have shown that there are rhythms in gene expression in the mouse prefrontal cortex (PFC); however, the contribution of different cell types and potential variation by sex has not yet been determined. Of particular interes…
View article: Prophylactic nicotinamide mononucleotide (NMN) mitigates CSDS-induced depressive-like behaviors in mice via preserving of ATP level in the mPFC
Prophylactic nicotinamide mononucleotide (NMN) mitigates CSDS-induced depressive-like behaviors in mice via preserving of ATP level in the mPFC Open
Depression is a prevalent psychiatric disorder with accumulating evidence implicating dysregulation of extracellular adenosine triphosphate (ATP) levels in the medial prefrontal cortex (mPFC). It remains unclear whether facilitating endoge…
View article: An EEG Signature of MCH Neuron Activities Predicts Cocaine Seeking
An EEG Signature of MCH Neuron Activities Predicts Cocaine Seeking Open
Background Identifying biomarkers that predict substance use disorder (SUD) propensity may better strategize anti-addiction treatment. The melanin-concentrating hormone (MCH) neurons in the lateral hypothalamus (LH) critically mediates int…
View article: Privacy-Preserving Face Recognition Method Based on Randomization and Local Feature Learning
Privacy-Preserving Face Recognition Method Based on Randomization and Local Feature Learning Open
Personal privacy protection has been extensively investigated. The privacy protection of face recognition applications combines face privacy protection with face recognition. Traditional face privacy-protection methods encrypt or perturb f…
View article: Cue- versus reward-encoding basolateral amygdala projections to nucleus accumbens
Cue- versus reward-encoding basolateral amygdala projections to nucleus accumbens Open
In substance use disorders, drug use as unconditioned stimulus (US) reinforces drug taking. Meanwhile, drug-associated cues (conditioned stimulus [CS]) also gain incentive salience to promote drug seeking. The basolateral amygdala (BLA) is…
View article: Cue- versus reward-encoding basolateral amygdala projections to nucleus accumbens
Cue- versus reward-encoding basolateral amygdala projections to nucleus accumbens Open
Summary In substance use disorders, drug use as unconditioned stimulus (US) reinforces drug taking. Meanwhile, drug-associated cues (conditioned stimulus, CS) also gain incentive salience to promote drug seeking. The basolateral amygdala (…
View article: Contingent Amygdala Inputs Trigger Heterosynaptic LTP at Hippocampus-To-Accumbens Synapses
Contingent Amygdala Inputs Trigger Heterosynaptic LTP at Hippocampus-To-Accumbens Synapses Open
The nucleus accumbens shell (NAcSh) is a key brain region where environmental cues acquire incentive salience to reinforce motivated behaviors. Principal medium spiny neurons (MSNs) in the NAcSh receive extensive glutamatergic projections …
View article: AMPA and NMDA Receptor Trafficking at Cocaine-Generated Synapses
AMPA and NMDA Receptor Trafficking at Cocaine-Generated Synapses Open
Cocaine experience generates AMPA receptor (AMPAR)-silent synapses in the nucleus accumbens (NAc), which are thought to be new synaptic contacts enriched in GluN2B-containing NMDA receptors (NMDARs). After drug withdrawal, some of these sy…
View article: Efficient Reinforcement Learning Development with RLzoo
Efficient Reinforcement Learning Development with RLzoo Open
Many researchers and developers are exploring for adopting Deep Reinforcement Learning (DRL) techniques in their applications. They however often find such an adoption challenging. Existing DRL libraries provide poor support for prototypin…
View article: RLzoo: A Comprehensive and Adaptive Reinforcement Learning Library.
RLzoo: A Comprehensive and Adaptive Reinforcement Learning Library. Open
Recently, we have seen a rapidly growing adoption of Deep Reinforcement Learning (DRL) technologies. Fully achieving the promise of these technologies in practice is, however, extremely difficult. Users have to invest tremendous efforts in…
View article: Cortical and Thalamic Interaction with Amygdala-to-Accumbens Synapses
Cortical and Thalamic Interaction with Amygdala-to-Accumbens Synapses Open
The nucleus accumbens shell (NAcSh) regulates emotional and motivational responses, a function mediated, in part, by integrating and prioritizing extensive glutamatergic projections from limbic and paralimbic brain regions. Each of these i…
View article: Cocaine Triggers Glial-Mediated Synaptogenesis
Cocaine Triggers Glial-Mediated Synaptogenesis Open
Synaptogenesis is essential in forming new neurocircuits during development, and this is mediated in part by astrocyte-released thrombospondins (TSPs) and activation of their neuronal receptor, α2δ-1. Here, we show that this developmental …