Yanping Bao
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View article: Development of a Bayesian Network and Information Gain-Based Axis Dynamic Mechanism for Ankle Joint Rehabilitation
Development of a Bayesian Network and Information Gain-Based Axis Dynamic Mechanism for Ankle Joint Rehabilitation Open
In response to the personalized and precise rehabilitation needs for motor injuries and stroke associated with population aging, this study proposes a design method for an intelligent rehabilitation trainer that integrates Bayesian informa…
View article: Organ-specific proteomic aging clocks predict disease and longevity across diverse populations
Organ-specific proteomic aging clocks predict disease and longevity across diverse populations Open
Aging and age-related diseases share convergent pathways at the proteome level. Here, using plasma proteomics and machine learning, we developed organismal and ten organ-specific aging clocks in the UK Biobank ( n = 43,616) and validated t…
View article: Physical, cognitive, and mental health impacts of Omicron reinfection in patients with original SARS-CoV-2 infection: a community-based observational study
Physical, cognitive, and mental health impacts of Omicron reinfection in patients with original SARS-CoV-2 infection: a community-based observational study Open
Our results suggest that reinfection may be a risk factor for long COVID conditions. These findings provide information for the clinical management and healthcare services of long COVID and SARS-CoV-2 reinfection and highlight the importan…
View article: Progress in understanding how clock genes regulate aging and associated metabolic processes
Progress in understanding how clock genes regulate aging and associated metabolic processes Open
The circadian system, primarily governed by the suprachiasmatic nucleus of the hypothalamus, consists of a central clock and peripheral clocks distributed across various body tissues. Clock genes generate a 24-h oscillatory cycle via a tra…
View article: Associations between trajectories of plasma biomarkers for Alzheimer’s disease, brain structures, and cognitive function: a prospective cohort study in the UK Biobank
Associations between trajectories of plasma biomarkers for Alzheimer’s disease, brain structures, and cognitive function: a prospective cohort study in the UK Biobank Open
Plasma amyloid-β(Aβ)42/40 ratio, glial fibrillary acidic protein (GFAP), neurofilament light (NfL), and phosphorylated tau181(p-tau181) are promising biomarkers for Alzheimer’s disease (AD)-related pathology. We aimed to explore the longit…
View article: Optimization of Thermal Stress in High-Power Semiconductor Laser Array Packaging
Optimization of Thermal Stress in High-Power Semiconductor Laser Array Packaging Open
To suppress the thermal stress in high-power semiconductor laser array packaging, the classic asymmetric heat dissipation structure of the array packaging was transformed into a symmetric one by incorporating microchannel heat sinks. This …
View article: Psychoactive substances: novel molecular insights and therapeutic potential for Alzheimer's disease
Psychoactive substances: novel molecular insights and therapeutic potential for Alzheimer's disease Open
Alzheimer's disease (AD) is a major neurodegenerative disorder that causes severe cognitive decline and poses a significant burden on global health systems. Despite extensive research, effective treatments to stop neurodegeneration or prom…
View article: TN-AutoRCA: Benchmark Construction and Agentic Framework for Self-Improving Alarm-Based Root Cause Analysis in Telecommunication Networks
TN-AutoRCA: Benchmark Construction and Agentic Framework for Self-Improving Alarm-Based Root Cause Analysis in Telecommunication Networks Open
Root Cause Analysis (RCA) in telecommunication networks is a critical task, yet it presents a formidable challenge for Artificial Intelligence (AI) due to its complex, graph-based reasoning requirements and the scarcity of realistic benchm…
View article: Viral Metagenomics of the Bharal ( <i>Pseudois nayaur</i> ) within the Qinghai-Tibet Plateau Revealed Diverse Viruses
Viral Metagenomics of the Bharal ( <i>Pseudois nayaur</i> ) within the Qinghai-Tibet Plateau Revealed Diverse Viruses Open
The Qinghai-Tibetan Plateau (QTP) provides a home to diverse flora and fauna, and its ecosystems are unique worldwide. The study focused on the bharal, an endemic species found in the QTP and adjacent regions. We applied viral metagenomics…
View article: Causal Relationship between White Matter Tracts and Psychiatric Disorders: A Mendelian Randomization Study
Causal Relationship between White Matter Tracts and Psychiatric Disorders: A Mendelian Randomization Study Open
White matter tracts (WMTs), which are responsible for information transmission in the brain, are closely associated with the onset, development, and prognosis of psychiatric disorders, yet the underlying causal mechanisms of their associat…
View article: The role of the control of “life’s essential 8” for prevention on heart failure and all-cause mortality in patients with hypertension: the Kailuan cohort study
The role of the control of “life’s essential 8” for prevention on heart failure and all-cause mortality in patients with hypertension: the Kailuan cohort study Open
Enhanced control of LE8 is significantly associated with a reduced risk of heart failure and mortality in hypertensive patients, as well as a decreased likelihood of hypertension-related heart failure or mortality.
