Yongli Guo
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View article: Identification and functional analysis of a novel pathogenic variant in the <i>MYO6</i> gene in a family with autosomal dominant non-syndromic hearing loss: A case report
Identification and functional analysis of a novel pathogenic variant in the <i>MYO6</i> gene in a family with autosomal dominant non-syndromic hearing loss: A case report Open
Autosomal dominant non-syndromic hearing loss (ADNSHL) caused by MYO6 gene variation typically manifests as progressive post-lingual deafness. We identified an 11-member Chinese family across four generations with ADNSHL. We investigated t…
View article: Rapeseed Area Extraction Based on Time-Series Dual-Polarization Radar Vegetation Indices
Rapeseed Area Extraction Based on Time-Series Dual-Polarization Radar Vegetation Indices Open
Accurate, real-time, and dynamic monitoring of crop planting distributions in hilly areas with complex terrain and frequent meteorological changes is highly important for agricultural production. Dual-polarization SAR has high application …
View article: Development, optimization and application of a universal fluorescence multiplex PCR-based assay to detect BCOR genetic alterations in pediatric tumors
Development, optimization and application of a universal fluorescence multiplex PCR-based assay to detect BCOR genetic alterations in pediatric tumors Open
Accordingly, this assay provided an effective and convenient method for detecting BCOR- and YWHAE-related abnormalities in tumors.
View article: [The value of sequential organ failure assessment and its dynamic changes in predicting mortality in hematology intensive care unit].
[The value of sequential organ failure assessment and its dynamic changes in predicting mortality in hematology intensive care unit]. Open
Objective: To investigate the value of Sequential Organ Failure (SOFA) score and its dynamics (ΔSOFA) in predicting mortality in hematology care unit (HCU) . Methods: A retrospective clinical study was conducted on 79 critically ill hemato…
View article: Serum IL-6, IL-10, TNF-a changes in postpartum perineal oedema rehabilitation
Serum IL-6, IL-10, TNF-a changes in postpartum perineal oedema rehabilitation Open
Background: This study aims to evaluate the effectiveness of manual lymphatic drainage (MLD) combined with abdominal breathing in rehabilitating postpartum perineal oedema and Serum IL-6, IL-10, TNF-a. Methods: A total of 172 primiparous w…
View article: Development, optimization and application of a Universal Fluorescence Multiplex PCR-based assay to detect BCOR genetic alterations in pediatric tumors
Development, optimization and application of a Universal Fluorescence Multiplex PCR-based assay to detect BCOR genetic alterations in pediatric tumors Open
Background A number of genetic aberrations are associated with the BCL6-correpresor gene (BCOR), including internal tandem duplications (ITDs) and fusions (BCOR-CCNB3 and BCOR-MAML3), as well as YWHAE-NUTM2, which are found in clear cell s…
View article: [Role and mechanism of cysteine and glycine-rich protein 2 in the malignant progression of neuroblastoma].
[Role and mechanism of cysteine and glycine-rich protein 2 in the malignant progression of neuroblastoma]. Open
CSRP2 is highly expressed in high-risk NB with 3/4 INSS stages, and the expression levels of CSRP2 are negatively correlated with the overall survival of NB patients. CSRP2 significantly increased the proliferation and cell migration of NB…
View article: LncRNA ZNF674-AS1 drives cell growth and inhibits cisplatin-induced pyroptosis via up-regulating CA9 in neuroblastoma
LncRNA ZNF674-AS1 drives cell growth and inhibits cisplatin-induced pyroptosis via up-regulating CA9 in neuroblastoma Open
Neuroblastoma (NB) is a challenging pediatric extracranial solid tumor characterized by a poor prognosis and resistance to chemotherapy. Identifying targets to enhance chemotherapy sensitivity in NB is of utmost importance. Increasing evid…
View article: Spontaneous mutational patterns and novel mutations for bedaquiline and clofazimine resistance in <i>Mycobacterium tuberculosis</i>
Spontaneous mutational patterns and novel mutations for bedaquiline and clofazimine resistance in <i>Mycobacterium tuberculosis</i> Open
The 2022 World Health Organization guidelines recommend use of two core anti-tuberculosis (TB) drugs, bedaquiline (BDQ) and clofazimine (CFZ), for treatment of drug-resistant (DR)-TB. However, several mutated Mycobacterium tuberculosis (MT…
View article: Translational practice of fluorescence <i>in situ</i> hybridisation to identify neuroblastic tumours with <i>TERT</i> rearrangements
Translational practice of fluorescence <i>in situ</i> hybridisation to identify neuroblastic tumours with <i>TERT</i> rearrangements Open
Recently, telomerase reverse transcriptase ( TERT ) gene rearrangements have been identified in neuroblastoma (NB), the typical pathological type of neuroblastic tumours (NTs); however, the prevalence of TERT rearrangements in other types …
View article: Hypoglycemic activities of flowers of Xanthoceras sorbifolia and identification of anti-oxidant components by off-line UPLC-QTOF-MS/MS-free radical scavenging detection
Hypoglycemic activities of flowers of Xanthoceras sorbifolia and identification of anti-oxidant components by off-line UPLC-QTOF-MS/MS-free radical scavenging detection Open
