Yann Guérardel
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View article: Cell wall arabinogalactan is responsible for Fungitell® cross reactivity in nocardiosis
Cell wall arabinogalactan is responsible for Fungitell® cross reactivity in nocardiosis Open
Nocardiosis is a serious infection in immunosuppressed patients, especially transplant recipients. The slow-growing phenotype of the bacterium and the variety of symptoms complicate diagnosis and delay antimicrobial therapy, resulting in h…
View article: The glycocalyx of Lacticaseibacillus paracasei NPB01 presents two different rhamnose-rich polysaccharides with non-equivalent immunomodulating activities
The glycocalyx of Lacticaseibacillus paracasei NPB01 presents two different rhamnose-rich polysaccharides with non-equivalent immunomodulating activities Open
Lacticaseibacillus paracasei cell wall presents two capsular polysaccharides, CPS-1 and CPS-2, and a teichoic acid. CPS-1 is novel and it presents a branched heptasaccharide repeating unit, with the sequence →6)-α-d-Gal-(1→3)-β-l-Rha-(1→4)…
View article: Uncommon N-Glycan Structures in Anhydrobiotic Tardigrades
Uncommon N-Glycan Structures in Anhydrobiotic Tardigrades Open
View article: A glycosylated lipooctapeptide promotes uptake and growth of Mycobacterium abscessus in the host
A glycosylated lipooctapeptide promotes uptake and growth of Mycobacterium abscessus in the host Open
View article: Anemonefish use sialic acid metabolism as Trojan horse to avoid giant sea anemone stinging
Anemonefish use sialic acid metabolism as Trojan horse to avoid giant sea anemone stinging Open
Background Anemonefish association with sea anemones is a prime example of mutualistic symbiosis. These fish live inside the sea anemone, benefitting from the protection of its toxic nematocysts, and in return, protect the anemone from its…
View article: Biochemical characterization of the Escherichia coli surfaceome: a focus on type I fimbriae and flagella
Biochemical characterization of the Escherichia coli surfaceome: a focus on type I fimbriae and flagella Open
The Escherichia coli surfaceome consists mainly of the large surface organelles expressed by the organism to navigate and interact with the surrounding environment. The current study focuses on type I fimbriae and flagella. These large pol…
View article: Glycan-mediated adhesion mechanisms in antibiotic-resistant bacteria
Glycan-mediated adhesion mechanisms in antibiotic-resistant bacteria Open
View article: A ganglioside-based immune checkpoint enables senescent cells to evade immunosurveillance during aging
A ganglioside-based immune checkpoint enables senescent cells to evade immunosurveillance during aging Open
View article: Corrigendum to “Dissecting the Enterococcal Polysaccharide Antigen (EPA) structure to explore innate immune evasion and phage specificity” [Carbohydr. Polym. 347 (1 January 2025) 122686]
Corrigendum to “Dissecting the Enterococcal Polysaccharide Antigen (EPA) structure to explore innate immune evasion and phage specificity” [Carbohydr. Polym. 347 (1 January 2025) 122686] Open
View article: A dTDP-L-rhamnose 4-epimerase required for glycopeptidolipid biosynthesis in Mycobacterium abscessus
A dTDP-L-rhamnose 4-epimerase required for glycopeptidolipid biosynthesis in Mycobacterium abscessus Open
Mycobacterium abscessus causes severe lung infections in cystic fibrosis patients and exhibits smooth (S) or rough (R) morphotypes. Disruption of glycopeptidolipid (GPL) production results in the S-to-R transition but the underlying molecu…
View article: Lipidomic analyses reveal distinctive variations in homeoviscous adaptation among clinical strains of <i>Acinetobacter baumannii</i> , providing insights from an environmental adaptation perspective
Lipidomic analyses reveal distinctive variations in homeoviscous adaptation among clinical strains of <i>Acinetobacter baumannii</i> , providing insights from an environmental adaptation perspective Open
