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View article: Sirtuins in Women’s Health
Sirtuins in Women’s Health Open
The human sirtuins (SIRT1–SIRT7) are NAD+-dependent protein deacylases that orchestrate key cellular events such as metabolism, stress response, DNA repair, and aging. Accumulating evidence highlights their central role in women’s health. …
View article: Differential regulation of SIRT5 activity by reduced nicotinic acid riboside (NARH)
Differential regulation of SIRT5 activity by reduced nicotinic acid riboside (NARH) Open
NARH activates SIRT5 through allosteric binding, enhancing desuccinylase activity on physiological substrates.
View article: Differential Regulation of SIRT5 Activity by Reduced Nicotinic Acid Riboside (NARH)
Differential Regulation of SIRT5 Activity by Reduced Nicotinic Acid Riboside (NARH) Open
SIRT5, one of the human sirtuins, catalyzes the removal of acyl substitutions from lysine residues in a NAD + -dependent manner. In addition to the deacetylase activity, SIRT5 also demonstrates strong desuccinylase, demalonylase, and deglu…
View article: An Overview of Glutaminyl Cyclase as a Promising Drug Target for Alzheimer’s Disease
An Overview of Glutaminyl Cyclase as a Promising Drug Target for Alzheimer’s Disease Open
Alzheimer’s disease (AD) has become an increasingly pressing concern for the aging population. Current AD treatments mainly focus on cognitive and neuropsychiatric symptoms—with few FDA-approved treatments targeting disease progression its…
View article: Nonlinear relationship between serum high sensitivity C reactive protein to high density lipoprotein cholesterol ratio with non-alcoholic fatty liver disease
Nonlinear relationship between serum high sensitivity C reactive protein to high density lipoprotein cholesterol ratio with non-alcoholic fatty liver disease Open
Non-alcoholic fatty liver disease (NAFLD) has become an increasing public health concern. We examined the association between serum high-sensitivity C-reactive protein(hs-CRP)to high-density lipoprotein cholesterol (HDL-C) ratio (HCHR) and…
View article: Biochemical characterization and discovery of inhibitors for <i>Pf</i>Sir2A: new tricks for an old enzyme
Biochemical characterization and discovery of inhibitors for <i>Pf</i>Sir2A: new tricks for an old enzyme Open
Pf Sir2A controls the var virulence gene expression in malaria parasites. Inhibitors targeting Pf Sir2A are potential antimalarial agents. In the current study, 3-TYP and NR are identified as lead compounds for further inhibitor developmen…
View article: Biochemical Characterization and Inhibitor Discovery for PfSir2A — New Tricks for An Old Enzyme
Biochemical Characterization and Inhibitor Discovery for PfSir2A — New Tricks for An Old Enzyme Open
The Sir2 enzyme from Plasmodium falciparum (PfSir2A) is essential for the antigenic variation of this parasite, and its inhibition is expected to have therapeutic effects for malaria. Selective PfSir2A inhibitors are not available yet, par…
View article: Post-Translational Modifications and Diabetes
Post-Translational Modifications and Diabetes Open
Diabetes and its associated complications have increasingly become major challenges for global healthcare. The current therapeutic strategies involve insulin replacement therapy for type 1 diabetes (T1D) and small-molecule drugs for type 2…
View article: Activation of SIRT6 Deacetylation by DNA Strand Breaks
Activation of SIRT6 Deacetylation by DNA Strand Breaks Open
SIRT6 is an emerging regulator of longevity. Overexpression of SIRT6 extends the lifespan of mice. Conversely, SIRT6 knockout mice demonstrate severe metabolic defects and a shortened lifespan. The discrepancy between SIRT6's weak in vitro…
View article: Nicotinamide riboside activates SIRT5 deacetylation
Nicotinamide riboside activates SIRT5 deacetylation Open
Human sirtuins play important roles in various cellular events including DNA repair, gene silencing, mitochondrial biogenesis, insulin secretion and apoptosis. They regulate a wide array of protein and enzyme targets through their NAD + ‐d…
View article: Multifunctional activity-based chemical probes for sirtuins
Multifunctional activity-based chemical probes for sirtuins Open
Multifunctional activity-based chemical probes enable sirtuin labeling, affinity capture, PROTAC construction, and inhibitor discovery.
View article: Human EXOG Possesses Strong AP Hydrolysis Activity: Implication on Mitochondrial DNA Base Excision Repair
Human EXOG Possesses Strong AP Hydrolysis Activity: Implication on Mitochondrial DNA Base Excision Repair Open
Most oxidative damage on mitochondrial DNA is corrected by the base excision repair (BER) pathway. However, the enzyme that catalyzes the rate-limiting reaction─deoxyribose phosphate (dRP) removal─in the multienzymatic reaction pathway has…
View article: Emerging Role of Nicotinamide Riboside in Health and Diseases
Emerging Role of Nicotinamide Riboside in Health and Diseases Open
Among all the NAD+ precursors, nicotinamide riboside (NR) has gained the most attention as a potent NAD+-enhancement agent. This recently discovered vitamin, B3, has demonstrated excellent safety and efficacy profiles and is orally bioavai…
View article: Plasmodium falciparum Nicotinamidase as A Novel Antimalarial Target
Plasmodium falciparum Nicotinamidase as A Novel Antimalarial Target Open
Inhibition of Plasmodium falciparum nicotinamidase could represent a potential antimalarial since parasites require nicotinic acid to successfully recycle nicotinamide to NAD+, and importantly, humans lack this biosynthetic enzyme. Recentl…
View article: Facile synthesis of photoactivatable adenosine analogs
Facile synthesis of photoactivatable adenosine analogs Open
Photoactivatable adenosine analog-enabled capture and enrichment of adenosine binding protein (ABP).
