Yann Thoma
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View article: Therapeutic Drug Monitoring and Point-of-Care Technologies: Opportunities and Current Challenges
Therapeutic Drug Monitoring and Point-of-Care Technologies: Opportunities and Current Challenges Open
Background: This review re-evaluates therapeutic drug monitoring (TDM) by comparing the current analytical and subsequent clinical interpretation capabilities of hospital or community medical laboratories with the emerging potential of poi…
View article: Numerical Verification of Tucuxi, a Promising Bayesian Adaptation Tool for Model‐Informed Precision Dosing
Numerical Verification of Tucuxi, a Promising Bayesian Adaptation Tool for Model‐Informed Precision Dosing Open
Tucuxi, a Swiss‐developed Model‐Informed Precision Dosing (MIPD) software, aims to support clinical dosage decision‐making to achieve therapeutic concentration targets. This study assessed its predictive accuracy compared to NONMEM, a gold…
View article: Rifampicin Exposure in Tuberculosis Patients with Comorbidities in Sub-Saharan Africa: Prioritising Populations for Treatment—A Systematic Review and Meta-analysis
Rifampicin Exposure in Tuberculosis Patients with Comorbidities in Sub-Saharan Africa: Prioritising Populations for Treatment—A Systematic Review and Meta-analysis Open
Our results emphasise the need for individualised dosing and targeted TDM implementation among TB-HIV and TB-DM populations on rifampicin in SSA. Although all populations exhibited low Cmax levels, TB-HIV populations may be prio…
View article: Individualization of piperacillin dosage based on therapeutic drug monitoring with or without model-informed precision dosing: a scenario analysis
Individualization of piperacillin dosage based on therapeutic drug monitoring with or without model-informed precision dosing: a scenario analysis Open
Background Model-informed precision dosing (MIPD) combines population pharmacokinetic knowledge with therapeutic drug monitoring (TDM) to optimize dosage adjustment. It could improve target concentration attainment over empirical TDM, stil…
View article: Importance of Sex-Dependent Differences for Dosing Selection and Optimization of Chemotherapeutic Drugs
Importance of Sex-Dependent Differences for Dosing Selection and Optimization of Chemotherapeutic Drugs Open
Background: Despite major advances in cancer treatment in the past years, there is a need to optimize chemotherapeutic drug dosing strategies to reduce toxicities, suboptimal responses, and the risk of relapse. Most cancer drugs have a nar…
View article: State of the art of real-life concentration monitoring of rifampicin and its implementation contextualized in resource-limited settings: the Tanzanian case
State of the art of real-life concentration monitoring of rifampicin and its implementation contextualized in resource-limited settings: the Tanzanian case Open
The unique medical and socio-economic situation in each country affected by TB creates different epidemiological contexts, thus providing exploitable loopholes for the spread of the disease. Country-specific factors such as comorbidities, …
View article: Toward a Clinical Decision Support System for Monitoring Therapeutic Antituberculosis Medical Drugs in Tanzania (Project TuberXpert): Protocol for an Algorithm' Development and Implementation
Toward a Clinical Decision Support System for Monitoring Therapeutic Antituberculosis Medical Drugs in Tanzania (Project TuberXpert): Protocol for an Algorithm' Development and Implementation Open
Background The end tuberculosis (TB) strategy requires a novel patient treatment approach contrary to the one-size-fits-all model. It is well known that each patient’s physiology is different and leads to various rates of drug elimination.…
View article: Improving population scale statistical phasing with whole-genome sequencing data
Improving population scale statistical phasing with whole-genome sequencing data Open
Haplotype estimation, or phasing, has gained significant traction in large-scale projects due to its valuable contributions to population genetics, variant analysis, and the creation of reference panels for imputation and phasing of new sa…
View article: Identification and Quantification of Multiple Drugs by Machine Learning on Electrochemical Sensors for Therapeutic Drug Monitoring
Identification and Quantification of Multiple Drugs by Machine Learning on Electrochemical Sensors for Therapeutic Drug Monitoring Open
Electrochemical sensors play a pivotal role in advancing therapeutic drug monitoring (TDM) and personalized therapy. However, the insufficient selectivity of electrochemical sensors based on cytochromes P450 poses a great need for innovati…
View article: Automatic simulation of electrochemical sensors by machine learning for drugs quantification
Automatic simulation of electrochemical sensors by machine learning for drugs quantification Open
View article: Bayesian Vancomycin Model Selection for Therapeutic Drug Monitoring in Neonates
Bayesian Vancomycin Model Selection for Therapeutic Drug Monitoring in Neonates Open
The De Cock model was selected based on a comprehensive approach of model selection to individualize vancomycin dosing in our neonates.