Acinetobacter baumannii is known for its antibiotic resistance and is increasingly found outside of healthcare settings. To survive colder temperatures, bacteria, including A. baumannii , adapt by modifying glycerophospholipids (GPL) to ma…
View article: Dissecting the Enterococcal Polysaccharide Antigen (EPA) structure to explore innate immune evasion and phage specificity
Dissecting the Enterococcal Polysaccharide Antigen (EPA) structure to explore innate immune evasion and phage specificity Open
International audience
View article: Cell wall arabinogalactan is responsible for Fungitell® cross reactivity in nocardiosis
Cell wall arabinogalactan is responsible for Fungitell® cross reactivity in nocardiosis Open
Nocardiosis is a serious infection in immunosuppressed patients, especially transplant recipients. The slow-growing phenotype of the bacterium and the variety of symptoms complicate diagnosis and delay antimicrobial therapy, which results …
View article: The Enterococcal Polysaccharide Antigen: from structure to biosynthesis and function
The Enterococcal Polysaccharide Antigen: from structure to biosynthesis and function Open
L-Rhamnose-containing polysaccharides are produced by Streptococci and Enterococci. They define Lancefield serotypes and represent promising candidates for the design of glycoconjugate vaccines. The Enterococcal Polysaccharide Antigen prod…
View article: Anemonefish use sialic acid metabolism as Trojan horse to avoid giant sea anemone stinging
Anemonefish use sialic acid metabolism as Trojan horse to avoid giant sea anemone stinging Open
Anemonefish association with giant sea anemone is an iconic example of mutualistic symbiosis. Living inside the sea anemone without triggering the firing of highly toxic nematocysts present at the surface of sea anemone tentacles provides …
View article: Biochemical characterization of the<i>Escherichia coli</i>surfaceome: A focus on type I fimbriae and flagella
Biochemical characterization of the<i>Escherichia coli</i>surfaceome: A focus on type I fimbriae and flagella Open
The Escherichia coli surfaceome consists mainly of the large surface organelles expressed by the organism to navigate and interact with the surrounding environment. The current study focuses on type I fimbriae and flagella. These large pol…
View article: Dissecting the Enterococcal Polysaccharide Antigen (Epa) Structure to Explore Innate Immune Evasion and Phage Specificity
Dissecting the Enterococcal Polysaccharide Antigen (Epa) Structure to Explore Innate Immune Evasion and Phage Specificity Open
View article: MicroGlycoDB: A database of microbial glycans using Semantic Web technologies
MicroGlycoDB: A database of microbial glycans using Semantic Web technologies Open
Glycoconjugates are present on microbial surfaces and play critical roles in modulating interactions with the environment and the host. Extensive research on microbial glycans, including elucidating the structural diversity of the glycan m…
View article: The Mla system of diderm Firmicute Veillonella parvula reveals an ancestral transenvelope bridge for phospholipid trafficking
The Mla system of diderm Firmicute Veillonella parvula reveals an ancestral transenvelope bridge for phospholipid trafficking Open
View article: Unraveling the Interplay of Temperature Adaptation, Lipidomics, and Environmental Factors in<i>Acinetobacter baumannii</i>Clinical Strains
Unraveling the Interplay of Temperature Adaptation, Lipidomics, and Environmental Factors in<i>Acinetobacter baumannii</i>Clinical Strains Open
Acinetobacter baumannii has gained prominence due to its heightened antibiotic resistance and adaptability within healthcare settings. Unlike other Acinetobacter species, A. baumannii predominantly thrives within healthcare environments, w…
View article: Membrane lipid composition of Carnobacterium maltaromaticum CNCM I-3298, a highly cryoresistant lactic bacterium
Membrane lipid composition of Carnobacterium maltaromaticum CNCM I-3298, a highly cryoresistant lactic bacterium Open
View article: Bridges instead of boats? The Mla system of diderm Firmicute<i>Veillonella parvula</i>reveals an ancestral transenvelope core of phospholipid trafficking
