Yaning Shi
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View article: Quercetin Attenuates Cadmium-induced Renal Injury in Chickens via Suppression of Apoptosis and NLRP3 Inflammasome Activation
Quercetin Attenuates Cadmium-induced Renal Injury in Chickens via Suppression of Apoptosis and NLRP3 Inflammasome Activation Open
Background: Research has demonstrated that the heavy metal cadmium (Cd) causes significant damage to the kidneys. In contrast, the natural flavonoid quercetin (Que) possesses a variety of pharmacological effects that can alleviate the toxi…
View article: From Physicochemical Constraints to Clinical Prospects of Celastrol: Challenges and Nano Delivery Strategies
From Physicochemical Constraints to Clinical Prospects of Celastrol: Challenges and Nano Delivery Strategies Open
Celastrol (CeT) is the first pentacyclic triterpenoid compound isolated from the root bark of Tripterygium wilfordii. It has a broad spectrum of pharmacological activities, including anti-fibrosis, anti-tumor, anti-inflammation, imm…
View article: Research advances of extracellular vesicles in lung diseases
Research advances of extracellular vesicles in lung diseases Open
The lung is a vital organ in the respiratory system, and there is a critical need to develop more effective methods for lung health management. Extracellular vesicles (EVs) play an important role in intercellular communication. They exhibi…
View article: Research and application of 3D attribute fusion technology based on lithology probability analysis
Research and application of 3D attribute fusion technology based on lithology probability analysis Open
To address the challenges of seismic attribute selection and the low accuracy of characterizing single-phase river channels with a single seismic attribute, a 3D seismic attribute fusion technology based on lithology probability curve anal…
View article: Quercetin protects cadmium-induced kidney injury by regulating PI3K/AKT/mTOR and Nrf2/NQO1 pathways in rats
Quercetin protects cadmium-induced kidney injury by regulating PI3K/AKT/mTOR and Nrf2/NQO1 pathways in rats Open
View article: Sensitivity of renal cell carcinoma to cuproptosis: a bioinformatics analysis and experimental verification
Sensitivity of renal cell carcinoma to cuproptosis: a bioinformatics analysis and experimental verification Open
Purpose: Targeting cuproptosis is considered as a promising therapeutic strategy for the prevention of tumors. However, the potential role of cuproptosis and its related genes in clear cell renal cell carcinoma (ccRCC) remains elusi…
View article: Celastrol-Loaded Hyaluronic Acid/Cancer Cell Membrane Lipid Nanoparticles for Targeted Hepatocellular Carcinoma Prevention
Celastrol-Loaded Hyaluronic Acid/Cancer Cell Membrane Lipid Nanoparticles for Targeted Hepatocellular Carcinoma Prevention Open
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide, and its prevention and treatment face severe challenges. It is crucial to improve the targeting of drugs on tumor cells and tissues. Celastrol (C…
View article: Deciphering Biosynthesis Mechanism and Solution Properties of Cyclic Amylopectin
Deciphering Biosynthesis Mechanism and Solution Properties of Cyclic Amylopectin Open
A novel cyclic amylopectin (CA) was synthesized from waxy corn starch (WCS) using Bacillus stearothermophilus branching enzyme (BstBE), providing insights into its biosynthesis mechanism and solution properties. During the first 4 h, BstBE…
View article: Flower-Shaped PCR Scaffold-Based Lateral Flow Bioassay for Bacillus cereus Endospores Detection
Flower-Shaped PCR Scaffold-Based Lateral Flow Bioassay for Bacillus cereus Endospores Detection Open
Bacillus cereus, a foodborne pathogen, produces resilient endospores that are challenging to detect with conventional methods. This study presents a novel Flower-Shaped PCR Scaffold-based Lateral Flow Biosensor (FSPCRS-LFB), which employs …
View article: Protective effect of naringenin on cadmium chloride-induced renal injury via alleviating oxidative stress, endoplasmic reticulum stress, and autophagy in chickens
Protective effect of naringenin on cadmium chloride-induced renal injury via alleviating oxidative stress, endoplasmic reticulum stress, and autophagy in chickens Open
Cadmium (Cd) is a highly hazardous toxic substance that can cause serious harm to animals. Previous studies have indicated that cadmium chloride (CdCl 2 ) can damage organs, such as the liver, ovaries, and testicles. Naringenin (Nar) repre…
View article: Mechanisms of dihydromyricetin against hepatocellular carcinoma elucidated by network pharmacology combined with experimental validation