The ethyl acetate layer was rich in flavonoids and phenolic acids and had significant anti-oxidant activity, which could prevent hyperglycemia. This observed activity profile suggested X. sorbifolia flowers as a promising new source of tea…
View article: Epidemiological characteristics of paediatric burn patients in China from 2016 to 2019: a retrospective study
Epidemiological characteristics of paediatric burn patients in China from 2016 to 2019: a retrospective study Open
Background Epidemiological characteristics of paediatric burn can help to protect children from burn injuries. Most of the previous studies have been conducted on small scale and single centre in China. This study analysed the epidemiologi…
View article: <scp>TAF1D</scp> promotes proliferation by transcriptionally activating <scp>G2</scp>/M phase‐related genes in <scp><i>MYCN</i></scp>‐amplified neuroblastoma
<span>TAF1D</span> promotes proliferation by transcriptionally activating <span>G2</span>/M phase‐related genes in <span><i>MYCN</i></span>‐amplified neuroblastoma Open
High‐risk neuroblastoma (HR‐NB) is an aggressive childhood cancer that responds poorly to currently available therapies and is associated with only about a 50% 5‐year survival rate. MYCN amplification is a critical driver of these aggressi…
View article: Biological Activity of Optimized Codon Bovine Type III Interferon Expressed in Pichia Pastoris
Biological Activity of Optimized Codon Bovine Type III Interferon Expressed in Pichia Pastoris Open
Type III interferon (IFN-λs) exhibit potent antiviral activity and immunomodulatory effects in specific cells. Nucleotide fragements of bovine ifn-λ (boifn-λ) gene was synthetized after codon optimization. The boifn-λ gene was then amplifi…
View article: Supplementary Tables S1-S5 from Characterization of Functional Excision Repair Cross-Complementation Group 1 Variants and Their Association with Lung Cancer Risk and Prognosis
Supplementary Tables S1-S5 from Characterization of Functional Excision Repair Cross-Complementation Group 1 Variants and Their Association with Lung Cancer Risk and Prognosis Open
Supplementary Tables S1-S5 from Characterization of Functional Excision Repair Cross-Complementation Group 1 Variants and Their Association with Lung Cancer Risk and Prognosis
View article: Supplementary Tables S1-S5 from Characterization of Functional Excision Repair Cross-Complementation Group 1 Variants and Their Association with Lung Cancer Risk and Prognosis
Supplementary Tables S1-S5 from Characterization of Functional Excision Repair Cross-Complementation Group 1 Variants and Their Association with Lung Cancer Risk and Prognosis Open
Supplementary Tables S1-S5 from Characterization of Functional Excision Repair Cross-Complementation Group 1 Variants and Their Association with Lung Cancer Risk and Prognosis
View article: Better design leads to better results – Importance of virological outcome design in clinical trials for antiviral treatment of coronavirus disease 2019
Better design leads to better results – Importance of virological outcome design in clinical trials for antiviral treatment of coronavirus disease 2019 Open
Since the outbreak of the pandemic coronavirus disease 2019 (COVID-19), various articles on different fields of the disease published in medical and related journals increased in a way of explosion.A recent literature search at PubMed usin…
View article: Clinical relevance of BCOR internal tandem duplication and TP53 aberration in clear cell sarcoma of the kidney
Clinical relevance of BCOR internal tandem duplication and TP53 aberration in clear cell sarcoma of the kidney Open
Clear cell sarcoma of the kidney (CCSK) is the second most common pediatric renal malignancy, characterized by BCOR internal tandem duplication (ITD), YWHAE rearrangement, BCOR-CCNB3 fusion, and lack of other consistent structural alterati…
View article: Spontaneous Mutational Patterns and Novel Mutations for Delamanid Resistance in Mycobacterium tuberculosis
Spontaneous Mutational Patterns and Novel Mutations for Delamanid Resistance in Mycobacterium tuberculosis Open
Delamanid (DLM) and pretomanid (PTM) are recent additions to the anti-tuberculosis (TB) drug armamentarium, and they offer more effective options for drug-resistant TB treatment. In particular, DLM is included in Group C, which is recommen…
View article: Potential Roles of Three ABCB Genes in Quinclorac Resistance Identified in Echinochloa crus-galli var. zelayensis
Potential Roles of Three ABCB Genes in Quinclorac Resistance Identified in Echinochloa crus-galli var. zelayensis Open
Echinochloa crus-galli var. zelayensis is a variant of E. crus-galli (L) Beauv, and it is the most pernicious weed in the east of China. Quinclorac, as synthetic auxin herbicide, could control this kind of weed effectively. In this study, …
View article: Long-term outcomes of CO2 laser cauterization for 238 children congenital pyriform sinus fistula
Long-term outcomes of CO2 laser cauterization for 238 children congenital pyriform sinus fistula Open
Objective To evaluate the efficacy and safety of single CO 2 laser cauterization management for children CPSF, we collected patients underwent CO 2 laser cauterization for internal fistula and accessed the long-term outcomes. Methods: Retr…