Yanjun Zong
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View article: Hearing loss and pathological changes of cochlea in a mouse model carrying compound heterozygous variants in the <i>Gjb2</i> non‐coding region
Hearing loss and pathological changes of cochlea in a mouse model carrying compound heterozygous variants in the <i>Gjb2</i> non‐coding region Open
Background GJB2 gene variants are the most important cause of sensorineural hearing loss. A large number of clinical studies have focused on coding region variants, and a significant proportion of patients with single coding region variant…
View article: Novel compound heterozygous variants in the <i>TSPEAR</i> gene causing autosomal recessive hearing loss in a Chinese family
Novel compound heterozygous variants in the <i>TSPEAR</i> gene causing autosomal recessive hearing loss in a Chinese family Open
View article: The Effects of Viral Infections on the Molecular and Signaling Pathways Involved in the Development of the PAOs
The Effects of Viral Infections on the Molecular and Signaling Pathways Involved in the Development of the PAOs Open
Cytomegalovirus infection contributes to 10–30% of congenital hearing loss in children. Vertebrate peripheral auditory organs include the outer, middle, and inner ear. Their development is regulated by multiple signaling pathways. However,…
View article: Novel compound heterozygous variants in <scp><i>MARVELD2</i></scp> causing autosomal recessive hearing loss in two Chinese families
Novel compound heterozygous variants in <span><i>MARVELD2</i></span> causing autosomal recessive hearing loss in two Chinese families Open
Background Hereditary hearing loss is an important component of congenital hearing loss. MARVELD2 (OMIM ID:610572), located in the DFNB49 locus, which encodes a tight junction protein tricellulin playing an important role in the sensory ep…
View article: Inflammatory damage caused by Echovirus 30 in the suckling mouse brain and HMC3 cells
Inflammatory damage caused by Echovirus 30 in the suckling mouse brain and HMC3 cells Open
Echovirus 30 (E30), a member of the species B Enterovirus family, is a primary pathogen responsible for aseptic meningitis and encephalitis. E30 is associated with severe nervous system diseases and is a primary cause of child illness, dis…
View article: Cytomegalovirus Cause Congenital Hearing Loss by Regulating the Signaling Pathways in Developing Peripheral Auditory Organ
Cytomegalovirus Cause Congenital Hearing Loss by Regulating the Signaling Pathways in Developing Peripheral Auditory Organ Open
Cytomegalovirus infection contributes to 10-30% congenital hearing loss in children. Vertebrate peripheral auditory organs include the outer, middle and inner ear. Their development is regulated by multiple signaling pathways. However, mos…
View article: Cellular Processes Induced by HSV-1 Infections in Vestibular Neuritis
Cellular Processes Induced by HSV-1 Infections in Vestibular Neuritis Open
Herpesvirus is a prevalent pathogen that primarily infects human epithelial cells and has the ability to reside in neurons. In the field of otolaryngology, herpesvirus infection primarily leads to hearing loss and vestibular neuritis and i…
View article: Cellular Processes Induced by HSV-1 Infections in Vestibular Neuritis
Cellular Processes Induced by HSV-1 Infections in Vestibular Neuritis Open
Herpesvirus is a prevalent pathogen that primarily infects human epithelial cells and has the ability to reside in neurons. In the field of otolaryngology, herpesvirus infection primarily leads to hearing loss and vestibular neuritis, and …
View article: Cellular Processes Caused by Human Herpesviruses Infection
Cellular Processes Caused by Human Herpesviruses Infection Open
Herpesvirus is a prevalent pathogen that primarily infects human epithelial cells and has the ability to reside in neurons. In the field of otolaryngology, herpesvirus infection primarily leads to hearing loss and vestibular neuritis, and …
View article: Current drugs for HIV-1: from challenges to potential in HIV/AIDS
Current drugs for HIV-1: from challenges to potential in HIV/AIDS Open
The human immunodeficiency virus (HIV) persists in latently infected CD4 + T cells and integrates with the host genome until cell death. Acquired immunodeficiency syndrome (AIDS) is associated with HIV-1. Possibly, treating HIV/AIDS is an …
View article: Cytomembrane Trafficking Pathways of Connexin 26, 30, and 43
Cytomembrane Trafficking Pathways of Connexin 26, 30, and 43 Open
The connexin gene family is the most prevalent gene that contributes to hearing loss. Connexins 26 and 30, encoded by GJB2 and GJB6, respectively, are the most abundantly expressed connexins in the inner ear. Connexin 43, which is encoded …
View article: 11.4 T ultra-high static magnetic field has no effect on morphology but induces upregulation of TNF signaling pathway based on transcriptome analysis in zebrafish embryos
11.4 T ultra-high static magnetic field has no effect on morphology but induces upregulation of TNF signaling pathway based on transcriptome analysis in zebrafish embryos Open
As magnetic resonance imaging (MRI) scanners with ultra-high field (UHF) have optimal performance, scientists have been working to develop high-performance devices with strong magnetic fields to improve their diagnostic potential. However,…
View article: Coxsackievirus A6 Infection Causes Neurogenic Pathogenesis in a Neonatal Murine Model
Coxsackievirus A6 Infection Causes Neurogenic Pathogenesis in a Neonatal Murine Model Open
Coxsackievirus A6 (CVA6), a member of species A enterovirus, is associated with outbreaks of hand-foot-and-mouth disease and causes a large nationwide burden of disease. However, the molecular pathogenesis of CVA6 remains unclear. In the p…