View article: Development of a Bayesian Network-Based Parallel Mechanism for Lower Limb Gait Rehabilitation
Development of a Bayesian Network-Based Parallel Mechanism for Lower Limb Gait Rehabilitation Open
This study aims to address the clinical needs of hemiplegic and stroke patients with lower limb motor impairments, including gait abnormalities, muscle weakness, and loss of motor coordination during rehabilitation. To achieve this, it pro…
View article: Associations among sleep quality, sleep duration, and Alzheimer's disease biomarkers: A systematic review and meta‐analysis
Associations among sleep quality, sleep duration, and Alzheimer's disease biomarkers: A systematic review and meta‐analysis Open
INTRODUCTION Although sleep disturbances are widely recognized as risk factors for cognitive decline and Alzheimer's disease (AD), their influence on AD biomarkers remains unclear. This study aimed to clarify whether sleep quality or sleep…
View article: Case report: Exploring efficacy of tofacitinib in modulating interferon response in five case of anti-MDA5+ dermatomyositis with interstitial lung disease
Case report: Exploring efficacy of tofacitinib in modulating interferon response in five case of anti-MDA5+ dermatomyositis with interstitial lung disease Open
A case report highlights the challenges faced in managing a 66-year-old Chinese woman diagnosed with anti-MDA5 antibody-positive dermatomyositis (MDA5-DM) complicated by rapidly progressive interstitial lung disease (RP-ILD). Despite aggre…
View article: DISRUPTION OF IMPULSIVITY BEHAVIORS IN CANNABIS USERS IN ADOLESCENTS AND YOUNG ADULTS: A META-ANALYSIS OF FUNCTIONAL NEUROIMAGING STUDIES
DISRUPTION OF IMPULSIVITY BEHAVIORS IN CANNABIS USERS IN ADOLESCENTS AND YOUNG ADULTS: A META-ANALYSIS OF FUNCTIONAL NEUROIMAGING STUDIES Open
Background Cannabis is a widely used controlled psychoactive substance. Increased dopamine excitation transmission reduced the capacity of controlling impulsivity behaviors which contributed to their growing desire to drugs, especially tee…
View article: IMPULSIVE AND AGGRESSIVE PHENOTYPES OF METHCATHINONE ABUSERS AND RELATED GENETIC STUDY
IMPULSIVE AND AGGRESSIVE PHENOTYPES OF METHCATHINONE ABUSERS AND RELATED GENETIC STUDY Open
Background In recent years, the number and types of new psychoactive substances have increased. Methcathinone is one of the most commonly abused new psychoactive substances. Studies have shown that methcathinone can cause emotional excitem…
View article: Trajectories of general and central obesity beyond middle age in relation to late‐life cognitive decline and dementia
Trajectories of general and central obesity beyond middle age in relation to late‐life cognitive decline and dementia Open
Objective The objective was to evaluate the longitudinal patterns of central and general obesity, identify their genetic and behavioral risk determinants, and investigate the association of distinct obesity trajectories beyond middle age w…
View article: Study protocol: A national cross-sectional study on psychology and behaviour investigation of Chinese residents in 2024, PBICR
Study protocol: A national cross-sectional study on psychology and behaviour investigation of Chinese residents in 2024, PBICR Open
Introduction This study protocol specifies the primary research line and theoretical framework of the 2024 Survey of the Psychology and Behavior of the Chinese Population. It aims to establish a consistent database of Chinese residents’ ps…
View article: Gaming disorder: Neural mechanisms and ongoing debates
Gaming disorder: Neural mechanisms and ongoing debates Open
Background and aims The inclusion of gaming disorder as a new diagnosis in the 11th revision of the International Statistical Classification of Diseases (ICD-11) has caused ongoing debate. This review aimed to summarise the potential neura…
View article: Viral communities and identification of a parvovirus and two picornaviruses in geese with gout
Viral communities and identification of a parvovirus and two picornaviruses in geese with gout Open
In recent years, an emerging infectious disease characterized by urate deposition in viscera and joints has outbreak in the goose farms of China, causing substantial economic losses. Although goose astrovirus (GoAstV) was believed to be th…
View article: Evolution of Core Symptoms of Depression Disorders Among Chinese Adolescents Across Different Grades
Evolution of Core Symptoms of Depression Disorders Among Chinese Adolescents Across Different Grades Open
Background: Adolescence is a high‐risk period for depression, especially after the COVID‐19 pandemic, when adolescent depression has become increasingly severe. This study employs network analysis to identify core symptoms at various stage…
View article: Systematic review and meta-analysis of brain neuroimaging abnormalities in COVID-19 patients and survivors
Systematic review and meta-analysis of brain neuroimaging abnormalities in COVID-19 patients and survivors Open
Background Accumulating evidence indicates that COVID-19 may cause neurological complications detectable on brain imaging. Yet, the overall prevalence, modality-specific characteristics, and clinical implications of these neuroimaging abno…
View article: The Multimodal Nanomaterials of Phototherapy for Tumor Treatment
The Multimodal Nanomaterials of Phototherapy for Tumor Treatment Open
Tumor is a multiple disease in aged people, which seriously threat their physical and mental health. Photodynamic therapy (PDT) as a novel tumor treatment method has been applied in clinic. However, the limited penetration depth of the exc…