View article: Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) methods for the therapeutic drug monitoring of cytotoxic anticancer drugs: An update
Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) methods for the therapeutic drug monitoring of cytotoxic anticancer drugs: An update Open
View article: The TuberXpert project protocol: Towards a Clinical Decision Support System for therapeutic anti-tuberculosis medical drugs monitoring in Tanzania
The TuberXpert project protocol: Towards a Clinical Decision Support System for therapeutic anti-tuberculosis medical drugs monitoring in Tanzania Open
Introduction The End Tuberculosis (TB) Strategy requires a novel patient treatment approach contrary to the “one-size fits all” model. It is well known that each patient’s physiology is different and leads to various rates of drug eliminat…
View article: Improving population scale statistical phasing with whole-genome sequencing data
Improving population scale statistical phasing with whole-genome sequencing data Open
Haplotype estimation, or phasing, has gained significant traction in large-scale projects due to its valuable contributions to population genetics, variant analysis, and the creation of reference panels for imputation and phasing of new sa…
View article: Precision Oncology by Point-of-Care Therapeutic Drug Monitoring and Dosage Adjustment of Conventional Cytotoxic Chemotherapies: A Perspective
Precision Oncology by Point-of-Care Therapeutic Drug Monitoring and Dosage Adjustment of Conventional Cytotoxic Chemotherapies: A Perspective Open
Therapeutic drug monitoring (TDM) of conventional cytotoxic chemotherapies is strongly supported yet poorly implemented in daily practice in hospitals. Analytical methods for the quantification of cytotoxic drugs are instead widely present…
View article: Exploiting parallelization in positional Burrows–Wheeler transform (PBWT) algorithms for efficient haplotype matching and compression
Exploiting parallelization in positional Burrows–Wheeler transform (PBWT) algorithms for efficient haplotype matching and compression Open
Summary The positional Burrows–Wheeler transform (PBWT) data structure allows for efficient haplotype data matching and compression. Its performance makes it a powerful tool for bioinformatics. However, existing algorithms do not exploit p…
View article: Discrepancies Between Bayesian Vancomycin Models Can Affect Clinical Decisions in the Critically Ill
Discrepancies Between Bayesian Vancomycin Models Can Affect Clinical Decisions in the Critically Ill Open
Purpose. To assess the agreement in 24-hour area under the curve (AUC24) value estimates between commonly used vancomycin population pharmacokinetic models in the critically ill. Materials and Methods. Adults admitted to intensive care who…
View article: Implementation and Cross-Validation of a Pharmacokinetic Model for Precision Dosing of Busulfan in Hematopoietic Stem Cell Transplanted Children
Implementation and Cross-Validation of a Pharmacokinetic Model for Precision Dosing of Busulfan in Hematopoietic Stem Cell Transplanted Children Open
Busulfan, a drug used in conditioning prior to hematopoietic stem cell transplantation (HSCT) in children, has a narrow therapeutic margin. The model-informed precision dosing (MIPD) of busulfan is desirable, but there is a lack of validat…
View article: XSI—a genotype compression tool for compressive genomics in large biobanks
XSI—a genotype compression tool for compressive genomics in large biobanks Open
Motivation Generation of genotype data has been growing exponentially over the last decade. With the large size of recent datasets comes a storage and computational burden with ever increasing costs. To reduce this burden, we propose XSI, …
View article: Therapeutic drug monitoring of cefepime in a non-critically ill population: retrospective assessment and potential role for model-based dosing
Therapeutic drug monitoring of cefepime in a non-critically ill population: retrospective assessment and potential role for model-based dosing Open
Objectives To describe the therapeutic drug monitoring (TDM) of cefepime in non-critically ill adults and compare four different ways of dosing: conventional table-based; empirically adjusted following TDM; individualized based on a popula…
View article: Implementation and Comparison of Two Pharmacometric Tools for Model-Based Therapeutic Drug Monitoring and Precision Dosing of Daptomycin
Implementation and Comparison of Two Pharmacometric Tools for Model-Based Therapeutic Drug Monitoring and Precision Dosing of Daptomycin Open
Daptomycin is a candidate for therapeutic drug monitoring (TDM). The objectives of this work were to implement and compare two pharmacometric tools for daptomycin TDM and precision dosing. A nonparametric population PK model developed from…
View article: SpikeOnChip : A Custom Embedded Platform for Neuronal Activity Recording and Analysis
SpikeOnChip : A Custom Embedded Platform for Neuronal Activity Recording and Analysis Open
In this paper we present SpikeOnChip, a custom embedded platform for neuronal activity recording and online analysis. The SpikeOnChip platform was developed in the context of automated drug testing and toxicology assessments on neural tiss…
View article: Bayesian forecasting for intravenous tobramycin dosing in adults with Cystic Fibrosis using one versus two serum concentrations in a dosing interval
Bayesian forecasting for intravenous tobramycin dosing in adults with Cystic Fibrosis using one versus two serum concentrations in a dosing interval Open
Background Intravenous tobramycin requires therapeutic drug monitoring (TDM) to ensure safety and efficacy when used for prolonged treatment, as in infective exacerbations of Cystic Fibrosis (CF). The 24 hour area under the concentration t…
View article: The Steps to Therapeutic Drug Monitoring: A Structured Approach Illustrated With Imatinib
The Steps to Therapeutic Drug Monitoring: A Structured Approach Illustrated With Imatinib Open
Pharmacometric methods have hugely benefited from progress in analytical and computer sciences during the past decades, and play nowadays a central role in the clinical development of new medicinal drugs. It is time that these methods tran…
View article: Acceleration of the Pair-HMM forward algorithm on FPGA with cloud integration for GATK
Acceleration of the Pair-HMM forward algorithm on FPGA with cloud integration for GATK Open
The Pair-HMM forward algorithm is an essential algorithm found in many genomic related analyses. The high number of floating point operations in the algorithm makes it one of the main contributors to the compute time of analysis pipelines.…
View article: TUCUXI
TUCUXI Open
Therapeutic Drug Monitoring (TDM) is a key concept in precision medicine. The goal of TDM is to avoid therapeutic failure or toxic effects of a drug due to insufficient or excessive circulating concentration exposure related to between-pat…