Yanhua He
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View article: Characteristics and Driving Factors of PM2.5 Concentration Changes in Central China
Characteristics and Driving Factors of PM2.5 Concentration Changes in Central China Open
Despite nationwide control efforts, central China experiences persistently high annual PM2.5 concentrations (~50 μg/m3), which are particularly severe in January (exceeding 110 μg/m3). This study employs an integrated approach combining a …
View article: APOL2 Stabilizes Ku80 to Confer NHEJ‐Mediated Radioresistance in Gastric Cancer
APOL2 Stabilizes Ku80 to Confer NHEJ‐Mediated Radioresistance in Gastric Cancer Open
Radiotherapy is one of the most important adjuvant treatment methods for gastric cancer (GC). However, radioresistance remains a major clinical obstacle. In this study, APOL2 is identified as a key player in promoting non‐homologous end jo…
View article: PVC Nanoplastics Exposure Exacerbates Asthma through R‐Loop Accumulation and Subsequent STING Activation in Macrophages
PVC Nanoplastics Exposure Exacerbates Asthma through R‐Loop Accumulation and Subsequent STING Activation in Macrophages Open
Asthma is a chronic inflammatory respiratory disease influenced by genetic and environmental factors. Emerging evidence suggests that microplastics and nanoplastics (NPs) pose significant health risks. When inhaled, these tiny particles ca…
View article: How urban–rural interactions promote sustainable rural development: Evidence from the Chang–Zhu–Tan urban agglomeration, China
How urban–rural interactions promote sustainable rural development: Evidence from the Chang–Zhu–Tan urban agglomeration, China Open
View article: Transcriptome Profile Analysis of Mirna and Mrna in Chicken Embryo Gonad Sex Differentiation
Transcriptome Profile Analysis of Mirna and Mrna in Chicken Embryo Gonad Sex Differentiation Open
View article: Contextual Gradient Frameworks for Semantic Boundary Transference in Large Language Models
Contextual Gradient Frameworks for Semantic Boundary Transference in Large Language Models Open
Semantic boundary transference introduces a novel mechanism for enhancing the contextual adaptability and semantic coherence of computational language systems. The proposed framework incorporates a gradient-based approach to dynamically en…
View article: PMMA nanoplastics induce gastric epithelial cellular senescence and cGAS-STING-mediated inflammation via ROS overproduction and NHEJ suppression
PMMA nanoplastics induce gastric epithelial cellular senescence and cGAS-STING-mediated inflammation via ROS overproduction and NHEJ suppression Open
The increasing environmental presence of nanoplastics (NPs) has raised concerns about their potential impact on biological systems. We investigated the repercussions of polymethyl methacrylate (PMMA) NPs exposure on normal gastric epitheli…
View article: PRL1 and PRL3 promote macropinocytosis via its lipid phosphatase activity
PRL1 and PRL3 promote macropinocytosis via its lipid phosphatase activity Open
PRL1 and PRL3, members of the protein tyrosine phosphatase family, have been associated with cancer metastasis and poor prognosis. Despite extensive research on their protein phosphatase activity, their potential role as lipid phosphatases…
View article: Hydrolase Production via Food Waste Fermentation and Its Application to Enhance Anaerobic Digestion of Sewage Sludge
Hydrolase Production via Food Waste Fermentation and Its Application to Enhance Anaerobic Digestion of Sewage Sludge Open
In the present study, a novel strategy for the effective production of hydrolase via fermentation of food waste was developed to improve methane production from anaerobic digestion of waste activated sludge (WAS). Via the pre-fermentation …
View article: PDCA nursing in improving quality management efficacy in endoscopic submucosal dissection
PDCA nursing in improving quality management efficacy in endoscopic submucosal dissection Open
PDCA nursing can improve the quality of management of ESD surgery, shorten the length of hospital stay and cost, reduce the VAS and Zung scale scores to alleviate adverse emotions, improve the SF-36 score, and reduce postoperative complica…
View article: Antiviral efficacy of selective estrogen receptor modulators against SARS‐CoV‐2 infection in vitro and in vivo reveals bazedoxifene acetate as an entry inhibitor
Antiviral efficacy of selective estrogen receptor modulators against SARS‐CoV‐2 infection in vitro and in vivo reveals bazedoxifene acetate as an entry inhibitor Open
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the seventh member of the coronavirus family that can infect humans. Recently, more contagious and pathogenic variants of SARS‐CoV‐2 have been continuously emerging. Clinical …
View article: Longitudinal Study on the Characteristics of Traditional Chinese Medicine (TCM) Constitutions and Related Influencing Factors in Women in Hong Kong
Longitudinal Study on the Characteristics of Traditional Chinese Medicine (TCM) Constitutions and Related Influencing Factors in Women in Hong Kong Open
