Yannis Hara
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View article: Selective AMPKβ1 activation induces fetal hemoglobin in human erythroid cells and sickle cell mice via the noncanonical NRF2 pathway
Selective AMPKβ1 activation induces fetal hemoglobin in human erythroid cells and sickle cell mice via the noncanonical NRF2 pathway Open
Sickle cell disease (SCD), an inherited blood disorder caused by mutation of the β-globin gene, results in sickle-shaped erythrocytes, organ damage, and increased mortality. Current therapeutic options are limited, and innovative treatment…
View article: The <scp>IL</scp>‐4–<scp>IL</scp>‐<scp>4Rα</scp> axis modulates olfactory neuroimmune signaling to induce loss of smell
The <span>IL</span>‐4–<span>IL</span>‐<span>4Rα</span> axis modulates olfactory neuroimmune signaling to induce loss of smell Open
Background Loss of smell is a part of the diagnostic criteria for CRSwNP. Although the mechanistic understanding is poor, inhibition of IL‐4Rα and IL‐4/IL‐13 signaling improves loss of smell in CRSwNP patients. In the present study, we com…
View article: Genomic discovery and functional validation of MRP1 as a novel fetal hemoglobin modulator and potential therapeutic target in sickle cell disease
Genomic discovery and functional validation of MRP1 as a novel fetal hemoglobin modulator and potential therapeutic target in sickle cell disease Open
Sickle cell disease (SCD) remains a major health burden with limited treatment options. Despite promising gene-editing clinical trials, there is an unmet need for cost-effective therapies. As induction of fetal hemoglobin (HbF) is an estab…
View article: SGK1 inhibition induces fetal hemoglobin expression and delays polymerization in sickle erythroid cells
SGK1 inhibition induces fetal hemoglobin expression and delays polymerization in sickle erythroid cells Open
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