Yanling Wei
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View article: Single-cell RNA sequencing reveals immune cell dysfunction and rewired interaction networks in the peripheral blood of active tuberculosis patients
Single-cell RNA sequencing reveals immune cell dysfunction and rewired interaction networks in the peripheral blood of active tuberculosis patients Open
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a global health threat with poorly understood immune mechanisms. This exploratory study employed single-cell RNA sequencing (scRNA-seq) on peripheral blood mononuclear …
View article: Estradiol trajectories and early pregnancy loss: a retrospective study
Estradiol trajectories and early pregnancy loss: a retrospective study Open
Objective To investigate the association between early pregnancy estradiol (E2) trajectory patterns and the risk of early miscarriage in women with natural conception. Methods This retrospective study included 527 women aged 18–45 years wi…
View article: Nephrotoxicity of Phthalates: A Review Based on Epidemiological and Toxicological Evidence
Nephrotoxicity of Phthalates: A Review Based on Epidemiological and Toxicological Evidence Open
Phthalates are a widely used class of plasticizers known to cause various health issues. Although numerous review articles have addressed the multi-organ toxicities of Phthalates and their metabolites, a specialized review focusing on thei…
View article: Gut microbiota and metabolic signatures of anxiety in ulcerative colitis: a cross-sectional study
Gut microbiota and metabolic signatures of anxiety in ulcerative colitis: a cross-sectional study Open
Background: Patients with ulcerative colitis (UC) usually experience anxiety symptoms that seriously affect their quality of life, treatment, and prognosis. Dysbiosis of the gut microbiota plays an important role in UC and mental illness. …
View article: Inhibition of PGK1 ameliorates acute kidney injury through inactivating the PKM2/ALOX12/ferroptosis pathway in a study with male mice
Inhibition of PGK1 ameliorates acute kidney injury through inactivating the PKM2/ALOX12/ferroptosis pathway in a study with male mice Open
Despite decades of studies into the mechanisms underlying acute kidney injury (AKI), the effective clinical therapies are still limited. Here we report that the development of AKI was attenuated by conditional knockout of phosphoglycerate …
View article: PaO₂ and Mortality in Non-Cardiac Surgical ICU Patients: a Retrospective Cohort Study
PaO₂ and Mortality in Non-Cardiac Surgical ICU Patients: a Retrospective Cohort Study Open
Background Oxygen therapy is crucial for critically ill patients, but excessive oxygen can be harmful. While guidelines suggest a target oxygen saturation range of 94–98% for general critically ill patients, optimal PaO₂ levels in post-non…
View article: Role of pre-existing pathological changes in postoperative function and tendon elasticity after Achilles tendon rupture repair
Role of pre-existing pathological changes in postoperative function and tendon elasticity after Achilles tendon rupture repair Open
Aims Achilles tendon rupture is usually caused by mechanical forces and internal pathological changes, but the association of these changes with postoperative outcomes has not been well established. This study aims to explore the relations…
View article: Progesterone decline threshold in predicting early pregnancy loss: a retrospective study
Progesterone decline threshold in predicting early pregnancy loss: a retrospective study Open
Objective The single measurement of serum progesterone is considered a predictor for non-viable pregnancies. However, the dynamic change in progesterone during early pregnancy loss (EPL) remains uninvestigated. This study evaluated the ass…
View article: Outcomes of surgically treated traumatic neuromas of cutaneous nerves as complications of ankle arthroscopy: A 5-year follow-up
Outcomes of surgically treated traumatic neuromas of cutaneous nerves as complications of ankle arthroscopy: A 5-year follow-up Open
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View article: Risk factors for traumatic fracture related infection in surgically treated ankle fracture: A multicenter retrospective study
Risk factors for traumatic fracture related infection in surgically treated ankle fracture: A multicenter retrospective study Open
The risk factors of FRI were soft tissue conditions including bloody blisters and ankle dislocation, when dealing with ankle fractures. The results of this study will help surgeons to inform patients of the risk of FRI and prevent it accor…
View article: A chromosome-scale genome assembly of Giardia duodenalis by long-read sequencing of ten trophozoites
A chromosome-scale genome assembly of Giardia duodenalis by long-read sequencing of ten trophozoites Open
Giardia duodenalis, a protozoan parasite of important zoonotic concern, is estimated to cause approximately 280 million human infections annually worldwide. Currently, genome sequencing of G. duodenalis mainly relies on in vitro axenic clo…
View article: Global, regional, and national burden of varicella-zoster infections in adults aged 70 years and older from 1997 to 2021: Findings from the Global Burden of Disease Study
Global, regional, and national burden of varicella-zoster infections in adults aged 70 years and older from 1997 to 2021: Findings from the Global Burden of Disease Study Open
View article: Association between maternal smoking during pregnancy and smoking behaviors in adult offspring
Association between maternal smoking during pregnancy and smoking behaviors in adult offspring Open
Background Maternal smoking during pregnancy (MSP) is associated with offspring smoking. However, there is still scant evidence to support the association between MSP and smoking behaviors in adult offspring. Methods This is a prospective …
View article: Multi-omics assessment of gut microbiota in circadian rhythm disorders: a cross-sectional clinical study
Multi-omics assessment of gut microbiota in circadian rhythm disorders: a cross-sectional clinical study Open
Background The interaction between the host and microbiota is influenced by host circadian rhythm. However, it is unknown what the changes of gut microbiota and metabolites. Methods We conducted a cross-sectional study (n=72) in which part…
View article: Pseudomonas aeruginosa enhances anti-PD-1 efficacy in colorectal cancer by activating cytotoxic CD8+ T cells
Pseudomonas aeruginosa enhances anti-PD-1 efficacy in colorectal cancer by activating cytotoxic CD8+ T cells Open
Background Immune checkpoint therapy for colorectal cancer (CRC) has been found to be unsatisfactory for clinical treatment. Fecal microbiota transplantation (FMT) has been shown to remodel the intestinal flora, which may improve the thera…
View article: Causal association between metabolic syndrome and ovarian dysfunction: a bidirectional two-sample mendelian randomization
Causal association between metabolic syndrome and ovarian dysfunction: a bidirectional two-sample mendelian randomization Open
View article: Proton Pump Inhibitor Use, CYP2C19 genotypes, and Subsequent Incidence of Chronic Kidney Disease
Proton Pump Inhibitor Use, CYP2C19 genotypes, and Subsequent Incidence of Chronic Kidney Disease Open
Background The widespread use of proton pump inhibitors (PPIs) has generated concerns about side effects Numerous studies have suggested that PPIs use may increase the risk of kidney disease. In particular, it is unclear whether genotype o…
View article: Dimeric natural product panepocyclinol A inhibits STAT3 via di-covalent modification
Dimeric natural product panepocyclinol A inhibits STAT3 via di-covalent modification Open
View article: Correction: Association of daytime napping with incidence of chronic kidney disease and end-stage kidney disease: A prospective observational study
Correction: Association of daytime napping with incidence of chronic kidney disease and end-stage kidney disease: A prospective observational study Open
[This corrects the article DOI: 10.1371/journal.pone.0298375.].