Mechanisms of dihydromyricetin against hepatocellular carcinoma elucidated by network pharmacology combined with experimental validation Open
Dihydromyricetin (DMY) is extracted from vine tea, a traditional Chinese herbal medicine with anti-cancer, liver protection, and cholesterol-lowering effects. This study investigated the mechanism of DMY against hepatocellular carcinoma (H…
View article: Celastrol functions as an emerging manager of lipid metabolism: Mechanism and therapeutic potential
Celastrol functions as an emerging manager of lipid metabolism: Mechanism and therapeutic potential Open
Lipid metabolism disorders are pivotal in the development of various lipid-related diseases, such as obesity, atherosclerosis, non-alcoholic fatty liver disease, type 2 diabetes, and cancer. Celastrol, a bioactive compound extracted from t…
View article: A Chinese Short Text Classification Method for Tax Audit Reports based on Word Importance and Syntactic Enhancement BERT
A Chinese Short Text Classification Method for Tax Audit Reports based on Word Importance and Syntactic Enhancement BERT Open
Tax audit is an important part of the tax collection and management system, which directly affects the economic interests of the country and taxpayers. Therefore, reducing the enforcement risk in tax audit is crucial to continuously improv…
View article: GSH-specific fluorescent probe for sensing, bioimaging, rapid screening of natural inhibitor Celastrol and ccRCC theranostics
GSH-specific fluorescent probe for sensing, bioimaging, rapid screening of natural inhibitor Celastrol and ccRCC theranostics Open
High level of intracellular glutathione (GSH) has been identified as a major barrier for cancer therapy. Therefore, effective regulation of GSH can be regarded as a novel approach for cancer therapy. In this study, an off-on fluorescent pr…
View article: Resistin-like molecules: a marker, mediator and therapeutic target for multiple diseases
Resistin-like molecules: a marker, mediator and therapeutic target for multiple diseases Open
Resistin-like molecules (RELMs) are highly cysteine-rich proteins, including RELMα, RELMβ, Resistin, and RELMγ. However, RELMs exhibit significant differences in structure, distribution, and function. The expression of RELMs is regulated b…
View article: The Synergistic Effect of Ascorbic and Abscisic Acids on Enriching AVC-Dominated Avenanthramides in Oat Germination Process
The Synergistic Effect of Ascorbic and Abscisic Acids on Enriching AVC-Dominated Avenanthramides in Oat Germination Process Open
View article: Effect of microwave and hot air drying on the quality of quick-cooking mung bean
Effect of microwave and hot air drying on the quality of quick-cooking mung bean Open
Recently, consumers prefer ready-to-eat foods due to their advantageous minimal input of time and effort. Soaking-cooking-drying is a typical procedure for preparing quick-cooking beans, where drying is the last but not least step. Therefo…
View article: A Lipid Perspective on Regulated Pyroptosis
A Lipid Perspective on Regulated Pyroptosis Open
Pyroptosis is a novel pro-inflammatory cell programmed death dependent on Gasdermin (GSMD) family-mediated membrane pore formation and subsequent cell lysis, accompanied by the release of inflammatory factors and expanding inflammation in …
View article: Sensitivity of renal cell carcinoma to cuproptosis and cuproptosis related genes FDX1 combined with DLAT as an immunological and prognostic biomarker
Sensitivity of renal cell carcinoma to cuproptosis and cuproptosis related genes FDX1 combined with DLAT as an immunological and prognostic biomarker Open
Background Targeting cuproptosis is being considered as a novel and promising therapeutic strategy for the prevention of tumors. Nonetheless, the potential role of cuproptosis and its related genes in renal cell carcinoma (RCC) remains elu…
View article: Sanguinarine protects against indomethacin-induced small intestine injury in rats by regulating the Nrf2/NF-κB pathways
Sanguinarine protects against indomethacin-induced small intestine injury in rats by regulating the Nrf2/NF-κB pathways Open
In recent years, small intestine as a key target in the treatment of Inflammatory bowel disease caused by NSAIDs has become a hot topic. Sanguinarine (SA) is one of the main alkaloids in the Macleaya cordata extracts with strong pharmacolo…
View article: Wnt5a/Ror2 promotes vascular smooth muscle cells proliferation via activating PKC
Wnt5a/Ror2 promotes vascular smooth muscle cells proliferation via activating PKC Open
Wnt5a could effectively promote the proliferation of VSMCs, which might be related to the binding of Wnt5a and Ror2 to activate PKC.
