Yannick Chantran
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View article: Baseline Serum Tryptase: Sex‐ and Age‐Specific Reference Intervals in the Pediatric and Adult Population
Baseline Serum Tryptase: Sex‐ and Age‐Specific Reference Intervals in the Pediatric and Adult Population Open
International audience
View article: Hereditary alpha-tryptasemia and monoclonal mast cell disorders
Hereditary alpha-tryptasemia and monoclonal mast cell disorders Open
Monoclonal mast cell disorders (mMCD), including systemic mastocytosis, are characterized by the abnormal accumulation of clonal mast cells, often leading to elevated baseline serum tryptase (bST) levels. Thus, bST evaluation is useful for…
View article: Subtle Alterations in Hippocampal Neuronal Activity Coincide With Early Sex‐Specific Differences in Amyloidosis and Microglia in a Pre‐Symptomatic Mouse Model of Alzheimer‐Like Pathology
Subtle Alterations in Hippocampal Neuronal Activity Coincide With Early Sex‐Specific Differences in Amyloidosis and Microglia in a Pre‐Symptomatic Mouse Model of Alzheimer‐Like Pathology Open
Growing evidence highlights sex‐related differences in the pathogenesis of Alzheimer's disease (AD). Yet, early impact of sex on neuronal activity and microglia in the hippocampus, a main site of memory formation and one of the most vulner…
View article: Molecular allergen sensitization drives phenotypes of severe asthma in children: Evidence from a megacity cohort (<scp>SAMP</scp>)
Molecular allergen sensitization drives phenotypes of severe asthma in children: Evidence from a megacity cohort (<span>SAMP</span>) Open
Background Several major sensitization profiles have been described in children with asthma, but it remains unclear how these profiles relate to asthma phenotypes. The aim of this study was to determine allergenic sensitization profiles in…
View article: Comparison of prognostic scores according to <scp>WHO</scp> classification in 170 patients with advanced mastocytosis and C‐finding treated with midostaurin
Comparison of prognostic scores according to <span>WHO</span> classification in 170 patients with advanced mastocytosis and C‐finding treated with midostaurin Open
Advanced systemic mastocytosis (AdvSM) encompasses heterogeneous mastocytosis subtypes and is associated with poor outcomes. Although midostaurin was the first tyrosine kinase inhibitor to be approved for AdvSM patients, long‐lasting respo…
View article: Low-dose interleukin-2 in birch pollen allergy: a phase-2 randomized double-blind placebo-controlled trial
Low-dose interleukin-2 in birch pollen allergy: a phase-2 randomized double-blind placebo-controlled trial Open
s Background Regulatory T cells (Tregs) are pivotal in immune tolerance to allergens. Low-dose IL-2 (IL-2 LD ) expands and activates Tregs. We assessed IL-2 LD efficacy for controlling clinical responses to allergen exposures. Methods RHIN…
View article: Characteristics and outcomes associated with CD2 and CD25 expression on bone marrow mast cells in patients with systemic mastocytosis
Characteristics and outcomes associated with CD2 and CD25 expression on bone marrow mast cells in patients with systemic mastocytosis Open
Not available.