View article: Research on the Inheritance and Innovation of Traditional Dance in College Art Education
Research on the Inheritance and Innovation of Traditional Dance in College Art Education Open
As an important part of the traditional culture of the Chinese nation, the traditional dance has a profound historical accumulation and rich cultural connotation. Integrating traditional dance into art education in colleges and universitie…
View article: Association of daytime napping with incidence of chronic kidney disease and end-stage kidney disease: A prospective observational study
Association of daytime napping with incidence of chronic kidney disease and end-stage kidney disease: A prospective observational study Open
Background and aims Few studies have examined the relationship between daytime napping and risk of kidney diseases. We aimed to investigate the association of daytime napping with the incidence of chronic kidney disease (CKD) and end-stage…
View article: Efficacy of fecal microbiota transplantation in patients with Parkinson’s disease: clinical trial results from a randomized, placebo-controlled design
Efficacy of fecal microbiota transplantation in patients with Parkinson’s disease: clinical trial results from a randomized, placebo-controlled design Open
The occurrence and development of Parkinson's disease (PD) have been demonstrated to be related to gut dysbiosis, however, the impact of fecal microbiota transplantation (FMT) on microbiota engraftment in PD patients is uncertain. We perfo…
View article: Cystatin C–based estimated glomerular filtration rate and risk of stroke in the general population: a prospective cohort study
Cystatin C–based estimated glomerular filtration rate and risk of stroke in the general population: a prospective cohort study Open
Background Previous results on the association between the estimated glomerular filtration rate (eGFR) and stroke are mixed. Most studies derived the eGFR from serum creatinine, which is affected by non-kidney determinants and thus has pos…
View article: The role of complex interactions between the intestinal flora and host in regulating intestinal homeostasis and inflammatory bowel disease
The role of complex interactions between the intestinal flora and host in regulating intestinal homeostasis and inflammatory bowel disease Open
Pharmacological treatment of inflammatory bowel disease (IBD) is inefficient and difficult to discontinue appropriately, and enterobacterial interactions are expected to provide a new target for the treatment of IBD. We collected recent st…
View article: The role of Th17 cells in inflammatory bowel disease and the research progress
The role of Th17 cells in inflammatory bowel disease and the research progress Open
Th17 cells play an important role in the abnormal immune response in inflammatory bowel disease (IBD) and are involved in the development and progression of inflammation and fibrosis. An increasing amount of data has shown that gut microbe…
View article: Air Pollutants, Genetic Susceptibility, and Incident Age-Related Macular Degeneration: A Prospective Analysis of UK Biobank Data
Air Pollutants, Genetic Susceptibility, and Incident Age-Related Macular Degeneration: A Prospective Analysis of UK Biobank Data Open
View article: Development and validation of a deep learning-based approach to predict the Mayo endoscopic score of ulcerative colitis
Development and validation of a deep learning-based approach to predict the Mayo endoscopic score of ulcerative colitis Open
Background: The ulcerative colitis (UC) Mayo endoscopy score is a useful tool for evaluating the severity of UC in patients in clinical practice. Objectives: We aimed to develop and validate a deep learning-based approach to automatically …
View article: Sensitive, Low-Background-Signal Mirna Analysis Via the Self-Priming Initiated Color Reaction Loaded on Rolling Circle Amplification Product
Sensitive, Low-Background-Signal Mirna Analysis Via the Self-Priming Initiated Color Reaction Loaded on Rolling Circle Amplification Product Open
View article: PHF3 Technique: A Pyramid Hybrid Feature Fusion Framework for Severity Classification of Ulcerative Colitis Using Endoscopic Images
PHF3 Technique: A Pyramid Hybrid Feature Fusion Framework for Severity Classification of Ulcerative Colitis Using Endoscopic Images Open
Evaluating the severity of ulcerative colitis (UC) through the Mayo endoscopic subscore (MES) is crucial for understanding patient conditions and providing effective treatment. However, UC lesions present different characteristics in endos…
View article: A Method for Improving the Prediction of Outpatient Visits for Hospital Management: Bayesian Autoregressive Analysis
A Method for Improving the Prediction of Outpatient Visits for Hospital Management: Bayesian Autoregressive Analysis Open
The number of outpatient visits is generally influenced by various factors that are difficult to quantify and obtain, resulting in some irregular fluctuations. The traditional statistical methodology seldom considers these uncertainties. A…