View article: Human Sirtuin Regulators: The “Success” Stories
Human Sirtuin Regulators: The “Success” Stories Open
The human sirtuins are a group of NAD + -dependent protein deacylases. They “erase” acyl modifications from lysine residues in various cellular targets including histones, transcription factors, and metabolic enzymes. Through these far-rea…
View article: Small Molecule Regulators Targeting NAD+ Biosynthetic Enzymes
Small Molecule Regulators Targeting NAD+ Biosynthetic Enzymes Open
: Nicotinamide adenine dinucleotide (NAD+) is a key player in many metabolic pathways as an activated carrier of electrons. In addition to being the cofactor for redox re-actions, NAD+ also serves as the substrate for various enzymatic tra…
View article: Substrate-Dependent Sensitivity of SIRT1 to Nicotinamide Inhibition
Substrate-Dependent Sensitivity of SIRT1 to Nicotinamide Inhibition Open
SIRT1 is the most extensively studied human sirtuin with a broad spectrum of endogenous targets. It has been implicated in the regulation of a myriad of cellular events, such as gene transcription, mitochondria biogenesis, insulin secretio…
View article: Retraction: Divergent synthesis of 5-substituted pyrimidine 2′-deoxynucleosides and their incorporation into oligodeoxynucleotides for the survey of uracil DNA glycosylases
Retraction: Divergent synthesis of 5-substituted pyrimidine 2′-deoxynucleosides and their incorporation into oligodeoxynucleotides for the survey of uracil DNA glycosylases Open
Retraction of ‘Divergent synthesis of 5-substituted pyrimidine 2′-deoxynucleosides and their incorporation into oligodeoxynucleotides for the survey of uracil DNA glycosylases’ by Ai Tran et al. , Chem. Sci. , 2020, 11 , 11818–11826, DOI: …
View article: Retraction: Convenient synthesis of pyrimidine 2′-deoxyribonucleoside monophosphates with important epigenetic marks at the 5-position
Retraction: Convenient synthesis of pyrimidine 2′-deoxyribonucleoside monophosphates with important epigenetic marks at the 5-position Open
Retraction of ‘Convenient synthesis of pyrimidine 2′-deoxyribonucleoside monophosphates with important epigenetic marks at the 5-position’ by Song Zheng et al., Org. Biomol. Chem., 2020, 18, 5164–5173, DOI: 10.1039/D0OB00884B.
View article: Development of Second Generation Activity-Based Chemical Probes for Sirtuins
Development of Second Generation Activity-Based Chemical Probes for Sirtuins Open
NAD+ (nicotinamide adenine dinucleotide)-dependent protein deacylases, namely, the sirtuins, are important cell adaptor proteins that alter cell physiology in response to low calorie conditions. They are thought to mediate the beneficial e…
View article: IOX1 Suppresses Wnt Target Gene Transcription and Colorectal Cancer Tumorigenesis through Inhibition of KDM3 Histone Demethylases
IOX1 Suppresses Wnt Target Gene Transcription and Colorectal Cancer Tumorigenesis through Inhibition of KDM3 Histone Demethylases Open
Epigenetic activation of Wnt/β-catenin signaling plays a critical role in Wnt-induced tumorigenesis, notably in colorectal cancers. KDM3 and KDM4 histone demethylases have been reported to promote oncogenic Wnt signaling through demethylat…
View article: Author Correction: Activation of SIRT6 by DNA hypomethylating agents and clinical consequences on combination therapy in leukemia
Author Correction: Activation of SIRT6 by DNA hypomethylating agents and clinical consequences on combination therapy in leukemia Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: Retracted Article: Divergent synthesis of 5-substituted pyrimidine 2′-deoxynucleosides and their incorporation into oligodeoxynucleotides for the survey of uracil DNA glycosylases
Retracted Article: Divergent synthesis of 5-substituted pyrimidine 2′-deoxynucleosides and their incorporation into oligodeoxynucleotides for the survey of uracil DNA glycosylases Open
A divergent approach has been developed for the synthesis of epigenetically important pyrimidine 2′-deoxynucleosides from one common precursor. These nucleosides were incorporated into oligodeoxynucleotides for the survey of uracil DNA gly…
View article: Polarity of Hydrated Phosphatidylcholine Headgroups
Polarity of Hydrated Phosphatidylcholine Headgroups Open
The headgroup (H) stratum (sometimes called the polar region) of membrane bilayers is a relevant yet poorly understood solvation phase for small molecules and macromolecules interacting with the membranes. Solvation of compounds in bilayer…
View article: Development of Activity-Based Chemical Probes for Human Sirtuins
Development of Activity-Based Chemical Probes for Human Sirtuins Open
Sirtuins consume stoichiometric amounts of nicotinamide adenine dinucleotide (NAD+) to remove an acetyl group from lysine residues. These enzymes have been implicated in regulating various cellular events and have also been suggested to me…