Bridges instead of boats? The Mla system of diderm Firmicute<i>Veillonella parvula</i>reveals an ancestral transenvelope core of phospholipid trafficking Open
Despite extensive characterisation of envelope biogenesis systems in diderm bacteria, glycerophospholipid (GPL) trafficking remains poorly understood, and has only been studied in a handful of model species. Within the Proteobacteria, the …
View article: Multiple Mycobacterium abscessus O-acetyltransferases influence glycopeptidolipid structure and colony morphotype
Multiple Mycobacterium abscessus O-acetyltransferases influence glycopeptidolipid structure and colony morphotype Open
View article: Species-Specific N-Glycomes and Methylation Patterns of Oysters Crassostrea gigas and Ostrea edulis and Their Possible Consequences for the Norovirus–HBGA Interaction
Species-Specific N-Glycomes and Methylation Patterns of Oysters Crassostrea gigas and Ostrea edulis and Their Possible Consequences for the Norovirus–HBGA Interaction Open
Noroviruses, the major cause of acute viral gastroenteritis, are known to bind to histo-blood group antigens (HBGAs), including ABH groups and Lewis-type epitopes, which decorate the surface of erythrocytes and epithelial cells of their ho…
View article: The Autophagy Nucleation Factor ATG9 Forms Nanoclusters with the HIV-1 Receptor DC-SIGN and Regulates Early Antiviral Autophagy in Human Dendritic Cells
The Autophagy Nucleation Factor ATG9 Forms Nanoclusters with the HIV-1 Receptor DC-SIGN and Regulates Early Antiviral Autophagy in Human Dendritic Cells Open
Dendritic cells (DC) are critical cellular mediators of host immunity, notably by expressing a broad panel of pattern recognition receptors. One of those receptors, the C-type lectin receptor DC-SIGN, was previously reported as a regulator…
View article: Structure–function analysis of Lactiplantibacillus plantarum DltE reveals D-alanylated lipoteichoic acids as direct cues supporting Drosophila juvenile growth
Structure–function analysis of Lactiplantibacillus plantarum DltE reveals D-alanylated lipoteichoic acids as direct cues supporting Drosophila juvenile growth Open
Metazoans establish mutually beneficial interactions with their resident microorganisms. However, our understanding of the microbial cues contributing to host physiology remains elusive. Previously, we identified a bacterial machinery enco…
View article: Author response: Structure–function analysis of Lactiplantibacillus plantarum DltE reveals D-alanylated lipoteichoic acids as direct cues supporting Drosophila juvenile growth
Author response: Structure–function analysis of Lactiplantibacillus plantarum DltE reveals D-alanylated lipoteichoic acids as direct cues supporting Drosophila juvenile growth Open
View article: Membrane lipid composition of Carnobacterium maltaromaticum CNCM I-3298, a highly cryoresistant lactic acid bacterium
Membrane lipid composition of Carnobacterium maltaromaticum CNCM I-3298, a highly cryoresistant lactic acid bacterium Open
The growing consumption of fermented products has led to an increasing demand for lactic acid bacteria (LAB), especially for LAB tolerant to freezing/thawing conditions. Carnobacterium maltaromaticum is a psychrotrophic and freeze-thawing …
View article: Structural and functional analysis of natural capsid variants suggests sialic acid-independent entry of BK polyomavirus
Structural and functional analysis of natural capsid variants suggests sialic acid-independent entry of BK polyomavirus Open
BK polyomavirus (BKPyV) is an opportunistic pathogen that uses the b-series gangliosides GD1b and GT1b as entry receptors. Here, we characterize the impact of naturally occurring VP1 mutations on ganglioside binding, VP1 protein structure,…
View article: The Structure of Glycan Isolated from the Episymbiotic Microbial Community of Deep-Sea Vent Squat Lobsters
The Structure of Glycan Isolated from the Episymbiotic Microbial Community of Deep-Sea Vent Squat Lobsters Open