Yannic Döring
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Analysing complex excitation patterns in cardiac tissue using wave event networks Open
Cardiac dynamics is governed by complex electrical wave patterns, with disruptions leading to pathological conditions like atrial or ventricular fibrillation. Experimentally electrical excitation waves can be made visible by optical mappin…
Analysing complex excitation patterns in cardiac tissue using wave event networks Open
Cardiac dynamics is governed by complex electrical wave patterns, with disruptions leading to pathological conditions like atrial or ventricular fibrillation. Experimentally electrical excitation waves can be made visible by optical mappin…
View article: Cytosolic calcium handling signature: integration with clinical predictors enhances prediction of post-operative atrial fibrillation
Cytosolic calcium handling signature: integration with clinical predictors enhances prediction of post-operative atrial fibrillation Open
Background and Aims Atrial fibrillation (AF) is a prevalent complication after cardiac surgery, worsening patient outcomes. Considering the established role of Ca2+-handling abnormalities in AF pathogenesis, this study aimed to evaluate if…
View article: Impaired Intracellular Calcium Buffering Contributes to the Arrhythmogenic Substrate in Atrial Myocytes From Patients With Atrial Fibrillation
Impaired Intracellular Calcium Buffering Contributes to the Arrhythmogenic Substrate in Atrial Myocytes From Patients With Atrial Fibrillation Open
BACKGROUND: Alterations in the buffering of intracellular Ca 2+ , for which myofilament proteins play a key role, have been shown to promote cardiac arrhythmia. It is interesting that although studies report atrial myofibrillar degradation…
View article: Implications for neutrophils in cardiac arrhythmias
Implications for neutrophils in cardiac arrhythmias Open
Cardiac arrhythmias commonly occur as a result of aberrant electrical impulse formation or conduction in the myocardium. Frequently discussed triggers include underlying heart diseases such as myocardial ischemia, electrolyte imbalances, o…
Therapeutic efficacy of AAV-mediated restoration of PKP2 in arrhythmogenic cardiomyopathy Open
Arrhythmogenic cardiomyopathy is a severe cardiac disorder characterized by lethal arrhythmias and sudden cardiac death, with currently no effective treatment. Plakophilin 2 ( PKP2 ) is the most frequently affected gene. Here we show that …