View article: Discovery of potential anti-SARS-CoV-2 drugs based on large-scale screening in vitro and effect evaluation in vivo
Discovery of potential anti-SARS-CoV-2 drugs based on large-scale screening in vitro and effect evaluation in vivo Open
View article: miR-200c-141 Enhances Sheep Kidney Cell Reprogramming into Pluripotent Cells by Targeting ZEB1
miR-200c-141 Enhances Sheep Kidney Cell Reprogramming into Pluripotent Cells by Targeting ZEB1 Open
These results suggest that miR-200c-141 can promote the reprogramming of sheep somatic cells to iPSCs, and oar-miR-200c targeted ZEB1 3'UTR, significantly decreased expression of ZEB1, and increased expression of E-cadherin. Oar-miR-200c m…
View article: Longitudinal studies on the characteristics of TCM constitutions and related factors of adult Chinese women in Hong Kong
Longitudinal studies on the characteristics of TCM constitutions and related factors of adult Chinese women in Hong Kong Open
Background Traditional Chinese Medicine Constitution (TCMC, Named Tizhi in Chinese) is essential to reflect an individual’s body-mind and health. Understanding TCMCs and their influencing factors would be beneficial for improving the indiv…
View article: CRISPR-Cas13a-Based Detection for Bovine Viral Diarrhea Virus
CRISPR-Cas13a-Based Detection for Bovine Viral Diarrhea Virus Open
Bovine Viral Diarrhea Virus (BVDV) is the main pathogen of bovine viral diarrhea disease (BVD), which leads to enormous economic losses in the cattle industry. A sensitive and specific detection for BVDV is advantageous to the control of B…
View article: Effect of a medicinal and edible decoction YH0618 on chemotherapy-induced dermatologic toxicity: a randomized controlled trial
Effect of a medicinal and edible decoction YH0618 on chemotherapy-induced dermatologic toxicity: a randomized controlled trial Open
The trial was registered in the Chinese Clinical Trials Registry, ChiCTR-IOR-15006486.
View article: Impact of Traditional Chinese Medicine Constitution on Breast Cancer Incidence: A Case-Control and Cross-Sectional Study
Impact of Traditional Chinese Medicine Constitution on Breast Cancer Incidence: A Case-Control and Cross-Sectional Study Open
View article: Retraction Note to: The efficacy of Guolin-Qigong on the body-mind health of Chinese women with breast cancer: a randomized controlled trial
Retraction Note to: The efficacy of Guolin-Qigong on the body-mind health of Chinese women with breast cancer: a randomized controlled trial Open
View article: LDHs enhanced the immune response of animals to foot-and-mouth disease virus
LDHs enhanced the immune response of animals to foot-and-mouth disease virus Open
Background: Foot-and-mouth disease (FMD) is a highly transmissible disease that leads to vast economic losses in many countries. Prevention using inactivated vaccines is one effective measure used to control FMD. Unfortunately, inactivated…
View article: Transcriptomic analysis of bovine monocytes in response to non-cytopathic bovine viral diarrhea virus infection
Transcriptomic analysis of bovine monocytes in response to non-cytopathic bovine viral diarrhea virus infection Open
Background: Monocytes are significant players in the detection of invading pathogens, particularly in pathogen defense. Bovine Viral Diarrhea Virus (BVDV) can cause a persistent infection and immune suppression if animals are infected with…
View article: Optimization of rural settlements and the governance of rural relative poverty
Optimization of rural settlements and the governance of rural relative poverty Open
摘要:
View article: Transcriptomic analysis of bovine monocytes in response to non-cytopathic bovine viral diarrhea virus infection
Transcriptomic analysis of bovine monocytes in response to non-cytopathic bovine viral diarrhea virus infection Open
Background: Monocytes are significant players in the detection of invading pathogens, particularly in pathogen defense. Bovine Viral Diarrhea Virus (BVDV) can cause a persistent infection and immune suppression if animals are infected with…
View article: Zika Virus Induces Autophagy in Human Umbilical Vein Endothelial Cells
Zika Virus Induces Autophagy in Human Umbilical Vein Endothelial Cells Open
Autophagy is a common strategy for cell protection; however, some viruses can in turn adopt cellular autophagy to promote viral replication. Zika virus (ZIKV) is the pathogen that causes Zika viral disease, and it is a mosquito-borne virus…
View article: Oxidative stress contributes to the impaired sonic hedgehog pathway in type 1 diabetic mice with myocardial infarction
Oxidative stress contributes to the impaired sonic hedgehog pathway in type 1 diabetic mice with myocardial infarction Open
Our previous study demonstrated that an impaired sonic hedgehog (Shh) pathway contributed to cardiac dysfunction in type 1 diabetic mice with myocardial infarction (MI). The present study aimed to test the hypothesis that oxidative stress …