View article: Higher levels of basal serum tryptase are associated with sensitization, FeNO, allergic morbidity, and lower control of allergic asthma in teenagers from the PARIS birth cohort
Higher levels of basal serum tryptase are associated with sensitization, FeNO, allergic morbidity, and lower control of allergic asthma in teenagers from the PARIS birth cohort Open
Basal serum tryptase (bST) is a critical biomarker to confirm acute tryptase elevation in suspected mast cell activation like anaphylaxis and to evaluate mast cell burden in systemic mastocytosis workup. Better appraisal of genetic, physio…
View article: Chicken meat allergy in children: Complex sensitization profiles with newly described allergen candidates
Chicken meat allergy in children: Complex sensitization profiles with newly described allergen candidates Open
Chicken meat allergy (ChMA) has an estimated incidence of 0.6%–5%.1 Symptoms range from mild oral syndrome to systemic reactions. Individual sensitization profiles remain poorly understood. The objective was to exhaustively and individuall…
View article: Molecular allergen sensitization drives phenotypes of severe asthma in children: evidence from a megacity cohort (SAMP)
Molecular allergen sensitization drives phenotypes of severe asthma in children: evidence from a megacity cohort (SAMP) Open
Background : Several major sensitization profiles have been described in children with asthma, but it remains unclear how these profiles relate to asthma phenotypes. The aim of this study was to determine allergenic sensitization profiles …
View article: Case Report: A family history of peanut allergy and hereditary alpha-tryptasemia
Case Report: A family history of peanut allergy and hereditary alpha-tryptasemia Open
Context Hereditary alpha-tryptasemia (HαT) is associated with elevated basal serum tryptase (bST) and is associated with a higher risk of severe anaphylactic reactions in patients with clonal mast cell disorders or IgE-mediated Hymenoptera…
View article: Delayed inflammation decrease is associated with mortality in Tocilizumab-treated critically ill SARS-CoV-2 patients: A retrospective matched-cohort analysis
Delayed inflammation decrease is associated with mortality in Tocilizumab-treated critically ill SARS-CoV-2 patients: A retrospective matched-cohort analysis Open
Little is known about the immuno-inflammatory response to Tocilizumab and its association with outcome in critically-ill SARS-CoV2 pneumonia. In this multicenter retrospective cohort of SARS-CoV-2 patients admitted to three intensive care …
View article: <i>Capsicum</i>Allergy: Involvement of Cap a 7, a New Clinically Relevant Gibberellin-Regulated Protein Cross-Reactive With Cry j 7, the Gibberellin-Regulated Protein From Japanese Cedar Pollen
<i>Capsicum</i>Allergy: Involvement of Cap a 7, a New Clinically Relevant Gibberellin-Regulated Protein Cross-Reactive With Cry j 7, the Gibberellin-Regulated Protein From Japanese Cedar Pollen Open
The Capsicum genus belongs to the Solanaceae family. Bell or chili peppers are consumed worldwide, but allergy to Capsicum is rare. It is involved in the celery-birch-mugwort-spice syndrome and cross-reactivities were reported with latex. …
View article: Impairment of Neutrophil Functions and Homeostasis in COVID-19 Patients: Association With Disease Severity
Impairment of Neutrophil Functions and Homeostasis in COVID-19 Patients: Association With Disease Severity Open
Background Emerging data based on analyses of peripheral and pulmonary immune responses to SARS-CoV-2 increasingly suggest that a dysregulated immune response underpins the development of severe disease in COVID-19 patients. Neutrophils ar…
View article: An algorithm to safely manage oral food challenge in an office-based setting for children with multiple food allergies
An algorithm to safely manage oral food challenge in an office-based setting for children with multiple food allergies Open
Background: In France, from 30% to 35% of children suffer from multiple food allergies (MFA). The gold standard to diagnosis a food allergy is the oral food challenge (OFC) which is conducted in a hospital setting due to risk of anaphylaxi…
View article: Weak immunogenicity of SARS-CoV-2 vaccine in patients with hematologic malignancies
Weak immunogenicity of SARS-CoV-2 vaccine in patients with hematologic malignancies Open
This study evaluated the safety and immunogenicity of BNT162b2 vaccine in patients with hematological malignancies. Antibodies blocking spike binding to immobilized ACE-2 (NAb) correlated with anti-Spike (S) IgG d42 titers (Spearman r = 0.…
View article: Correction to: Elevated plasma IL-6 and CRP levels are associated with adverse clinical outcomes and death in critically ill SARS-CoV-2 patients: infammatory response of SARS-CoV-2 patients
Correction to: Elevated plasma IL-6 and CRP levels are associated with adverse clinical outcomes and death in critically ill SARS-CoV-2 patients: infammatory response of SARS-CoV-2 patients Open
An amendment to this paper has been published and can be accessed via the original article.
View article: IgG1 Subclass Restriction and Biochemical Peculiarities of Monoclonal Immunoglobulins in Scleromyxedema
IgG1 Subclass Restriction and Biochemical Peculiarities of Monoclonal Immunoglobulins in Scleromyxedema Open
Significant isotype restriction of both heavy and light chains, and peculiar biochemical properties suggest that monoclonal Ig might be involved in pathophysiological events of SME.
View article: Distinct serum anti-Aβ antibody patterns in hemorrhagic and inflammatory cerebral amyloid angiopathy manifestations
Distinct serum anti-Aβ antibody patterns in hemorrhagic and inflammatory cerebral amyloid angiopathy manifestations Open
Objective To study blood anti-Aβ antibodies in the context of spontaneous inflammatory or hemorrhagic CAA manifestations, which are similar to complications occurring after monoclonal anti-Aβ antibody immunotherapies. Methods In this case-…