View article: New dawn for cancer cell death: Emerging role of lipid metabolism
New dawn for cancer cell death: Emerging role of lipid metabolism Open
View article: Sensitivity of Renal Cell Carcinoma to Cuproptosis and its Related Genes FDX1 Combined with DLAT as an Immunological and Prognostic Biomarker
Sensitivity of Renal Cell Carcinoma to Cuproptosis and its Related Genes FDX1 Combined with DLAT as an Immunological and Prognostic Biomarker Open
View article: Avian Eggshell Membrane as a Novel Biomaterial: A Review
Avian Eggshell Membrane as a Novel Biomaterial: A Review Open
The eggshell membrane (ESM), mainly composed of collagen-like proteins, is readily available as a waste product of the egg industry. As a novel biomaterial, ESM is attractive for its applications in the nutraceutical, cosmetic, and pharmac…
View article: Ultrasound-Assisted Extraction of Bound Phenolic Compounds from the Residue of Apocynum Venetum Tea and Their Antioxidant Activities
Ultrasound-Assisted Extraction of Bound Phenolic Compounds from the Residue of Apocynum Venetum Tea and Their Antioxidant Activities Open
View article: Celastrol ameliorates vascular neointimal hyperplasia through Wnt5a-involved autophagy
Celastrol ameliorates vascular neointimal hyperplasia through Wnt5a-involved autophagy Open
Neointimal hyperplasia caused by the excessive proliferation of vascular smooth muscle cells (VSMCs) is the pathological basis of restenosis. However, there are few effective strategies to prevent restenosis. Celastrol, a pentacyclic trite…
View article: Challenges and Countermeasures of China's Cyberspace Governance in the New Era
Challenges and Countermeasures of China's Cyberspace Governance in the New Era Open
In the context of the new era, countries are constantly competing and cooperating in the field of cyberspace. China is facing an increasingly complex international environment. Meanwhile, the number of domestic cyber citizens is increasing…
View article: Steroid receptor RNA activator inhibits the migration, invasion and stemness characteristics of renal cell carcinoma cells
Steroid receptor RNA activator inhibits the migration, invasion and stemness characteristics of renal cell carcinoma cells Open
Renal cell carcinoma (RCC) has a high mortality rate among urological malignancies, and its underlying mechanisms remain unclear. Steroid receptor RNA coactivator (SRA) belongs to the long non‑coding RNAs (lncRNAs) and has been demonstrate…
View article: The crosstalk: exosomes and lipid metabolism
The crosstalk: exosomes and lipid metabolism Open
Exosomes have been considered as novel and potent vehicles of intercellular communication, instead of “cell dust”. Exosomes are consistent with anucleate cells, and organelles with lipid bilayer consisting of the proteins and abundant lipi…
View article: Research on the construction of safety risk management objective system based on causes-means
Research on the construction of safety risk management objective system based on causes-means Open